Abstract:
:The US Air Force has implemented the widespread use of JP-8 jet fuel in its operations, although a thorough understanding of its potential effects upon exposed personnel is unclear. Previous work has reported that JP-8 exposure is immunosuppressive. Exposure of mice to JP-8 for 1 h/day resulted in immediate secretion of two immunosuppressive agents; namely, interleukin-10 (IL-10) and prostaglandin E2 (PGE2). Thus, it was of interest to determine if jet fuel exposure might promote tumor growth and metastasis. The syngeneic B16 tumor model was used for these studies. Animals were injected intravenously with tumor cells, and lung colonies were enumerated. Animals were also examined for metastatic spread of the tumor. Mice were either exposed to 1000 mg/m3 JP-8 (1 h/ day) for 7 days before tumor injection or were exposed to JP-8 at the time of tumor injection. All animals were killed 17 days after tumor injection. In the present study, JP8 exposure potentiated the growth and metastases of B16 tumors in an animal model. Exposure of mice to JP-8 for 1 h/day before tumor induction resulted in an approximately 8.7-fold increase in tumors, whereas those mice exposed to JP8 at the time of tumor induction had a 5.6-fold increase in tumor numbers. Thus, low concentration JP-8 jet fuel exposures have significant immune suppressive effects on the immune system that can result in increased tumor formation and metastases. We have now extended the observations to an experimental subcutaneous tumor model. JP8 exposure at the time of tumor induction in this model did not affect the growth of the tumor. However, JP8-exposed, tumor-bearing animals died at an accelerated rate as compared with air-exposed, tumor-bearing mice.
journal_name
Toxicol Ind Healthjournal_title
Toxicology and industrial healthauthors
Harris DT,Sakiestewa D,Titone D,He X,Hyde J,Witten Mdoi
10.1177/0748233708090908subject
Has Abstractpub_date
2007-11-01 00:00:00pages
617-23issue
10eissn
0748-2337issn
1477-0393journal_volume
23pub_type
杂志文章abstract::Kinetic interactions among chemicals present in a mixture can influence the relationship between administered and delivered or effective dose; these interactions are distinct from dynamic interactions such as, for example, competition between two chemicals for receptor binding sites. The relationship between administe...
journal_title:Toxicology and industrial health
pub_type: 杂志文章,评审
doi:10.1177/074823378900500507
更新日期:1989-10-01 00:00:00
abstract::The aim of the present study was to assess the influence of curcumin on liver regeneration after partial hepatectomy (PH) in rats. A total of 24 male Sprague Dawley rats were divided into three groups: sham-operated (SH), PH, and PH + curcumin; each group contains eight animals. The rats in curcumin-treated groups wer...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712469658
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVE:For several decades, there has been increasing evidence for excess incidence of lung cancer among workers in the rubber industry. The purpose of this study was to assess the risk of lung cancer occurrence among Egyptian workers involved in the rubber industry using two circulating protein biomarkers. METHODS...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233720923504
更新日期:2020-04-01 00:00:00
abstract::Insulin resistance (IR) is recognized as a contributory factor for a variety of liver diseases. The present study investigates the susceptibility of liver to the toxic actions of carbon tetrachloride (CCl(4)) in a rat model of IR, induced by feeding a high-fructose diet (60 g/100 g) for 30 days. A sub-lethal dose of C...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233709359273
更新日期:2010-03-01 00:00:00
abstract::The bromoalkane, 1-bromopropane (1-BP), may damage the reproductive system though oxidative stress, while the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) plays an important role in regulating intracellular antioxidant levels against oxidative stress. This study explored the role of oxidativ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233720979427
更新日期:2020-12-11 00:00:00
abstract::Endothelial adhesion plays an important role in the process of atherosclerosis, which is regulated by endothelial adhesion molecules and chemoattractant molecules. In some areas of China, citreoviridin (CIT) is considered a risk factor for the development of atherosclerosis. Here, we investigated the role of CIT in ad...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713483194
更新日期:2015-03-01 00:00:00
abstract::Natural products possessing antioxidant properties play a very crucial role in ameliorating deleterious effects of reactive oxygen species. This study investigated the chemoprotective properties of methanolic extract of Vernonia amygdalina (MEVA) in an experimental model of hepatic oxidative damage induced by 2-acetyl...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713498436
更新日期:2016-01-01 00:00:00
abstract::Using the Environmental Exposure and Sensitivity Inventory (EESI), a standardized instrument for measuring chemical sensitivity, we obtained and compared ratings of symptoms, chemical (inhalant) intolerances, other intolerances (e.g., drugs, caffeine, alcohol, skin contactants), lifeimpact, and masking (ongoing exposu...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379901500312
更新日期:1999-04-01 00:00:00
abstract::A comparative potency method for cancer risk assessment has been developed based on a constant relative potency hypothesis. This method was developed and tested using data from a battery of short-term mutagenesis bioassays, animal tumorigenicity data and human lung cancer risk estimations. This data base was developed...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823378500100412
更新日期:1985-12-01 00:00:00
abstract::The concentrations of heavy metals (cadmium (Cd), copper (Cu), nickel (Ni), lead (Pb) and zinc (Zn)) were measured in hepatopancreas and muscle of a commercial shrimp (Metapenaeus affinis), in the muscle, liver and gills of two fish species (Thryssa vitrirostris and Johnius belangerii) and in the sediment samples take...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713475498
更新日期:2015-06-01 00:00:00
abstract::Diazinon (DZN) is one of the most widely used insecticides in agricultural pest control. Previous studies have shown that DZN may induce hepatotoxicity. Reactive oxygen species and apoptosis pathways are involved in the toxicity of DZN. Crocin, a constituent of saffron, has hepatoprotective effects due to its antioxid...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713475519
更新日期:2015-04-01 00:00:00
abstract::This study was realized to investigate the possible beneficial effect of thymoquinone (TQ), the major active component of volatile oil of Nigella sativa seeds, against lead (Pb)-induced inhibition of rat testicular functions. Adult rats were randomized into four groups: a control group receiving no treatment; a Pb gro...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233714548474
更新日期:2016-06-01 00:00:00
abstract::The effects of different methylmercury (MeHg) forms on the immune system and the hypothalamic pituitary adrenal (HPA) axis were assessed. The lymphocyte response to Concanavalin A (Con A) stimulation, blood levels of interleukin-6 (IL-6), adrenocorticotrophin hormone (ACTH), and corticosterone in the presence of diffe...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379701300105
更新日期:1997-01-01 00:00:00
abstract::Microbiological studies were carried out on microbial contamination and antimicrobial activity of sea cucumber Holothuria polii collected from Mediterranean Sea at Abu-kir shore of Alexandria, Egypt. The obtained results revealed the presence of isolates of five human Gram-negative pathogenic bacteria, representing fi...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712448116
更新日期:2013-11-01 00:00:00
abstract::Elaeagnus angustifolia was analyzed for determination of metals, phytoconstituents, bactericidal, fungicidal and insecticidal effects and to explore its chemical and biological potential. The root, branches, leaves, stem bark and root bark parts of E. angustifolia were found to contain iron, lead, copper, cadmium, zin...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713498459
更新日期:2016-01-01 00:00:00
abstract::In summary, we have described our method of treating phosgene inhalation injury. We have presented two serious cases in detail which demonstrate that survival was associated with aggressive therapy. Several points should be mentioned. The pulmonary edema and resulting fluid and foam production can be so copious as to ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823378500100207
更新日期:1985-10-01 00:00:00
abstract::Polycyclic aromatic hydrocarbons have mutagenic and carcinogenic properties and some of them are classified as probable or possible human carcinogens. Aim of this study was to evaluate the genotoxic risk in workers exposed to diesel exaust. Environmental and biological monitoring exposure to polycyclic aromatic hydroc...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233707077436
更新日期:2007-02-01 00:00:00
abstract::Exposure estimates produced using predictive exposure assessment methods are associated with a number of uncertainties that relate to the inherent variability of the values for a given input parameter (e.g., body weight, ingestion rate, inhalation rate) and to unknowns concerning the representativeness of the assumpti...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:
更新日期:1992-09-01 00:00:00
abstract::Ferric nitrilotriacetate (Fe-NTA) is a known renal carcinogen and has been shown to adversely induce oxidative stress and tissue toxicity after both acute and chronic exposure. Present studies were designed to study the hepatoprotective and antioxidant potential of butylated hydroxyanisole (BHA), a phenolic antioxidan...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233714554409
更新日期:2015-11-01 00:00:00
abstract::Paraphenylene diamine (PPD) hair dye poisoning is a common health problem in the Middle East and Indian subcontinent. It is the most common cause of suicide intent especially among females. We hereby present a 27-year-old female who presented with a clinical feature of PPD poisoning due to a suicidal attempt, and she ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712448118
更新日期:2014-09-01 00:00:00
abstract::This study on the effect of genetically modified (GM) and non-GM canola on soybean was carried out for physiological and biochemical biosafety assessment of GM canola. Methanolic extracts of GM and non-GM canola were assessed on seed germination and growth of soybean (Glycine max L.) under sterilized conditions. The e...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713501366
更新日期:2016-03-01 00:00:00
abstract::Trivalent chromium (Cr) is an environmental contaminant, which is extensively used in tanning industries throughout the world and causes various forms of health hazards in tannery workers. Therefore, a cross-sectional study design was used to evaluate the DNA damage and oxidative stress condition in tannery workers ex...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712457447
更新日期:2014-06-01 00:00:00
abstract::Paraquat has been shown to be a highly toxic compound for humans and animals, and many cases of acute poisoning and death have been reported over the past few decades. The present study was undertaken to evaluate comprehensively herbicides (Paraquat) and some plant extracts to biochemical aspects of Lymnaea natalensis...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713498457
更新日期:2016-01-01 00:00:00
abstract::Recently, we have detailed a DNA alkaline unwinding assay (DAUA) that can be used to rapidly measure chemically induced strand breaks in mammalian cells (Daniel et al., 1985). In this paper we present further development of this assay, including: (1) studies on the relationship between DNA adducts and DNA strand break...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823378900500506
更新日期:1989-10-01 00:00:00
abstract::Maneb is a dithiocarbamate fungicide that contains manganese. Dithiocarbamates are considered to be chemicals of low toxicity. An experimental group (n = 10) received maneb (obtained from Hoecht-Shering) at a concentration of 250 ppm in distilled water five days a week (treatment time is three weeks). It was orally ad...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233706070851
更新日期:2006-10-01 00:00:00
abstract::The technologically interesting properties of palladium nanoparticles (Pd-NPs) allowed their widespread industrial application, although concerns emerged on increasing general and occupational levels of exposure. In this context, to assess the toxicological behavior of Pd-NPs, and particularly their endocrine disrupti...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233719851702
更新日期:2019-06-01 00:00:00
abstract::Widespread use of mobile phones which are a major source of electromagnetic fields might affect living organisms. However, there has been no investigation concerning prenatal exposure to electromagnetic fields or their roles in the development of the pyramidal cells of the cornu ammonis in postnatal life. Two groups o...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233709106442
更新日期:2009-07-01 00:00:00
abstract:OBJECTIVE:Polycyclic aromatic hydrocarbons (PAHs) are potent environmental pollutants. Benzo[α]pyrene (B[α]P) is the major compound of PAHs that acts by activating aryl hydrocarbon receptor (AhR) in cells. B[α]P is a known carcinogen and an immunotoxicant; however, its role with regard to nuclear factor of activated T ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233714555153
更新日期:2016-07-01 00:00:00
abstract::This study was designed to determine if long-term exposure to high doses of methoxychlor (M) would alter pituitary or testicular endocrine functions in either an estrogenic or antiandrogenic manner. Weanling male Long-Evans hooded rats were dosed daily with M (po) at 0, 200, 300, or 400 mg kg-1 day-1 for 10 months. Me...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379901500105
更新日期:1999-01-01 00:00:00
abstract::The aim of this study was to investigate the different testicular toxicity and the role of apoptosis in the possible mechanism induced by the two isomers of bromopropanes (BPs) in the same dosage. Following the 14-day treatment with a single dose of 1-BP and 2-BP (1 g/kg), male rats were killed and a series of experim...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233710373083
更新日期:2010-09-01 00:00:00