Abstract:
:The implantation of ventricular assist devices (VADs) is a valuable option in patients with end-stage heart failure. The number of VAD implantations is growing worldwide. Between July 1987 and July 2010, we implanted 1,598 VADs in 1,455 patients. The majority were male (81.0%), and their mean age was 49.4 years (range 0.3-82 years). Indications for implantation were: cardiomyopathy (n = 1,074), post-cardiotomy heart failure (n = 282), acute myocardial infarction (n = 83), graft failure after heart transplantation (n = 64), and others (n = 61). In 55.5%, the VAD implanted was left ventricular, in 39.5% biventricular, and in 4.8% right ventricular. Until 1995, the implanted pumps were mostly pulsatile. Today, however, more than 95% of the implanted VADs are continuous-flow rotary pumps. The average support time was 148.6 days (range 0-1,836 days). The percentage of biventricular VADs has dropped over the years to 20% in 2009. Three hundred forty-seven patients could be successfully bridged to heart transplantation. In 122 patients (8.3%), the device could be explanted after myocardial recovery. In 2009, 31.4% of the patients were implanted for permanent support. During the study period, 521 patients could be discharged home or to a rehabilitation center. Implantation of ventricular assist devices is now an established treatment for patients with both acute and chronic end-stage heart failure. Small implantable left ventricular assist devices of the second and third generation are now broadly employed worldwide, with growing acceptance and decreasing complications. The percentage of biventricular support has dropped over the years to 20%.
journal_name
J Cardiovasc Transl Resjournal_title
Journal of cardiovascular translational researchauthors
Krabatsch T,Schweiger M,Stepanenko A,Kukucka M,Vierecke J,Lehmkuhl HB,Huebler M,Hennig E,Potapov E,Hetzer Rdoi
10.1007/s12265-011-9268-0subject
Has Abstractpub_date
2011-06-01 00:00:00pages
332-9issue
3eissn
1937-5387issn
1937-5395journal_volume
4pub_type
杂志文章abstract::Proper atrioventricular canal (AVC) patterning and subsequent valvulogenesis is a complex process, and defects can result in disease or early death. The zebrafish Danio rerio has become a useful model system for studying AVC development, and much progress has been made in dissecting out the critical steps. Here, we re...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,多中心研究
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journal_title:Journal of cardiovascular translational research
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journal_title:Journal of cardiovascular translational research
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journal_title:Journal of cardiovascular translational research
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
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journal_title:Journal of cardiovascular translational research
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journal_title:Journal of cardiovascular translational research
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,评审
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Journal of cardiovascular translational research
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pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章
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