Abstract：
:The V-LAP™ measures left atrial pressure (LAP) and enables bi-directional communications with an external unit, designed to monitor heart failure patients. We hereby describe the pre-clinical experience. Following an ex vivo phase, the system was implanted at the interatrial septum of 10 ovine subjects. LAP readouts were compared with pulmonary capillary wedge pressure (PCWP) at index procedure and 1, 2 and 3-6 months after the implantation, at rest and after volume loading. Histopathology assessment (n = 8) was performed up to 50 weeks post procedure. Procedural success was 100%. Measurements showed a mean difference of 0.19 ± 2.51 mmHg. During this period, correlation of V-LAP™ with PCWP was excellent (R2 = 0.95, for 119 total measurements). There were no major adverse events related to the V-LAP™ system. In an animal model, the implantation of the novel wireless left atrial pressure sensor V-LAP™ was feasible, safe, and showed good accuracy and precision.
journal_name
J Cardiovasc Transl Resjournal_title
Journal of cardiovascular translational researchauthors
Perl L,Soifer E,Bartunek J,Erdheim D,Köhler F,Abraham WT,Meerkin Ddoi
10.1007/s12265-018-9856-3subject
Has Abstractpub_date
2019-08-01 00:00:00pages
290-298issue
4eissn
1937-5387issn
1937-5395pii
10.1007/s12265-018-9856-3journal_volume
12pub_type
杂志文章abstract：:Heart failure is a worldwide pandemic influencing 26 million individuals worldwide and is expanding. Imbalanced redox homeostasis in cardiac cells alters the structure and function of the cells, which leads to contractile dysfunction, myocardial hypertrophy, and fibrosis in chronic heart failure. Various targets and a...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
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journal_title：Journal of cardiovascular translational research
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
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journal_title：Journal of cardiovascular translational research
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
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journal_title：Journal of cardiovascular translational research
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journal_title：Journal of cardiovascular translational research
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journal_title：Journal of cardiovascular translational research
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journal_title：Journal of cardiovascular translational research
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journal_title：Journal of cardiovascular translational research
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journal_title：Journal of cardiovascular translational research
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journal_title：Journal of cardiovascular translational research
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journal_title：Journal of cardiovascular translational research
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journal_title：Journal of cardiovascular translational research
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
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abstract：:It has been previously demonstrated that ticagrelor can reduce mortality compared to clopidogrel in acute coronary syndrome (ACS) patients. However, the mechanism for this mortality reduction remains uncertain. The objective of the present study is to assess the impact of chronic ticagrelor treatment on microvascular ...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
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