Abstract:
:Malathion can be ingested, inhaled, or absorbed through the skin, but acute toxicity is maximized when administered orally. Intravenous lipid emulsion (ILE) treatment is used as a new therapeutic method in cases of systemic toxicity caused by some lipid soluble agents. This study aimed to examine the potential treatment effect of ILE on rat lung tissue in a toxicokinetic model of malathion exposure. Twenty-one adult Wistar albino rats were randomly divided into three equal groups. The groups were organized as group I (control), group II (malathion), and group III (malathion + ILE treatment). Malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) were evaluated in lung tissues. Immunohistochemical and Western blot analyses were performed to determine the bax, bcl-2, and caspase-3 expression levels. Tissue GSH-Px and SOD activities were decreased and MDA levels were increased in the malathion group. ILE administration increased GSH-Px and SOD activity and decreased MDA levels compared to the malathion group. Furthermore, expression of bax, bcl-2, and caspase-3 significantly increased in the malathion group, and ILE infusion reduced these expression levels. The present study revealed that acute oral malathion administration increased oxidative stress and apoptosis in the lung tissue of rats. ILE infusion prevented oxidative stress and decreased the deleterious effects of malathion. Taken together, the findings of our study suggest that lipid emulsion infusion has treatment efficacy on malathion-induced lung toxicity.
journal_name
Toxicol Ind Healthjournal_title
Toxicology and industrial healthauthors
Uysal M,Karaman Sdoi
10.1177/0748233717748080subject
Has Abstractpub_date
2018-02-01 00:00:00pages
110-118issue
2eissn
0748-2337issn
1477-0393journal_volume
34pub_type
杂志文章abstract::The aryl hydrocarbon receptor (AHR) is one of the principal xenobiotic, nuclear receptor that is responsible for the early events involved in the transcription of a complex set of genes comprising the CYP450 gene family. In the present computational study, homology modelling and molecular docking were carried out with...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712463774
更新日期:2014-09-01 00:00:00
abstract::Pesticides are omnipresent in environment, water, fruits, and vegetables and are considered as risk factors for human health. Consumers are mainly exposed to pesticides through diet, and the main question to be answered concerns the impact of such exposure on health. In this study, we developed a mouse model to mimic ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233714548207
更新日期:2016-07-01 00:00:00
abstract::The US Air Force has implemented the widespread use of JP-8 jet fuel in its operations, although a thorough understanding of its potential effects upon exposed personnel is unclear. Previous work has reported that JP-8 exposure is immunosuppressive. In the present study, the effects of in-utero JP-8 jet fuel exposure ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233708089045
更新日期:2007-10-01 00:00:00
abstract::The technologically interesting properties of palladium nanoparticles (Pd-NPs) allowed their widespread industrial application, although concerns emerged on increasing general and occupational levels of exposure. In this context, to assess the toxicological behavior of Pd-NPs, and particularly their endocrine disrupti...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233719851702
更新日期:2019-06-01 00:00:00
abstract::Widespread use of mobile phones which are a major source of electromagnetic fields might affect living organisms. However, there has been no investigation concerning prenatal exposure to electromagnetic fields or their roles in the development of the pyramidal cells of the cornu ammonis in postnatal life. Two groups o...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233709106442
更新日期:2009-07-01 00:00:00
abstract:INTRODUCTION:Spirometry is the main pulmonary function test routinely employed in the occupational medicine practice. Its interpretation depends on the choice of the theoretical reference values. Therefore, our objective was to retrospectively evaluate the differences in the spirometric interpretation according to the ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233720912059
更新日期:2020-02-01 00:00:00
abstract::Most of the mobile phones in Turkey emit 900 MHz radiation which is mainly absorbed by the skin and, to a lesser extent, muscle. The aim of this study was to investigate the effects the 900 MHz electromagnetic irradiation emitted by these devices on the induction of histopathologic changes in skin and the effect of me...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1191/0748233704th207oa
更新日期:2004-09-01 00:00:00
abstract::The inhalation toxicity of methanol and toluene was investigated in rats. Young Sprague Dawley rats of both sexes were exposed to vapors of methanol (300 ppm, 3000 ppm), toluene (30 ppm, 300 ppm) or methanol/toluene (300/30 ppm, 300/300 ppm, 3000/30 ppm, and 3000/300 ppm) six hrs per day, five days/week for four weeks...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379401000310
更新日期:1994-05-01 00:00:00
abstract::The aim of this study was to evaluate indoor air quality and factors affecting expired carbon monoxide (CO) levels in a coffeehouse environment. This cross-sectional study was conducted at 16 randomly selected coffeehouses in Duzce, Turkey, during November 2007 to March 2008. A total of 547 people, average age 46.72 ±...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233710383888
更新日期:2011-04-01 00:00:00
abstract::Some studies have shown increased DNA damage among car painters, but other professionals working in auto body and paint shops have not been extensively assessed. The aim of this study was to assess DNA damage in different types of auto body shop workers by measuring micronucleus (MN) levels in exfoliated buccal cells....
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233710375948
更新日期:2010-10-01 00:00:00
abstract::The aim of this study was to analyze the biochemical alterations in the gills of Venus verrucosa under exposure for 6 days to three doses of lambda-cyhalothrin (λ-cyh) (100, 250, and 500 µg L-1). Malondialdehyde, lipid hydroperoxide, and hydrogen peroxide levels in the gills of treated groups increased. λ-Cyh exposure...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233720961219
更新日期:2020-11-01 00:00:00
abstract::Paraquat has been shown to be a highly toxic compound for humans and animals, and many cases of acute poisoning and death have been reported over the past few decades. The present study was undertaken to evaluate comprehensively herbicides (Paraquat) and some plant extracts to biochemical aspects of Lymnaea natalensis...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713498457
更新日期:2016-01-01 00:00:00
abstract::The hypolipidemic effect of 10% fruit fibers in rats fed with high-fat diet (HFD) was evaluated. This study was conducted on a total of 50 male Albino rats divided into 10 equal groups fed with different types of dietary fruits. The feeding period lasted for 24 weeks. Fasting blood samples were collected and sera sepa...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712472526
更新日期:2015-03-01 00:00:00
abstract::Trivalent chromium (Cr) is an environmental contaminant, which is extensively used in tanning industries throughout the world and causes various forms of health hazards in tannery workers. Therefore, a cross-sectional study design was used to evaluate the DNA damage and oxidative stress condition in tannery workers ex...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712457447
更新日期:2014-06-01 00:00:00
abstract::This investigation gives detailed analysis of peripheral marker enzymes as well as neurobehavioral tests following chronic aluminium (Al) exposure (10 mg/kg b.w. for 12 weeks intragastrically). We observed a significant decrease in the levels of serum cholinesterase after toxicity. The enzymatic activity of cytochrome...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1191/0748233706th242oa
更新日期:2006-02-01 00:00:00
abstract::The morphological consequences of chronic exposition to low doses of cadmium (Cd) in the Leydig cells population were investigated in 40 sexually mature male mice at morphological and ultrastructural levels. Animals were orally exposed to cadmium (0.015 g/L of CdCl(2) in drinking water) for 3, 6, 12 and 18 months and ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233710371111
更新日期:2010-09-01 00:00:00
abstract::Organophosphate poisoning is a life-threatening condition, which is being responsible for the symptoms due to cholinergic effects. Clinical status and blood levels of cholinesterase are used its diagnosis. While atropine and pralidoxime (PAM) appear as essential medications, hemofiltration treatments and lipid solutio...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712462478
更新日期:2014-06-01 00:00:00
abstract::The aim of this study was to evaluate the antiapoptotic and proliferative activity of curcumin (Cur) on the ovarian follicles in mice exposed to whole body ionizing radiation (Rd). The mice were exposed to 8.3 gray whole body Rd, and Cur groups were given as a daily dose of 100 mg/kg of Cur for 10 days (10 days before...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233711425080
更新日期:2012-10-01 00:00:00
abstract::Molecular mechanisms in the pathogenesis of silicosis are not fully understood. Exposure to crystalline silica leads to the activation of signaling pathways controlling the production and secretion of inflammatory mediators. Inflammatory cytokines are noted as important candidate genes for fibrotic lung diseases. Cyto...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712445048
更新日期:2013-10-01 00:00:00
abstract::The Agency for Toxic Substances and Disease Registry (ATSDR) prepared this health consultation to provide support for assessing the public health implications of hazardous chemical exposure, primarily through drinking water, related to releases of chromated copper arsenate (CCA) in the port of Djibouti. CCA from a shi...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233707076810
更新日期:2007-05-01 00:00:00
abstract::In the last few decades the need for new approaches to assess DNA damage has been increasing due to the implications that different insults on genetic material may have on human health. In this context, the identification of how chemical agents with different mechanisms of action (i.e., antineoplastic drugs) damage DN...
journal_title:Toxicology and industrial health
pub_type: 杂志文章,评审
doi:10.1191/0748233705th224oa
更新日期:2005-09-01 00:00:00
abstract::Enzymes with hydroxylating activity on alkanes have potential application as biotransformation catalysts in chemical and pharmaceutical industry. Genome of Alcanivorax borkumensis, a marine bacterium with hydrocarbon dissimilation activity, contains at least two P450 monooxygenases and two nonheme monooxygenases, AlkB...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233711416953
更新日期:2012-07-01 00:00:00
abstract::The mechanism by which granulocyte colony-stimulating factor (G-CSF) could lead to the protection from liver injury is not well known. Therefore, the resolution of this role needs further basic and clinical experimental investigation. Acute liver injury was induced in rats by single intraperitoneal injection of a 0.50...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712440136
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVES:Various authors who studied the effects of aluminium (Al) exposure on the neurocognitive system in the last 30 years have reached different and often contradictory conclusions. The aim of this study is to help clarify the effects that the metal causes on cognitive ability in a group of naval welders exposed ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712456062
更新日期:2014-05-01 00:00:00
abstract::The effects of trona (Kaun), a food additive, on the redox status of the liver and kidney of male Wistar rats were investigated. A total of 60 male rats (145 ± 2.52 g) were grouped into four: A, B, C and D, where group A (the control) received 1 mL of distilled water orally while those in groups B, C and D (test group...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712469654
更新日期:2015-02-01 00:00:00
abstract::Male infertility can be caused by environmental factors, genetic defects, physiological and endocrine deficiencies and testicular pathologies. Aluminium (Al) can cause male infertility through a number of mechanisms. The aim of our study was thus to determine whether vitamin E (VitE) has protective effects on Al-induc...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233720919663
更新日期:2020-04-01 00:00:00
abstract::Environmental Impact Assessment is essentially a process comprising four elements: identification, prediction, evaluation, and monitoring. Properly conducted EIA studies can identify linkages between injurious events and/or activities and their damaging consequences. This aids in making the risk management decision. T...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379100700541
更新日期:1991-09-01 00:00:00
abstract::Cyclophosphamide (CP) is an alkylating agent that has been considered effective for cancer treatment. Lycopene, the pigment in tomato fruits, has beneficial effect in the treatment of some diseases. The goal of this study is to evaluate the protective effect of lycopene alone or combined with melatonin (Mel) in inhibi...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712459916
更新日期:2014-07-01 00:00:00
abstract::Environmental pollution, primarily from industrialization, has caused significant adverse effects to humans, animals, and the ecosystem. Attempts have been made to reduce and prevent these pollutants through better waste management practices. Incineration is one such practice, which seeks to prevent adverse health imp...
journal_title:Toxicology and industrial health
pub_type: 杂志文章,评审
doi:
更新日期:1996-03-01 00:00:00
abstract::The purpose of this study was to evaluate the potential influence of occupational ionizing radiation (IR) exposure on health professionals, assessing DNA damage using the comet and micronucleus (MN) assays and analyzing relative risks, correlations, and associated factors between outcomes and socioeconomic and lifesty...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233720932081
更新日期:2020-05-01 00:00:00