General overview of the Seventh International Symposium on Stem Cell Therapy and Cardiovascular Innovations.


:The Seventh International Symposium on Stem Cell Therapy and Cardiovascular Innovations was held in Madrid on the 6th and 7th of May 2010. Gathering for the seventh consecutive year the most relevant researchers and opinion leaders on cardiovascular cell therapy, it has become the most important worldwide event on this field. A comprehensive review of the last developments on cell therapy, surgery for heart failure and tissue engineering was made, and the results of three clinical trials were reported. The Symposium was dedicated to the memory of Professor Helmut Drexler.


Gutiérrez E,Sanz-Ruiz R,Alvarez EV,Villa A,Fernández L,Vázquez S,Lorenzo J,Fernández-Santos E,Sánchez PL,Fernández-Avilés F




Has Abstract


2011-04-01 00:00:00












  • Therapeutic Targeting of Interleukin-11 Signalling Reduces Pressure Overload-Induced Cardiac Fibrosis in Mice.

    abstract::There are currently no specific treatments for cardiac fibrosis. We tested the efficacy of a neutralising anti-IL11 antibody (X203) to reduce cardiac fibrosis in two preclinical models: transverse aortic constriction (TAC) and chronic angiotensin II infusion (AngII). In the first model, male C57BL/6J mice were subject...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章


    authors: Corden B,Lim WW,Song W,Chen X,Ko NSJ,Su L,Tee NGZ,Adami E,Schafer S,Cook SA

    更新日期:2020-06-26 00:00:00

  • The CD40-CD40L Dyad as Immunotherapeutic Target in Cardiovascular Disease.

    abstract::Chronic inflammation drives the development of atherosclerosis. Despite optimal treatment of classical cardiovascular risk factors, a substantial portion of the population has elevated inflammatory biomarkers and develops atherosclerosis-related complications, indicating that a residual inflammatory risk drives athero...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审


    authors: Bosmans LA,Bosch L,Kusters PJH,Lutgens E,Seijkens TTP

    更新日期:2020-03-28 00:00:00

  • Translational Challenges in Cardiovascular Tissue Engineering.

    abstract::Valvular heart disease and congenital heart defects represent a major cause of death around the globe. Although current therapy strategies have rapidly evolved over the decades and are nowadays safe, effective, and applicable to many affected patients, the currently used artificial prostheses are still suboptimal. The...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审


    authors: Emmert MY,Fioretta ES,Hoerstrup SP

    更新日期:2017-04-01 00:00:00

  • Electrophysiology Translational Considerations in Cardio-Oncology: QT and Beyond.

    abstract::With improved screening and the advent of many novel therapeutics, patients with cancer are living longer and often surviving their disease. Cardiovascular complications have significant impact on both short- and long-term morbidity and mortality in these patients. While a great deal of attention has been paid to card...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审


    authors: Alomar M,Fradley MG

    更新日期:2020-06-01 00:00:00

  • Identification of streptococcal m-protein cardiopathogenic epitopes in experimental autoimmune valvulitis.

    abstract::The M protein of rheumatogenic group A streptococci induces carditis and valvulitis in Lewis rats and may play a role in pathogenesis of rheumatic heart disease. To identify the epitopes of M5 protein that produce valvulitis, synthetic peptides spanning A, B, and C repeat regions contained within the extracellular dom...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章


    authors: Kirvan CA,Galvin JE,Hilt S,Kosanke S,Cunningham MW

    更新日期:2014-03-01 00:00:00

  • Reducing Microvascular Dysfunction in Revascularized Patients with ST-Elevation Myocardial Infarction by Off-Target Properties of Ticagrelor versus Prasugrel. Rationale and Design of the REDUCE-MVI Study.

    abstract::Microvascular injury is present in a large proportion of patients with ST-elevation myocardial infarction (STEMI) despite successful revascularization. Ticagrelor potentially mitigates this process by exerting additional adenosine-mediated effects. This study aims to determine whether ticagrelor is associated with a b...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,随机对照试验


    authors: Janssens GN,van Leeuwen MAH,van der Hoeven NW,de Waard GA,Nijveldt R,Diletti R,Zijlstra F,von Birgelen C,Escaned J,Valgimigli M,van Royen N

    更新日期:2016-06-01 00:00:00

  • Imaging of oxidation-specific epitopes with targeted nanoparticles to detect high-risk atherosclerotic lesions: progress and future directions.

    abstract::Oxidation-specific epitopes (OSE) within developing atherosclerotic lesions are key antigens that drive innate and adaptive immune responses in atherosclerosis, leading to chronic inflammation. Oxidized phospholipids and malondialdehyde-lysine epitopes are well-characterized OSE present in human atherosclerotic lesion...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审


    authors: Briley-Saebo K,Yeang C,Witztum JL,Tsimikas S

    更新日期:2014-11-01 00:00:00

  • Novel antiplatelet agents: ALX-0081, a Nanobody directed towards von Willebrand factor.

    abstract::This manuscript reviews the studies performed with ALX-0081 (INN: caplacizumab), a Nanobody targeting von Willebrand factor, in the context of current antithrombotic therapy in coronary artery disease. ALX-0081 specifically inhibits platelet adhesion to the vessel wall, and may control platelet aggregation and subsequ...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审


    authors: Bartunek J,Barbato E,Heyndrickx G,Vanderheyden M,Wijns W,Holz JB

    更新日期:2013-06-01 00:00:00

  • NADPH oxidase and cardiac failure.

    abstract::Increases in oxidative stress in the heart play an important role in mediating hypertrophy, apoptosis, fibrosis, mitochondrial dysfunction, and the consequent development of heart failure. Although it has been widely believed that electron leakage from the mitochondrial electron transport chain is the primary source o...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审


    authors: Kuroda J,Sadoshima J

    更新日期:2010-08-01 00:00:00

  • Outcomes of Direct Flow Medical vs Sapien 3 Transcatheter Aortic Valve Devices.

    abstract::This retrospective study was aimed to compare the safety and efficacy of the Direct Flow Medical (DFM) valve with the more established Sapien 3 (S3) valve in transfemoral TAVI in high-risk aortic stenosis (AS) patients. Between February 2014 and August 2016, 99 and 68 patients had the S3 and DFM valves at our center, ...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章


    authors: Gamal AS,Akleh S,Zaman A,Das R,Abushouk AI,Edwards R

    更新日期:2020-10-01 00:00:00

  • Animal models of dyssynchrony.

    abstract::Cardiac resynchronization therapy (CRT) is an important therapy for patients with heart failure and conduction pathology, but the benefits are heterogeneous between patients and approximately a third of patients do not show signs of clinical or echocardiographic response. This calls for a better understanding of the u...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审


    authors: Strik M,van Middendorp LB,Vernooy K

    更新日期:2012-04-01 00:00:00

  • Severity of Hypertension Correlates with Risk of Thromboembolic Stroke.

    abstract::Hypertension plays a significant role in the development of atrial fibrillation (AF) and its complications. The coexistence of the two diseases increases the risk of thromboembolism events. Although CHADS2 and CHA2DS2-VASc scores have been used in the evaluation of the thromboembolism events in AF patients, the differ...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章


    authors: Pang H,Han B,Fu Q,Cao Q

    更新日期:2017-08-01 00:00:00

  • The left ventricular outflow in hypertrophic cardiomyopathy: from structure to function.

    abstract::Left ventricular outflow tract obstruction (LVOTO) is one of the defining features of hypertrophic cardiomyopathy (HCM) and one of the main determinants of prognosis. Although the importance of obstruction was recognized since the original description by Teare and Brock, its exact cause and methods for its relief are ...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审


    authors: Yacoub MH,El-Hamamsy I,Said K,Magdi G,Abul Enein F,George R,Rossi A,Olivotto I,Cecchi F

    更新日期:2009-12-01 00:00:00

  • Correction to: Sex and Gender Differences in Ischemic Heart Disease: Endocrine Vascular Disease Approach (EVA) Study Design.

    abstract::The authors of this study protocol would like to amend it and clarify that medication adherence was assessed using the 4-item validated Morisky, Green, Levine scale [Morisky DE, Green LW, Levine DM. Concurrent and predictive validity of a self-reported measure of medication adherence. Med Care. 1986 Jan;24(1):67-74] r...

    journal_title:Journal of cardiovascular translational research

    pub_type: 已发布勘误


    authors: Raparelli V,Proietti M,Lenzi A,Basili S,EVA Collaborators.

    更新日期:2020-02-01 00:00:00

  • Targeting cyclic nucleotide phosphodiesterase in the heart: therapeutic implications.

    abstract::The second messengers, cAMP and cGMP, regulate a number of physiological processes in the myocardium, from acute contraction/relaxation to chronic gene expression and cardiac structural remodeling. Emerging evidence suggests that multiple spatiotemporally distinct pools of cyclic nucleotides can discriminate specific ...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审


    authors: Miller CL,Yan C

    更新日期:2010-10-01 00:00:00

  • Prevalence of Cardiac Amyloidosis in Patients with Carpal Tunnel Syndrome.

    abstract::Carpal tunnel syndrome (CTS) is a common finding among patients with cardiac amyloidosis. We sought to determine the prevalence of cardiac amyloidosis in patients who had undergone CTS surgery. From 2005 to 2014, 308 patients ≥ 60 years underwent CTS surgery. Of these, 233 (76%) agreed to participate in the study and ...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章


    authors: Zegri-Reiriz I,de Haro-Del Moral FJ,Dominguez F,Salas C,de la Cuadra P,Plaza A,Krsnik I,Gonzalez-Lopez E,Garcia-Pavia P

    更新日期:2019-12-01 00:00:00

  • Perspectives on the 2014 ESC/EACTS Guidelines on Myocardial Revascularization : Fifty Years of Revascularization: Where Are We and Where Are We Heading?

    abstract::The joint European Society of Cardiology and European Association of Cardio-Thoracic Surgery (ESC/EACTS) guidelines on myocardial revascularization collect and summarize the evidence regarding decision-making, diagnostics, and therapeutics in various clinical scenarios of coronary artery disease, including elective, u...

    journal_title:Journal of cardiovascular translational research

    pub_type: 历史文章,杂志文章,实务指引,评审


    authors: Costa F,Ariotti S,Valgimigli M,Kolh P,Windecker S,Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS).

    更新日期:2015-06-01 00:00:00

  • Regulation of mammalian microRNA expression.

    abstract::MicroRNAs are widely expressed, approximately 22-nucleotide-long non-protein-coding RNAs. They are first transcribed as much longer primary transcripts, which then undergo a series of processing steps to yield the single-stranded, mature microRNAs. Like other classes of RNAs in a cell, the biogenesis of microRNAs is u...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审


    authors: Zhang X,Zeng Y

    更新日期:2010-06-01 00:00:00

  • Multiple Non-coding ANRIL Transcripts Are Associated with Risk of Coronary Artery Disease: a Promising Circulating Biomarker.

    abstract::Multiple ANRIL transcriptional isoforms, such as lncANRIL and circANRIL have been identified. We sought to explore their diagnostic value in patients with coronary artery disease (CAD). First, we selected six target ANRIL isoforms and measured their expression in CAD patients and controls in the peripheral blood. Thei...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章


    authors: Fang J,Pan Z,Wang D,Lv J,Dong Y,Xu R,Jin Y,Sheng J,Yin X,Xie X,Wang X,Guo X

    更新日期:2020-06-22 00:00:00

  • How do mutations in contractile proteins cause the primary familial cardiomyopathies?

    abstract::In this article, the available evidence about the functional effects of the contractile protein mutations that cause hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) is assessed. The molecular mechanism of the contractile apparatus of cardiac muscle and its regulation by Ca(2+) and PKA phosphorylatio...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审


    authors: Marston SB

    更新日期:2011-06-01 00:00:00

  • Exome Sequencing Identifies Candidate Genetic Modifiers of Syndromic and Familial Thoracic Aortic Aneurysm Severity.

    abstract::Thoracic aortic aneurysm (TAA) is a genetic disease predisposing to aortic dissection. It is important to identify the genetic modifiers controlling penetrance and expressivity to improve clinical prognostication. Exome sequencing was performed in 27 subjects with syndromic or familial TAA presenting with extreme phen...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章


    authors: Landis BJ,Schubert JA,Lai D,Jegga AG,Shikany AR,Foroud T,Ware SM,Hinton RB

    更新日期:2017-08-01 00:00:00

  • Cell therapy for cardiovascular disease: a comparison of methods of delivery.

    abstract::The field of myocardial regeneration utilizing novel cell-based therapies, gene transfer, and growth factors may prove to play an important role in the future management of ischemic heart disease and cardiomyopathy. Phases I and II clinical trials have been published for a variety of biologics utilizing four methods o...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审


    authors: Dib N,Khawaja H,Varner S,McCarthy M,Campbell A

    更新日期:2011-04-01 00:00:00

  • Genomic DNA pooling strategy for next-generation sequencing-based rare variant discovery in abdominal aortic aneurysm regions of interest-challenges and limitations.

    abstract::The costs and efforts for sample preparation of hundreds of individuals, their genomic enrichment for regions of interest, and sufficient deep sequencing bring a significant burden to next-generation sequencing-based experiments. We investigated whether pooling of samples at the level of genomic DNA would be a more ve...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,多中心研究


    authors: Harakalova M,Nijman IJ,Medic J,Mokry M,Renkens I,Blankensteijn JD,Kloosterman W,Baas AF,Cuppen E

    更新日期:2011-06-01 00:00:00

  • Upregulation of Circulating Cardiomyocyte-Enriched miR-1 and miR-133 Associate with the Risk of Coronary Artery Disease in Type 2 Diabetes Patients and Serve as Potential Biomarkers.

    abstract::Circulating miRNAs are increasingly suggested as clinical biomarker for diseases. We evaluated the expression of circulating cardiomyocyte-enriched miR-1 and miR-133 by real-time PCR in blood from patients with type 2 diabetes (T2D) without and with coronary artery disease (CAD) and healthy controls, investigated thei...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章


    authors: Al-Muhtaresh HA,Salem AH,Al-Kafaji G

    更新日期:2019-08-01 00:00:00

  • Complement Factor C5a Is Increased in Blood of Patients with Abdominal Aortic Aneurysm and Has Prognostic Potential for Aneurysm Growth.

    abstract::In this observational case-control study, circulating levels of complement factors C3a and C5a and leukotriene B4 (LTB4) were analysed in abdominal aortic aneurysm (AAA) patients regarding their association with diagnosis and prognosis. Serum C5a was significantly raised in AAA patients compared to healthy controls-me...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章


    authors: Zagrapan B,Eilenberg W,Scheuba A,Klopf J,Brandau A,Story J,Dosch K,Hayden H,Domenig CM,Fuchs L,Schernthaner R,Ristl R,Huk I,Neumayer C,Brostjan C

    更新日期:2020-12-17 00:00:00

  • The baroreceptor as a therapeutic target for heart failure.

    abstract::Sympathoactivation is a prominent feature of heart failure (HF). Its role in cardiac remodeling and arrhythmogenesis is well-recognized today, although incomplete understanding of autonomic mechanisms was a barrier to development of contemporary medical therapies. Despite widespread availability of drugs and devices, ...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审


    authors: Gronda E,Lovett EG,Tarascio M,Georgakopoulos D,Grassi G,Vanoli E

    更新日期:2014-04-01 00:00:00

  • Pediatric cardiac devices--an FDA pediatrician's perspective of the challenges and potential solutions.

    abstract::The advancement of pediatric medical devices is an important challenge currently facing the Food and Drug Administration and the medical community. In this manuscript, the challenges are described and possible solutions presented. ...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章


    authors: Dolcimascolo F

    更新日期:2009-06-01 00:00:00

  • Synergistic effect between lipoprotein lipase and apolipoprotein C3 genes in determining the severity of coronary artery disease.

    abstract::A number of genetic variants have been identified in the lipoprotein lipase (LPL) gene. We aimed to investigate the possible associations between LPL gene and apolipoprotein C3 (APOC3) gene polymorphisms with coronary artery disease (CAD) and its severity, as well as the interaction between these polymorphisms and cla...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章


    authors: Abd-El-Aziz TA,Mohamed RH,El-Shal AS

    更新日期:2013-06-01 00:00:00

  • Role of specific microRNAs in regulation of vascular smooth muscle cell differentiation and the response to injury.

    abstract::Vascular smooth muscle cells (VSMCs) exhibit remarkable plasticity during postnatal development. Vascular injury initiates and perpetuates VSMCs dedifferentiation to a synthetic phenotype, which has been increasingly recognized to play a central role in neointimal hyperplasia during the pathogenesis of vascular prolif...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章,评审


    authors: Song Z,Li G

    更新日期:2010-06-01 00:00:00

  • Left Ventricular Assist Devices for Acute Myocardial Infarct Size Reduction: Meta-analysis.

    abstract::We conducted a meta-analysis of preclinical studies that tested left ventricular assist device (LVAD) therapy for reducing myocardial infarct size in experimental acute myocardial infarction (AMI). Twenty-six articles were included with a total of 488 experimental animal subjects. The meta-analysis showed that infarct...

    journal_title:Journal of cardiovascular translational research

    pub_type: 杂志文章


    authors: Miyashita S,Kariya T,Yamada KP,Bikou O,Tharakan S,Kapur NK,Ishikawa K

    更新日期:2020-08-28 00:00:00