Abstract:
:It has been previously demonstrated that ticagrelor can reduce mortality compared to clopidogrel in acute coronary syndrome (ACS) patients. However, the mechanism for this mortality reduction remains uncertain. The objective of the present study is to assess the impact of chronic ticagrelor treatment on microvascular circulation. A total of 120 participants aged 20-85 years with clinical diagnosis of ACS will be randomized in a 1:1 fashion to the following two groups: ticagrelor 90 mg twice daily; clopidogrel 75 mg once daily. To evaluate the status of microcirculation, the primary end point is coronary microvascular dysfunction measured using an index of microcirculatory resistance (IMR) at 6 months after receiving the study agent. The purpose of this trial is to investigate whether ticagrelor, beyond its antiplatelet efficacy, could improve coronary microcirculation more effectively than clopidogrel for patients with ACS.
journal_name
J Cardiovasc Transl Resjournal_title
Journal of cardiovascular translational researchauthors
Park K,Cho YR,Park JS,Park TH,Kim MH,Kim YDdoi
10.1007/s12265-017-9783-8subject
Has Abstractpub_date
2018-02-01 00:00:00pages
42-49issue
1eissn
1937-5387issn
1937-5395pii
10.1007/s12265-017-9783-8journal_volume
11pub_type
杂志文章abstract::Variability of response to clopidogrel and prasugrel is a multifactorial process, with clinical consequences, and drug-drug interactions have been proposed as potential factors. Biological modulation of clopidogrel response has been demonstrated for atorvastatin and omeprazole. However, investigations assessing clinic...
journal_title:Journal of cardiovascular translational research
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-013-9526-4
更新日期:2014-03-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Journal of cardiovascular translational research
pub_type: 信件
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更新日期:2017-02-01 00:00:00
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journal_title:Journal of cardiovascular translational research
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journal_title:Journal of cardiovascular translational research
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更新日期:2010-06-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-010-9166-x
更新日期:2010-06-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-012-9433-0
更新日期:2013-04-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
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更新日期:2012-04-01 00:00:00
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journal_title:Journal of cardiovascular translational research
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doi:10.1007/s12265-015-9629-1
更新日期:2015-07-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-017-9754-0
更新日期:2017-08-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-018-9857-2
更新日期:2019-08-01 00:00:00
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journal_title:Journal of cardiovascular translational research
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journal_title:Journal of cardiovascular translational research
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journal_title:Journal of cardiovascular translational research
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
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abstract::Over the past decade, several longitudinal epidemiological studies have brought attention to the haptoglobin genotype and its importance in determining diabetic vascular disease risk. This manuscript presents an overview of the biology of the haptoglobin genotype and reviews the literature concerning its role in the d...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-012-9361-z
更新日期:2012-08-01 00:00:00
abstract::Both Type 1 and Type 2 diabetes can lead to debilitating microvascular complications such as retinopathy, nephropathy and neuropathy, as well as macrovascular complications such as cardiovascular diseases including atherosclerosis and hypertension. Diabetic complications have been attributed to several contributing fa...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-012-9368-5
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abstract::A number of genetic variants have been identified in the lipoprotein lipase (LPL) gene. We aimed to investigate the possible associations between LPL gene and apolipoprotein C3 (APOC3) gene polymorphisms with coronary artery disease (CAD) and its severity, as well as the interaction between these polymorphisms and cla...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
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abstract::Previously, we found that miR-492 delayed the progression of atherosclerosis (AS) by acting as an up-stream regulator of resistin. Therefore, we hypothesized that the anti-atherogenic effects of exercise are related to miR-492-mediated downregulation of resistin and repair of endothelial injury. In this study, we inve...
journal_title:Journal of cardiovascular translational research
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journal_title:Journal of cardiovascular translational research
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journal_title:Journal of cardiovascular translational research
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
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abstract::One of the first principles taught to medical students when they begin their study of human anatomy is that all structures within the body should be described as seen in the anatomical position. In this position, the subject is standing upright and facing the observer. The observer then views left-sided structures to ...
journal_title:Journal of cardiovascular translational research
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