abstract：:This study aimed to analyze the relationship between cardiac autonomic modulation (CAM) and cardiovascular parameters (blood pressure and resting heart rate) in a sample of 256 adults, grouped by body mass index and sufficient moderate-to-vigorous physical activity (≥150 min/week). The sample showed different cardiova...

journal_title：Journal of cardiovascular translational research

authors： Tebar WR,Ritti-Dias RM,Mota J,Saraiva BTC,Damato TM,Delfino LD,Farah BQ,Vanderlei LCM,Christofaro DGD

更新日期：2021-01-22 00:00:00

abstract：:Acute pulmonary embolism (APE) is a common sudden venous thromboembolism with high rates of morbidity and mortality. Several studies have concluded that microRNA-134 could be a potential biomarker for APE. However, the sensitivity of these studies varies widely. This study aimed to evaluate the diagnostic value of cir...

journal_title：Journal of cardiovascular translational research

authors： Liu Y,Xie M,Gao X,Liu R

更新日期：2021-01-06 00:00:00

abstract：:In this observational case-control study, circulating levels of complement factors C3a and C5a and leukotriene B4 (LTB4) were analysed in abdominal aortic aneurysm (AAA) patients regarding their association with diagnosis and prognosis. Serum C5a was significantly raised in AAA patients compared to healthy controls-me...

journal_title：Journal of cardiovascular translational research

authors： Zagrapan B,Eilenberg W,Scheuba A,Klopf J,Brandau A,Story J,Dosch K,Hayden H,Domenig CM,Fuchs L,Schernthaner R,Ristl R,Huk I,Neumayer C,Brostjan C

更新日期：2020-12-17 00:00:00

abstract：:We compared the effects of ezetimibe/rosuvastatin 10/5 mg versus rosuvastatin 20 mg on carotid atherosclerotic plaque inflammation measured by 18FDG PET/CT. Fifty patients with acute coronary syndrome (ACS) were randomly assigned to the ezetimibe/rosuvastatin 10/5 mg and rosuvastatin 20 mg groups. The primary outcome ...

journal_title：Journal of cardiovascular translational research

authors： Oh M,Kim H,Shin EW,Sung C,Kim DH,Moon DH,Kim N,Eo JS,Kim JW,Lee CW

更新日期：2020-12-01 00:00:00

abstract：:COVID-19 is a syndrome that includes more than just isolated respiratory disease, as severe acute respiratory syndrome-coronavirus 2 (SARS-CoV2) also interacts with the cardiovascular, nervous, renal, and immune system at multiple levels, increasing morbidity in patients with underlying cardiometabolic conditions and ...

journal_title：Journal of cardiovascular translational research

authors： Fudim M,Qadri YJ,Ghadimi K,MacLeod DB,Molinger J,Piccini JP,Whittle J,Wischmeyer PE,Patel MR,Ulloa L

更新日期：2020-12-01 00:00:00

abstract：:Using unipolar atrial electrogram morphology as guidance for ablative therapy is regaining interest. Although standardly used in clinical practice during ablative therapy, the impact of filter settings on morphology of unipolar AF potentials is unknown. Thirty different filters were applied to 2,557,045 high-resolutio...

journal_title：Journal of cardiovascular translational research

authors： Starreveld R,Knops P,Roos-Serote M,Kik C,Bogers AJJC,Brundel BJJM,de Groot NMS

更新日期：2020-12-01 00:00:00

abstract：:Heart failure is a worldwide pandemic influencing 26 million individuals worldwide and is expanding. Imbalanced redox homeostasis in cardiac cells alters the structure and function of the cells, which leads to contractile dysfunction, myocardial hypertrophy, and fibrosis in chronic heart failure. Various targets and a...

journal_title：Journal of cardiovascular translational research

authors： Vashi R,Patel BM

更新日期：2020-11-25 00:00:00

abstract：:Graphical abstract. ...

journal_title：Journal of cardiovascular translational research

authors： Kapur S,Sweeney MO,Sauer W,MacRae CA

更新日期：2020-10-13 00:00:00

abstract：:This retrospective study was aimed to compare the safety and efficacy of the Direct Flow Medical (DFM) valve with the more established Sapien 3 (S3) valve in transfemoral TAVI in high-risk aortic stenosis (AS) patients. Between February 2014 and August 2016, 99 and 68 patients had the S3 and DFM valves at our center, ...

journal_title：Journal of cardiovascular translational research

authors： Gamal AS,Akleh S,Zaman A,Das R,Abushouk AI,Edwards R

更新日期：2020-10-01 00:00:00

abstract：:We conducted a meta-analysis of preclinical studies that tested left ventricular assist device (LVAD) therapy for reducing myocardial infarct size in experimental acute myocardial infarction (AMI). Twenty-six articles were included with a total of 488 experimental animal subjects. The meta-analysis showed that infarct...

journal_title：Journal of cardiovascular translational research

authors： Miyashita S,Kariya T,Yamada KP,Bikou O,Tharakan S,Kapur NK,Ishikawa K

更新日期：2020-08-28 00:00:00

abstract：:Circular RNAs (circRNAs) are single-strand covalently closed circular noncoding RNAs that are endogenous transcripts generated from linear precursor mRNA through a backsplicing mechanism. With the development of high-throughput sequencing technology, a number of circRNAs have been identified and proved to play key rol...

journal_title：Journal of cardiovascular translational research

authors： Li B,Li Y,Hu L,Liu Y,Zhou Q,Wang M,An Y,Li P

更新日期：2020-08-01 00:00:00

abstract：:Different arrhythmogenic substrates for atrial fibrillation (AF) may underlie aortic valve (AV) and mitral valve (MV) disease. We located conduction disorders during sinus rhythm by high-resolution epicardial mapping in patients undergoing AV (n = 85) or MV (n = 54) surgery. Extent and distribution of conduction delay...

journal_title：Journal of cardiovascular translational research

authors： van der Does LJME,Lanters EAH,Teuwen CP,Mouws EMJP,Yaksh A,Knops P,Kik C,Bogers AJJC,de Groot NMS

更新日期：2020-08-01 00:00:00

abstract：:Atherosclerosis is the primary cause of heart attacks, and while efforts to prevent its development or progression have historically focused largely on reducing cholesterol levels, there is now important proof-of-principle data that supports the role that inflammation plays in atherogenesis. Heat shock protein 27 (HSP...

journal_title：Journal of cardiovascular translational research

authors： Inia JA,O'Brien ER

更新日期：2020-07-13 00:00:00

abstract：:There are currently no specific treatments for cardiac fibrosis. We tested the efficacy of a neutralising anti-IL11 antibody (X203) to reduce cardiac fibrosis in two preclinical models: transverse aortic constriction (TAC) and chronic angiotensin II infusion (AngII). In the first model, male C57BL/6J mice were subject...

journal_title：Journal of cardiovascular translational research

authors： Corden B,Lim WW,Song W,Chen X,Ko NSJ,Su L,Tee NGZ,Adami E,Schafer S,Cook SA

更新日期：2020-06-26 00:00:00

abstract：:Multiple ANRIL transcriptional isoforms, such as lncANRIL and circANRIL have been identified. We sought to explore their diagnostic value in patients with coronary artery disease (CAD). First, we selected six target ANRIL isoforms and measured their expression in CAD patients and controls in the peripheral blood. Thei...

journal_title：Journal of cardiovascular translational research

authors： Fang J,Pan Z,Wang D,Lv J,Dong Y,Xu R,Jin Y,Sheng J,Yin X,Xie X,Wang X,Guo X

更新日期：2020-06-22 00:00:00

abstract：:This retrospective observational study aimed to establish the first prescription and its dispensation (primary adherence) in the first 30 days of the four pharmacotherapeutic classes recommended after a type 1 STEMI episode, determine the potential risk factors for lack of primary adherence, and evaluate the potential...

journal_title：Journal of cardiovascular translational research

authors： Padilla López A,Alós-Almiñana M,Peris JE

更新日期：2020-06-15 00:00:00

abstract：:With improved screening and the advent of many novel therapeutics, patients with cancer are living longer and often surviving their disease. Cardiovascular complications have significant impact on both short- and long-term morbidity and mortality in these patients. While a great deal of attention has been paid to card...

journal_title：Journal of cardiovascular translational research

authors： Alomar M,Fradley MG

更新日期：2020-06-01 00:00:00

abstract：:Syncope is defined as a transient loss of consciousness due to cerebral hypoperfusion, characterized by a rapid onset, short duration, and spontaneous complete recovery. It is usually a benign event, but sometimes it may represent the initial presentation of several cardiac disorders associated with sudden cardiac dea...

journal_title：Journal of cardiovascular translational research

authors： D'Ascenzi F,Zorzi A,Sciaccaluga C,Berrettini U,Mondillo S,Brignole M

更新日期：2020-06-01 00:00:00

abstract：:Chronic inflammation drives the development of atherosclerosis. Despite optimal treatment of classical cardiovascular risk factors, a substantial portion of the population has elevated inflammatory biomarkers and develops atherosclerosis-related complications, indicating that a residual inflammatory risk drives athero...

journal_title：Journal of cardiovascular translational research

authors： Bosmans LA,Bosch L,Kusters PJH,Lutgens E,Seijkens TTP

更新日期：2020-03-28 00:00:00

abstract：:Plasma ceramides (Cer), a subset of bioactive lipids, have mechanistic links to development of atherosclerosis and are related to major adverse cardiovascular events (MACEs). Previous researches have demonstrated vulnerable plaques contribute to acute cardiovascular events and poor prognosis. This study aimed to explo...

journal_title：Journal of cardiovascular translational research

authors： Pan W,Dong H,Sun R,Zhao L,Sun M,Li L,Yu X,Liu J,Wu J,Yang F,Yu B

更新日期：2020-03-24 00:00:00

abstract：:Sex differences in coronary artery disease (CAD) are well established, with women presenting with non-obstructive CAD more often than men do. However, recent evidence has identified coronary microvascular dysfunction as the underlying cause for cardiac complaints, yet sex-specific prevalence numbers are inconclusive. ...

journal_title：Journal of cardiovascular translational research

authors： Groepenhoff F,Bots SH,Kessler EL,Sickinghe AA,Eikendal ALM,Leiner T,den Ruijter HM

更新日期：2020-02-01 00:00:00

abstract：:The authors of this study protocol would like to amend it and clarify that medication adherence was assessed using the 4-item validated Morisky, Green, Levine scale [Morisky DE, Green LW, Levine DM. Concurrent and predictive validity of a self-reported measure of medication adherence. Med Care. 1986 Jan;24(1):67-74] r...

journal_title：Journal of cardiovascular translational research

authors： Raparelli V,Proietti M,Lenzi A,Basili S,EVA Collaborators.

更新日期：2020-02-01 00:00:00

abstract：:Carpal tunnel syndrome (CTS) is a common finding among patients with cardiac amyloidosis. We sought to determine the prevalence of cardiac amyloidosis in patients who had undergone CTS surgery. From 2005 to 2014, 308 patients ≥ 60 years underwent CTS surgery. Of these, 233 (76%) agreed to participate in the study and ...

journal_title：Journal of cardiovascular translational research

authors： Zegri-Reiriz I,de Haro-Del Moral FJ,Dominguez F,Salas C,de la Cuadra P,Plaza A,Krsnik I,Gonzalez-Lopez E,Garcia-Pavia P

更新日期：2019-12-01 00:00:00

abstract：:Calcific aortic valve disease (CAVD) is characterized by progressive mineralization of the aortic valve. Lipid infiltration and oxidative stress are the driving forces for the initiation and development of this disease. However, it remains unknown whether oxidized high-density lipoprotein (ox-HDL) plays a role in the ...

journal_title：Journal of cardiovascular translational research

authors： Sun JT,Chen YY,Mao JY,Wang YP,Chen YF,Hu X,Yang K,Liu Y

更新日期：2019-12-01 00:00:00

abstract：:Ligustrazine is one of the alkaloid compounds isolated from the traditional Chinese herb, which shows protective effects on cardiovascular disorders. High homocysteine (Hcy) level can predict cardiovascular-related events including death. In this study, we used Hcy to stimulate the human umbilical vein endothelial cel...

journal_title：Journal of cardiovascular translational research

authors： Fan X,Wang E,He J,Zhang L,Zeng X,Gui Y,Sun Q,Song Y,Yuan H

更新日期：2019-12-01 00:00:00

abstract：:Circulating miRNAs are increasingly suggested as clinical biomarker for diseases. We evaluated the expression of circulating cardiomyocyte-enriched miR-1 and miR-133 by real-time PCR in blood from patients with type 2 diabetes (T2D) without and with coronary artery disease (CAD) and healthy controls, investigated thei...

journal_title：Journal of cardiovascular translational research

authors： Al-Muhtaresh HA,Salem AH,Al-Kafaji G

更新日期：2019-08-01 00:00:00

abstract：:The V-LAP™ measures left atrial pressure (LAP) and enables bi-directional communications with an external unit, designed to monitor heart failure patients. We hereby describe the pre-clinical experience. Following an ex vivo phase, the system was implanted at the interatrial septum of 10 ovine subjects. LAP readouts w...

journal_title：Journal of cardiovascular translational research

authors： Perl L,Soifer E,Bartunek J,Erdheim D,Köhler F,Abraham WT,Meerkin D

更新日期：2019-08-01 00:00:00

abstract：:Non-invasive means of evaluating appropriate cardiac unloading remain to be established. We hypothesized that myocardial deformation assessed by echocardiographic speckle-tracking strain analysis can reliably estimate the degree of left ventricular (LV) unloading under mechanical circulatory support. A total of 24 Yor...

journal_title：Journal of cardiovascular translational research

authors： Hammoudi N,Watanabe S,Bikou O,Ceccaldi A,Fish K,Yamada KP,Miyashita S,Lebreton G,Hajjar RJ,Ishikawa K

更新日期：2019-04-01 00:00:00

abstract：:Extracellular vesicles (EVs) are small-sized membrane-surrounded structures released from cells into the blood, which play important roles in regulating various biological processes. However, the role of EVs in Doxorubicin (DOX)-induced cardiomyocytes senescence remains elusive. In this study, we found that human seru...

journal_title：Journal of cardiovascular translational research

authors： Liu Y,Liu Z,Xie Y,Zhao C,Xu J

更新日期：2019-02-01 00:00:00

abstract：:Previously, we found that miR-492 delayed the progression of atherosclerosis (AS) by acting as an up-stream regulator of resistin. Therefore, we hypothesized that the anti-atherogenic effects of exercise are related to miR-492-mediated downregulation of resistin and repair of endothelial injury. In this study, we inve...

journal_title：Journal of cardiovascular translational research

authors： Cai Y,Xie KL,Zheng F,Liu SX

更新日期：2018-12-01 00:00:00

abstract：:The administration of the selective β3 adrenergic receptor (β3AR) agonist BRL-37344 protects from myocardial ischemia/reperfusion injury (IRI), although the lack of clinical approval limits its translatability. We tested the cardioprotective effect of mirabegron, the first-in-class β3AR agonist approved for human use....

journal_title：Journal of cardiovascular translational research

authors： Rossello X,Piñero A,Fernández-Jiménez R,Sánchez-González J,Pizarro G,Galán-Arriola C,Lobo-Gonzalez M,Vilchez JP,García-Prieto J,García-Ruiz JM,García-Álvarez A,Sanz-Rosa D,Ibanez B

更新日期：2018-08-01 00:00:00

abstract：:It has been previously demonstrated that ticagrelor can reduce mortality compared to clopidogrel in acute coronary syndrome (ACS) patients. However, the mechanism for this mortality reduction remains uncertain. The objective of the present study is to assess the impact of chronic ticagrelor treatment on microvascular ...

journal_title：Journal of cardiovascular translational research

authors： Park K,Cho YR,Park JS,Park TH,Kim MH,Kim YD

更新日期：2018-02-01 00:00:00

abstract：:Thoracic aortic aneurysm (TAA) is a genetic disease predisposing to aortic dissection. It is important to identify the genetic modifiers controlling penetrance and expressivity to improve clinical prognostication. Exome sequencing was performed in 27 subjects with syndromic or familial TAA presenting with extreme phen...

journal_title：Journal of cardiovascular translational research

authors： Landis BJ,Schubert JA,Lai D,Jegga AG,Shikany AR,Foroud T,Ware SM,Hinton RB

更新日期：2017-08-01 00:00:00

abstract：:Hypertension plays a significant role in the development of atrial fibrillation (AF) and its complications. The coexistence of the two diseases increases the risk of thromboembolism events. Although CHADS2 and CHA2DS2-VASc scores have been used in the evaluation of the thromboembolism events in AF patients, the differ...

journal_title：Journal of cardiovascular translational research

authors： Pang H,Han B,Fu Q,Cao Q

更新日期：2017-08-01 00:00:00

abstract：:Valvular heart disease and congenital heart defects represent a major cause of death around the globe. Although current therapy strategies have rapidly evolved over the decades and are nowadays safe, effective, and applicable to many affected patients, the currently used artificial prostheses are still suboptimal. The...

journal_title：Journal of cardiovascular translational research

authors： Emmert MY,Fioretta ES,Hoerstrup SP

更新日期：2017-04-01 00:00:00

abstract：:The number of recreational/non-elite athletes participating in marathons is increasing, but data regarding impact of endurance exercise on cardiovascular health are conflicting. This study evaluated 79 recreational athletes of the 2016 Barcelona Marathon (72% men; mean age 39 ± 6 years; 71% ≥35 years). Blood samples w...

journal_title：Journal of cardiovascular translational research

authors： Roca E,Nescolarde L,Lupón J,Barallat J,Januzzi JL,Liu P,Cruz Pastor M,Bayes-Genis A

更新日期：2017-04-01 00:00:00

abstract：:A previously developed poly-L-lactide scaffold releasing granulocyte colony-stimulating factor (PLLA/GCSF) was tested in a rabbit chronic model of myocardial infarction (MI) as a ventricular patch. Control groups were constituted by healthy, chronic MI and nonfunctionalized PLLA scaffold. PLLA-based electrospun scaffo...

journal_title：Journal of cardiovascular translational research

authors： Spadaccio C,Nappi F,De Marco F,Sedati P,Taffon C,Nenna A,Crescenzi A,Chello M,Trombetta M,Gambardella I,Rainer A

更新日期：2017-02-01 00:00:00

abstract：:Recently, a new surgical technique to rescue infarcted myocardium (AGTP) has already tested (NCT01473433, AdiFLAP Trial). Here, we present the new minimally invasive AGTP (mi-AGTP) by thoracoscopy. ...

journal_title：Journal of cardiovascular translational research

authors： Gálvez-Montón C,Gastelurrutia P,Diaz-Güemes I,Sanchez-Margallo FM,Bayes-Genis A

更新日期：2017-02-01 00:00:00

abstract：:Sympathetic stimulation modulates L-type calcium channel (LTCC) gating to contribute to increased systolic heart function. Rad is a monomeric G-protein that interacts with LTCC. Genetic deletion of Rad (Rad-/-) renders LTCC in a sympathomimetic state. The study goal was to use a clinically inspired pharmacological str...

journal_title：Journal of cardiovascular translational research

authors： Levitan BM,Manning JR,Withers CN,Smith JD,Shaw RM,Andres DA,Sorrell VL,Satin J

更新日期：2016-12-01 00:00:00

abstract：:Intercellular communication mediated by exosomes, nano-sized extracellular vesicles, is crucial for preserving vascular integrity and in the development of cardiovascular and other diseases. As natural carriers of signal molecules, exosomes released from sources such as blood cells, endothelial cells, immune cells, sm...

journal_title：Journal of cardiovascular translational research

authors： Kishore R,Garikipati VNS,Gumpert A

更新日期：2016-06-01 00:00:00