Abstract:
:Excessive exposure to nickel may cause health effects on the blood, lung, nose, kidney, reproductive system, skin and the unborn child. In the present study, we found that Ni²⁺ exposure led to a time- and dose-dependent proliferation arrest and death in human leukemia HL-60 cells. In the presence of 1 mM Ni²⁺, reactive oxygen species (ROS) generation (indicated by the level of malondialdehyde) increased to 323% and histone acetylation decreased to 32%. Interestingly, quercetin (QU) dose dependently prevented Ni²⁺-induced cell proliferation arrest and death from 0 to 80 μM but showed similar activity of scavenging ROS at the concentrations of 20, 40 and 80 µM. When the effect of QU on histone acetylation was studied, QU significantly prevented Ni²⁺-induced histone hypoacetylation at 40 or 80 µM. Moreover, increase in histone acetylation by trichostatin A could also significantly enhance the protection effect of QU at 10 or 20 µM but not at higher concentrations. Thus, our results further confirmed the critical role of ROS and histone hypoacetylation in the cytotoxicity of Ni²⁺ exposure and proved that QU is a potentially useful native dietary compound to efficiently prevent Ni²⁺-caused cytotoxicity through both diminishing ROS generation and increasing histone acetylation.
journal_name
Toxicol Ind Healthjournal_title
Toxicology and industrial healthauthors
Chen J,Han J,Wang Jdoi
10.1177/0748233711433940subject
Has Abstractpub_date
2013-05-01 00:00:00pages
360-6issue
4eissn
0748-2337issn
1477-0393pii
0748233711433940journal_volume
29pub_type
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