Abstract:
:In this article, the available evidence about the functional effects of the contractile protein mutations that cause hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) is assessed. The molecular mechanism of the contractile apparatus of cardiac muscle and its regulation by Ca(2+) and PKA phosphorylation have been extensively studied. Therefore, when a number of point mutations in the contractile protein genes were found to cause the well-defined phenotypes of HCM and DCM, it was expected that the diseases could be explained at the molecular level. However, the search for a distinctive molecular phenotype did not yield rapid results. Now that a substantial number of mutations that cause HCM or DCM have been investigated in physiologically relevant systems and with a range of experimental techniques, a pattern is emerging. In the case of HCM, the hypothesis that the major effect of mutations is to increase myofibrillar Ca(2+)-sensitivity seems to be well established, but the mechanisms by which an increase in myofibrillar Ca(2+)-sensitivity induces hypertrophy remain obscure. In contrast, DCM mutations are not correlated with a specific effect on Ca(2+)-sensitivity. It has recently been proposed that DCM mutations uncouple troponin I phosphorylation from Ca(2+)-sensitivity changes, albeit based on only a few mutations so far. A plausible link between uncoupling and DCM has been proposed via blunting of the response to α-adrenergic stimulation.
journal_name
J Cardiovasc Transl Resjournal_title
Journal of cardiovascular translational researchauthors
Marston SBdoi
10.1007/s12265-011-9266-2subject
Has Abstractpub_date
2011-06-01 00:00:00pages
245-55issue
3eissn
1937-5387issn
1937-5395journal_volume
4pub_type
杂志文章,评审abstract::Ischemic heart disease (IHD) or myocardial ischemia is one of the leading causes of mortality all over the world. There is a definite need for new approaches to improve therapies and diagnostics. The pathological process leading to IHD is associated with an altered expression of genes that are important for cardiac fu...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-010-9168-8
更新日期:2010-06-01 00:00:00
abstract::Cardiovascular disease is the leading cause of death in men and women in the USA; yet, coronary artery disease (CAD) continues to be underrecognized and underdiagnosed in women. Noninvasive and invasive imaging techniques are constantly being developed in order to more accurately assess CAD. At the same time, the impa...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-013-9500-1
更新日期:2013-10-01 00:00:00
abstract::It is just over 100 years since details emerged of the anatomical arrangement of the histologically specialised cardiomyocytes responsible for initiation and propagation of the cardiac impulse. Shortly thereafter, histological criteria were established to permit their location in autopsied human hearts. These criteria...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-012-9433-0
更新日期:2013-04-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-014-9590-4
更新日期:2014-11-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-017-9754-0
更新日期:2017-08-01 00:00:00
abstract::We compared the effects of ezetimibe/rosuvastatin 10/5 mg versus rosuvastatin 20 mg on carotid atherosclerotic plaque inflammation measured by 18FDG PET/CT. Fifty patients with acute coronary syndrome (ACS) were randomly assigned to the ezetimibe/rosuvastatin 10/5 mg and rosuvastatin 20 mg groups. The primary outcome ...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s12265-020-10009-4
更新日期:2020-12-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
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更新日期:2020-07-13 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-013-9446-3
更新日期:2013-06-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-016-9718-9
更新日期:2017-02-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-013-9481-0
更新日期:2013-08-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-020-10031-6
更新日期:2020-12-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,多中心研究
doi:10.1007/s12265-009-9091-z
更新日期:2009-06-01 00:00:00
abstract::Graphical abstract. ...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-020-10077-6
更新日期:2020-10-13 00:00:00
abstract::Cardiac resynchronization therapy (CRT) has been clinically proven to improve symptoms, exercise capacity, and quality of life and promote reduction in ventricular dimensions. When combined with a defibrillator (CRT-D), significant reductions in all-cause mortality alone and in combination with cause-specific hospital...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-008-9051-z
更新日期:2008-12-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-010-9163-0
更新日期:2010-06-01 00:00:00
abstract::Over the past decade, several longitudinal epidemiological studies have brought attention to the haptoglobin genotype and its importance in determining diabetic vascular disease risk. This manuscript presents an overview of the biology of the haptoglobin genotype and reviews the literature concerning its role in the d...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-012-9361-z
更新日期:2012-08-01 00:00:00
abstract::The Seventh International Symposium on Stem Cell Therapy and Cardiovascular Innovations was held in Madrid on the 6th and 7th of May 2010. Gathering for the seventh consecutive year the most relevant researchers and opinion leaders on cardiovascular cell therapy, it has become the most important worldwide event on thi...
journal_title:Journal of cardiovascular translational research
pub_type:
doi:10.1007/s12265-010-9247-x
更新日期:2011-04-01 00:00:00
abstract::It has been previously demonstrated that ticagrelor can reduce mortality compared to clopidogrel in acute coronary syndrome (ACS) patients. However, the mechanism for this mortality reduction remains uncertain. The objective of the present study is to assess the impact of chronic ticagrelor treatment on microvascular ...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-017-9783-8
更新日期:2018-02-01 00:00:00
abstract::Blood-based biomarker testing of insulin resistance (IR) and beta cell dysfunction may identify diabetes risk earlier than current glycemia-based approaches. This retrospective cohort study assessed 1,687 US patients at risk for cardiovascular disease (CVD) under routine clinical care with a comprehensive panel of 19 ...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,多中心研究
doi:10.1007/s12265-014-9577-1
更新日期:2014-08-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 历史文章,杂志文章,实务指引,评审
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更新日期:2015-06-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
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更新日期:2012-04-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-012-9434-z
更新日期:2013-04-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-015-9629-1
更新日期:2015-07-01 00:00:00
abstract::Apoptosis of endothelial cells (ECs) has been suggested to play a role in atherosclerosis. We studied the synergism of hypercholesterolemia with Chlamydia pneumoniae and influenza virus infections on EC morphology and intimal changes in a minipig model. The coronary artery was excised at euthanasia (19 weeks of age) a...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-013-9463-2
更新日期:2013-08-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-020-10086-5
更新日期:2020-12-17 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-011-9345-4
更新日期:2012-06-01 00:00:00
abstract::Circulating miRNAs are increasingly suggested as clinical biomarker for diseases. We evaluated the expression of circulating cardiomyocyte-enriched miR-1 and miR-133 by real-time PCR in blood from patients with type 2 diabetes (T2D) without and with coronary artery disease (CAD) and healthy controls, investigated thei...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-018-9857-2
更新日期:2019-08-01 00:00:00
abstract::The authors of this study protocol would like to amend it and clarify that medication adherence was assessed using the 4-item validated Morisky, Green, Levine scale [Morisky DE, Green LW, Levine DM. Concurrent and predictive validity of a self-reported measure of medication adherence. Med Care. 1986 Jan;24(1):67-74] r...
journal_title:Journal of cardiovascular translational research
pub_type: 已发布勘误
doi:10.1007/s12265-019-09870-9
更新日期:2020-02-01 00:00:00
abstract::Fibroblasts play a major role in normal cardiac physiology and in the response of the heart to injury and disease. Cardiac electrophysiological research has primarily focused on the mechanisms of remodeling that accompany cardiac disease with an emphasis on myocyte electrophysiology. Recently, there has been increasin...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-012-9408-1
更新日期:2012-12-01 00:00:00
abstract::Sex differences in coronary artery disease (CAD) are well established, with women presenting with non-obstructive CAD more often than men do. However, recent evidence has identified coronary microvascular dysfunction as the underlying cause for cardiac complaints, yet sex-specific prevalence numbers are inconclusive. ...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-019-09906-0
更新日期:2020-02-01 00:00:00