Abstract:
BACKGROUND AND PURPOSE:Experimental stroke models are essential to study in vivo pathophysiological processes of focal cerebral ischemia. In this study, an embolic stroke model in rats was applied (1) to characterize early development of regional cerebral blood flow and metabolism with positron emission tomography (PET) using [(15)O]H(2)O and [(18)F]-2-fluoro-2-deoxy-D-glucose (FDG); and (2) to identify potential parameters for predicting tissue fate. METHODS:Remote occlusion of the middle cerebral artery was induced in 10 Wistar rats by injection of 4 TiO(2) macrospheres. Sequential [(15)O]H(2)O-PET (baseline, 5, 30, 60 minutes after middle cerebral artery occlusion) and FDG-PET measurements (75 minutes after middle cerebral artery occlusion) were performed. [(15)O]H(2)O-PET data and FDG kinetic parameters were compared with MRIs and histology at 24 hours. RESULTS:Regional cerebral blood flow decreased substantially within 30 minutes after middle cerebral artery occlusion (41% to 58% of baseline regional cerebral blood flow; P<0.001) with no relevant changes between 30 and 60 minutes. At 60 minutes, regional cerebral blood flow correlated well with the unidirectional transport parameter K1 of FDG in all animals (r=0.86±0.09; P<0.001). Tissue fate could be accurately predicted taking into account K1 and net influx rate constant Ki of FDG. The infarct volume predicted by FDG-PET (375.8±102.3 mm(3)) correlated significantly with the infarct size determined by MRI after 24 hours (360.8±93.7 mm(3); r=0.85). CONCLUSIONS:Hypoperfused tissue can be identified by decreased K1 of FDG. Acute ischemic tissue can be well characterized using K1 and Ki allowing for discrimination between infarct core and early viable tissue. Because FDG-PET is widely spread, our findings can be easily translated into clinical application for early diagnoses of ischemia.
journal_name
Strokejournal_title
Strokeauthors
Walberer M,Backes H,Rueger MA,Neumaier B,Endepols H,Hoehn M,Fink GR,Schroeter M,Graf Rdoi
10.1161/STROKEAHA.111.624551subject
Has Abstractpub_date
2012-01-01 00:00:00pages
193-8issue
1eissn
0039-2499issn
1524-4628pii
STROKEAHA.111.624551journal_volume
43pub_type
杂志文章相关文献
STROKE文献大全abstract:BACKGROUND AND PURPOSE:The effect of smoking reduction on cardiovascular disease outcomes has not been studied in Asian populations. METHODS:A total of 475 734 Korean men aged 30 to 58 years, stratified into 9 groups based on smoking status at 2 different time points (1990 and 1992), were followed from 1992 to 2001 fo...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.512632
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Ischemic injury triggers multiple pathological responses in the brain tissue, including spreading depolarizations across the cerebral cortex (cortical spreading depolarizations [CSD]). Microglia have been recently shown to play a significant role in the propagation of CSD. However, the intracellu...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.120.032766
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The purpose of this work was to investigate how stroke rehabilitation professionals understand the concept of motivation and the ways that they use this concept in their clinical practice. METHODS:This qualitative study used semistructured, in-depth interviews with the professionals working in t...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/hs0202.102367
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:This study reviews the perioperative use of red blood cell transfusion in cerebrovascular neurosurgery. The current algorithm for preoperative ordering of red cells is historical and dated. More blood is ordered than is actually transfused, and considerable variability exists between different in...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/hs0402.105296
更新日期:2002-04-01 00:00:00
abstract::Leukoaraiosis is a common finding in stroke patients and has been strongly associated with risk of incident stroke and dementia. Leukoaraiosis may also be an independent predictor of stroke outcomes. There is increasing evidence from neuroimaging to support the concept that some leukoaraiosis is caused by white matter...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/STROKEAHA.110.596056
更新日期:2010-10-01 00:00:00
abstract::Atrial septal aneurysm is an uncommon occult cardiac source of cerebral embolism. It is usually asymptomatic, and clinical cardiologic examination and electrocardiography fail to reveal its presence. We report a case of a 34-year-old woman with sudden right hemiplegia and aphasia from occlusion of the left carotid sip...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.19.5.640
更新日期:1988-05-01 00:00:00
abstract::The frequency of clinically significant coronary artery disease (CAD) among stroke patients and the impact of CAD on stroke rehabilitation were studied in 132 patients with first thrombotic or embolic stroke who participated in comprehensive rehabilitation. Sixty-one patients (46%) had a history of CAD, and 16 of the ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.19.1.42
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Delayed paraplegia remains a devastating complication after ischemic spinal cord injury associated with aortic surgery and trauma. Although apoptosis has been implicated in the pathogenesis of delayed neurodegeneration, mechanisms responsible for the delayed paraplegia remain incompletely underst...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.600429
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Intracranial internal carotid artery calcification is associated with cerebrovascular risk factors and stroke, but few quantification methods are available. We tested the reliability of visual scoring, semiautomated Agatston score, and calcium volume measurement in patients with recent stroke. M...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.115.009716
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Sonothrombolysis is a new treatment approach in acute ischemic stroke. The results of a monocenter, randomized clinical study are presented. METHODS:Subjects with acute middle cerebral artery main stem occlusion were randomized into a target group receiving 1-hour transcranial continuous insonat...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/STROKEAHA.107.503870
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND:Cerebral fat embolism syndrome is a rare, but potentially lethal, complication of long bone fractures. Neurological symptoms are variable, and the clinical diagnosis is difficult. The purpose of this case study is to demonstrate the value of diffusion-weighted MRI of the brain for early diagnosis of fat embo...
journal_title:Stroke
pub_type: 杂志文章
doi:
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Leukocytes have been implicated in the development of ischemic atherosclerotic vascular diseases. In a prospective study we investigated whether the plasma concentrations of inflammatory mediators, ie, proteases and cytokines, as markers for systemic leukocyte activation, are increased in patient...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.27.10.1734
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The lipophilic calcium channel antagonist flunarizine has been demonstrated to be neuroprotective in several models of cerebral ischemia. Ischemic spinal cord injury may have a similar pathophysiology and hence may respond in a similar fashion. This study was designed to investigate the effects o...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.10.1547
更新日期:1993-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The mechanisms of immune reaction involved in the pathogenesis and clinical course of acute vascular incidents are still not completely understood. The aim of this study was to examine the presence of immune complexes (IC) in the acute stroke setting and the first month thereafter and to characte...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.str.0000014562.75483.6b
更新日期:2002-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:To prevent new cardiovascular events after stroke, prescribed preventive drugs should be used continuously. This study measures persistent use of preventive drugs after stroke and identifies factors associated with persistence. METHODS:A 1-year cohort (21,077 survivors) from Riks-Stroke, the Swe...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.109.566950
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Development of translational functional imaging modalities for atherosclerosis risk stratification is sought for stroke prediction. Our group has developed late-phase contrast-enhanced ultrasound (LP-CEUS) to quantify microbubble contrast retention within carotid atherosclerosis and shown it to s...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.111.631200
更新日期:2011-12-01 00:00:00
abstract::Transient visual disturbance following cardiac catheterization has been regarded as a benign and transient complication. We describe two cases of computed-tomography-documented occipital infarction after cardiac catheterization that emphasize a complication more serious than previously thought. ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.19.6.773
更新日期:1988-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Zinc protoporphyrin (ZnPP) has multiple actions. It is an interleukin-1 antagonist as well as a hemeoxygenase inhibitor. Interleukin-1 is produced in ischemic brain and probably contributes to ischemic injury, although the role of heme oxygenase during ischemia is unknown. Whether ZnPP treatment ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.26.6.1035
更新日期:1995-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Several prospective studies have shown significant associations between plasma fibrinogen, viscosity, C-reactive protein (CRP), fibrin D-dimer, or tissue plasminogen activator (tPA) antigen and the risk of primary cardiovascular events. Little has been published on the associations of these varia...
journal_title:Stroke
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/01.STR.0000181754.38408.4c
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The presence of white-matter hyperintensities (WMHs) has been linked to intracerebral hemorrhage (ICH). We sought to determine whether the severity of WMHs influences hematoma growth and ICH volume. METHODS:We retrospectively reviewed prospectively collected clinical, laboratory, and radiologic ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.109.564955
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Knowledge of cerebral blood volume (CBV) is invaluable in identifying the primary cause of brain swelling in patients with stroke or severe head injury, and it might also help in clinical decision making in patients thought to have hemodynamic transient ischemic attacks (TIAs). This investigation...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.28.10.1998
更新日期:1997-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There is increasing interest in defining stroke lesion volume thresholds to predict poststroke outcome. However, there is a paucity of data on factors that impact the association between critical infarct thresholds volume and outcome. We sought to determine whether lesion thresholds best predicti...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.013982
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Less than half of acute ischemic stroke patients treated with mechanical thrombectomy obtain permanent clinical benefits. Consequently, there is an urgent need to identify mechanisms implicated in the limited efficacy of early reperfusion. We evaluated the predictors and prognostic significance o...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.015648
更新日期:2017-03-01 00:00:00
abstract::Clinicopathologic correlations were reviewed in 100 cases of recent cerebral infarctions in the internal carotid artery distribution. The most frequent cause of death was transtentorial herniation, followed in frequency by pneumonia, cardiac causes, and pulmonary embolism. Thirty-six percent of all patients and 47% of...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.12.4.474
更新日期:1981-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The importance of perioperative cognitive decline has long been debated. We recently demonstrated a significant correlation between perioperative cognitive decline and long-term cognitive dysfunction. Despite this association, some still question the importance of these changes in cognitive funct...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/hs1201.099803
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We aimed to determine the effect of intracisternal administration of an endothelin-A receptor antagonist (BQ-123) against vasospasm in a monkey model and to determine whether this drug would have adverse interactions with intracisternal tissue plasminogen activator (TPA). METHODS:Thirty-three mo...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.27.9.1629
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Evidence suggests that an alteration in cerebral hemodynamics plays a relevant role in the occurrence of stroke in patients with carotid occlusion. The purpose of the present study was to evaluate the relationships among baseline characteristics, type and number of collateral pathways, cerebral v...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.32.7.1552
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There is expanding literature to show that certain patients admitted during the weekend have worse outcomes than similar patients admitted during the week. Although many clinicians have hypothesized the presence of this "weekend effect" with patients with intracerebral hemorrhage, there is a pauc...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.108.546572
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The aim of this study was to assess the prevalence of extracranial carotid artery atherosclerosis and its relation to principal cardiovascular risk factors at different ages in a sample of the general population. METHODS:B-mode ultrasonography was used to investigate the carotid district in 457 ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.6.1133
更新日期:1994-06-01 00:00:00
abstract::TCD recording of flow velocities in intracranial vessels was first described by Aaslid in 1982. The utility of this instrument becomes more apparent as it is used in different clinical settings and compared with angiographic findings (Figures 1 and 2). Its importance in early detection of vasospasm in subarachnoid hem...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.19.7.915
更新日期:1988-07-01 00:00:00