Abstract:
:Apoptosis of endothelial cells (ECs) has been suggested to play a role in atherosclerosis. We studied the synergism of hypercholesterolemia with Chlamydia pneumoniae and influenza virus infections on EC morphology and intimal changes in a minipig model. The coronary artery was excised at euthanasia (19 weeks of age) and serial sections were processed for the detection of EC apoptosis, histology, and transmission electron microscopy (TEM) studies. There was a significantly higher number of TUNEL-positive ECs in infected compared to noninfected groups [0.2942 % (interquartile ranges (IR), 0.2941; n = 26) versus 0 % (IR, 0; n = 12), p < 0.01]. Caspase-3 staining was negative. Cholesterol diet together with infections induced widening of the subendothelial space and appearance of increased numbers of foam cells. TEM revealed degenerative changes in cytoplasmic organelles and signs of EC necrosis. In conclusion, infection leads to an increase in coronary EC death and seems to exacerbate cholesterol-induced intimal thickening and foam cell accumulation.
journal_name
J Cardiovasc Transl Resjournal_title
Journal of cardiovascular translational researchauthors
Birck MM,Saraste A,Hyttel P,Odermarsky M,Liuba P,Saukko P,Hansen AK,Pesonen Edoi
10.1007/s12265-013-9463-2subject
Has Abstractpub_date
2013-08-01 00:00:00pages
579-87issue
4eissn
1937-5387issn
1937-5395journal_volume
6pub_type
杂志文章abstract::The potency of specific transcription factors as cell fate determinants was first demonstrated by the discovery of MyoD, a master gene for skeletal muscle transdifferentiation. More recently, the induction of pluripotency in somatic cells using a combination of stem cell-specific transcription factors has been reporte...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-012-9412-5
更新日期:2013-02-01 00:00:00
abstract::The clinical success of left ventricular assist devices (LVADs) has been tempered by significant hemorrhagic and thromboembolic complications. In the case of LVADs, where the biomaterial is in direct contact with the blood circulation, significant changes in systemic immunologic and thrombostatic functions have been w...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-008-9072-7
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-019-09924-y
更新日期:2020-06-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-012-9433-0
更新日期:2013-04-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 信件
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更新日期:2017-02-01 00:00:00
abstract::Thoracic aortic aneurysm (TAA) is a genetic disease predisposing to aortic dissection. It is important to identify the genetic modifiers controlling penetrance and expressivity to improve clinical prognostication. Exome sequencing was performed in 27 subjects with syndromic or familial TAA presenting with extreme phen...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
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更新日期:2017-08-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-012-9386-3
更新日期:2012-10-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-009-9116-7
更新日期:2009-09-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-008-9017-1
更新日期:2008-09-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-013-9500-1
更新日期:2013-10-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-013-9468-x
更新日期:2013-08-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-019-09936-8
更新日期:2020-08-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-010-9166-x
更新日期:2010-06-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-020-10045-0
更新日期:2020-06-15 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-019-09948-4
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-020-09989-0
更新日期:2020-06-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,多中心研究
doi:10.1007/s12265-014-9577-1
更新日期:2014-08-01 00:00:00
abstract::In this observational case-control study, circulating levels of complement factors C3a and C5a and leukotriene B4 (LTB4) were analysed in abdominal aortic aneurysm (AAA) patients regarding their association with diagnosis and prognosis. Serum C5a was significantly raised in AAA patients compared to healthy controls-me...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-020-10086-5
更新日期:2020-12-17 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
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更新日期:2013-08-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,多中心研究
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
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更新日期:2020-08-01 00:00:00
abstract::Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiomyopathy with substantial heterogeneity in phenotypic expression and clinical course. Traditionally, two-dimensional echocardiography has been the easiest and most reliable technique for establishing a diagnosis of HCM. However, cardiovascular magnetic...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-009-9136-3
更新日期:2009-12-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-007-9005-x
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-018-9812-2
更新日期:2019-04-01 00:00:00
abstract::Graphical abstract. ...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-020-10077-6
更新日期:2020-10-13 00:00:00
abstract::CD147, a member of the immunoglobulin super family, is a well-known potent inducer of extracellular matrix metalloproteinases. Studies show that CD147 is upregulated in inflammatory diseases. Atherosclerosis is a chronic inflammatory disease of the artery wall. Further understanding of the functions of CD147 in athero...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
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更新日期:2015-02-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-014-9546-8
更新日期:2014-04-01 00:00:00
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journal_title:Journal of cardiovascular translational research
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更新日期:2020-12-01 00:00:00