The left ventricular outflow in hypertrophic cardiomyopathy: from structure to function.

Abstract:

:Left ventricular outflow tract obstruction (LVOTO) is one of the defining features of hypertrophic cardiomyopathy (HCM) and one of the main determinants of prognosis. Although the importance of obstruction was recognized since the original description by Teare and Brock, its exact cause and methods for its relief are still being hotly debated. We believe that a rational approach to solving these issues depends on thorough understanding of the specific structure and functions of the left ventricular outflow tract (LVOT) in health and disease. There is now compelling evidence that the LVOT performs a series of vital sophisticated functions which are mediated by the design characteristics, structure, and biological properties of its component parts and that dysregulation of one or more of these functions results in obstruction and other abnormalities. We here review the integrated functions of the LVOT, its structural and functional relationships, with particular reference to its component parts (the major players) and their role in HCM. This knowledge is essential to evolve tailored restorative techniques for treating HCM.

authors

Yacoub MH,El-Hamamsy I,Said K,Magdi G,Abul Enein F,George R,Rossi A,Olivotto I,Cecchi F

doi

10.1007/s12265-009-9153-2

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

510-7

issue

4

eissn

1937-5387

issn

1937-5395

journal_volume

2

pub_type

杂志文章,评审
  • Impact of diabetes mellitus on the clinical response to cardiac resynchronization therapy in elderly people.

    abstract::Heart failure (HF) and type 2 diabetes mellitus (T2DM) exhibit a well-established interrelationship and a growing prevalence, in particular in elderly people. Cardiac resynchronization therapy (CRT) has been shown to improve myocardial function in patients with HF and cardiac dyssynchrony. However, reports on CRT in d...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章

    doi:10.1007/s12265-014-9545-9

    authors: Sardu C,Marfella R,Santulli G

    更新日期:2014-04-01 00:00:00

  • Cell therapy for cardiovascular disease: a comparison of methods of delivery.

    abstract::The field of myocardial regeneration utilizing novel cell-based therapies, gene transfer, and growth factors may prove to play an important role in the future management of ischemic heart disease and cardiomyopathy. Phases I and II clinical trials have been published for a variety of biologics utilizing four methods o...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-010-9253-z

    authors: Dib N,Khawaja H,Varner S,McCarthy M,Campbell A

    更新日期:2011-04-01 00:00:00

  • An early study on the mechanisms that allow tissue-engineered vascular grafts to resist intimal hyperplasia.

    abstract::Intimal hyperplasia is one of the prominent failure mechanisms for arteriovenous fistulas and arteriovenous access grafts. Human tissue-engineered vascular grafts (TEVGs) were implanted as arteriovenous grafts in a novel baboon model. Ultrasound was used to monitor flow rates and vascular diameters throughout the stud...

    journal_title:Journal of cardiovascular translational research

    pub_type: 评论,杂志文章

    doi:10.1007/s12265-011-9306-y

    authors: Prichard HL,Manson RJ,DiBernardo L,Niklason LE,Lawson JH,Dahl SL

    更新日期:2011-10-01 00:00:00

  • Remote at-home detection and monitoring of functional chronotropic incompetence in heart failure patients.

    abstract::Chronotropic incompetence (CI) is common in heart failure (HF) patients and is associated with worsening outcome. Detecting and tracking functional CI during activities of daily living could provide insight into its contribution to HF symptoms and facilitate effective HF patient management. HF patients (n = 180, NYHA ...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s12265-010-9227-1

    authors: Katra RP,Chakravarthy N,Libbus I

    更新日期:2011-02-01 00:00:00

  • Correction to: Sex and Gender Differences in Ischemic Heart Disease: Endocrine Vascular Disease Approach (EVA) Study Design.

    abstract::The authors of this study protocol would like to amend it and clarify that medication adherence was assessed using the 4-item validated Morisky, Green, Levine scale [Morisky DE, Green LW, Levine DM. Concurrent and predictive validity of a self-reported measure of medication adherence. Med Care. 1986 Jan;24(1):67-74] r...

    journal_title:Journal of cardiovascular translational research

    pub_type: 已发布勘误

    doi:10.1007/s12265-019-09870-9

    authors: Raparelli V,Proietti M,Lenzi A,Basili S,EVA Collaborators.

    更新日期:2020-02-01 00:00:00

  • Haptoglobin genotype and its role in diabetic cardiovascular disease.

    abstract::Over the past decade, several longitudinal epidemiological studies have brought attention to the haptoglobin genotype and its importance in determining diabetic vascular disease risk. This manuscript presents an overview of the biology of the haptoglobin genotype and reviews the literature concerning its role in the d...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-012-9361-z

    authors: Costacou T,Levy AP

    更新日期:2012-08-01 00:00:00

  • Sex-Specific Aspects in the Pathophysiology and Imaging of Coronary Macro- and Microvascular Disease.

    abstract::Sex differences in coronary artery disease (CAD) are well established, with women presenting with non-obstructive CAD more often than men do. However, recent evidence has identified coronary microvascular dysfunction as the underlying cause for cardiac complaints, yet sex-specific prevalence numbers are inconclusive. ...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-019-09906-0

    authors: Groepenhoff F,Bots SH,Kessler EL,Sickinghe AA,Eikendal ALM,Leiner T,den Ruijter HM

    更新日期:2020-02-01 00:00:00

  • Ligustrazine Protects Homocysteine-Induced Apoptosis in Human Umbilical Vein Endothelial Cells by Modulating Mitochondrial Dysfunction.

    abstract::Ligustrazine is one of the alkaloid compounds isolated from the traditional Chinese herb, which shows protective effects on cardiovascular disorders. High homocysteine (Hcy) level can predict cardiovascular-related events including death. In this study, we used Hcy to stimulate the human umbilical vein endothelial cel...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章

    doi:10.1007/s12265-019-09900-6

    authors: Fan X,Wang E,He J,Zhang L,Zeng X,Gui Y,Sun Q,Song Y,Yuan H

    更新日期:2019-12-01 00:00:00

  • Comprehensive biomarker testing of glycemia, insulin resistance, and beta cell function has greater sensitivity to detect diabetes risk than fasting glucose and HbA1c and is associated with improved glycemic control in clinical practice.

    abstract::Blood-based biomarker testing of insulin resistance (IR) and beta cell dysfunction may identify diabetes risk earlier than current glycemia-based approaches. This retrospective cohort study assessed 1,687 US patients at risk for cardiovascular disease (CVD) under routine clinical care with a comprehensive panel of 19 ...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s12265-014-9577-1

    authors: Varvel SA,Voros S,Thiselton DL,Pottala JV,Dall T,Warnick GR,McConnell JP,Ghaedi L,Sasinowski M,Graham T

    更新日期:2014-08-01 00:00:00

  • General overview of the Seventh International Symposium on Stem Cell Therapy and Cardiovascular Innovations.

    abstract::The Seventh International Symposium on Stem Cell Therapy and Cardiovascular Innovations was held in Madrid on the 6th and 7th of May 2010. Gathering for the seventh consecutive year the most relevant researchers and opinion leaders on cardiovascular cell therapy, it has become the most important worldwide event on thi...

    journal_title:Journal of cardiovascular translational research

    pub_type:

    doi:10.1007/s12265-010-9247-x

    authors: Gutiérrez E,Sanz-Ruiz R,Alvarez EV,Villa A,Fernández L,Vázquez S,Lorenzo J,Fernández-Santos E,Sánchez PL,Fernández-Avilés F

    更新日期:2011-04-01 00:00:00

  • The CD40-CD40L Dyad as Immunotherapeutic Target in Cardiovascular Disease.

    abstract::Chronic inflammation drives the development of atherosclerosis. Despite optimal treatment of classical cardiovascular risk factors, a substantial portion of the population has elevated inflammatory biomarkers and develops atherosclerosis-related complications, indicating that a residual inflammatory risk drives athero...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-020-09994-3

    authors: Bosmans LA,Bosch L,Kusters PJH,Lutgens E,Seijkens TTP

    更新日期:2020-03-28 00:00:00

  • Nutrition as a vehicle for cardiovascular translational research.

    abstract::It is becoming increasingly evident that poor nutrition plays an important role in inducing cardiovascular disease. Just as importantly, data now support the contention that appropriate nutritional interventions may have just as important an effect in preventing or delaying the appearance of cardiovascular disease. If...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-009-9116-7

    authors: Rodriguez-Leyva D,McCullough RS,Pierce GN

    更新日期:2009-09-01 00:00:00

  • The Effects of Valvular Heart Disease on Atrial Conduction During Sinus Rhythm.

    abstract::Different arrhythmogenic substrates for atrial fibrillation (AF) may underlie aortic valve (AV) and mitral valve (MV) disease. We located conduction disorders during sinus rhythm by high-resolution epicardial mapping in patients undergoing AV (n = 85) or MV (n = 54) surgery. Extent and distribution of conduction delay...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章

    doi:10.1007/s12265-019-09936-8

    authors: van der Does LJME,Lanters EAH,Teuwen CP,Mouws EMJP,Yaksh A,Knops P,Kik C,Bogers AJJC,de Groot NMS

    更新日期:2020-08-01 00:00:00

  • Pediatric cardiac devices--an FDA pediatrician's perspective of the challenges and potential solutions.

    abstract::The advancement of pediatric medical devices is an important challenge currently facing the Food and Drug Administration and the medical community. In this manuscript, the challenges are described and possible solutions presented. ...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章

    doi:10.1007/s12265-009-9100-2

    authors: Dolcimascolo F

    更新日期:2009-06-01 00:00:00

  • Arterial stiffness in prehypertension: a possible vicious cycle.

    abstract::The pathophysiological abnormalities associated with increased arterial stiffness and/or abnormal pressure wave reflection may play crucial roles in increasing the risk of development of cardiovascular events. On the other hand, prehypertension, defined as a systolic blood pressure of 120-139 and/or a diastolic blood ...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-011-9345-4

    authors: Tomiyama H,Yamashina A

    更新日期:2012-06-01 00:00:00

  • Perspectives on the 2014 ESC/EACTS Guidelines on Myocardial Revascularization : Fifty Years of Revascularization: Where Are We and Where Are We Heading?

    abstract::The joint European Society of Cardiology and European Association of Cardio-Thoracic Surgery (ESC/EACTS) guidelines on myocardial revascularization collect and summarize the evidence regarding decision-making, diagnostics, and therapeutics in various clinical scenarios of coronary artery disease, including elective, u...

    journal_title:Journal of cardiovascular translational research

    pub_type: 历史文章,杂志文章,实务指引,评审

    doi:10.1007/s12265-015-9632-6

    authors: Costa F,Ariotti S,Valgimigli M,Kolh P,Windecker S,Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS).

    更新日期:2015-06-01 00:00:00

  • Review and Updates in Regenerative and Personalized Medicine, Preclinical Animal Models, and Clinical Care in Cardiovascular Medicine.

    abstract::The goal of this paper is to provide an updated review for scientists and clinicians on the major areas in cardiovascular medicine published in the Journal. Leading topics in regenerative and personalized medicine are presented along with a critical overview of the field. New standards in large preclinical animal mode...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-015-9657-x

    authors: Barbato E,Barton PJ,Bartunek J,Huber S,Ibanez B,Judge DP,Lara-Pezzi E,Stolen CM,Taylor A,Hall JL

    更新日期:2015-11-01 00:00:00

  • Endothelial cell death and intimal foam cell accumulation in the coronary artery of infected hypercholesterolemic minipigs.

    abstract::Apoptosis of endothelial cells (ECs) has been suggested to play a role in atherosclerosis. We studied the synergism of hypercholesterolemia with Chlamydia pneumoniae and influenza virus infections on EC morphology and intimal changes in a minipig model. The coronary artery was excised at euthanasia (19 weeks of age) a...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章

    doi:10.1007/s12265-013-9463-2

    authors: Birck MM,Saraste A,Hyttel P,Odermarsky M,Liuba P,Saukko P,Hansen AK,Pesonen E

    更新日期:2013-08-01 00:00:00

  • Innovations in the development of cardiac resynchronization therapy devices with defibrillation capability-the Boston Scientific experience.

    abstract::Cardiac resynchronization therapy (CRT) has been clinically proven to improve symptoms, exercise capacity, and quality of life and promote reduction in ventricular dimensions. When combined with a defibrillator (CRT-D), significant reductions in all-cause mortality alone and in combination with cause-specific hospital...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章

    doi:10.1007/s12265-008-9051-z

    authors: Yong P,Deperalta E

    更新日期:2008-12-01 00:00:00

  • Describing the cardiac components--attitudinally appropriate nomenclature.

    abstract::One of the first principles taught to medical students when they begin their study of human anatomy is that all structures within the body should be described as seen in the anatomical position. In this position, the subject is standing upright and facing the observer. The observer then views left-sided structures to ...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章

    doi:10.1007/s12265-012-9434-z

    authors: Anderson RH,Spicer DE,Hlavacek AJ,Hill A,Loukas M

    更新日期:2013-04-01 00:00:00

  • Efficiency of intramyocardial injections of autologous bone marrow mononuclear cells in patients with ischemic heart failure: a randomized study.

    abstract::Intramyocardial transplantation of autologous bone marrow mononuclear cells (BMMC) is believed to be a promising method for the treatment of patients with chronic ischemic heart disease. The aim of this study was to evaluate long-term results of intramyocardial bone marrow cell transplantation in patients with severe ...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s12265-009-9123-8

    authors: Pokushalov E,Romanov A,Chernyavsky A,Larionov P,Terekhov I,Artyomenko S,Poveshenko O,Kliver E,Shirokova N,Karaskov A,Dib N

    更新日期:2010-04-01 00:00:00

  • Estrogenic Impact on Cardiac Ischemic/Reperfusion Injury.

    abstract::The increase in cardiovascular disease and metabolic syndrome incidence following the onset of menopause has highlighted the role of estrogen as a cardiometabolic protective agent. Specifically regarding the heart, estrogen induced an improvement in cardiac function, preserved calcium homeostasis, and inhibited the mi...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章

    doi:10.1007/s12265-016-9675-3

    authors: Sivasinprasasn S,Shinlapawittayatorn K,Chattipakorn SC,Chattipakorn N

    更新日期:2016-02-01 00:00:00

  • Implications for Neuromodulation Therapy to Control Inflammation and Related Organ Dysfunction in COVID-19.

    abstract::COVID-19 is a syndrome that includes more than just isolated respiratory disease, as severe acute respiratory syndrome-coronavirus 2 (SARS-CoV2) also interacts with the cardiovascular, nervous, renal, and immune system at multiple levels, increasing morbidity in patients with underlying cardiometabolic conditions and ...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-020-10031-6

    authors: Fudim M,Qadri YJ,Ghadimi K,MacLeod DB,Molinger J,Piccini JP,Whittle J,Wischmeyer PE,Patel MR,Ulloa L

    更新日期:2020-12-01 00:00:00

  • Translational Challenges in Cardiovascular Tissue Engineering.

    abstract::Valvular heart disease and congenital heart defects represent a major cause of death around the globe. Although current therapy strategies have rapidly evolved over the decades and are nowadays safe, effective, and applicable to many affected patients, the currently used artificial prostheses are still suboptimal. The...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-017-9728-2

    authors: Emmert MY,Fioretta ES,Hoerstrup SP

    更新日期:2017-04-01 00:00:00

  • Targeting cyclic nucleotide phosphodiesterase in the heart: therapeutic implications.

    abstract::The second messengers, cAMP and cGMP, regulate a number of physiological processes in the myocardium, from acute contraction/relaxation to chronic gene expression and cardiac structural remodeling. Emerging evidence suggests that multiple spatiotemporally distinct pools of cyclic nucleotides can discriminate specific ...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-010-9203-9

    authors: Miller CL,Yan C

    更新日期:2010-10-01 00:00:00

  • The "missing" link between acute hemodynamic effect and clinical response.

    abstract::The hemodynamic, mechanical and electrical effects of cardiac resynchronization therapy (CRT) occur immediate and are lasting as long as CRT is delivered. Therefore, it is reasonable to assume that acute hemodynamic effects should predict long-term outcome. However, in the literature there is more evidence against tha...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-011-9331-x

    authors: Prinzen FW,Auricchio A

    更新日期:2012-04-01 00:00:00

  • Platelet function testing in patients with acute coronary syndrome.

    abstract::In patients with an acute coronary syndrome (ACS), inhibition of the platelet P2Y12 receptor is standard of care. The shortcomings of the most commonly used P2Y12 receptor inhibitor clopidogrel-that is its delayed onset of action, its interindividual response variability, and the phenomenon of high on-treatment platel...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-013-9450-7

    authors: Orban M,Sibbing D

    更新日期:2013-06-01 00:00:00

  • Mirabegron, a Clinically Approved β3 Adrenergic Receptor Agonist, Does Not Reduce Infarct Size in a Swine Model of Reperfused Myocardial Infarction.

    abstract::The administration of the selective β3 adrenergic receptor (β3AR) agonist BRL-37344 protects from myocardial ischemia/reperfusion injury (IRI), although the lack of clinical approval limits its translatability. We tested the cardioprotective effect of mirabegron, the first-in-class β3AR agonist approved for human use....

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章

    doi:10.1007/s12265-018-9819-8

    authors: Rossello X,Piñero A,Fernández-Jiménez R,Sánchez-González J,Pizarro G,Galán-Arriola C,Lobo-Gonzalez M,Vilchez JP,García-Prieto J,García-Ruiz JM,García-Álvarez A,Sanz-Rosa D,Ibanez B

    更新日期:2018-08-01 00:00:00

  • Complement Factor C5a Is Increased in Blood of Patients with Abdominal Aortic Aneurysm and Has Prognostic Potential for Aneurysm Growth.

    abstract::In this observational case-control study, circulating levels of complement factors C3a and C5a and leukotriene B4 (LTB4) were analysed in abdominal aortic aneurysm (AAA) patients regarding their association with diagnosis and prognosis. Serum C5a was significantly raised in AAA patients compared to healthy controls-me...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章

    doi:10.1007/s12265-020-10086-5

    authors: Zagrapan B,Eilenberg W,Scheuba A,Klopf J,Brandau A,Story J,Dosch K,Hayden H,Domenig CM,Fuchs L,Schernthaner R,Ristl R,Huk I,Neumayer C,Brostjan C

    更新日期:2020-12-17 00:00:00

  • How do mutations in contractile proteins cause the primary familial cardiomyopathies?

    abstract::In this article, the available evidence about the functional effects of the contractile protein mutations that cause hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) is assessed. The molecular mechanism of the contractile apparatus of cardiac muscle and its regulation by Ca(2+) and PKA phosphorylatio...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-011-9266-2

    authors: Marston SB

    更新日期:2011-06-01 00:00:00