Abstract：
:Chronotropic incompetence (CI) is common in heart failure (HF) patients and is associated with worsening outcome. Detecting and tracking functional CI during activities of daily living could provide insight into its contribution to HF symptoms and facilitate effective HF patient management. HF patients (n = 180, NYHA Class III/IV, ejection fraction (EF) ≤40%) were enrolled in a multi-center prospective monitoring study and had an external multi-sensor system applied to the chest and replaced weekly during a 90-day study. Medical information was collected at baseline and study close. Heart rate, respiration, activity, and body fluid data from the system were transmitted at regular intervals and used for offline analysis. Patients were primarily male (70%), with 61 ± 13 years mean age, 25 ± 5 kg/m(2) BMI, and 28 ± 7% EF. By correlating age-adjusted activity level and heart rate adaptation with a proprietary algorithm, functional CI was detected in 45% and ruled out in 29% of patients under conditions of daily living. In the remaining patients (26%), functional CI assessment was indeterminate due to insufficient age-adjusted activity level. Functional CI and No-CI groups were not significantly different in terms of baseline demographics, characteristics or HF outcome over the study period. β-blocker use was 16% in the CI group and 82% in the no-CI group (p < 0.001), and therefore, could not explain the manifestation of functional CI. This proof-of-concept study suggests that a chronotropic response that may be functionally debilitating during activities of daily living in HF patients can be detected and tracked in a point-of-care telemonitoring approach using a non-invasive, adherent device.
journal_name
J Cardiovasc Transl Resjournal_title
Journal of cardiovascular translational researchauthors
Katra RP,Chakravarthy N,Libbus Idoi
10.1007/s12265-010-9227-1subject
Has Abstractpub_date
2011-02-01 00:00:00pages
14-20issue
1eissn
1937-5387issn
1937-5395journal_volume
4pub_type
杂志文章,多中心研究abstract：:Graphical abstract. ...
journal_title：Journal of cardiovascular translational research
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abstract：:Diseases of the electrical conduction system that lead to irregularities in cardiac rhythm can have morbid and often lethal clinical outcomes. Linkage analysis has been the principal tool used to discover the genetic mutations responsible for Mendelian arrhythmic disease. Although the majority of arrhythmias can be ac...
journal_title：Journal of cardiovascular translational research
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-010-9253-z
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
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journal_title：Journal of cardiovascular translational research
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
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更新日期：2009-12-01 00:00:00
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journal_title：Journal of cardiovascular translational research
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,随机对照试验
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更新日期：2010-04-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s12265-020-10009-4
更新日期：2020-12-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-020-09978-3
更新日期：2020-03-24 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
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更新日期：2012-12-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-008-9051-z
更新日期：2008-12-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-019-09903-3
更新日期：2019-12-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
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journal_title：Journal of cardiovascular translational research
pub_type： 评论,杂志文章
doi：10.1007/s12265-011-9306-y
更新日期：2011-10-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-017-9753-1
更新日期：2017-08-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-020-10031-6
更新日期：2020-12-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
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journal_title：Journal of cardiovascular translational research
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doi：10.1007/s12265-020-10054-z
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
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更新日期：2011-12-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
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更新日期：2013-06-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
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journal_title：Journal of cardiovascular translational research
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journal_title：Journal of cardiovascular translational research
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更新日期：2020-08-01 00:00:00
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更新日期：2018-12-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
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更新日期：2012-10-01 00:00:00
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