Abstract：
:Ischemic heart disease (IHD) or myocardial ischemia is one of the leading causes of mortality all over the world. There is a definite need for new approaches to improve therapies and diagnostics. The pathological process leading to IHD is associated with an altered expression of genes that are important for cardiac functions. Micro-RNAs (miRNAs) have emerged as one of the central players regulating gene expression via degradation or translational inhibition of their target genes. Increasing evidence indicates that miRNAs may serve as potential diagnostic biomarkers and innovative therapeutic targets in several human diseases including cardiovascular disease. Here, we review the latest advances in the identification and validation of myocardial ischemia-related miRNAs and their target genes and discuss the roles of specific miRNAs in regulating ischemia-related cardiac injury, including apoptosis, fibrosis, arrhythmia, and angiogenesis.
journal_name
J Cardiovasc Transl Resjournal_title
Journal of cardiovascular translational researchauthors
Yu S,Li Gdoi
10.1007/s12265-010-9168-8subject
Has Abstractpub_date
2010-06-01 00:00:00pages
241-5issue
3eissn
1937-5387issn
1937-5395journal_volume
3pub_type
杂志文章,评审abstract：:Circulating miRNAs are increasingly suggested as clinical biomarker for diseases. We evaluated the expression of circulating cardiomyocyte-enriched miR-1 and miR-133 by real-time PCR in blood from patients with type 2 diabetes (T2D) without and with coronary artery disease (CAD) and healthy controls, investigated thei...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-018-9857-2
更新日期：2019-08-01 00:00:00
abstract：:The field of myocardial regeneration utilizing novel cell-based therapies, gene transfer, and growth factors may prove to play an important role in the future management of ischemic heart disease and cardiomyopathy. Phases I and II clinical trials have been published for a variety of biologics utilizing four methods o...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-010-9253-z
更新日期：2011-04-01 00:00:00
abstract：:There are currently no specific treatments for cardiac fibrosis. We tested the efficacy of a neutralising anti-IL11 antibody (X203) to reduce cardiac fibrosis in two preclinical models: transverse aortic constriction (TAC) and chronic angiotensin II infusion (AngII). In the first model, male C57BL/6J mice were subject...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-020-10054-z
更新日期：2020-06-26 00:00:00
abstract：:Reperfusion injury may offset the optimal salvage of myocardium achieved during primary coronary angioplasty. Thus, coronary reperfusion must be combined with cardioprotective adjunctive therapies in order to optimize myocardial salvage and minimize infarct size. Forty-three patients with their first ST-elevation myoc...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12265-010-9252-0
更新日期：2011-02-01 00:00:00
abstract：:Microvascular injury is present in a large proportion of patients with ST-elevation myocardial infarction (STEMI) despite successful revascularization. Ticagrelor potentially mitigates this process by exerting additional adenosine-mediated effects. This study aims to determine whether ticagrelor is associated with a b...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12265-016-9691-3
更新日期：2016-06-01 00:00:00
abstract：:This study aimed to analyze the relationship between cardiac autonomic modulation (CAM) and cardiovascular parameters (blood pressure and resting heart rate) in a sample of 256 adults, grouped by body mass index and sufficient moderate-to-vigorous physical activity (≥150 min/week). The sample showed different cardiova...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-021-10101-3
更新日期：2021-01-22 00:00:00
abstract：:Circular RNAs (circRNAs) are single-strand covalently closed circular noncoding RNAs that are endogenous transcripts generated from linear precursor mRNA through a backsplicing mechanism. With the development of high-throughput sequencing technology, a number of circRNAs have been identified and proved to play key rol...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-019-09912-2
更新日期：2020-08-01 00:00:00
abstract：:Different arrhythmogenic substrates for atrial fibrillation (AF) may underlie aortic valve (AV) and mitral valve (MV) disease. We located conduction disorders during sinus rhythm by high-resolution epicardial mapping in patients undergoing AV (n = 85) or MV (n = 54) surgery. Extent and distribution of conduction delay...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-019-09936-8
更新日期：2020-08-01 00:00:00
abstract：:In this observational case-control study, circulating levels of complement factors C3a and C5a and leukotriene B4 (LTB4) were analysed in abdominal aortic aneurysm (AAA) patients regarding their association with diagnosis and prognosis. Serum C5a was significantly raised in AAA patients compared to healthy controls-me...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-020-10086-5
更新日期：2020-12-17 00:00:00
abstract：:Sympathetic stimulation modulates L-type calcium channel (LTCC) gating to contribute to increased systolic heart function. Rad is a monomeric G-protein that interacts with LTCC. Genetic deletion of Rad (Rad-/-) renders LTCC in a sympathomimetic state. The study goal was to use a clinically inspired pharmacological str...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-016-9716-y
更新日期：2016-12-01 00:00:00
abstract：:COVID-19 is a syndrome that includes more than just isolated respiratory disease, as severe acute respiratory syndrome-coronavirus 2 (SARS-CoV2) also interacts with the cardiovascular, nervous, renal, and immune system at multiple levels, increasing morbidity in patients with underlying cardiometabolic conditions and ...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-020-10031-6
更新日期：2020-12-01 00:00:00
abstract：:Chronic inflammation drives the development of atherosclerosis. Despite optimal treatment of classical cardiovascular risk factors, a substantial portion of the population has elevated inflammatory biomarkers and develops atherosclerosis-related complications, indicating that a residual inflammatory risk drives athero...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-020-09994-3
更新日期：2020-03-28 00:00:00
abstract：:The joint European Society of Cardiology and European Association of Cardio-Thoracic Surgery (ESC/EACTS) guidelines on myocardial revascularization collect and summarize the evidence regarding decision-making, diagnostics, and therapeutics in various clinical scenarios of coronary artery disease, including elective, u...
journal_title：Journal of cardiovascular translational research
pub_type： 历史文章,杂志文章,实务指引,评审
doi：10.1007/s12265-015-9632-6
更新日期：2015-06-01 00:00:00
abstract：:Plasma ceramides (Cer), a subset of bioactive lipids, have mechanistic links to development of atherosclerosis and are related to major adverse cardiovascular events (MACEs). Previous researches have demonstrated vulnerable plaques contribute to acute cardiovascular events and poor prognosis. This study aimed to explo...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-020-09978-3
更新日期：2020-03-24 00:00:00
abstract：:Across biomedicine, there is a major drive to develop stem cell (SC) treatments for debilitating diseases. Most effective treatments restore an embryonic phenotype to adult SCs. This has led to two emerging paradigms in SC biology: the application of developmental biology studies and the manipulation of the SC niche. ...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-012-9386-3
更新日期：2012-10-01 00:00:00
abstract：:A number of genetic variants have been identified in the lipoprotein lipase (LPL) gene. We aimed to investigate the possible associations between LPL gene and apolipoprotein C3 (APOC3) gene polymorphisms with coronary artery disease (CAD) and its severity, as well as the interaction between these polymorphisms and cla...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-013-9446-3
更新日期：2013-06-01 00:00:00
abstract：:Infusion catheters, when used in combination with balloons, are subjected to pressure created by inflation of the balloon. The compression can reduce the catheter flow area and cause elevated shear stresses in the fluid. A model and experiments were developed with a range of applied balloon pressures to investigate wh...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-014-9595-z
更新日期：2014-12-01 00:00:00
abstract：:The hemodynamic, mechanical and electrical effects of cardiac resynchronization therapy (CRT) occur immediate and are lasting as long as CRT is delivered. Therefore, it is reasonable to assume that acute hemodynamic effects should predict long-term outcome. However, in the literature there is more evidence against tha...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-011-9331-x
更新日期：2012-04-01 00:00:00
abstract：:One of the first principles taught to medical students when they begin their study of human anatomy is that all structures within the body should be described as seen in the anatomical position. In this position, the subject is standing upright and facing the observer. The observer then views left-sided structures to ...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-012-9434-z
更新日期：2013-04-01 00:00:00
abstract：:Multiple ANRIL transcriptional isoforms, such as lncANRIL and circANRIL have been identified. We sought to explore their diagnostic value in patients with coronary artery disease (CAD). First, we selected six target ANRIL isoforms and measured their expression in CAD patients and controls in the peripheral blood. Thei...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-020-10053-0
更新日期：2020-06-22 00:00:00
abstract：:The V-LAP™ measures left atrial pressure (LAP) and enables bi-directional communications with an external unit, designed to monitor heart failure patients. We hereby describe the pre-clinical experience. Following an ex vivo phase, the system was implanted at the interatrial septum of 10 ovine subjects. LAP readouts w...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-018-9856-3
更新日期：2019-08-01 00:00:00
abstract：:Fibroblasts play a major role in normal cardiac physiology and in the response of the heart to injury and disease. Cardiac electrophysiological research has primarily focused on the mechanisms of remodeling that accompany cardiac disease with an emphasis on myocyte electrophysiology. Recently, there has been increasin...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-012-9408-1
更新日期：2012-12-01 00:00:00
abstract：:In this article, the available evidence about the functional effects of the contractile protein mutations that cause hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) is assessed. The molecular mechanism of the contractile apparatus of cardiac muscle and its regulation by Ca(2+) and PKA phosphorylatio...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-011-9266-2
更新日期：2011-06-01 00:00:00
abstract：:Although most cardiac cell therapy trials have focused on patients with acute myocardial infarction, attempts at "regenerating" chronically failing hearts have also been performed. These studies have entailed use of skeletal myoblasts and bone marrow-derived cells. In the case of skeletal myoblasts, the randomized pla...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-008-9017-1
更新日期：2008-09-01 00:00:00
abstract：:Both Type 1 and Type 2 diabetes can lead to debilitating microvascular complications such as retinopathy, nephropathy and neuropathy, as well as macrovascular complications such as cardiovascular diseases including atherosclerosis and hypertension. Diabetic complications have been attributed to several contributing fa...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-012-9368-5
更新日期：2012-08-01 00:00:00
abstract：:This retrospective study was aimed to compare the safety and efficacy of the Direct Flow Medical (DFM) valve with the more established Sapien 3 (S3) valve in transfemoral TAVI in high-risk aortic stenosis (AS) patients. Between February 2014 and August 2016, 99 and 68 patients had the S3 and DFM valves at our center, ...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-019-09948-4
更新日期：2020-10-01 00:00:00
abstract：:Comprehensive diagnostic criteria, accurate prognostic indicators, and effective treatment for patients with heart failure and a preserved ejection fraction (HFpEF) represent a critically important unmet need in cardiovascular medicine. Novel approaches to fill this unmet need are likely to be facilitated by targeting...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-013-9472-1
更新日期：2013-08-01 00:00:00
abstract：:Ligustrazine is one of the alkaloid compounds isolated from the traditional Chinese herb, which shows protective effects on cardiovascular disorders. High homocysteine (Hcy) level can predict cardiovascular-related events including death. In this study, we used Hcy to stimulate the human umbilical vein endothelial cel...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-019-09900-6
更新日期：2019-12-01 00:00:00
abstract：:Proper atrioventricular canal (AVC) patterning and subsequent valvulogenesis is a complex process, and defects can result in disease or early death. The zebrafish Danio rerio has become a useful model system for studying AVC development, and much progress has been made in dissecting out the critical steps. Here, we re...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-011-9313-z
更新日期：2011-12-01 00:00:00
abstract：:The goal of this paper is to provide an updated review for scientists and clinicians on the major areas in cardiovascular medicine published in the Journal. Leading topics in regenerative and personalized medicine are presented along with a critical overview of the field. New standards in large preclinical animal mode...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-015-9657-x
更新日期：2015-11-01 00:00:00
