Potential of early [(18)F]-2-fluoro-2-deoxy-D-glucose positron emission tomography for identifying hypoperfusion and predicting fate of tissue in a rat embolic stroke model.

Abstract:

BACKGROUND AND PURPOSE:Experimental stroke models are essential to study in vivo pathophysiological processes of focal cerebral ischemia. In this study, an embolic stroke model in rats was applied (1) to characterize early development of regional cerebral blood flow and metabolism with positron emission tomography (PET) using [(15)O]H(2)O and [(18)F]-2-fluoro-2-deoxy-D-glucose (FDG); and (2) to identify potential parameters for predicting tissue fate. METHODS:Remote occlusion of the middle cerebral artery was induced in 10 Wistar rats by injection of 4 TiO(2) macrospheres. Sequential [(15)O]H(2)O-PET (baseline, 5, 30, 60 minutes after middle cerebral artery occlusion) and FDG-PET measurements (75 minutes after middle cerebral artery occlusion) were performed. [(15)O]H(2)O-PET data and FDG kinetic parameters were compared with MRIs and histology at 24 hours. RESULTS:Regional cerebral blood flow decreased substantially within 30 minutes after middle cerebral artery occlusion (41% to 58% of baseline regional cerebral blood flow; P<0.001) with no relevant changes between 30 and 60 minutes. At 60 minutes, regional cerebral blood flow correlated well with the unidirectional transport parameter K1 of FDG in all animals (r=0.86±0.09; P<0.001). Tissue fate could be accurately predicted taking into account K1 and net influx rate constant Ki of FDG. The infarct volume predicted by FDG-PET (375.8±102.3 mm(3)) correlated significantly with the infarct size determined by MRI after 24 hours (360.8±93.7 mm(3); r=0.85). CONCLUSIONS:Hypoperfused tissue can be identified by decreased K1 of FDG. Acute ischemic tissue can be well characterized using K1 and Ki allowing for discrimination between infarct core and early viable tissue. Because FDG-PET is widely spread, our findings can be easily translated into clinical application for early diagnoses of ischemia.

journal_name

Stroke

journal_title

Stroke

authors

Walberer M,Backes H,Rueger MA,Neumaier B,Endepols H,Hoehn M,Fink GR,Schroeter M,Graf R

doi

10.1161/STROKEAHA.111.624551

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

193-8

issue

1

eissn

0039-2499

issn

1524-4628

pii

STROKEAHA.111.624551

journal_volume

43

pub_type

杂志文章

相关文献

STROKE文献大全
  • Risk of stroke and myocardial infarction after reduction or cessation of cigarette smoking: a cohort study in korean men.

    abstract:BACKGROUND AND PURPOSE:The effect of smoking reduction on cardiovascular disease outcomes has not been studied in Asian populations. METHODS:A total of 475 734 Korean men aged 30 to 58 years, stratified into 9 groups based on smoking status at 2 different time points (1990 and 1992), were followed from 1992 to 2001 fo...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.107.512632

    authors: Song YM,Cho HJ

    更新日期:2008-09-01 00:00:00

  • Microglial Calcium Waves During the Hyperacute Phase of Ischemic Stroke.

    abstract:BACKGROUND AND PURPOSE:Ischemic injury triggers multiple pathological responses in the brain tissue, including spreading depolarizations across the cerebral cortex (cortical spreading depolarizations [CSD]). Microglia have been recently shown to play a significant role in the propagation of CSD. However, the intracellu...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.120.032766

    authors: Liu L,Kearns KN,Eli I,Sharifi KA,Soldozy S,Carlson EW,Scott KW,Sluzewski MF,Acton ST,Stauderman KA,Kalani MYS,Park M,Tvrdik P

    更新日期:2021-01-01 00:00:00

  • The concept of patient motivation: a qualitative analysis of stroke professionals' attitudes.

    abstract:BACKGROUND AND PURPOSE:The purpose of this work was to investigate how stroke rehabilitation professionals understand the concept of motivation and the ways that they use this concept in their clinical practice. METHODS:This qualitative study used semistructured, in-depth interviews with the professionals working in t...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/hs0202.102367

    authors: Maclean N,Pound P,Wolfe C,Rudd A

    更新日期:2002-02-01 00:00:00

  • Blood use in cerebrovascular neurosurgery.

    abstract:BACKGROUND AND PURPOSE:This study reviews the perioperative use of red blood cell transfusion in cerebrovascular neurosurgery. The current algorithm for preoperative ordering of red cells is historical and dated. More blood is ordered than is actually transfused, and considerable variability exists between different in...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/hs0402.105296

    authors: Couture DE,Ellegala DB,Dumont AS,Mintz PD,Kassell NF

    更新日期:2002-04-01 00:00:00

  • Leukoaraiosis and stroke.

    abstract::Leukoaraiosis is a common finding in stroke patients and has been strongly associated with risk of incident stroke and dementia. Leukoaraiosis may also be an independent predictor of stroke outcomes. There is increasing evidence from neuroimaging to support the concept that some leukoaraiosis is caused by white matter...

    journal_title:Stroke

    pub_type: 杂志文章,评审

    doi:10.1161/STROKEAHA.110.596056

    authors: Smith EE

    更新日期:2010-10-01 00:00:00

  • Cardioembolic stroke from atrial septal aneurysm.

    abstract::Atrial septal aneurysm is an uncommon occult cardiac source of cerebral embolism. It is usually asymptomatic, and clinical cardiologic examination and electrocardiography fail to reveal its presence. We report a case of a 34-year-old woman with sudden right hemiplegia and aphasia from occlusion of the left carotid sip...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.19.5.640

    authors: Di Pasquale G,Andreoli A,Grazi P,Dominici P,Pinelli G

    更新日期:1988-05-01 00:00:00

  • Stroke rehabilitation outcome: impact of coronary artery disease.

    abstract::The frequency of clinically significant coronary artery disease (CAD) among stroke patients and the impact of CAD on stroke rehabilitation were studied in 132 patients with first thrombotic or embolic stroke who participated in comprehensive rehabilitation. Sixty-one patients (46%) had a history of CAD, and 16 of the ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.19.1.42

    authors: Roth EJ,Mueller K,Green D

    更新日期:1988-01-01 00:00:00

  • Delayed paraplegia after spinal cord ischemic injury requires caspase-3 activation in mice.

    abstract:BACKGROUND AND PURPOSE:Delayed paraplegia remains a devastating complication after ischemic spinal cord injury associated with aortic surgery and trauma. Although apoptosis has been implicated in the pathogenesis of delayed neurodegeneration, mechanisms responsible for the delayed paraplegia remain incompletely underst...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.110.600429

    authors: Kakinohana M,Kida K,Minamishima S,Atochin DN,Huang PL,Kaneki M,Ichinose F

    更新日期:2011-08-01 00:00:00

  • Intracranial Carotid Calcification on Cranial Computed Tomography: Visual Scoring Methods, Semiautomated Scores, and Volume Measurements in Patients With Stroke.

    abstract:BACKGROUND AND PURPOSE:Intracranial internal carotid artery calcification is associated with cerebrovascular risk factors and stroke, but few quantification methods are available. We tested the reliability of visual scoring, semiautomated Agatston score, and calcium volume measurement in patients with recent stroke. M...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.115.009716

    authors: Subedi D,Zishan US,Chappell F,Gregoriades ML,Sudlow C,Sellar R,Wardlaw J

    更新日期:2015-09-01 00:00:00

  • Sonothrombolysis with transcranial color-coded sonography and recombinant tissue-type plasminogen activator in acute middle cerebral artery main stem occlusion: results from a randomized study.

    abstract:BACKGROUND AND PURPOSE:Sonothrombolysis is a new treatment approach in acute ischemic stroke. The results of a monocenter, randomized clinical study are presented. METHODS:Subjects with acute middle cerebral artery main stem occlusion were randomized into a target group receiving 1-hour transcranial continuous insonat...

    journal_title:Stroke

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/STROKEAHA.107.503870

    authors: Eggers J,König IR,Koch B,Händler G,Seidel G

    更新日期:2008-05-01 00:00:00

  • Early diagnosis of cerebral fat embolism syndrome by diffusion-weighted MRI (starfield pattern).

    abstract:BACKGROUND:Cerebral fat embolism syndrome is a rare, but potentially lethal, complication of long bone fractures. Neurological symptoms are variable, and the clinical diagnosis is difficult. The purpose of this case study is to demonstrate the value of diffusion-weighted MRI of the brain for early diagnosis of fat embo...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:

    authors: Parizel PM,Demey HE,Veeckmans G,Verstreken F,Cras P,Jorens PG,De Schepper AM

    更新日期:2001-12-01 00:00:00

  • Leukocyte activation detected by increased plasma levels of inflammatory mediators in patients with ischemic cerebrovascular diseases.

    abstract:BACKGROUND AND PURPOSE:Leukocytes have been implicated in the development of ischemic atherosclerotic vascular diseases. In a prospective study we investigated whether the plasma concentrations of inflammatory mediators, ie, proteases and cytokines, as markers for systemic leukocyte activation, are increased in patient...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.27.10.1734

    authors: Elneihoum AM,Falke P,Axelsson L,Lundberg E,Lindgärde F,Ohlsson K

    更新日期:1996-10-01 00:00:00

  • Effects of flunarizine on neurological recovery and spinal cord blood flow in experimental spinal cord ischemia in rabbits.

    abstract:BACKGROUND AND PURPOSE:The lipophilic calcium channel antagonist flunarizine has been demonstrated to be neuroprotective in several models of cerebral ischemia. Ischemic spinal cord injury may have a similar pathophysiology and hence may respond in a similar fashion. This study was designed to investigate the effects o...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.24.10.1547

    authors: Johnson SH,Kraimer JM,Graeber GM

    更新日期:1993-10-01 00:00:00

  • Increased circulating immune complexes in acute stroke: the triggering role of Chlamydia pneumoniae and cytomegalovirus.

    abstract:BACKGROUND AND PURPOSE:The mechanisms of immune reaction involved in the pathogenesis and clinical course of acute vascular incidents are still not completely understood. The aim of this study was to examine the presence of immune complexes (IC) in the acute stroke setting and the first month thereafter and to characte...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.str.0000014562.75483.6b

    authors: Tarnacka B,Gromadzka G,Członkowska A

    更新日期:2002-04-01 00:00:00

  • Persistent use of secondary preventive drugs declines rapidly during the first 2 years after stroke.

    abstract:BACKGROUND AND PURPOSE:To prevent new cardiovascular events after stroke, prescribed preventive drugs should be used continuously. This study measures persistent use of preventive drugs after stroke and identifies factors associated with persistence. METHODS:A 1-year cohort (21,077 survivors) from Riks-Stroke, the Swe...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.109.566950

    authors: Glader EL,Sjölander M,Eriksson M,Lundberg M

    更新日期:2010-02-01 00:00:00

  • Late-phase contrast-enhanced ultrasound reflects biological features of instability in human carotid atherosclerosis.

    abstract:BACKGROUND AND PURPOSE:Development of translational functional imaging modalities for atherosclerosis risk stratification is sought for stroke prediction. Our group has developed late-phase contrast-enhanced ultrasound (LP-CEUS) to quantify microbubble contrast retention within carotid atherosclerosis and shown it to s...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.111.631200

    authors: Shalhoub J,Monaco C,Owen DR,Gauthier T,Thapar A,Leen EL,Davies AH

    更新日期:2011-12-01 00:00:00

  • Two cases of occipital infarction following cardiac catheterization.

    abstract::Transient visual disturbance following cardiac catheterization has been regarded as a benign and transient complication. We describe two cases of computed-tomography-documented occipital infarction after cardiac catheterization that emphasize a complication more serious than previously thought. ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.19.6.773

    authors: Oliva A,Scherokman B

    更新日期:1988-06-01 00:00:00

  • Preischemic but not postischemic zinc protoporphyrin treatment reduces infarct size and edema accumulation after temporary focal cerebral ischemia in rats.

    abstract:BACKGROUND AND PURPOSE:Zinc protoporphyrin (ZnPP) has multiple actions. It is an interleukin-1 antagonist as well as a hemeoxygenase inhibitor. Interleukin-1 is produced in ischemic brain and probably contributes to ischemic injury, although the role of heme oxygenase during ischemia is unknown. Whether ZnPP treatment ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.26.6.1035

    authors: Kadoya C,Domino EF,Yang GY,Stern JD,Betz AL

    更新日期:1995-06-01 00:00:00

  • Associations of inflammatory and hemostatic variables with the risk of recurrent stroke.

    abstract:BACKGROUND AND PURPOSE:Several prospective studies have shown significant associations between plasma fibrinogen, viscosity, C-reactive protein (CRP), fibrin D-dimer, or tissue plasminogen activator (tPA) antigen and the risk of primary cardiovascular events. Little has been published on the associations of these varia...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1161/01.STR.0000181754.38408.4c

    authors: Woodward M,Lowe GD,Campbell DJ,Colman S,Rumley A,Chalmers J,Neal BC,Patel A,Jenkins AJ,Kemp BE,MacMahon SW

    更新日期:2005-10-01 00:00:00

  • Relationship between white-matter hyperintensities and hematoma volume and growth in patients with intracerebral hemorrhage.

    abstract:BACKGROUND AND PURPOSE:The presence of white-matter hyperintensities (WMHs) has been linked to intracerebral hemorrhage (ICH). We sought to determine whether the severity of WMHs influences hematoma growth and ICH volume. METHODS:We retrospectively reviewed prospectively collected clinical, laboratory, and radiologic ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.109.564955

    authors: Lou M,Al-Hazzani A,Goddeau RP Jr,Novak V,Selim M

    更新日期:2010-01-01 00:00:00

  • A new method for quantitative regional cerebral blood volume measurements using computed tomography.

    abstract:BACKGROUND AND PURPOSE:Knowledge of cerebral blood volume (CBV) is invaluable in identifying the primary cause of brain swelling in patients with stroke or severe head injury, and it might also help in clinical decision making in patients thought to have hemodynamic transient ischemic attacks (TIAs). This investigation...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.28.10.1998

    authors: Muizelaar JP,Fatouros PP,Schröder ML

    更新日期:1997-10-01 00:00:00

  • White Matter Hyperintensity-Adjusted Critical Infarct Thresholds to Predict a Favorable 90-Day Outcome.

    abstract:BACKGROUND AND PURPOSE:There is increasing interest in defining stroke lesion volume thresholds to predict poststroke outcome. However, there is a paucity of data on factors that impact the association between critical infarct thresholds volume and outcome. We sought to determine whether lesion thresholds best predicti...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.116.013982

    authors: Patti J,Helenius J,Puri AS,Henninger N

    更新日期:2016-10-01 00:00:00

  • Vessel Wall Enhancement and Blood-Cerebrospinal Fluid Barrier Disruption After Mechanical Thrombectomy in Acute Ischemic Stroke.

    abstract:BACKGROUND AND PURPOSE:Less than half of acute ischemic stroke patients treated with mechanical thrombectomy obtain permanent clinical benefits. Consequently, there is an urgent need to identify mechanisms implicated in the limited efficacy of early reperfusion. We evaluated the predictors and prognostic significance o...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.116.015648

    authors: Renú A,Laredo C,Lopez-Rueda A,Llull L,Tudela R,San-Roman L,Urra X,Blasco J,Macho J,Oleaga L,Chamorro A,Amaro S

    更新日期:2017-03-01 00:00:00

  • Mechanisms and timing of deaths from cerebral infarction.

    abstract::Clinicopathologic correlations were reviewed in 100 cases of recent cerebral infarctions in the internal carotid artery distribution. The most frequent cause of death was transtentorial herniation, followed in frequency by pneumonia, cardiac causes, and pulmonary embolism. Thirty-six percent of all patients and 47% of...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.12.4.474

    authors: Bounds JV,Wiebers DO,Whisnant JP,Okazaki H

    更新日期:1981-07-01 00:00:00

  • Report of the substudy assessing the impact of neurocognitive function on quality of life 5 years after cardiac surgery.

    abstract:BACKGROUND AND PURPOSE:The importance of perioperative cognitive decline has long been debated. We recently demonstrated a significant correlation between perioperative cognitive decline and long-term cognitive dysfunction. Despite this association, some still question the importance of these changes in cognitive funct...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/hs1201.099803

    authors: Newman MF,Grocott HP,Mathew JP,White WD,Landolfo K,Reves JG,Laskowitz DT,Mark DB,Blumenthal JA,Neurologic Outcome Research Group and the Cardiothoracic Anesthesia Research Endeavors (CARE) Investigators of the Duke Heart Center.

    更新日期:2001-12-01 00:00:00

  • Effect of BQ-123 and tissue plasminogen activator on vasospasm after subarachnoid hemorrhage in monkeys.

    abstract:BACKGROUND AND PURPOSE:We aimed to determine the effect of intracisternal administration of an endothelin-A receptor antagonist (BQ-123) against vasospasm in a monkey model and to determine whether this drug would have adverse interactions with intracisternal tissue plasminogen activator (TPA). METHODS:Thirty-three mo...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.27.9.1629

    authors: Kim CJ,Bassiouny M,Macdonald RL,Weir B,Johns LM

    更新日期:1996-09-01 00:00:00

  • Effect of collateral blood flow and cerebral vasomotor reactivity on the outcome of carotid artery occlusion.

    abstract:BACKGROUND AND PURPOSE:Evidence suggests that an alteration in cerebral hemodynamics plays a relevant role in the occurrence of stroke in patients with carotid occlusion. The purpose of the present study was to evaluate the relationships among baseline characteristics, type and number of collateral pathways, cerebral v...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.32.7.1552

    authors: Vernieri F,Pasqualetti P,Matteis M,Passarelli F,Troisi E,Rossini PM,Caltagirone C,Silvestrini M

    更新日期:2001-07-01 00:00:00

  • Influence of weekend hospital admission on short-term mortality after intracerebral hemorrhage.

    abstract:BACKGROUND AND PURPOSE:There is expanding literature to show that certain patients admitted during the weekend have worse outcomes than similar patients admitted during the week. Although many clinicians have hypothesized the presence of this "weekend effect" with patients with intracerebral hemorrhage, there is a pauc...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.108.546572

    authors: Crowley RW,Yeoh HK,Stukenborg GJ,Medel R,Kassell NF,Dumont AS

    更新日期:2009-07-01 00:00:00

  • Carotid plaque, aging, and risk factors. A study of 457 subjects.

    abstract:BACKGROUND AND PURPOSE:The aim of this study was to assess the prevalence of extracranial carotid artery atherosclerosis and its relation to principal cardiovascular risk factors at different ages in a sample of the general population. METHODS:B-mode ultrasonography was used to investigate the carotid district in 457 ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.25.6.1133

    authors: Fabris F,Zanocchi M,Bo M,Fonte G,Poli L,Bergoglio I,Ferrario E,Pernigotti L

    更新日期:1994-06-01 00:00:00

  • Transcranial Doppler.

    abstract::TCD recording of flow velocities in intracranial vessels was first described by Aaslid in 1982. The utility of this instrument becomes more apparent as it is used in different clinical settings and compared with angiographic findings (Figures 1 and 2). Its importance in early detection of vasospasm in subarachnoid hem...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.19.7.915

    authors: DeWitt LD,Wechsler LR

    更新日期:1988-07-01 00:00:00