Abstract：
:Increases in oxidative stress in the heart play an important role in mediating hypertrophy, apoptosis, fibrosis, mitochondrial dysfunction, and the consequent development of heart failure. Although it has been widely believed that electron leakage from the mitochondrial electron transport chain is the primary source of oxidative stress in the failing heart, increasing lines of evidence suggest that enzymes which produce reactive oxygen species may also contribute to it. NADPH oxidases are transmembrane enzymes dedicated to producing superoxide (O(2)(-)) by transferring an electron from NAD(P)H to molecular oxygen. Nox4 is a major NADPH oxidase isoform expressed in the heart. Nox4 is localized primarily at mitochondria in cardiac myocytes, and upregulation of Nox4 hypertrophic stimuli enhances O(2)(-) production, apoptosis, and mitochondrial dysfunction, thereby playing an important role in mediating cardiac dysfunction. Since Nox4 could be a key molecule mediating oxidative stress and pathological hypertrophy, it may serve as an important target of heart failure treatment. In this review, the importance of NADPH oxidases as sources of increased oxidative stress in the failing heart and the role of Nox4 in mediating growth and death of cardiac myocytes are discussed.
journal_name
J Cardiovasc Transl Resjournal_title
Journal of cardiovascular translational researchauthors
Kuroda J,Sadoshima Jdoi
10.1007/s12265-010-9184-8subject
Has Abstractpub_date
2010-08-01 00:00:00pages
314-20issue
4eissn
1937-5387issn
1937-5395journal_volume
3pub_type
杂志文章,评审abstract：:Biomarkers of blood lipid modification and oxidative stress have been associated with increased cardiovascular morbidity. We sought to determine whether these biomarkers were related to functional indices of stenosis severity among patients with stable coronary artery disease. We studied 197 consecutive patients with ...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-013-9468-x
更新日期：2013-08-01 00:00:00
abstract：:Cardiac cell therapy has emerged as a controversial yet promising therapeutic strategy. Both experimental data and clinical applications in this field have shown modest but tangible benefits on cardiac structure and function and underscore that transplanted stem-progenitor cells can attenuate the postinfarct microenvi...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
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更新日期：2010-12-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
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更新日期：2020-12-17 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-018-9812-2
更新日期：2019-04-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,随机对照试验
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更新日期：2010-04-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
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更新日期：2020-06-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-018-9856-3
更新日期：2019-08-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-008-9017-1
更新日期：2008-09-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 评论,杂志文章
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更新日期：2011-10-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
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更新日期：2010-06-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-009-9100-2
更新日期：2009-06-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-011-9345-4
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
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更新日期：2014-04-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type：
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更新日期：2011-04-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 历史文章,杂志文章,实务指引,评审
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更新日期：2015-06-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-013-9500-1
更新日期：2013-10-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-013-9450-7
更新日期：2013-06-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-011-9266-2
更新日期：2011-06-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
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更新日期：2020-08-28 00:00:00
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journal_title：Journal of cardiovascular translational research
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pub_type： 杂志文章,评审
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journal_title：Journal of cardiovascular translational research
pub_type： 信件
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更新日期：2017-02-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
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更新日期：2016-06-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
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更新日期：2020-06-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
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更新日期：2016-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2013-08-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
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pub_type： 杂志文章,多中心研究
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