Abstract:
:Many nonsteroidal anti-inflammatory drugs exert their effects by inhibiting the synthesis of prostanoids. More specifically, these agents block the synthesis of prostaglandin endoperoxide G2 from arachidonic acid by competing with arachidonate for binding to the cyclooxygenase active site of prostaglandin endoperoxide synthase. Studies of the molecular biology of prostaglandin endoperoxide synthase indicate that there is a single gene for the enzyme. Thus, tissue-specific effects of nonsteroidal anti-inflammatory drugs probably result from differences in drug distribution and/or metabolism and not from the existence of tissue-specific prostaglandin endoperoxide synthase isozymes. Aspirin causes inactivation of prostaglandin endoperoxide synthase by first binding to the cyclooxygenase active site and then acetylating the protein at Ser530. Although the cyclooxygenase activity is inactivated, the hydroperoxidase activity of prostaglandin endoperoxide synthase is unaltered by Aspirin or other nonsteroidal anti-inflammatory drugs. Replacement of Ser530 of the native enzyme with an alanine residue by site-directed mutagenesis yields a prostaglandin endoperoxide synthase with unaltered catalytic and substrate binding activities. Thus, the hydroxyl group of Ser530 is not essential for enzyme activity. Instead, it appears likely that acetylation of prostaglandin endoperoxide synthase by Aspirin simply places a bulky acetyl group at or near the cyclooxygenase active site, thereby interfering with arachidonic acid binding.
journal_name
Strokejournal_title
Strokeauthors
Smith WL,DeWitt DL,Shimokawa T,Kraemer SA,Meade EAsubject
Has Abstractpub_date
1990-12-01 00:00:00pages
IV24-8issue
12 Suppleissn
0039-2499issn
1524-4628journal_volume
21pub_type
杂志文章相关文献
STROKE文献大全abstract::To compare the diagnostic yields of transesophageal and transthoracic echocardiography in the detection of potential cardiac sources of embolism, 63 patients (mean +/- SD age 63 +/- 15 [range 18-87] years) with transient ischemic attacks or stroke underwent both procedures. Transthoracic echocardiography revealed a po...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.22.6.727
更新日期:1991-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We previously reported increased incidence of ischemic stroke among both blacks and whites with diabetes mellitus, especially in those aged <55 years. With rising prevalence of diabetes mellitus in the past decade, we revisit the impact of diabetes mellitus on stroke incidence in the same populat...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.113.001318
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Anticoagulation is a highly effective secondary prevention in patients with cardioembolic stroke and atrial fibrillation/flutter (AF). However, the condition remains underdiagnosed, because paroxysmal AF may be missed by diagnostic tests in the acute phase. In this study, the sensitivity of AF de...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/STROKEAHA.111.642199
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The Alberta Stroke program early CT score (ASPECTS) is a semiquantative scale for estimating extent and distribution of early ischemic changes within the MCA territory in the acute stroke setting. Good interobserver agreement of total ASPECTS is demonstrated for noncontrast CT (NCCT) and other im...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.112.665208
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Because the blood circulation system of retina and brain are closely related to each other, we examined whether stroke is associated with localized retinal nerve fiber layer defects (RNFLDs). METHODS:Patients with acute ischemic stroke as part of a hospital-based study group were compared with t...
journal_title:Stroke
pub_type: 杂志文章,随机对照试验
doi:10.1161/STROKEAHA.113.004629
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Downregulation of the tumor suppressor, phosphatase and tensin homolog deleted on chromosome 10 (PTEN), is thought to be a novel neuroprotective strategy in ischemic stroke, but the underlying mechanisms remain unclear. In this study, we aimed to validate the use of PTEN regulation of gamma-amino...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.579011
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:We report the clinical and neuroimaging findings of a patient who sustained multiple cerebral infarcts after the ingestion of concentrated hydrogen peroxide solution sold as a "health food" product. CASE DESCRIPTION:An 84-year-old man sustained focal neurological deficits immediately after ingesting 30 mL o...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.25.5.1065
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Recombinant activated factor VII (rFVIIa) reduces hematoma expansion and improves outcome after intracerebral hemorrhage (ICH), with an apparent increase in nonfatal thromboembolic events (TEs) with higher doses. Despite low incidences of such events in rFVIIa-treated hemophiliacs, the frequency ...
journal_title:Stroke
pub_type: 杂志文章,meta分析
doi:10.1161/STROKEAHA.107.493601
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Cancer is a risk factor for ischemic stroke. Little is known about cancer among young adults with ischemic stroke. We studied the frequency of cancer and its association with long-term risk of death among young patients with first-ever ischemic stroke. METHODS:1002 patients aged 15 to 49 years, ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.115.008694
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Ipsilateral thalamic diaschisis (ITD) describes the reduction of thalamic function, metabolism, and perfusion resulting from a distant lesion of the ipsilateral hemisphere. Our aim was to evaluate the perfusion characteristics and clinical impact of ITD in acute middle cerebral artery stroke, whi...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.020698
更新日期:2018-04-01 00:00:00
abstract::A xenon-133 method was used to measure cerebral blood flow (CBF) before and after cerebrospinal fluid (CSF) removal in patients with normal pressure hydrocephalus (NPH). Preliminary results suggested that shunting should be performed on patients whose CBF increased after CSF removal. There was a significant increase i...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.18.6.1074
更新日期:1987-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Neutrophil Extracellular Traps (NETs) are DNA extracellular networks decorated with histones and granular proteins produced by activated neutrophils. NETs have been identified as major triggers and structural factors of thrombosis. A recent study designated extracellular DNA threads from NETs as ...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/STROKEAHA.117.019896
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Because no population-based estimates are available for asymptomatic retinal emboli, we aimed to assess prevalence and associations of this sign in a defined older Australian urban population. METHODS:A total of 3654 persons aged 49 years or older, representing 82% of residents in an urban area ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.28.1.63
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:A high rate of postprocedure complications in the Stenting versus Aggressive Medical Therapy for Intracranial Arterial Stenosis (SAMMPRIS) trial has raised concerns whether such results are representative of intracranial stent placement in actual routine practice. METHODS:Using the Nationwide In...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.002567
更新日期:2013-12-01 00:00:00
abstract::The frequency of angiographically defined asymptomatic CAD in patients with carotid disease is 40%. Although the prognosis of patients with asymptomatic 1-vessel or 2-vessel CAD is good (annual cardiac mortality rate less than 2%), the prognosis of asymptomatic 3-vessel disease or left main CAD is substantially less f...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.str.23.3.433
更新日期:1992-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There is debate regarding the approach for analysis of modified Rankin scale scores, the most common functional outcome scale used in acute stroke trials. METHODS:We propose to use tests to assess treatment differences addressing the metric, "if a patient is chosen at random from each treatment ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.111.632935
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Deep intracerebral hemorrhage (ICH) and lacunar infarcts are the result of small vessel disease, whereas nonlacunar infarcts are often caused by large artery atherosclerosis or cardiac embolism. We hypothesized that patients with deep ICH and lacunar infarcts have similar retinal microvascular si...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.109.569764
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The aim of this study was to determine the 30-day mortality and morbidity of intracerebral hemorrhage in a large metropolitan population and to determine the most important predictors of 30-day outcome. METHODS:We reviewed the medical records and computed tomographic films for all cases of spont...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.7.987
更新日期:1993-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Vasogenic brain edema is a frequent complication of ischemic stroke. The mechanism of the blood-brain barrier opening that underlies the edema formation is poorly understood. In the present study we examined the response of endothelial cells cultured from adult human brain to thrombogenic and fib...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.26.2.265
更新日期:1995-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:It is unclear whether intracerebral hemorrhage (ICH) is associated with dynamic or static exercise. Our aim was to assess whether such an association exists. METHODS:A case-control study was undertaken involving 331 consecutive cases of primary ICH and 331 age- and sex-matched community-based ne...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/hs0202.102878
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Most randomized controlled trials of venous thromboembolism prophylaxis have focused on reduction of deep vein thrombosis, predominantly asymptomatic deep vein thrombosis, detected on imaging. We aimed to estimate the effects of graduated compression stockings on venous thromboembolism events, su...
journal_title:Stroke
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/STROKEAHA.111.680298
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The migratory efficiency of mesenchymal stem cells (MSC) toward cerebral infarct after transplantation is limited. Valproate (VPA) and lithium enhance in vitro migration of MSC by upregulating CXC chemokine receptor 4 and matrix metalloproteinase-9, respectively. Ability of VPA and lithium to pro...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.110.612788
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Intravenous thrombolysis for acute ischemic stroke is beneficial within 4.5 hours of symptom onset, but the effect rapidly decreases over time, necessitating quick diagnostic in-hospital work-up. Initial time strain occasionally results in treatment of patients with an alternate diagnosis (stroke...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.111.000126
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Ventricular assist devices (VADs) have advanced the management of end-stage heart failure. However, these devices are associated with hemorrhagic and thrombotic complications, including stroke. We assessed the incidence, risk factors, and outcomes of ischemic and hemorrhagic stroke after VAD plac...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.116.014049
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Patients with carotid occlusive disease and stage 2 cerebral hemodynamic failure, characterized by an increased oxygen extraction fraction (OEF) as measured by positron emission tomography (PET) and otherwise known as misery perfusion, have a high risk of cerebral ischemia and subsequent stroke. ...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.str.0000027638.19392.7e
更新日期:2002-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Lamotrigine (LTG) is an anticonvulsant drug whose mechanism of action may involve the inhibition of glutamate release by blocking voltage-dependent sodium channels. Glutamate neurotoxicity may contribute to cerebral ischemic damage after recovery from cardiac arrest. Thus, LTG may prevent the bra...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.28.11.2230
更新日期:1997-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There is no consensus on whether anticoagulation should be continued or temporarily stopped in patients suffering acute ischemic stroke while using anticoagulation. We assessed treatment variations and outcomes in these patients. METHODS:Post hoc analysis of PASS (Preventive Antibiotics in Strok...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.021514
更新日期:2018-07-01 00:00:00
abstract::Background and Purpose- To identify the specific post-endovascular stroke therapy (EVT) peak systolic blood pressure (SBP) threshold that best discriminates good from bad functional outcomes (a priori hypothesized to be 160 mm Hg), we conducted a prospective, multicenter, cohort study with a prespecified analysis plan...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.119.026889
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The ankle-brachial index (ABI) is a fast, cheap, noninvasive indicator of atherosclerotic burden that may also be a predictor of stroke recurrence. In this systematic review and meta-analysis, we sought to explore ABI's merit as a marker for stroke recurrence and vascular risk by synthesizing the...
journal_title:Stroke
pub_type: 杂志文章,meta分析,评审
doi:10.1161/STROKEAHA.115.011321
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:This study evaluated the safety and efficacy of aggressive mechanical clot disruption (AMCD) in acute stroke patients with persisting middle cerebral artery (MCA) or internal carotid artery (ICA) occlusion after thrombolytic therapy. METHODS:Retrospective case series were used from a prospective...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000152331.93770.18
更新日期:2005-02-01 00:00:00