Abstract:
:The clinical success of left ventricular assist devices (LVADs) has been tempered by significant hemorrhagic and thromboembolic complications. In the case of LVADs, where the biomaterial is in direct contact with the blood circulation, significant changes in systemic immunologic and thrombostatic functions have been well documented. Although further investigation is warranted, significant advances have been made in both cellular biology and LVAD technology to better understand the delicate balance between the procoagulant milieu predisposing to thrombosis and the risks of both surgical and non-surgical bleeding.
journal_name
J Cardiovasc Transl Resjournal_title
Journal of cardiovascular translational researchauthors
John R,Lee Sdoi
10.1007/s12265-008-9072-7subject
Has Abstractpub_date
2009-03-01 00:00:00pages
63-70issue
1eissn
1937-5387issn
1937-5395journal_volume
2pub_type
杂志文章,评审abstract::The advancement of pediatric medical devices is an important challenge currently facing the Food and Drug Administration and the medical community. In this manuscript, the challenges are described and possible solutions presented. ...
journal_title:Journal of cardiovascular translational research
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journal_title:Journal of cardiovascular translational research
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abstract::Valvular heart disease and congenital heart defects represent a major cause of death around the globe. Although current therapy strategies have rapidly evolved over the decades and are nowadays safe, effective, and applicable to many affected patients, the currently used artificial prostheses are still suboptimal. The...
journal_title:Journal of cardiovascular translational research
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journal_title:Journal of cardiovascular translational research
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journal_title:Journal of cardiovascular translational research
pub_type: 历史文章,杂志文章,实务指引,评审
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journal_title:Journal of cardiovascular translational research
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journal_title:Journal of cardiovascular translational research
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
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journal_title:Journal of cardiovascular translational research
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
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更新日期:2011-08-01 00:00:00
abstract::The pathophysiological abnormalities associated with increased arterial stiffness and/or abnormal pressure wave reflection may play crucial roles in increasing the risk of development of cardiovascular events. On the other hand, prehypertension, defined as a systolic blood pressure of 120-139 and/or a diastolic blood ...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
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更新日期:2012-06-01 00:00:00
abstract::This retrospective observational study aimed to establish the first prescription and its dispensation (primary adherence) in the first 30 days of the four pharmacotherapeutic classes recommended after a type 1 STEMI episode, determine the potential risk factors for lack of primary adherence, and evaluate the potential...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
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更新日期:2020-06-15 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章
doi:10.1007/s12265-018-9812-2
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journal_title:Journal of cardiovascular translational research
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更新日期:2019-12-01 00:00:00
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journal_title:Journal of cardiovascular translational research
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abstract::We examined whether there is a relationship between repolarization abnormalities on electrocardiography (EKG) and deformation abnormalities by echocardiography. Analysis of baseline EKGs and mechanical (echo-based deformation) changes was performed in 128 patients with a clinical diagnosis of hypertrophic cardiomyopat...
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pub_type: 杂志文章
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更新日期:2013-08-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
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abstract::Extracellular vesicles (EVs) are small-sized membrane-surrounded structures released from cells into the blood, which play important roles in regulating various biological processes. However, the role of EVs in Doxorubicin (DOX)-induced cardiomyocytes senescence remains elusive. In this study, we found that human seru...
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abstract::Circular RNAs (circRNAs) are single-strand covalently closed circular noncoding RNAs that are endogenous transcripts generated from linear precursor mRNA through a backsplicing mechanism. With the development of high-throughput sequencing technology, a number of circRNAs have been identified and proved to play key rol...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
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journal_title:Journal of cardiovascular translational research
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,多中心研究
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abstract::Cardiovascular disease is the leading cause of death in men and women in the USA; yet, coronary artery disease (CAD) continues to be underrecognized and underdiagnosed in women. Noninvasive and invasive imaging techniques are constantly being developed in order to more accurately assess CAD. At the same time, the impa...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
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更新日期:2013-10-01 00:00:00
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
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abstract::Blood-based biomarker testing of insulin resistance (IR) and beta cell dysfunction may identify diabetes risk earlier than current glycemia-based approaches. This retrospective cohort study assessed 1,687 US patients at risk for cardiovascular disease (CVD) under routine clinical care with a comprehensive panel of 19 ...
journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,多中心研究
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更新日期:2014-08-01 00:00:00
abstract::Circulating miRNAs are increasingly suggested as clinical biomarker for diseases. We evaluated the expression of circulating cardiomyocyte-enriched miR-1 and miR-133 by real-time PCR in blood from patients with type 2 diabetes (T2D) without and with coronary artery disease (CAD) and healthy controls, investigated thei...
journal_title:Journal of cardiovascular translational research
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journal_title:Journal of cardiovascular translational research
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journal_title:Journal of cardiovascular translational research
pub_type: 杂志文章,评审
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journal_title:Journal of cardiovascular translational research
pub_type: 评论,杂志文章
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