Abstract：
:The administration of the selective β3 adrenergic receptor (β3AR) agonist BRL-37344 protects from myocardial ischemia/reperfusion injury (IRI), although the lack of clinical approval limits its translatability. We tested the cardioprotective effect of mirabegron, the first-in-class β3AR agonist approved for human use. A dose-response study was conducted in 6 pigs to select the highest intravenous dose of mirabegron without significant detrimental hemodynamic effect. Subsequently, closed chest anterior myocardial infarction (45 min ischemia followed by reperfusion) was performed in 26 pigs which randomly received either mirabegron (10 μg/kg) or placebo 5 min before reperfusion. Day-7 cardiac magnetic resonance (CMR) showed no differences in infarct size (35.0 ± 2.0% of left ventricle (LV) vs. 35.9 ± 2.4% in mirabegron and placebo respectively, p = 0.782) or LV ejection fraction (36.3 ± 1.1 vs. 34.6 ± 1.9%, p = 0.430). Consistent results were obtained on day-45 CMR. In conclusion, the intravenous administration of the clinically available selective β3AR agonist mirabegron does not reduce infarct size in a swine model of IRI.
journal_name
J Cardiovasc Transl Resjournal_title
Journal of cardiovascular translational researchauthors
Rossello X,Piñero A,Fernández-Jiménez R,Sánchez-González J,Pizarro G,Galán-Arriola C,Lobo-Gonzalez M,Vilchez JP,García-Prieto J,García-Ruiz JM,García-Álvarez A,Sanz-Rosa D,Ibanez Bdoi
10.1007/s12265-018-9819-8subject
Has Abstractpub_date
2018-08-01 00:00:00pages
310-318issue
4eissn
1937-5387issn
1937-5395pii
10.1007/s12265-018-9819-8journal_volume
11pub_type
杂志文章abstract：:Heart failure is a worldwide pandemic influencing 26 million individuals worldwide and is expanding. Imbalanced redox homeostasis in cardiac cells alters the structure and function of the cells, which leads to contractile dysfunction, myocardial hypertrophy, and fibrosis in chronic heart failure. Various targets and a...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-020-10083-8
更新日期：2020-11-25 00:00:00
abstract：:Chronic inflammation drives the development of atherosclerosis. Despite optimal treatment of classical cardiovascular risk factors, a substantial portion of the population has elevated inflammatory biomarkers and develops atherosclerosis-related complications, indicating that a residual inflammatory risk drives athero...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-020-09994-3
更新日期：2020-03-28 00:00:00
abstract：:One of the first principles taught to medical students when they begin their study of human anatomy is that all structures within the body should be described as seen in the anatomical position. In this position, the subject is standing upright and facing the observer. The observer then views left-sided structures to ...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-012-9434-z
更新日期：2013-04-01 00:00:00
abstract：:Pediatric Cardiac Care Consortium is a registry of cardiac catheterizations, surgical operations, and autopsies performed for infants, children, and adults with congenital heart disease. Four examples of use of PCCC data to evaluate variability in morphology, management, and outcomes for the procedures are described. ...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,多中心研究
doi：10.1007/s12265-009-9091-z
更新日期：2009-06-01 00:00:00
abstract：:Circular RNAs (circRNAs) are single-strand covalently closed circular noncoding RNAs that are endogenous transcripts generated from linear precursor mRNA through a backsplicing mechanism. With the development of high-throughput sequencing technology, a number of circRNAs have been identified and proved to play key rol...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-019-09912-2
更新日期：2020-08-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-010-9253-z
更新日期：2011-04-01 00:00:00
abstract：:The clinical success of left ventricular assist devices (LVADs) has been tempered by significant hemorrhagic and thromboembolic complications. In the case of LVADs, where the biomaterial is in direct contact with the blood circulation, significant changes in systemic immunologic and thrombostatic functions have been w...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-008-9072-7
更新日期：2009-03-01 00:00:00
abstract：:MicroRNAs are widely expressed, approximately 22-nucleotide-long non-protein-coding RNAs. They are first transcribed as much longer primary transcripts, which then undergo a series of processing steps to yield the single-stranded, mature microRNAs. Like other classes of RNAs in a cell, the biogenesis of microRNAs is u...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-010-9166-x
更新日期：2010-06-01 00:00:00
abstract：:The authors of this study protocol would like to amend it and clarify that medication adherence was assessed using the 4-item validated Morisky, Green, Levine scale [Morisky DE, Green LW, Levine DM. Concurrent and predictive validity of a self-reported measure of medication adherence. Med Care. 1986 Jan;24(1):67-74] r...
journal_title：Journal of cardiovascular translational research
pub_type： 已发布勘误
doi：10.1007/s12265-019-09870-9
更新日期：2020-02-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-018-9812-2
更新日期：2019-04-01 00:00:00
abstract：:Cardiac resynchronization therapy (CRT) has been clinically proven to improve symptoms, exercise capacity, and quality of life and promote reduction in ventricular dimensions. When combined with a defibrillator (CRT-D), significant reductions in all-cause mortality alone and in combination with cause-specific hospital...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-008-9051-z
更新日期：2008-12-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-010-9226-2
更新日期：2010-12-01 00:00:00
abstract：:Graphical abstract. ...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-020-10077-6
更新日期：2020-10-13 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-020-10031-6
更新日期：2020-12-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-013-9472-1
更新日期：2013-08-01 00:00:00
abstract：:Over the past decade, several longitudinal epidemiological studies have brought attention to the haptoglobin genotype and its importance in determining diabetic vascular disease risk. This manuscript presents an overview of the biology of the haptoglobin genotype and reviews the literature concerning its role in the d...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-012-9361-z
更新日期：2012-08-01 00:00:00
abstract：:Extracellular vesicles (EVs) are small-sized membrane-surrounded structures released from cells into the blood, which play important roles in regulating various biological processes. However, the role of EVs in Doxorubicin (DOX)-induced cardiomyocytes senescence remains elusive. In this study, we found that human seru...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-018-9847-4
更新日期：2019-02-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-012-9433-0
更新日期：2013-04-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-010-9184-8
更新日期：2010-08-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12265-009-9123-8
更新日期：2010-04-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-010-9203-9
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journal_title：Journal of cardiovascular translational research
pub_type： 历史文章,杂志文章,实务指引,评审
doi：10.1007/s12265-015-9632-6
更新日期：2015-06-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s12265-020-10009-4
更新日期：2020-12-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
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更新日期：2015-11-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-009-9100-2
更新日期：2009-06-01 00:00:00
abstract：:Acute pulmonary embolism (APE) is a common sudden venous thromboembolism with high rates of morbidity and mortality. Several studies have concluded that microRNA-134 could be a potential biomarker for APE. However, the sensitivity of these studies varies widely. This study aimed to evaluate the diagnostic value of cir...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-020-10087-4
更新日期：2021-01-06 00:00:00
abstract：:Sympathoactivation is a prominent feature of heart failure (HF). Its role in cardiac remodeling and arrhythmogenesis is well-recognized today, although incomplete understanding of autonomic mechanisms was a barrier to development of contemporary medical therapies. Despite widespread availability of drugs and devices, ...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-014-9546-8
更新日期：2014-04-01 00:00:00
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journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-011-9345-4
更新日期：2012-06-01 00:00:00
abstract：:Plasma ceramides (Cer), a subset of bioactive lipids, have mechanistic links to development of atherosclerosis and are related to major adverse cardiovascular events (MACEs). Previous researches have demonstrated vulnerable plaques contribute to acute cardiovascular events and poor prognosis. This study aimed to explo...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章
doi：10.1007/s12265-020-09978-3
更新日期：2020-03-24 00:00:00
abstract：:In patients with an acute coronary syndrome (ACS), inhibition of the platelet P2Y12 receptor is standard of care. The shortcomings of the most commonly used P2Y12 receptor inhibitor clopidogrel-that is its delayed onset of action, its interindividual response variability, and the phenomenon of high on-treatment platel...
journal_title：Journal of cardiovascular translational research
pub_type： 杂志文章,评审
doi：10.1007/s12265-013-9450-7
更新日期：2013-06-01 00:00:00
