An early study on the mechanisms that allow tissue-engineered vascular grafts to resist intimal hyperplasia.

Abstract:

:Intimal hyperplasia is one of the prominent failure mechanisms for arteriovenous fistulas and arteriovenous access grafts. Human tissue-engineered vascular grafts (TEVGs) were implanted as arteriovenous grafts in a novel baboon model. Ultrasound was used to monitor flow rates and vascular diameters throughout the study. Intimal hyperplasia in the outflow vein of TEVGs was assessed at the anastomosis and at juxta-anastomotic regions via histological analysis, and was compared to intimal hyperplasia with polytetrafluoroethylene (PTFE) grafts in the baboon model and in literature reports from other animal models. Less venous intimal hyperplasia was observed in histological sections with arteriovenous TEVGs than with arteriovenous PTFE grafts. TEVGs were associated with a mild, noninflammatory intimal hyperplasia. The extent of intimal tissue that formed with TEVG placement correlated with the rate of blood flow through tissue engineered vascular grafts at 2 weeks postimplant. Outflow vein dilatation was observed with increased flow rate. Both mid-graft flow rates and outflow vein diameters reached a plateau by week 4, which suggested that venous remodeling and intimal hyperplasia largely occurred within the first 4 weeks of implant in the baboon model. Given their compliant and noninflammatory nature, TEVGs appear resistant to triggers for venous intimal hyperplasia that are common for PTFE arteriovenous grafts, including (1) abundant proinflammatory macrophage populations that are associated with PTFE grafts and (2) compliance mismatch between PTFE grafts and the outflow vein. Our findings suggest that arteriovenous TEVGs develop only a mild form of venous intimal hyperplasia, which results from the typical hemodynamic changes that are associated with arteriovenous settings.

authors

Prichard HL,Manson RJ,DiBernardo L,Niklason LE,Lawson JH,Dahl SL

doi

10.1007/s12265-011-9306-y

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

674-82

issue

5

eissn

1937-5387

issn

1937-5395

journal_volume

4

pub_type

评论,杂志文章
  • General overview of the Seventh International Symposium on Stem Cell Therapy and Cardiovascular Innovations.

    abstract::The Seventh International Symposium on Stem Cell Therapy and Cardiovascular Innovations was held in Madrid on the 6th and 7th of May 2010. Gathering for the seventh consecutive year the most relevant researchers and opinion leaders on cardiovascular cell therapy, it has become the most important worldwide event on thi...

    journal_title:Journal of cardiovascular translational research

    pub_type:

    doi:10.1007/s12265-010-9247-x

    authors: Gutiérrez E,Sanz-Ruiz R,Alvarez EV,Villa A,Fernández L,Vázquez S,Lorenzo J,Fernández-Santos E,Sánchez PL,Fernández-Avilés F

    更新日期:2011-04-01 00:00:00

  • Predictive Value of Circulating microRNA-134 Levels for Early Diagnosis of Acute Pulmonary Embolism: Meta-analysis.

    abstract::Acute pulmonary embolism (APE) is a common sudden venous thromboembolism with high rates of morbidity and mortality. Several studies have concluded that microRNA-134 could be a potential biomarker for APE. However, the sensitivity of these studies varies widely. This study aimed to evaluate the diagnostic value of cir...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-020-10087-4

    authors: Liu Y,Xie M,Gao X,Liu R

    更新日期:2021-01-06 00:00:00

  • Targeting cyclic nucleotide phosphodiesterase in the heart: therapeutic implications.

    abstract::The second messengers, cAMP and cGMP, regulate a number of physiological processes in the myocardium, from acute contraction/relaxation to chronic gene expression and cardiac structural remodeling. Emerging evidence suggests that multiple spatiotemporally distinct pools of cyclic nucleotides can discriminate specific ...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-010-9203-9

    authors: Miller CL,Yan C

    更新日期:2010-10-01 00:00:00

  • Regulation of mammalian microRNA expression.

    abstract::MicroRNAs are widely expressed, approximately 22-nucleotide-long non-protein-coding RNAs. They are first transcribed as much longer primary transcripts, which then undergo a series of processing steps to yield the single-stranded, mature microRNAs. Like other classes of RNAs in a cell, the biogenesis of microRNAs is u...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-010-9166-x

    authors: Zhang X,Zeng Y

    更新日期:2010-06-01 00:00:00

  • Remote at-home detection and monitoring of functional chronotropic incompetence in heart failure patients.

    abstract::Chronotropic incompetence (CI) is common in heart failure (HF) patients and is associated with worsening outcome. Detecting and tracking functional CI during activities of daily living could provide insight into its contribution to HF symptoms and facilitate effective HF patient management. HF patients (n = 180, NYHA ...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s12265-010-9227-1

    authors: Katra RP,Chakravarthy N,Libbus I

    更新日期:2011-02-01 00:00:00

  • The biological basis of thrombosis and bleeding in patients with ventricular assist devices.

    abstract::The clinical success of left ventricular assist devices (LVADs) has been tempered by significant hemorrhagic and thromboembolic complications. In the case of LVADs, where the biomaterial is in direct contact with the blood circulation, significant changes in systemic immunologic and thrombostatic functions have been w...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-008-9072-7

    authors: John R,Lee S

    更新日期:2009-03-01 00:00:00

  • The Dynamics of Cardiovascular Biomarkers in non-Elite Marathon Runners.

    abstract::The number of recreational/non-elite athletes participating in marathons is increasing, but data regarding impact of endurance exercise on cardiovascular health are conflicting. This study evaluated 79 recreational athletes of the 2016 Barcelona Marathon (72% men; mean age 39 ± 6 years; 71% ≥35 years). Blood samples w...

    journal_title:Journal of cardiovascular translational research

    pub_type: 信件

    doi:10.1007/s12265-017-9744-2

    authors: Roca E,Nescolarde L,Lupón J,Barallat J,Januzzi JL,Liu P,Cruz Pastor M,Bayes-Genis A

    更新日期:2017-04-01 00:00:00

  • The baroreceptor as a therapeutic target for heart failure.

    abstract::Sympathoactivation is a prominent feature of heart failure (HF). Its role in cardiac remodeling and arrhythmogenesis is well-recognized today, although incomplete understanding of autonomic mechanisms was a barrier to development of contemporary medical therapies. Despite widespread availability of drugs and devices, ...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-014-9546-8

    authors: Gronda E,Lovett EG,Tarascio M,Georgakopoulos D,Grassi G,Vanoli E

    更新日期:2014-04-01 00:00:00

  • Estrogenic Impact on Cardiac Ischemic/Reperfusion Injury.

    abstract::The increase in cardiovascular disease and metabolic syndrome incidence following the onset of menopause has highlighted the role of estrogen as a cardiometabolic protective agent. Specifically regarding the heart, estrogen induced an improvement in cardiac function, preserved calcium homeostasis, and inhibited the mi...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章

    doi:10.1007/s12265-016-9675-3

    authors: Sivasinprasasn S,Shinlapawittayatorn K,Chattipakorn SC,Chattipakorn N

    更新日期:2016-02-01 00:00:00

  • Perspectives on the 2014 ESC/EACTS Guidelines on Myocardial Revascularization : Fifty Years of Revascularization: Where Are We and Where Are We Heading?

    abstract::The joint European Society of Cardiology and European Association of Cardio-Thoracic Surgery (ESC/EACTS) guidelines on myocardial revascularization collect and summarize the evidence regarding decision-making, diagnostics, and therapeutics in various clinical scenarios of coronary artery disease, including elective, u...

    journal_title:Journal of cardiovascular translational research

    pub_type: 历史文章,杂志文章,实务指引,评审

    doi:10.1007/s12265-015-9632-6

    authors: Costa F,Ariotti S,Valgimigli M,Kolh P,Windecker S,Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS).

    更新日期:2015-06-01 00:00:00

  • Haptoglobin genotype and its role in diabetic cardiovascular disease.

    abstract::Over the past decade, several longitudinal epidemiological studies have brought attention to the haptoglobin genotype and its importance in determining diabetic vascular disease risk. This manuscript presents an overview of the biology of the haptoglobin genotype and reviews the literature concerning its role in the d...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-012-9361-z

    authors: Costacou T,Levy AP

    更新日期:2012-08-01 00:00:00

  • Genomic DNA pooling strategy for next-generation sequencing-based rare variant discovery in abdominal aortic aneurysm regions of interest-challenges and limitations.

    abstract::The costs and efforts for sample preparation of hundreds of individuals, their genomic enrichment for regions of interest, and sufficient deep sequencing bring a significant burden to next-generation sequencing-based experiments. We investigated whether pooling of samples at the level of genomic DNA would be a more ve...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s12265-011-9263-5

    authors: Harakalova M,Nijman IJ,Medic J,Mokry M,Renkens I,Blankensteijn JD,Kloosterman W,Baas AF,Cuppen E

    更新日期:2011-06-01 00:00:00

  • Innovations in the development of cardiac resynchronization therapy devices with defibrillation capability-the Boston Scientific experience.

    abstract::Cardiac resynchronization therapy (CRT) has been clinically proven to improve symptoms, exercise capacity, and quality of life and promote reduction in ventricular dimensions. When combined with a defibrillator (CRT-D), significant reductions in all-cause mortality alone and in combination with cause-specific hospital...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章

    doi:10.1007/s12265-008-9051-z

    authors: Yong P,Deperalta E

    更新日期:2008-12-01 00:00:00

  • Exome Sequencing Identifies Candidate Genetic Modifiers of Syndromic and Familial Thoracic Aortic Aneurysm Severity.

    abstract::Thoracic aortic aneurysm (TAA) is a genetic disease predisposing to aortic dissection. It is important to identify the genetic modifiers controlling penetrance and expressivity to improve clinical prognostication. Exome sequencing was performed in 27 subjects with syndromic or familial TAA presenting with extreme phen...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章

    doi:10.1007/s12265-017-9753-1

    authors: Landis BJ,Schubert JA,Lai D,Jegga AG,Shikany AR,Foroud T,Ware SM,Hinton RB

    更新日期:2017-08-01 00:00:00

  • NADPH oxidase and cardiac failure.

    abstract::Increases in oxidative stress in the heart play an important role in mediating hypertrophy, apoptosis, fibrosis, mitochondrial dysfunction, and the consequent development of heart failure. Although it has been widely believed that electron leakage from the mitochondrial electron transport chain is the primary source o...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-010-9184-8

    authors: Kuroda J,Sadoshima J

    更新日期:2010-08-01 00:00:00

  • Function of CD147 in atherosclerosis and atherothrombosis.

    abstract::CD147, a member of the immunoglobulin super family, is a well-known potent inducer of extracellular matrix metalloproteinases. Studies show that CD147 is upregulated in inflammatory diseases. Atherosclerosis is a chronic inflammatory disease of the artery wall. Further understanding of the functions of CD147 in athero...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-015-9608-6

    authors: Wang C,Jin R,Zhu X,Yan J,Li G

    更新日期:2015-02-01 00:00:00

  • Comparison of High-Dose Rosuvastatin Versus Low-Dose Rosuvastatin Plus Ezetimibe on Carotid Atherosclerotic Plaque Inflammation in Patients with Acute Coronary Syndrome.

    abstract::We compared the effects of ezetimibe/rosuvastatin 10/5 mg versus rosuvastatin 20 mg on carotid atherosclerotic plaque inflammation measured by 18FDG PET/CT. Fifty patients with acute coronary syndrome (ACS) were randomly assigned to the ezetimibe/rosuvastatin 10/5 mg and rosuvastatin 20 mg groups. The primary outcome ...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1007/s12265-020-10009-4

    authors: Oh M,Kim H,Shin EW,Sung C,Kim DH,Moon DH,Kim N,Eo JS,Kim JW,Lee CW

    更新日期:2020-12-01 00:00:00

  • The origin and arrhythmogenic potential of fibroblasts in cardiac disease.

    abstract::Fibroblasts play a major role in normal cardiac physiology and in the response of the heart to injury and disease. Cardiac electrophysiological research has primarily focused on the mechanisms of remodeling that accompany cardiac disease with an emphasis on myocyte electrophysiology. Recently, there has been increasin...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-012-9408-1

    authors: Vasquez C,Morley GE

    更新日期:2012-12-01 00:00:00

  • Complement Factor C5a Is Increased in Blood of Patients with Abdominal Aortic Aneurysm and Has Prognostic Potential for Aneurysm Growth.

    abstract::In this observational case-control study, circulating levels of complement factors C3a and C5a and leukotriene B4 (LTB4) were analysed in abdominal aortic aneurysm (AAA) patients regarding their association with diagnosis and prognosis. Serum C5a was significantly raised in AAA patients compared to healthy controls-me...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章

    doi:10.1007/s12265-020-10086-5

    authors: Zagrapan B,Eilenberg W,Scheuba A,Klopf J,Brandau A,Story J,Dosch K,Hayden H,Domenig CM,Fuchs L,Schernthaner R,Ristl R,Huk I,Neumayer C,Brostjan C

    更新日期:2020-12-17 00:00:00

  • Impact of balloon inflation pressure on cell viability with single and multi lumen catheters.

    abstract::Infusion catheters, when used in combination with balloons, are subjected to pressure created by inflation of the balloon. The compression can reduce the catheter flow area and cause elevated shear stresses in the fluid. A model and experiments were developed with a range of applied balloon pressures to investigate wh...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章

    doi:10.1007/s12265-014-9595-z

    authors: Dib N,Schwalbach DB,Plourde BD,Kohler RE,Dana D,Abraham JP

    更新日期:2014-12-01 00:00:00

  • Tiny Shuttles for Information Transfer: Exosomes in Cardiac Health and Disease.

    abstract::Intercellular communication mediated by exosomes, nano-sized extracellular vesicles, is crucial for preserving vascular integrity and in the development of cardiovascular and other diseases. As natural carriers of signal molecules, exosomes released from sources such as blood cells, endothelial cells, immune cells, sm...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-016-9682-4

    authors: Kishore R,Garikipati VNS,Gumpert A

    更新日期:2016-06-01 00:00:00

  • The "missing" link between acute hemodynamic effect and clinical response.

    abstract::The hemodynamic, mechanical and electrical effects of cardiac resynchronization therapy (CRT) occur immediate and are lasting as long as CRT is delivered. Therefore, it is reasonable to assume that acute hemodynamic effects should predict long-term outcome. However, in the literature there is more evidence against tha...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-011-9331-x

    authors: Prinzen FW,Auricchio A

    更新日期:2012-04-01 00:00:00

  • Maternal and neonatal exposure to environmental tobacco smoke targets pro-inflammatory genes in neonatal arteries.

    abstract::Maternal mainstream tobacco smoking is known to have adverse outcomes on fetal respiratory function; however, no data is currently available on the effects of passive exposure to tobacco smoking and environmental tobacco smoke (ETS) on fetal systemic arterial structure and function. Eight pregnant rhesus macaque monke...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章

    doi:10.1007/s12265-010-9226-2

    authors: Villablanca AC,Pinkerton KE,Rutledge JC

    更新日期:2010-12-01 00:00:00

  • How do mutations in contractile proteins cause the primary familial cardiomyopathies?

    abstract::In this article, the available evidence about the functional effects of the contractile protein mutations that cause hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) is assessed. The molecular mechanism of the contractile apparatus of cardiac muscle and its regulation by Ca(2+) and PKA phosphorylatio...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-011-9266-2

    authors: Marston SB

    更新日期:2011-06-01 00:00:00

  • Serum Extracellular Vesicles Retard H9C2 Cell Senescence by Suppressing miR-34a Expression.

    abstract::Extracellular vesicles (EVs) are small-sized membrane-surrounded structures released from cells into the blood, which play important roles in regulating various biological processes. However, the role of EVs in Doxorubicin (DOX)-induced cardiomyocytes senescence remains elusive. In this study, we found that human seru...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章

    doi:10.1007/s12265-018-9847-4

    authors: Liu Y,Liu Z,Xie Y,Zhao C,Xu J

    更新日期:2019-02-01 00:00:00

  • Pediatric Cardiac Care Consortium: an instrument for evidence-based clinical decision support.

    abstract::Pediatric Cardiac Care Consortium is a registry of cardiac catheterizations, surgical operations, and autopsies performed for infants, children, and adults with congenital heart disease. Four examples of use of PCCC data to evaluate variability in morphology, management, and outcomes for the procedures are described. ...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s12265-009-9091-z

    authors: Pyles LA,Hills CM,Larson VE,Moller JH

    更新日期:2009-06-01 00:00:00

  • Non-invasive Thoracic Impedance Changes in COVID-19 Pulmonary Infection.

    abstract::Graphical abstract. ...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章

    doi:10.1007/s12265-020-10077-6

    authors: Kapur S,Sweeney MO,Sauer W,MacRae CA

    更新日期:2020-10-13 00:00:00

  • Getting to the heart of tissue engineering.

    abstract::Cardiovascular disease affects 80 million people in the USA and is the leading cause of death. Significant limitations of current treatments necessitate the development of novel strategies. Cardiovascular tissue engineering is an emerging field focused on the development of biological substitutes to restore, maintain,...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-007-9005-x

    authors: Khait L,Hecker L,Blan NR,Coyan G,Migneco F,Huang YC,Birla RK

    更新日期:2008-03-01 00:00:00

  • Emerging MRI methods in translational cardiovascular research.

    abstract::Cardiac magnetic resonance imaging (CMR) has become a reference standard modality for imaging of left ventricular (LV) structure and function and, using late gadolinium enhancement, for imaging myocardial infarction. Emerging CMR techniques enable a more comprehensive examination of the heart, making CMR an excellent ...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审

    doi:10.1007/s12265-011-9275-1

    authors: Vandsburger MH,Epstein FH

    更新日期:2011-08-01 00:00:00

  • Aerobic Exercise Prevents Insulin Resistance Through the Regulation of miR-492/Resistin Axis in Aortic Endothelium.

    abstract::Previously, we found that miR-492 delayed the progression of atherosclerosis (AS) by acting as an up-stream regulator of resistin. Therefore, we hypothesized that the anti-atherogenic effects of exercise are related to miR-492-mediated downregulation of resistin and repair of endothelial injury. In this study, we inve...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章

    doi:10.1007/s12265-018-9828-7

    authors: Cai Y,Xie KL,Zheng F,Liu SX

    更新日期:2018-12-01 00:00:00