Serum Extracellular Vesicles Retard H9C2 Cell Senescence by Suppressing miR-34a Expression.

Abstract:

:Extracellular vesicles (EVs) are small-sized membrane-surrounded structures released from cells into the blood, which play important roles in regulating various biological processes. However, the role of EVs in Doxorubicin (DOX)-induced cardiomyocytes senescence remains elusive. In this study, we found that human serum EVs inhibited DOX-induced senescence in H9C2 cells, which was abolished by miR-34a mimic. Our study also proved that miR-34a mediated DOX-induced H9C2 cell senescence by targeting phosphatase 1 nuclear targeting subunit (PNUTS). In addition to the downregulation of miR-34a, EVs could upregulate the expression of PNUTS. Moreover, the inhibitory effect of serum EVs on DOX-induced H9C2 cell senescence was also impeded by PNUTS siRNA. In conclusion, our study suggests that serum EVs retard H9C2 cell senescence through the miR-34a/PNUTS pathway, providing a potential therapy for cardiac aging.

authors

Liu Y,Liu Z,Xie Y,Zhao C,Xu J

doi

10.1007/s12265-018-9847-4

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

45-50

issue

1

eissn

1937-5387

issn

1937-5395

pii

10.1007/s12265-018-9847-4

journal_volume

12

pub_type

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