Abstract:
:Graphical abstract.
journal_name
J Cardiovasc Transl Resjournal_title
Journal of cardiovascular translational researchauthors
Kapur S,Sweeney MO,Sauer W,MacRae CAdoi
10.1007/s12265-020-10077-6subject
Has Abstractpub_date
2020-10-13 00:00:00eissn
1937-5387issn
1937-5395pii
10.1007/s12265-020-10077-6pub_type
杂志文章abstract::Cardiac cell therapy has emerged as a controversial yet promising therapeutic strategy. Both experimental data and clinical applications in this field have shown modest but tangible benefits on cardiac structure and function and underscore that transplanted stem-progenitor cells can attenuate the postinfarct microenvi...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-010-9198-2
更新日期:2010-12-01 00:00:00
abstract::Apoptosis of endothelial cells (ECs) has been suggested to play a role in atherosclerosis. We studied the synergism of hypercholesterolemia with Chlamydia pneumoniae and influenza virus infections on EC morphology and intimal changes in a minipig model. The coronary artery was excised at euthanasia (19 weeks of age) a...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-013-9463-2
更新日期:2013-08-01 00:00:00
abstract::Both Type 1 and Type 2 diabetes can lead to debilitating microvascular complications such as retinopathy, nephropathy and neuropathy, as well as macrovascular complications such as cardiovascular diseases including atherosclerosis and hypertension. Diabetic complications have been attributed to several contributing fa...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-012-9368-5
更新日期:2012-08-01 00:00:00
abstract::Syncope is defined as a transient loss of consciousness due to cerebral hypoperfusion, characterized by a rapid onset, short duration, and spontaneous complete recovery. It is usually a benign event, but sometimes it may represent the initial presentation of several cardiac disorders associated with sudden cardiac dea...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-020-09989-0
更新日期:2020-06-01 00:00:00
abstract::It is just over 100 years since details emerged of the anatomical arrangement of the histologically specialised cardiomyocytes responsible for initiation and propagation of the cardiac impulse. Shortly thereafter, histological criteria were established to permit their location in autopsied human hearts. These criteria...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-012-9433-0
更新日期:2013-04-01 00:00:00
abstract::Infusion catheters, when used in combination with balloons, are subjected to pressure created by inflation of the balloon. The compression can reduce the catheter flow area and cause elevated shear stresses in the fluid. A model and experiments were developed with a range of applied balloon pressures to investigate wh...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-014-9595-z
更新日期:2014-12-01 00:00:00
abstract::The implantation of ventricular assist devices (VADs) is a valuable option in patients with end-stage heart failure. The number of VAD implantations is growing worldwide. Between July 1987 and July 2010, we implanted 1,598 VADs in 1,455 patients. The majority were male (81.0%), and their mean age was 49.4 years (range...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-011-9268-0
更新日期:2011-06-01 00:00:00
abstract::It has been previously demonstrated that ticagrelor can reduce mortality compared to clopidogrel in acute coronary syndrome (ACS) patients. However, the mechanism for this mortality reduction remains uncertain. The objective of the present study is to assess the impact of chronic ticagrelor treatment on microvascular ...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-017-9783-8
更新日期:2018-02-01 00:00:00
abstract::This study aimed to analyze the relationship between cardiac autonomic modulation (CAM) and cardiovascular parameters (blood pressure and resting heart rate) in a sample of 256 adults, grouped by body mass index and sufficient moderate-to-vigorous physical activity (≥150 min/week). The sample showed different cardiova...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-021-10101-3
更新日期:2021-01-22 00:00:00
abstract::Vascular smooth muscle cells (VSMCs) exhibit remarkable plasticity during postnatal development. Vascular injury initiates and perpetuates VSMCs dedifferentiation to a synthetic phenotype, which has been increasingly recognized to play a central role in neointimal hyperplasia during the pathogenesis of vascular prolif...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-010-9163-0
更新日期:2010-06-01 00:00:00
abstract::Atherosclerosis is the primary cause of heart attacks, and while efforts to prevent its development or progression have historically focused largely on reducing cholesterol levels, there is now important proof-of-principle data that supports the role that inflammation plays in atherogenesis. Heat shock protein 27 (HSP...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-020-10000-z
更新日期:2020-07-13 00:00:00
abstract::Variability of response to clopidogrel and prasugrel is a multifactorial process, with clinical consequences, and drug-drug interactions have been proposed as potential factors. Biological modulation of clopidogrel response has been demonstrated for atorvastatin and omeprazole. However, investigations assessing clinic...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-012-9442-z
更新日期:2013-06-01 00:00:00
abstract::The pathophysiological abnormalities associated with increased arterial stiffness and/or abnormal pressure wave reflection may play crucial roles in increasing the risk of development of cardiovascular events. On the other hand, prehypertension, defined as a systolic blood pressure of 120-139 and/or a diastolic blood ...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-011-9345-4
更新日期:2012-06-01 00:00:00
abstract::Carpal tunnel syndrome (CTS) is a common finding among patients with cardiac amyloidosis. We sought to determine the prevalence of cardiac amyloidosis in patients who had undergone CTS surgery. From 2005 to 2014, 308 patients ≥ 60 years underwent CTS surgery. Of these, 233 (76%) agreed to participate in the study and ...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-019-09895-0
更新日期:2019-12-01 00:00:00
abstract::Plasma ceramides (Cer), a subset of bioactive lipids, have mechanistic links to development of atherosclerosis and are related to major adverse cardiovascular events (MACEs). Previous researches have demonstrated vulnerable plaques contribute to acute cardiovascular events and poor prognosis. This study aimed to explo...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-020-09978-3
更新日期:2020-03-24 00:00:00
abstract::Although most cardiac cell therapy trials have focused on patients with acute myocardial infarction, attempts at "regenerating" chronically failing hearts have also been performed. These studies have entailed use of skeletal myoblasts and bone marrow-derived cells. In the case of skeletal myoblasts, the randomized pla...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-008-9017-1
更新日期:2008-09-01 00:00:00
abstract::Intimal hyperplasia is one of the prominent failure mechanisms for arteriovenous fistulas and arteriovenous access grafts. Human tissue-engineered vascular grafts (TEVGs) were implanted as arteriovenous grafts in a novel baboon model. Ultrasound was used to monitor flow rates and vascular diameters throughout the stud...
journal_title:Journal of cardiovascular translational research
pub_type: 评论,杂志文章
doi:10.1007/s12265-011-9306-y
更新日期:2011-10-01 00:00:00
abstract::Cardiac resynchronization therapy (CRT) has been clinically proven to improve symptoms, exercise capacity, and quality of life and promote reduction in ventricular dimensions. When combined with a defibrillator (CRT-D), significant reductions in all-cause mortality alone and in combination with cause-specific hospital...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-008-9051-z
更新日期:2008-12-01 00:00:00
abstract::Cardiac rehabilitation (CR) following myocardial infarction is vastly underused. As such, the aim of this study was to test a digital health intervention (DHI) as an adjunct to CR. Patients undergoing standard Mayo Clinic CR were recruited prior to CR (n = 25) or after 3 months CR (n = 17). Changes in risk factors and...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-015-9629-1
更新日期:2015-07-01 00:00:00
abstract::Previously, we found that miR-492 delayed the progression of atherosclerosis (AS) by acting as an up-stream regulator of resistin. Therefore, we hypothesized that the anti-atherogenic effects of exercise are related to miR-492-mediated downregulation of resistin and repair of endothelial injury. In this study, we inve...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-018-9828-7
更新日期:2018-12-01 00:00:00
abstract::Despite important roles in mammalian gene regulation, the critical targeting mechanism of DNA methylation for specific DNA sequences remains unclear. Recently, small non-coding RNAs were reported to be essential for DNA methylation in plants as well as in mice, suggesting that small non-coding RNAs might interact with...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-010-9167-9
更新日期:2010-06-01 00:00:00
abstract::Recently, a new surgical technique to rescue infarcted myocardium (AGTP) has already tested (NCT01473433, AdiFLAP Trial). Here, we present the new minimally invasive AGTP (mi-AGTP) by thoracoscopy. ...
journal_title:Journal of cardiovascular translational research
pub_type: 信件
doi:10.1007/s12265-016-9721-1
更新日期:2017-02-01 00:00:00
abstract::The hemodynamic, mechanical and electrical effects of cardiac resynchronization therapy (CRT) occur immediate and are lasting as long as CRT is delivered. Therefore, it is reasonable to assume that acute hemodynamic effects should predict long-term outcome. However, in the literature there is more evidence against tha...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-011-9331-x
更新日期:2012-04-01 00:00:00
abstract::A previously developed poly-L-lactide scaffold releasing granulocyte colony-stimulating factor (PLLA/GCSF) was tested in a rabbit chronic model of myocardial infarction (MI) as a ventricular patch. Control groups were constituted by healthy, chronic MI and nonfunctionalized PLLA scaffold. PLLA-based electrospun scaffo...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-016-9718-9
更新日期:2017-02-01 00:00:00
abstract::Non-invasive means of evaluating appropriate cardiac unloading remain to be established. We hypothesized that myocardial deformation assessed by echocardiographic speckle-tracking strain analysis can reliably estimate the degree of left ventricular (LV) unloading under mechanical circulatory support. A total of 24 Yor...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-018-9812-2
更新日期:2019-04-01 00:00:00
abstract::Over the past decade, several longitudinal epidemiological studies have brought attention to the haptoglobin genotype and its importance in determining diabetic vascular disease risk. This manuscript presents an overview of the biology of the haptoglobin genotype and reviews the literature concerning its role in the d...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-012-9361-z
更新日期:2012-08-01 00:00:00
abstract::This manuscript reviews the studies performed with ALX-0081 (INN: caplacizumab), a Nanobody targeting von Willebrand factor, in the context of current antithrombotic therapy in coronary artery disease. ALX-0081 specifically inhibits platelet adhesion to the vessel wall, and may control platelet aggregation and subsequ...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-012-9435-y
更新日期:2013-06-01 00:00:00
abstract::Diseases of the electrical conduction system that lead to irregularities in cardiac rhythm can have morbid and often lethal clinical outcomes. Linkage analysis has been the principal tool used to discover the genetic mutations responsible for Mendelian arrhythmic disease. Although the majority of arrhythmias can be ac...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-008-9030-4
更新日期:2008-06-01 00:00:00
abstract::Calcific aortic valve disease (CAVD) is characterized by progressive mineralization of the aortic valve. Lipid infiltration and oxidative stress are the driving forces for the initiation and development of this disease. However, it remains unknown whether oxidized high-density lipoprotein (ox-HDL) plays a role in the ...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-019-09903-3
更新日期:2019-12-01 00:00:00
abstract::Reperfusion injury may offset the optimal salvage of myocardium achieved during primary coronary angioplasty. Thus, coronary reperfusion must be combined with cardioprotective adjunctive therapies in order to optimize myocardial salvage and minimize infarct size. Forty-three patients with their first ST-elevation myoc...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s12265-010-9252-0
更新日期:2011-02-01 00:00:00