Abstract:
:Circulating miRNAs are increasingly suggested as clinical biomarker for diseases. We evaluated the expression of circulating cardiomyocyte-enriched miR-1 and miR-133 by real-time PCR in blood from patients with type 2 diabetes (T2D) without and with coronary artery disease (CAD) and healthy controls, investigated their association with the risk of CAD risk and their potential as biomarkers. The two miRNAs were upregulated in patients with T2D and CAD compared with controls, associated with CAD risk and remained significant after adjustment for multiple confounders. LDL-C was a positive predictor for miR-1 and miR-133, and mean blood pressure was also a positive predictor for miR-133. Both miRNAs strongly distinguished CAD from controls. miR-1 significantly distinguished CAD from T2D with higher diagnostic ability than miR-133, whereas the miR-1/miR-133 combination improved the diagnostic value. Upregulation of circulating miR-1 and miR-133 associate with the risk of CAD in T2D patients and may serve as diagnostic biomarkers.
journal_name
J Cardiovasc Transl Resjournal_title
Journal of cardiovascular translational researchauthors
Al-Muhtaresh HA,Salem AH,Al-Kafaji Gdoi
10.1007/s12265-018-9857-2subject
Has Abstractpub_date
2019-08-01 00:00:00pages
347-357issue
4eissn
1937-5387issn
1937-5395pii
10.1007/s12265-018-9857-2journal_volume
12pub_type
杂志文章abstract::Plasma ceramides (Cer), a subset of bioactive lipids, have mechanistic links to development of atherosclerosis and are related to major adverse cardiovascular events (MACEs). Previous researches have demonstrated vulnerable plaques contribute to acute cardiovascular events and poor prognosis. This study aimed to explo...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
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更新日期:2020-03-24 00:00:00
abstract::The M protein of rheumatogenic group A streptococci induces carditis and valvulitis in Lewis rats and may play a role in pathogenesis of rheumatic heart disease. To identify the epitopes of M5 protein that produce valvulitis, synthetic peptides spanning A, B, and C repeat regions contained within the extracellular dom...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-013-9526-4
更新日期:2014-03-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-013-9446-3
更新日期:2013-06-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,随机对照试验
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更新日期:2011-02-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-012-9433-0
更新日期:2013-04-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
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更新日期:2012-08-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-020-10053-0
更新日期:2020-06-22 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-011-9331-x
更新日期:2012-04-01 00:00:00
abstract::Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiomyopathy with substantial heterogeneity in phenotypic expression and clinical course. Traditionally, two-dimensional echocardiography has been the easiest and most reliable technique for establishing a diagnosis of HCM. However, cardiovascular magnetic...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
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更新日期:2009-12-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
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更新日期:2013-08-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 信件
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更新日期:2017-02-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-016-9682-4
更新日期:2016-06-01 00:00:00
abstract::Valvular heart disease and congenital heart defects represent a major cause of death around the globe. Although current therapy strategies have rapidly evolved over the decades and are nowadays safe, effective, and applicable to many affected patients, the currently used artificial prostheses are still suboptimal. The...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-017-9728-2
更新日期:2017-04-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-013-9468-x
更新日期:2013-08-01 00:00:00
abstract::Despite important roles in mammalian gene regulation, the critical targeting mechanism of DNA methylation for specific DNA sequences remains unclear. Recently, small non-coding RNAs were reported to be essential for DNA methylation in plants as well as in mice, suggesting that small non-coding RNAs might interact with...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-010-9167-9
更新日期:2010-06-01 00:00:00
abstract::CD147, a member of the immunoglobulin super family, is a well-known potent inducer of extracellular matrix metalloproteinases. Studies show that CD147 is upregulated in inflammatory diseases. Atherosclerosis is a chronic inflammatory disease of the artery wall. Further understanding of the functions of CD147 in athero...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-015-9608-6
更新日期:2015-02-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-014-9545-9
更新日期:2014-04-01 00:00:00
abstract::The goal of this paper is to provide an updated review for scientists and clinicians on the major areas in cardiovascular medicine published in the Journal. Leading topics in regenerative and personalized medicine are presented along with a critical overview of the field. New standards in large preclinical animal mode...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-015-9657-x
更新日期:2015-11-01 00:00:00
abstract::It is becoming increasingly evident that poor nutrition plays an important role in inducing cardiovascular disease. Just as importantly, data now support the contention that appropriate nutritional interventions may have just as important an effect in preventing or delaying the appearance of cardiovascular disease. If...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-009-9116-7
更新日期:2009-09-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
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更新日期:2017-08-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
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更新日期:2012-12-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-012-9412-5
更新日期:2013-02-01 00:00:00
abstract::In this article, the available evidence about the functional effects of the contractile protein mutations that cause hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) is assessed. The molecular mechanism of the contractile apparatus of cardiac muscle and its regulation by Ca(2+) and PKA phosphorylatio...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-011-9266-2
更新日期:2011-06-01 00:00:00
abstract::Chronotropic incompetence (CI) is common in heart failure (HF) patients and is associated with worsening outcome. Detecting and tracking functional CI during activities of daily living could provide insight into its contribution to HF symptoms and facilitate effective HF patient management. HF patients (n = 180, NYHA ...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,多中心研究
doi:10.1007/s12265-010-9227-1
更新日期:2011-02-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-010-9226-2
更新日期:2010-12-01 00:00:00
abstract::Cardiac magnetic resonance imaging (CMR) has become a reference standard modality for imaging of left ventricular (LV) structure and function and, using late gadolinium enhancement, for imaging myocardial infarction. Emerging CMR techniques enable a more comprehensive examination of the heart, making CMR an excellent ...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-011-9275-1
更新日期:2011-08-01 00:00:00
abstract::Ischemic heart disease (IHD) or myocardial ischemia is one of the leading causes of mortality all over the world. There is a definite need for new approaches to improve therapies and diagnostics. The pathological process leading to IHD is associated with an altered expression of genes that are important for cardiac fu...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-010-9168-8
更新日期:2010-06-01 00:00:00
abstract::Diseases of the electrical conduction system that lead to irregularities in cardiac rhythm can have morbid and often lethal clinical outcomes. Linkage analysis has been the principal tool used to discover the genetic mutations responsible for Mendelian arrhythmic disease. Although the majority of arrhythmias can be ac...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-008-9030-4
更新日期:2008-06-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
doi:10.1007/s12265-012-9386-3
更新日期:2012-10-01 00:00:00