Synergistic effect between lipoprotein lipase and apolipoprotein C3 genes in determining the severity of coronary artery disease.

abstract：:Reperfusion injury may offset the optimal salvage of myocardium achieved during primary coronary angioplasty. Thus, coronary reperfusion must be combined with cardioprotective adjunctive therapies in order to optimize myocardial salvage and minimize infarct size. Forty-three patients with their first ST-elevation myoc...

journal_title：Journal of cardiovascular translational research

authors： Garcia S,Henry TD,Wang YL,Chavez IJ,Pedersen WR,Lesser JR,Shroff GR,Moore L,Traverse JH

更新日期：2011-02-01 00:00:00

abstract：:Cardiac magnetic resonance imaging (CMR) has become a reference standard modality for imaging of left ventricular (LV) structure and function and, using late gadolinium enhancement, for imaging myocardial infarction. Emerging CMR techniques enable a more comprehensive examination of the heart, making CMR an excellent ...

journal_title：Journal of cardiovascular translational research

authors： Vandsburger MH,Epstein FH

更新日期：2011-08-01 00:00:00

abstract：:Cardiac resynchronization therapy (CRT) has been clinically proven to improve symptoms, exercise capacity, and quality of life and promote reduction in ventricular dimensions. When combined with a defibrillator (CRT-D), significant reductions in all-cause mortality alone and in combination with cause-specific hospital...

journal_title：Journal of cardiovascular translational research

authors： Yong P,Deperalta E

更新日期：2008-12-01 00:00:00

abstract：:The clinical success of left ventricular assist devices (LVADs) has been tempered by significant hemorrhagic and thromboembolic complications. In the case of LVADs, where the biomaterial is in direct contact with the blood circulation, significant changes in systemic immunologic and thrombostatic functions have been w...

journal_title：Journal of cardiovascular translational research

authors： John R,Lee S

更新日期：2009-03-01 00:00:00

abstract：:The potency of specific transcription factors as cell fate determinants was first demonstrated by the discovery of MyoD, a master gene for skeletal muscle transdifferentiation. More recently, the induction of pluripotency in somatic cells using a combination of stem cell-specific transcription factors has been reporte...

journal_title：Journal of cardiovascular translational research

authors： Inagawa K,Ieda M

更新日期：2013-02-01 00:00:00

abstract：:Plasma ceramides (Cer), a subset of bioactive lipids, have mechanistic links to development of atherosclerosis and are related to major adverse cardiovascular events (MACEs). Previous researches have demonstrated vulnerable plaques contribute to acute cardiovascular events and poor prognosis. This study aimed to explo...

journal_title：Journal of cardiovascular translational research

authors： Pan W,Dong H,Sun R,Zhao L,Sun M,Li L,Yu X,Liu J,Wu J,Yang F,Yu B

更新日期：2020-03-24 00:00:00

abstract：:The pathophysiological abnormalities associated with increased arterial stiffness and/or abnormal pressure wave reflection may play crucial roles in increasing the risk of development of cardiovascular events. On the other hand, prehypertension, defined as a systolic blood pressure of 120-139 and/or a diastolic blood ...

journal_title：Journal of cardiovascular translational research

authors： Tomiyama H,Yamashina A

更新日期：2012-06-01 00:00:00

abstract：:The goal of this paper is to provide an updated review for scientists and clinicians on the major areas in cardiovascular medicine published in the Journal. Leading topics in regenerative and personalized medicine are presented along with a critical overview of the field. New standards in large preclinical animal mode...

journal_title：Journal of cardiovascular translational research

authors： Barbato E,Barton PJ,Bartunek J,Huber S,Ibanez B,Judge DP,Lara-Pezzi E,Stolen CM,Taylor A,Hall JL

更新日期：2015-11-01 00:00:00

abstract：:Increases in oxidative stress in the heart play an important role in mediating hypertrophy, apoptosis, fibrosis, mitochondrial dysfunction, and the consequent development of heart failure. Although it has been widely believed that electron leakage from the mitochondrial electron transport chain is the primary source o...

journal_title：Journal of cardiovascular translational research

authors： Kuroda J,Sadoshima J

更新日期：2010-08-01 00:00:00

abstract：:Diseases of the electrical conduction system that lead to irregularities in cardiac rhythm can have morbid and often lethal clinical outcomes. Linkage analysis has been the principal tool used to discover the genetic mutations responsible for Mendelian arrhythmic disease. Although the majority of arrhythmias can be ac...

journal_title：Journal of cardiovascular translational research

authors： Perez MV,Wheeler M,Ho M,Pavlovic A,Wang P,Ashley EA

更新日期：2008-06-01 00:00:00

abstract：:Pediatric Cardiac Care Consortium is a registry of cardiac catheterizations, surgical operations, and autopsies performed for infants, children, and adults with congenital heart disease. Four examples of use of PCCC data to evaluate variability in morphology, management, and outcomes for the procedures are described. ...

journal_title：Journal of cardiovascular translational research

authors： Pyles LA,Hills CM,Larson VE,Moller JH

更新日期：2009-06-01 00:00:00

abstract：:In patients with an acute coronary syndrome (ACS), inhibition of the platelet P2Y12 receptor is standard of care. The shortcomings of the most commonly used P2Y12 receptor inhibitor clopidogrel-that is its delayed onset of action, its interindividual response variability, and the phenomenon of high on-treatment platel...

journal_title：Journal of cardiovascular translational research

authors： Orban M,Sibbing D

更新日期：2013-06-01 00:00:00

abstract：:Intimal hyperplasia is one of the prominent failure mechanisms for arteriovenous fistulas and arteriovenous access grafts. Human tissue-engineered vascular grafts (TEVGs) were implanted as arteriovenous grafts in a novel baboon model. Ultrasound was used to monitor flow rates and vascular diameters throughout the stud...

journal_title：Journal of cardiovascular translational research

authors： Prichard HL,Manson RJ,DiBernardo L,Niklason LE,Lawson JH,Dahl SL

更新日期：2011-10-01 00:00:00

abstract：:Despite important roles in mammalian gene regulation, the critical targeting mechanism of DNA methylation for specific DNA sequences remains unclear. Recently, small non-coding RNAs were reported to be essential for DNA methylation in plants as well as in mice, suggesting that small non-coding RNAs might interact with...

journal_title：Journal of cardiovascular translational research

authors： Park CW,Zeng Y,Steer CJ

更新日期：2010-06-01 00:00:00

abstract：:Chronotropic incompetence (CI) is common in heart failure (HF) patients and is associated with worsening outcome. Detecting and tracking functional CI during activities of daily living could provide insight into its contribution to HF symptoms and facilitate effective HF patient management. HF patients (n = 180, NYHA ...

journal_title：Journal of cardiovascular translational research

authors： Katra RP,Chakravarthy N,Libbus I

更新日期：2011-02-01 00:00:00

abstract：:The field of myocardial regeneration utilizing novel cell-based therapies, gene transfer, and growth factors may prove to play an important role in the future management of ischemic heart disease and cardiomyopathy. Phases I and II clinical trials have been published for a variety of biologics utilizing four methods o...

journal_title：Journal of cardiovascular translational research

authors： Dib N,Khawaja H,Varner S,McCarthy M,Campbell A

更新日期：2011-04-01 00:00:00

abstract：:Cardiac cell therapy has emerged as a controversial yet promising therapeutic strategy. Both experimental data and clinical applications in this field have shown modest but tangible benefits on cardiac structure and function and underscore that transplanted stem-progenitor cells can attenuate the postinfarct microenvi...

journal_title：Journal of cardiovascular translational research

authors： Maltais S,Tremblay JP,Perrault LP,Ly HQ

更新日期：2010-12-01 00:00:00

abstract：:Heart failure is a worldwide pandemic influencing 26 million individuals worldwide and is expanding. Imbalanced redox homeostasis in cardiac cells alters the structure and function of the cells, which leads to contractile dysfunction, myocardial hypertrophy, and fibrosis in chronic heart failure. Various targets and a...

journal_title：Journal of cardiovascular translational research

authors： Vashi R,Patel BM

更新日期：2020-11-25 00:00:00

abstract：:The joint European Society of Cardiology and European Association of Cardio-Thoracic Surgery (ESC/EACTS) guidelines on myocardial revascularization collect and summarize the evidence regarding decision-making, diagnostics, and therapeutics in various clinical scenarios of coronary artery disease, including elective, u...

journal_title：Journal of cardiovascular translational research

authors： Costa F,Ariotti S,Valgimigli M,Kolh P,Windecker S,Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS).

更新日期：2015-06-01 00:00:00

abstract：:It has been previously demonstrated that ticagrelor can reduce mortality compared to clopidogrel in acute coronary syndrome (ACS) patients. However, the mechanism for this mortality reduction remains uncertain. The objective of the present study is to assess the impact of chronic ticagrelor treatment on microvascular ...

journal_title：Journal of cardiovascular translational research

authors： Park K,Cho YR,Park JS,Park TH,Kim MH,Kim YD

更新日期：2018-02-01 00:00:00

abstract：:Hypertension plays a significant role in the development of atrial fibrillation (AF) and its complications. The coexistence of the two diseases increases the risk of thromboembolism events. Although CHADS2 and CHA2DS2-VASc scores have been used in the evaluation of the thromboembolism events in AF patients, the differ...

journal_title：Journal of cardiovascular translational research

authors： Pang H,Han B,Fu Q,Cao Q

更新日期：2017-08-01 00:00:00

abstract：:Ligustrazine is one of the alkaloid compounds isolated from the traditional Chinese herb, which shows protective effects on cardiovascular disorders. High homocysteine (Hcy) level can predict cardiovascular-related events including death. In this study, we used Hcy to stimulate the human umbilical vein endothelial cel...

journal_title：Journal of cardiovascular translational research

authors： Fan X,Wang E,He J,Zhang L,Zeng X,Gui Y,Sun Q,Song Y,Yuan H

更新日期：2019-12-01 00:00:00

abstract：:Proper atrioventricular canal (AVC) patterning and subsequent valvulogenesis is a complex process, and defects can result in disease or early death. The zebrafish Danio rerio has become a useful model system for studying AVC development, and much progress has been made in dissecting out the critical steps. Here, we re...

journal_title：Journal of cardiovascular translational research

authors： Peal DS,Lynch SN,Milan DJ

更新日期：2011-12-01 00:00:00

abstract：:Circulating miRNAs are increasingly suggested as clinical biomarker for diseases. We evaluated the expression of circulating cardiomyocyte-enriched miR-1 and miR-133 by real-time PCR in blood from patients with type 2 diabetes (T2D) without and with coronary artery disease (CAD) and healthy controls, investigated thei...

journal_title：Journal of cardiovascular translational research

authors： Al-Muhtaresh HA,Salem AH,Al-Kafaji G

更新日期：2019-08-01 00:00:00

abstract：:This retrospective study was aimed to compare the safety and efficacy of the Direct Flow Medical (DFM) valve with the more established Sapien 3 (S3) valve in transfemoral TAVI in high-risk aortic stenosis (AS) patients. Between February 2014 and August 2016, 99 and 68 patients had the S3 and DFM valves at our center, ...

journal_title：Journal of cardiovascular translational research

authors： Gamal AS,Akleh S,Zaman A,Das R,Abushouk AI,Edwards R

更新日期：2020-10-01 00:00:00

abstract：:Circular RNAs (circRNAs) are single-strand covalently closed circular noncoding RNAs that are endogenous transcripts generated from linear precursor mRNA through a backsplicing mechanism. With the development of high-throughput sequencing technology, a number of circRNAs have been identified and proved to play key rol...

journal_title：Journal of cardiovascular translational research

authors： Li B,Li Y,Hu L,Liu Y,Zhou Q,Wang M,An Y,Li P

更新日期：2020-08-01 00:00:00

abstract：:Syncope is defined as a transient loss of consciousness due to cerebral hypoperfusion, characterized by a rapid onset, short duration, and spontaneous complete recovery. It is usually a benign event, but sometimes it may represent the initial presentation of several cardiac disorders associated with sudden cardiac dea...

journal_title：Journal of cardiovascular translational research

authors： D'Ascenzi F,Zorzi A,Sciaccaluga C,Berrettini U,Mondillo S,Brignole M

更新日期：2020-06-01 00:00:00

abstract：:Left ventricular outflow tract obstruction (LVOTO) is one of the defining features of hypertrophic cardiomyopathy (HCM) and one of the main determinants of prognosis. Although the importance of obstruction was recognized since the original description by Teare and Brock, its exact cause and methods for its relief are ...

journal_title：Journal of cardiovascular translational research

authors： Yacoub MH,El-Hamamsy I,Said K,Magdi G,Abul Enein F,George R,Rossi A,Olivotto I,Cecchi F

更新日期：2009-12-01 00:00:00

abstract：:Non-invasive means of evaluating appropriate cardiac unloading remain to be established. We hypothesized that myocardial deformation assessed by echocardiographic speckle-tracking strain analysis can reliably estimate the degree of left ventricular (LV) unloading under mechanical circulatory support. A total of 24 Yor...

journal_title：Journal of cardiovascular translational research

authors： Hammoudi N,Watanabe S,Bikou O,Ceccaldi A,Fish K,Yamada KP,Miyashita S,Lebreton G,Hajjar RJ,Ishikawa K

更新日期：2019-04-01 00:00:00

abstract：:There are currently no specific treatments for cardiac fibrosis. We tested the efficacy of a neutralising anti-IL11 antibody (X203) to reduce cardiac fibrosis in two preclinical models: transverse aortic constriction (TAC) and chronic angiotensin II infusion (AngII). In the first model, male C57BL/6J mice were subject...

journal_title：Journal of cardiovascular translational research

authors： Corden B,Lim WW,Song W,Chen X,Ko NSJ,Su L,Tee NGZ,Adami E,Schafer S,Cook SA

更新日期：2020-06-26 00:00:00