Abstract:
:Thoracic aortic aneurysm (TAA) is a genetic disease predisposing to aortic dissection. It is important to identify the genetic modifiers controlling penetrance and expressivity to improve clinical prognostication. Exome sequencing was performed in 27 subjects with syndromic or familial TAA presenting with extreme phenotypes (15 with severe TAA; 12 with mild or absent TAA). Family-based analysis of a subset of the cohort identified variants, genes, and pathways segregating with TAA severity among three families. A rare missense variant in ADCK4 (p.Arg63Trp) segregated with mild TAA in each family. Genes and pathways identified in families were further investigated in the entire cohort using the optimal unified sequence kernel association test, finding significance for the gene COL15A1 (p = 0.025) and the retina homeostasis pathway (p = 0.035). Thus, we identified candidate genetic modifiers of TAA severity by exome-based study of extreme phenotypes, which may lead to improved risk stratification and development of new medical therapies.
journal_name
J Cardiovasc Transl Resjournal_title
Journal of cardiovascular translational researchauthors
Landis BJ,Schubert JA,Lai D,Jegga AG,Shikany AR,Foroud T,Ware SM,Hinton RBdoi
10.1007/s12265-017-9753-1subject
Has Abstractpub_date
2017-08-01 00:00:00pages
423-432issue
4eissn
1937-5387issn
1937-5395pii
10.1007/s12265-017-9753-1journal_volume
10pub_type
杂志文章abstract::The V-LAP™ measures left atrial pressure (LAP) and enables bi-directional communications with an external unit, designed to monitor heart failure patients. We hereby describe the pre-clinical experience. Following an ex vivo phase, the system was implanted at the interatrial septum of 10 ovine subjects. LAP readouts w...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-018-9856-3
更新日期:2019-08-01 00:00:00
abstract::Chronic inflammation drives the development of atherosclerosis. Despite optimal treatment of classical cardiovascular risk factors, a substantial portion of the population has elevated inflammatory biomarkers and develops atherosclerosis-related complications, indicating that a residual inflammatory risk drives athero...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-020-09994-3
更新日期:2020-03-28 00:00:00
abstract::Despite important roles in mammalian gene regulation, the critical targeting mechanism of DNA methylation for specific DNA sequences remains unclear. Recently, small non-coding RNAs were reported to be essential for DNA methylation in plants as well as in mice, suggesting that small non-coding RNAs might interact with...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-010-9167-9
更新日期:2010-06-01 00:00:00
abstract::Hypertension plays a significant role in the development of atrial fibrillation (AF) and its complications. The coexistence of the two diseases increases the risk of thromboembolism events. Although CHADS2 and CHA2DS2-VASc scores have been used in the evaluation of the thromboembolism events in AF patients, the differ...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-017-9754-0
更新日期:2017-08-01 00:00:00
abstract::Cardiac rehabilitation (CR) following myocardial infarction is vastly underused. As such, the aim of this study was to test a digital health intervention (DHI) as an adjunct to CR. Patients undergoing standard Mayo Clinic CR were recruited prior to CR (n = 25) or after 3 months CR (n = 17). Changes in risk factors and...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-015-9629-1
更新日期:2015-07-01 00:00:00
abstract::The Seventh International Symposium on Stem Cell Therapy and Cardiovascular Innovations was held in Madrid on the 6th and 7th of May 2010. Gathering for the seventh consecutive year the most relevant researchers and opinion leaders on cardiovascular cell therapy, it has become the most important worldwide event on thi...
journal_title:Journal of cardiovascular translational research
pub_type:
doi:10.1007/s12265-010-9247-x
更新日期:2011-04-01 00:00:00
abstract::The costs and efforts for sample preparation of hundreds of individuals, their genomic enrichment for regions of interest, and sufficient deep sequencing bring a significant burden to next-generation sequencing-based experiments. We investigated whether pooling of samples at the level of genomic DNA would be a more ve...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,多中心研究
doi:10.1007/s12265-011-9263-5
更新日期:2011-06-01 00:00:00
abstract::Both Type 1 and Type 2 diabetes can lead to debilitating microvascular complications such as retinopathy, nephropathy and neuropathy, as well as macrovascular complications such as cardiovascular diseases including atherosclerosis and hypertension. Diabetic complications have been attributed to several contributing fa...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-012-9368-5
更新日期:2012-08-01 00:00:00
abstract::Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiomyopathy with substantial heterogeneity in phenotypic expression and clinical course. Traditionally, two-dimensional echocardiography has been the easiest and most reliable technique for establishing a diagnosis of HCM. However, cardiovascular magnetic...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-009-9136-3
更新日期:2009-12-01 00:00:00
abstract::Sex differences in coronary artery disease (CAD) are well established, with women presenting with non-obstructive CAD more often than men do. However, recent evidence has identified coronary microvascular dysfunction as the underlying cause for cardiac complaints, yet sex-specific prevalence numbers are inconclusive. ...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-019-09906-0
更新日期:2020-02-01 00:00:00
abstract::Vascular smooth muscle cells (VSMCs) exhibit remarkable plasticity during postnatal development. Vascular injury initiates and perpetuates VSMCs dedifferentiation to a synthetic phenotype, which has been increasingly recognized to play a central role in neointimal hyperplasia during the pathogenesis of vascular prolif...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-010-9163-0
更新日期:2010-06-01 00:00:00
abstract::A previously developed poly-L-lactide scaffold releasing granulocyte colony-stimulating factor (PLLA/GCSF) was tested in a rabbit chronic model of myocardial infarction (MI) as a ventricular patch. Control groups were constituted by healthy, chronic MI and nonfunctionalized PLLA scaffold. PLLA-based electrospun scaffo...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-016-9718-9
更新日期:2017-02-01 00:00:00
abstract::The clinical success of left ventricular assist devices (LVADs) has been tempered by significant hemorrhagic and thromboembolic complications. In the case of LVADs, where the biomaterial is in direct contact with the blood circulation, significant changes in systemic immunologic and thrombostatic functions have been w...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-008-9072-7
更新日期:2009-03-01 00:00:00
abstract::Maternal mainstream tobacco smoking is known to have adverse outcomes on fetal respiratory function; however, no data is currently available on the effects of passive exposure to tobacco smoking and environmental tobacco smoke (ETS) on fetal systemic arterial structure and function. Eight pregnant rhesus macaque monke...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-010-9226-2
更新日期:2010-12-01 00:00:00
abstract::In this observational case-control study, circulating levels of complement factors C3a and C5a and leukotriene B4 (LTB4) were analysed in abdominal aortic aneurysm (AAA) patients regarding their association with diagnosis and prognosis. Serum C5a was significantly raised in AAA patients compared to healthy controls-me...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-020-10086-5
更新日期:2020-12-17 00:00:00
abstract::Comprehensive diagnostic criteria, accurate prognostic indicators, and effective treatment for patients with heart failure and a preserved ejection fraction (HFpEF) represent a critically important unmet need in cardiovascular medicine. Novel approaches to fill this unmet need are likely to be facilitated by targeting...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-013-9472-1
更新日期:2013-08-01 00:00:00
abstract::The implantation of ventricular assist devices (VADs) is a valuable option in patients with end-stage heart failure. The number of VAD implantations is growing worldwide. Between July 1987 and July 2010, we implanted 1,598 VADs in 1,455 patients. The majority were male (81.0%), and their mean age was 49.4 years (range...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-011-9268-0
更新日期:2011-06-01 00:00:00
abstract::The administration of the selective β3 adrenergic receptor (β3AR) agonist BRL-37344 protects from myocardial ischemia/reperfusion injury (IRI), although the lack of clinical approval limits its translatability. We tested the cardioprotective effect of mirabegron, the first-in-class β3AR agonist approved for human use....
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-018-9819-8
更新日期:2018-08-01 00:00:00
abstract::Atherosclerosis is the primary cause of heart attacks, and while efforts to prevent its development or progression have historically focused largely on reducing cholesterol levels, there is now important proof-of-principle data that supports the role that inflammation plays in atherogenesis. Heat shock protein 27 (HSP...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-020-10000-z
更新日期:2020-07-13 00:00:00
abstract::Oxidation-specific epitopes (OSE) within developing atherosclerotic lesions are key antigens that drive innate and adaptive immune responses in atherosclerosis, leading to chronic inflammation. Oxidized phospholipids and malondialdehyde-lysine epitopes are well-characterized OSE present in human atherosclerotic lesion...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-014-9590-4
更新日期:2014-11-01 00:00:00
abstract::This retrospective study was aimed to compare the safety and efficacy of the Direct Flow Medical (DFM) valve with the more established Sapien 3 (S3) valve in transfemoral TAVI in high-risk aortic stenosis (AS) patients. Between February 2014 and August 2016, 99 and 68 patients had the S3 and DFM valves at our center, ...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-019-09948-4
更新日期:2020-10-01 00:00:00
abstract::Multiple ANRIL transcriptional isoforms, such as lncANRIL and circANRIL have been identified. We sought to explore their diagnostic value in patients with coronary artery disease (CAD). First, we selected six target ANRIL isoforms and measured their expression in CAD patients and controls in the peripheral blood. Thei...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-020-10053-0
更新日期:2020-06-22 00:00:00
abstract::Pediatric Cardiac Care Consortium is a registry of cardiac catheterizations, surgical operations, and autopsies performed for infants, children, and adults with congenital heart disease. Four examples of use of PCCC data to evaluate variability in morphology, management, and outcomes for the procedures are described. ...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,多中心研究
doi:10.1007/s12265-009-9091-z
更新日期:2009-06-01 00:00:00
abstract::Cardiac resynchronization therapy (CRT) is an important therapy for patients with heart failure and conduction pathology, but the benefits are heterogeneous between patients and approximately a third of patients do not show signs of clinical or echocardiographic response. This calls for a better understanding of the u...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-011-9336-5
更新日期:2012-04-01 00:00:00
abstract::Cardiovascular disease is the leading cause of death in men and women in the USA; yet, coronary artery disease (CAD) continues to be underrecognized and underdiagnosed in women. Noninvasive and invasive imaging techniques are constantly being developed in order to more accurately assess CAD. At the same time, the impa...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-013-9500-1
更新日期:2013-10-01 00:00:00
abstract::In this article, the available evidence about the functional effects of the contractile protein mutations that cause hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) is assessed. The molecular mechanism of the contractile apparatus of cardiac muscle and its regulation by Ca(2+) and PKA phosphorylatio...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-011-9266-2
更新日期:2011-06-01 00:00:00
abstract::Different arrhythmogenic substrates for atrial fibrillation (AF) may underlie aortic valve (AV) and mitral valve (MV) disease. We located conduction disorders during sinus rhythm by high-resolution epicardial mapping in patients undergoing AV (n = 85) or MV (n = 54) surgery. Extent and distribution of conduction delay...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-019-09936-8
更新日期:2020-08-01 00:00:00
abstract::In patients with an acute coronary syndrome (ACS), inhibition of the platelet P2Y12 receptor is standard of care. The shortcomings of the most commonly used P2Y12 receptor inhibitor clopidogrel-that is its delayed onset of action, its interindividual response variability, and the phenomenon of high on-treatment platel...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-013-9450-7
更新日期:2013-06-01 00:00:00
abstract::Blood-based biomarker testing of insulin resistance (IR) and beta cell dysfunction may identify diabetes risk earlier than current glycemia-based approaches. This retrospective cohort study assessed 1,687 US patients at risk for cardiovascular disease (CVD) under routine clinical care with a comprehensive panel of 19 ...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,多中心研究
doi:10.1007/s12265-014-9577-1
更新日期:2014-08-01 00:00:00
abstract::COVID-19 is a syndrome that includes more than just isolated respiratory disease, as severe acute respiratory syndrome-coronavirus 2 (SARS-CoV2) also interacts with the cardiovascular, nervous, renal, and immune system at multiple levels, increasing morbidity in patients with underlying cardiometabolic conditions and ...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-020-10031-6
更新日期:2020-12-01 00:00:00