Abstract：
:Hepatocarcinogens are agents that increase the incidence of liver cancer in exposed animals or humans. It is now established that carcinogenic exposures have a widespread impact on the transcriptome, inducing both adaptive and adverse changes in the activities of genes and pathways. Chemical hepatocarcinogens have also been shown to affect expression of microRNA (miRNA), the evolutionarily conserved noncoding RNA that regulates gene expression posttranscriptionally. Considerable effort has been invested into examining the involvement of mRNA in chemical hepatocarcinogenesis and their potential usage for the classification and prediction of new chemical entities. For miRNA, there has been an increasing number of studies reported over the past decade, although not to the same degree as for transcriptomic studies. Current data suggest that it is unlikely that any gene or miRNA signature associated with short-term carcinogen exposure can replace the rodent bioassay. In this review, we discuss the application of transcriptomic and miRNA profiles to increase mechanistic understanding of chemical carcinogens and to aid in their classification.
journal_name
Toxicol Ind Healthjournal_title
Toxicology and industrial healthauthors
Nicolaidou V,Koufaris Cdoi
10.1177/0748233720922710subject
Has Abstractpub_date
2020-05-01 00:00:00pages
386-397issue
5eissn
0748-2337issn
1477-0393journal_volume
36pub_type
杂志文章abstract：:An analytical method using natural analcime zeolite modified with tppz (2,3,5,6-tetra-pyridylpyrazine) for preconcentration of cadmium, in a column system, and their sequential determination by flame atomic absorption spectrometry (FAAS), was developed. In this work, cadmium was adsorbed onto natural analcime zeolite ...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233711422730
更新日期：2012-10-01 00:00:00
abstract：:The developmental toxicity of 2,4-Pentanedione (2,4-PD; CAS No. 123-54-6), a widely used industrial chemical, was investigated by vapour exposure, because of its widespread use, and potential for human exposure. Timed-pregnant Fischer 344 rats were exposed on gestational days (gd) 6 to 15 inclusive to analytically mea...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/074823379000600308
更新日期：1990-05-01 00:00:00
abstract：:Yoghurt is a popular dairy product in Iran because of its beneficial influence on human health and nutritional value. Aflatoxin M1 (AFM1) is the metabolite of potential carcinogen aflatoxin B1, which can contaminate milk through the feed and is not eliminated by common processing heat treatment. An analytical method u...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233710394236
更新日期：2011-08-01 00:00:00
abstract：:The Norplant* system is composed of a set of six Silastic* (silicone polydimethysiloxane) capsules measuring 34 mm by 2.4 mm, each containing 36 mg of levonorgestrel and sealed at either end with a medical grade silicone elastomer adhesive. Levonorgestrel is a synthetic progestin, widely used in combination oral contr...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/074823379501100104
更新日期：1995-01-01 00:00:00
abstract：:A more complicated pathology was observed in female pigs infected with Mycoplasma hyopneumoniae, when the same were exposed to 20 ppm dietary levels of fumonisin B1 (FB1) starting 14 days before infection for a period of 42 days as was assessed by gross pathology and pathomorphological examinations or computed tomogra...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233714543735
更新日期：2016-06-01 00:00:00
abstract：:The aim of this study was to investigate the different testicular toxicity and the role of apoptosis in the possible mechanism induced by the two isomers of bromopropanes (BPs) in the same dosage. Following the 14-day treatment with a single dose of 1-BP and 2-BP (1 g/kg), male rats were killed and a series of experim...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233710373083
更新日期：2010-09-01 00:00:00
abstract：:Recently, we have detailed a DNA alkaline unwinding assay (DAUA) that can be used to rapidly measure chemically induced strand breaks in mammalian cells (Daniel et al., 1985). In this paper we present further development of this assay, including: (1) studies on the relationship between DNA adducts and DNA strand break...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/074823378900500506
更新日期：1989-10-01 00:00:00
abstract：:Groups of five male and five female rats were fed diets containing from 0% to 2.5% di(2-ethylhexyl)terephthalate (DEHT) or 1.2% di(2-ethylhexyl)phthalate (DEHP) for 21 days. Feed consumption and body weight gains were collected and, at study termination, animals were examined for alterations in body weight, difference...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/074823378700300206
更新日期：1987-06-01 00:00:00
abstract：OBJECTIVE:For several decades, there has been increasing evidence for excess incidence of lung cancer among workers in the rubber industry. The purpose of this study was to assess the risk of lung cancer occurrence among Egyptian workers involved in the rubber industry using two circulating protein biomarkers. METHODS...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233720923504
更新日期：2020-04-01 00:00:00
abstract：:Young adult CD-1 male mice were housed in individual cages throughout the study. Groups of 10 to 20 mice were given gradually increasing doses of delta-9-tetrahydrocannabinol (THC) at 6.25 to 25 mg/kg i.p., trifluoperazine (TFP) at 6 to 12 mg/kg p.o., phenobarbital sodium (PS) at 20 to 35 mg/kg p.o., morphine sulfate ...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/074823378900500604
更新日期：1989-12-01 00:00:00
abstract：:Malathion can be ingested, inhaled, or absorbed through the skin, but acute toxicity is maximized when administered orally. Intravenous lipid emulsion (ILE) treatment is used as a new therapeutic method in cases of systemic toxicity caused by some lipid soluble agents. This study aimed to examine the potential treatme...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233717748080
更新日期：2018-02-01 00:00:00
abstract：:The present paper summarizes the proposed time-dependent sensitization (TDS) and partial limbic kindling model for illness from low-level chemicals; reviews and critiques prior studies on CNS aspects of multiple chemical sensitivity (MCS); and outlines possible experimental approaches to future studies. TDS is the pro...
journal_title：Toxicology and industrial health
pub_type： 杂志文章,评审
doi：
更新日期：1994-07-01 00:00:00
abstract：:Kinetic interactions among chemicals present in a mixture can influence the relationship between administered and delivered or effective dose; these interactions are distinct from dynamic interactions such as, for example, competition between two chemicals for receptor binding sites. The relationship between administe...
journal_title：Toxicology and industrial health
pub_type： 杂志文章,评审
doi：10.1177/074823378900500507
更新日期：1989-10-01 00:00:00
abstract：:Reports about vanadium (V) inhalation toxicity on the hematopoietic system, specifically about coagulation are limited. Therefore, we decided to evaluate the effects of V with a complete blood count and morphologic analysis of platelets on blood smears. CD-1 male mice inhaled V2O5 0.02 M 1 h twice weekly over 12 weeks...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1191/0748233706th250oa
更新日期：2006-04-01 00:00:00
abstract：OBJECTIVE:Polycyclic aromatic hydrocarbons (PAHs) are potent environmental pollutants. Benzo[α]pyrene (B[α]P) is the major compound of PAHs that acts by activating aryl hydrocarbon receptor (AhR) in cells. B[α]P is a known carcinogen and an immunotoxicant; however, its role with regard to nuclear factor of activated T ...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233714555153
更新日期：2016-07-01 00:00:00
abstract：:The aim of the present study was to determine the effects of extremely low-frequency magnetic field (ELF-MF) on accumulation of manganese (Mn) in the kidney, liver and brain of rats. A total of 40 rats were randomly divided into eight groups. Four control groups received 0, 3.75, 15 and 60 mg Mn per kg body weight ora...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233713480204
更新日期：2015-06-01 00:00:00
abstract：:The Agency for Toxic Substances and Disease Registry (ATSDR) prepared this health consultation to provide support for assessing the public health implications of hazardous chemical exposure, primarily through drinking water, related to releases of chromated copper arsenate (CCA) in the port of Djibouti. CCA from a shi...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233707076810
更新日期：2007-05-01 00:00:00
abstract：:Lead (Pb) is one of several environmental pollutants that adversely affect human health by producing toxicity at the tissue level. The aim of the study was to understand the effects of Pb on the metabolic profiles of liver and gastrocnemius muscle of mice in relation to carbohydrate and fat metabolisms. Swiss albino m...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233720937196
更新日期：2020-07-01 00:00:00
abstract：:Electrical and electronic waste (E-waste) has now become the fastest growing solid waste around the world. Primitive recycling operations for E-waste have resulted in severe contamination of toxic metals and organic chemicals in the related areas. In this study, six dust and soil samples collected from E-waste recycli...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233711399313
更新日期：2011-10-01 00:00:00
abstract：:Chloropentafluorobenzene (CPFB) has been identified as a candidate simulant for nonpersistent chemical warfare agents. Acute toxicity studies have shown that CPFB has limited adverse effects on laboratory animals. A 21-day inhalation study of rats and mice to 2.5, 0.8, and 0.25 mg CPFB/liter resulted in reduced weight...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/074823379100700406
更新日期：1991-07-01 00:00:00
abstract：STUDY OBJECTIVES:Asbestos bodies (ABs) form as asbestos fibers become coated by a cellular iron- and protein-rich matrix. ABs have been reported in lymph nodes and a few extrapulmonary sites, but no data exist as to their formation outside of the lung. It is not clear whether the AB found in these extrapulmonary areas ...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1191/0748233701th090oa
更新日期：2001-02-01 00:00:00
abstract：:Wild alligators exposed to persistent organochlorine contaminants, municipal waste compounds, and contemporary-use herbicides exhibit reproductive alterations that are thought to be caused by endocrine disruption. This study tests the hypothesis that these alterations, at least in part, result from exposure of alligat...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1191/074823399678846565
更新日期：1999-01-01 00:00:00
abstract：:Most of the mobile phones in Turkey emit 900 MHz radiation which is mainly absorbed by the skin and, to a lesser extent, muscle. The aim of this study was to investigate the effects the 900 MHz electromagnetic irradiation emitted by these devices on the induction of histopathologic changes in skin and the effect of me...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1191/0748233704th207oa
更新日期：2004-09-01 00:00:00
abstract：:As one of the main components of risk assessment, exposure assessment plays a key role in evaluating risk. Many different scenarios can be developed to estimate the risk from exposure to chemicals such as persistent organic pollutants (POPs). The US Food and Drug Administration (FDA)'s Center for Food Safety and Appli...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1191/0748233701th104oa
更新日期：2001-06-01 00:00:00
abstract：:1,2-Dichloropropane (1,2-DCP), a solvent, which is the main component of the cleaner used in the offset printing companies in Japan, is suspected to be the causative agent of bile duct cancer, which has been recently reported at high incidence in those offset printing workplaces. While there are some reports about the...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233714568801
更新日期：2016-09-01 00:00:00
abstract：:Molecular mechanisms in the pathogenesis of silicosis are not fully understood. Exposure to crystalline silica leads to the activation of signaling pathways controlling the production and secretion of inflammatory mediators. Inflammatory cytokines are noted as important candidate genes for fibrotic lung diseases. Cyto...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233712445048
更新日期：2013-10-01 00:00:00
abstract：:A comparative potency method for cancer risk assessment has been developed based on a constant relative potency hypothesis. This method was developed and tested using data from a battery of short-term mutagenesis bioassays, animal tumorigenicity data and human lung cancer risk estimations. This data base was developed...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/074823378500100412
更新日期：1985-12-01 00:00:00
abstract：:The present study investigates the toxic effects of acrylamide (ACR) administered to rats at two doses on (i) oxidative stress and disruption of pro-oxidant/antioxidant balance in hepatic cells and (ii) its correlation with metallothioneins (MTs) genes expression, DNA damage and histomorphological changes. Treated rat...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233717696613
更新日期：2017-08-01 00:00:00
abstract：:Chloroethane (CE) gas carcinogenicity is analyzed and determined from a National Toxicology Program (NTP) bioassay where an inhalation concentration of 15,000 ppm CE gas in air produced the highest incidence of an uncommon-to-rare tumor ever observed by the NTP. Persistently inhaled CE produces endometrial cancers in ...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233708100371
更新日期：2008-11-01 00:00:00
abstract：:Elaeagnus angustifolia was analyzed for determination of metals, phytoconstituents, bactericidal, fungicidal and insecticidal effects and to explore its chemical and biological potential. The root, branches, leaves, stem bark and root bark parts of E. angustifolia were found to contain iron, lead, copper, cadmium, zin...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233713498459
更新日期：2016-01-01 00:00:00
