Abstract:
:Oxidation-specific epitopes (OSE) within developing atherosclerotic lesions are key antigens that drive innate and adaptive immune responses in atherosclerosis, leading to chronic inflammation. Oxidized phospholipids and malondialdehyde-lysine epitopes are well-characterized OSE present in human atherosclerotic lesions, particularly in pathologically defined vulnerable plaques. Using murine and human OSE-specific antibodies as targeting agents, we have developed radionuclide and magnetic resonance based nanoparticles, containing gadolinium, manganese or lipid-coated ultrasmall superparamagnetic iron oxide, to non-invasively image OSE within experimental atherosclerotic lesions. These methods quantitate plaque burden, allow detection of lesion progression and regression, plaque stabilization, and accumulation of OSE within macrophage-rich areas of the artery wall, suggesting they detect the most active lesions. Future studies will focus on using "natural" antibodies, lipopeptides, and mimotopes for imaging applications. These approaches should enhance the clinical translation of this technique to image, monitor, evaluate efficacy of novel therapeutic agents, and guide optimal therapy of high-risk atherosclerotic lesions.
journal_name
J Cardiovasc Transl Resjournal_title
Journal of cardiovascular translational researchauthors
Briley-Saebo K,Yeang C,Witztum JL,Tsimikas Sdoi
10.1007/s12265-014-9590-4subject
Has Abstractpub_date
2014-11-01 00:00:00pages
719-36issue
8eissn
1937-5387issn
1937-5395journal_volume
7pub_type
杂志文章,评审abstract::Pediatric Cardiac Care Consortium is a registry of cardiac catheterizations, surgical operations, and autopsies performed for infants, children, and adults with congenital heart disease. Four examples of use of PCCC data to evaluate variability in morphology, management, and outcomes for the procedures are described. ...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,多中心研究
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abstract::Multiple ANRIL transcriptional isoforms, such as lncANRIL and circANRIL have been identified. We sought to explore their diagnostic value in patients with coronary artery disease (CAD). First, we selected six target ANRIL isoforms and measured their expression in CAD patients and controls in the peripheral blood. Thei...
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journal_title:Journal of cardiovascular translational research
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journal_title:Journal of cardiovascular translational research
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pub_type: 杂志文章,评审
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journal_title:Journal of cardiovascular translational research
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Journal of cardiovascular translational research
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更新日期:2018-08-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
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更新日期:2012-04-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-012-9361-z
更新日期:2012-08-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-020-10086-5
更新日期:2020-12-17 00:00:00
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journal_title:Journal of cardiovascular translational research
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pub_type: 杂志文章,评审
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journal_title:Journal of cardiovascular translational research
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journal_title:Journal of cardiovascular translational research
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journal_title:Journal of cardiovascular translational research
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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