Abstract:
BACKGROUND AND PURPOSE:Less than half of acute ischemic stroke patients treated with mechanical thrombectomy obtain permanent clinical benefits. Consequently, there is an urgent need to identify mechanisms implicated in the limited efficacy of early reperfusion. We evaluated the predictors and prognostic significance of vessel wall permeability impairment and its association with blood-cerebrospinal fluid barrier (BCSFB) disruption after acute stroke treated with thrombectomy. METHODS:A prospective cohort of acute stroke patients treated with stent retrievers was analyzed. Vessel wall permeability impairment was identified as gadolinium vessel wall enhancement (GVE) in a 24- to 48-hour follow-up contrast-enhanced magnetic resonance imaging, and severe BCSFB disruption was defined as subarachnoid hemorrhage or gadolinium sulcal enhancement (present across >10 slices). Infarct volume was evaluated in follow-up magnetic resonance imaging, and clinical outcome was evaluated with the modified Rankin Scale at day 90. RESULTS:A total of 60 patients (median National Institutes of Health Stroke Scale score, 18) were analyzed, of whom 28 (47%) received intravenous alteplase before mechanical thrombectomy. Overall, 34 (57%) patients had GVE and 27 (45%) had severe BCSFB disruption. GVE was significantly associated with alteplase use before thrombectomy and with more stent retriever passes, along with the presence of severe BCSFB disruption. GVE was associated with poor clinical outcome, and both GVE and severe BCSFB disruption were associated with increased final infarct volume. CONCLUSIONS:These findings may support the clinical relevance of direct vessel damage and BCSFB disruption after acute stroke and reinforce the need for further improvements in reperfusion strategies. Further validation in larger cohorts of patients is warranted.
journal_name
Strokejournal_title
Strokeauthors
Renú A,Laredo C,Lopez-Rueda A,Llull L,Tudela R,San-Roman L,Urra X,Blasco J,Macho J,Oleaga L,Chamorro A,Amaro Sdoi
10.1161/STROKEAHA.116.015648subject
Has Abstractpub_date
2017-03-01 00:00:00pages
651-657issue
3eissn
0039-2499issn
1524-4628pii
STROKEAHA.116.015648journal_volume
48pub_type
杂志文章相关文献
STROKE文献大全abstract::Background and Purpose- The optimal antithrombotic strategy to balance thromboembolic and bleeding events, especially acute stroke, for patients with atrial fibrillation following coronary stenting remains a matter of debate. We conducted a network meta-analysis to identify the antithrombotic regimen associated with t...
journal_title:Stroke
pub_type: 杂志文章,meta分析
doi:10.1161/STROKEAHA.119.026078
更新日期:2019-08-01 00:00:00
abstract::Nontraumatic intracerebral hemorrhage (ICH) remains a devastating condition with 30-day mortality rates of 35% to 52%. Until the pathophysiology of this condition is better understood, it will not be possible to develop effective therapies. Studies of cerebral blood flow and metabolism in patients with acute ICH show ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.595058
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Research on the relationship between caffeine-containing medicines (CCMs) and the risk of hemorrhagic stroke (HS) is sparse. The aim of this study is to evaluate the association between CCMs and the risk of HS. METHODS:We performed a multicenter case-control study in South Korea, from 2002 to 20...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.111.674077
更新日期:2013-08-01 00:00:00
abstract::Platinum microelectrodes were used to measure H2 clearance in mouse brain, and the clearance curves were used to calculate regional cerebral blood flow (rCBF). The curves were usually biexponential, whether or not electrode placement was confined to the cortex. When calculated by the height over area method, rCBF in a...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.8.1.103
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We studied the relationship between cigarette smoking and stroke incidence and mortality in the Chinese adult population. METHODS:We conducted a prospective cohort study in a nationally representative sample of 169 871 Chinese men and women aged 40 years and older. Data on cigarette smoking and ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.505305
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The National Institutes of Health Stroke Scale (NIHSS) is the gold standard to assess patients with acute stroke. We aimed to examine the feasibility and reliability of prehospital real-time cellular video phone (VP) in performing the NIHSS. METHODS:Forty physicians prospectively performed a sim...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.600296
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke is the leading cause of disability in the Western world; however, few therapies are at hand to decrease this burden. SUMMARY OF REVIEW:Endothelial progenitor cells (EPCs) have been introduced in cardiovascular medicine as factotums. EPCs can repair damaged endothelium and attenuate the de...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.507251
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We sought to evaluate the diagnostic accuracy of ultrasound criteria for recanalization during real-time transcranial Doppler monitoring of intra-arterial reperfusion procedures in acute ischemic stroke patients in an international, multicenter study. METHODS:Consecutive acute ischemic stroke pa...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.112.675074
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Carotid artery stenting (CAS) is an alternative to carotid endarterectomy (CEA) for stroke prevention. The value of this therapy relative to CEA remains uncertain. METHODS:In 10 958 Medicare patients aged 66 years or older between 2004 and 2006, we analyzed in-hospital, 1-year stroke, myocardial...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.608992
更新日期:2011-07-01 00:00:00
abstract::Background and Purpose- Enhancement of erythrophagocytosis by macrophages in a timely manner can limit the toxic effects of erythrocyte metabolites and promote brain recovery after intracerebral hemorrhage (ICH). In the current study, we investigated the therapeutic effect of retinoid X receptor agonist, bexarotene, i...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.119.027037
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We hypothesize that in acute middle cerebral artery stroke, thrombus lengths measured in thin-slice nonenhanced CT images define a limit beyond which systemic thrombolysis will fail to recanalize occluded arteries. METHODS:In 138 patients who presented with acute middle cerebral artery stroke an...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.609693
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Progression of asymptomatic carotid artery stenosis (ACAS) in patients with >50% luminal narrowing is considered a potential risk factor for ischemic stroke; however, subclinical molecular biomarkers of ACAS progression are lacking. Recent studies suggest a regulatory function for several microRN...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.013650
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Sulcal effacement with preserved underlying gray-white matter junction (isolated sulcal effacement [ISE]) in acute ischemic stroke may not represent irreversible parenchymal injury. We aimed to evaluate the frequency and significance of ISE in patients with large vessel occlusion acute ischemic s...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/STROKEAHA.115.009304
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Evidence of a relationship of fish intake to stroke incidence or mortality is weak. This report examines the association of fish consumption with stroke. METHODS:A cohort of 2107 men aged 40 to 55 years from the Chicago Western Electric Study who were free of coronary heart disease and stroke th...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.27.2.204
更新日期:1996-02-01 00:00:00
abstract::Many nonsteroidal anti-inflammatory drugs exert their effects by inhibiting the synthesis of prostanoids. More specifically, these agents block the synthesis of prostaglandin endoperoxide G2 from arachidonic acid by competing with arachidonate for binding to the cyclooxygenase active site of prostaglandin endoperoxide...
journal_title:Stroke
pub_type: 杂志文章
doi:
更新日期:1990-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Osteogenic protein-1 (OP1) not only possesses trophic activity on bone tissue but also influences neuronal survival and differentiation in vitro. Specific receptors for OP1 are present in brain and spinal cord and can be upregulated during cerebral contusion. OP1 is a member of the transforming g...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.30.1.126
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We sought to identify the most powerful binary measures of the treatment effect of tissue plasminogen activator (tPA) in the National Institute of Neurological Disorders and Stroke (NINDS) rTPA Stroke Trial. METHODS:Using the Classification and Regression Tree (CART) algorithm, we evaluated bina...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.10.2335
更新日期:2000-10-01 00:00:00
abstract::To evaluate the role of platelet function in the pathogenesis of cerebral vasospasm, we compared sequential changes of platelet aggregability and beta-thromboglobulin and thromboxane B2 concentrations in blood samples from the internal jugular and peripheral vein of 13 patients with aneurysmal subarachnoid hemorrhage....
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.22.7.854
更新日期:1991-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:It is still unclear that impaired cerebrovascular reactivity (CVR) to acetazolamide is comparable to elevated oxygen extraction fraction (OEF) on positron emission tomography (PET) in patients with occlusive carotid diseases. Therefore, in this study, the authors aimed to clarify whether OEF is e...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000198878.66000.4e
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Anticoagulation is a highly effective secondary prevention in patients with cardioembolic stroke and atrial fibrillation/flutter (AF). However, the condition remains underdiagnosed, because paroxysmal AF may be missed by diagnostic tests in the acute phase. In this study, the sensitivity of AF de...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/STROKEAHA.111.642199
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We tested the hypothesis that intravenous administration of basic fibroblast growth factor (bFGF) during 4 hours of permanent focal ischemia would affect acute brain injury. METHODS:Halothane-anesthetized cats underwent left middle cerebral artery (MCA) occlusion for 4 hours. Control cats receiv...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.28.3.609
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke is associated with increased risk of dementia. There has been a decline in mortality from stroke among persons 65 and over in recent decades in the US. It is not clear, however, how this process has affected incidence of various dementias. METHODS:We evaluated over time changes in stroke ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000217971.88034.e9
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There is no consensus on whether anticoagulation should be continued or temporarily stopped in patients suffering acute ischemic stroke while using anticoagulation. We assessed treatment variations and outcomes in these patients. METHODS:Post hoc analysis of PASS (Preventive Antibiotics in Strok...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.021514
更新日期:2018-07-01 00:00:00
abstract::Previous studies suggest that rheological changes associated with ischemia may produce postischemic hypoperfusion. We tested whether intracarotid or intravenous infusions of saline improve neurological outcome from incomplete cerebral ischemia in rats. Rats were anesthetized with 1.4% isoflurane in air, and ischemia w...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.22.6.797
更新日期:1991-06-01 00:00:00
abstract::The nature of alpha-adrenergic receptors in human cerebral arteries was characterized, and alteration of these receptors after subarachnoid hemorrhage was examined using a radioligand binding assay. Norepinephrine content of control arteries was also analyzed and compared with that of arteries after subarachnoid hemor...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.19.1.80
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although the mechanisms that contribute to intracranial aneurysm (IA) formation and rupture are not totally elucidated, inflammation and matrix remodeling are incriminated. Because tPA (tissue-type plasminogen activator) controls both inflammatory and matrix remodeling processes, we hypothesized ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.117.017305
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There has been a nonstandard surgical procedure and extensive international controversy in minimally invasive surgery (MIS) for the management of spontaneous supratentorial intracerebral hemorrhage. This meta-analysis assessed the effectiveness of MIS as compared with other treatment options, inc...
journal_title:Stroke
pub_type: 杂志文章,meta分析
doi:10.1161/STROKEAHA.112.667535
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke unit care is one of the most powerful interventions available to help stroke patients. There are limited data available to assess the impact of stroke units in routine clinical practice outside randomized clinical trials. This article uses data from the 2001 to 2002 National Stroke Audit t...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000149618.14922.8a
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We examined the possibility that activation of the human brain renin-angiotensin system is involved in enhancement of ischemic brain damage using chimeric transgenic mice with human renin (hRN) and human angiotensinogen (hANG) genes. METHODS:Chimeric (hRN/hANG-Tg) mice were generated by mating o...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.108.519801
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The role of extracellular Ca2+ in the maintenance of chronic vasospasm after subarachnoid hemorrhage (SAH) is largely unknown. Indeed, studies thus far have been limited to demonstrations that L-type Ca(2+)-channel antagonists were unable to reverse the spasm. This study tested whether SAH-induce...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.27.10.1896
更新日期:1996-10-01 00:00:00