Abstract:
:Microvascular injury is present in a large proportion of patients with ST-elevation myocardial infarction (STEMI) despite successful revascularization. Ticagrelor potentially mitigates this process by exerting additional adenosine-mediated effects. This study aims to determine whether ticagrelor is associated with a better microvascular function compared to prasugrel as maintenance therapy after STEMI. A total of 110 patients presenting with STEMI and additional intermediate stenosis in another coronary artery will be studied after successful percutaneous coronary intervention (PCI) of the infarct-related artery. Patients will be randomized to treatment with ticagrelor or prasugrel for 1 year. FFR-guided PCI of the non-infarct-related artery will be performed at 1 month. Microvascular function will be assessed by measurement of the index of microcirculatory resistance (IMR) in the infarct-related artery and non-infarct-related artery, immediately after primary PCI and after 1 month. The REDUCE-MVI study will establish whether ticagrelor as a maintenance therapy may improve microvascular function in patients after revascularized STEMI.
journal_name
J Cardiovasc Transl Resjournal_title
Journal of cardiovascular translational researchauthors
Janssens GN,van Leeuwen MAH,van der Hoeven NW,de Waard GA,Nijveldt R,Diletti R,Zijlstra F,von Birgelen C,Escaned J,Valgimigli M,van Royen Ndoi
10.1007/s12265-016-9691-3subject
Has Abstractpub_date
2016-06-01 00:00:00pages
249-256issue
3eissn
1937-5387issn
1937-5395pii
10.1007/s12265-016-9691-3journal_volume
9pub_type
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journal_title:Journal of cardiovascular translational research
pub_type: 历史文章,杂志文章,实务指引,评审
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
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更新日期:2008-12-01 00:00:00
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journal_title:Journal of cardiovascular translational research
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