The protective roles of some lichen species on colloidal bismuth subcitrate genotoxicity.

Abstract:

:Medicinal plants are increasingly being projected as suitable alternative source for the treatment of various diseases. However, toxic effects resulting from therapeutic bismuth compounds are still documented in animals and humans. This study described the genetic effects of five common lichen species and compared their activities on the genotoxicity induced by the colloidal bismuth subcitrate. After the application of colloidal bismuth subcitrate and lichen extracts, separate and together, human whole blood cultures were assessed by sister-chromatid exchange (SCE) and micronucleus tests. According to our results, the frequencies of SCE and micronucleus rate in peripheral lymphocytes were significantly increased by colloidal bismuth subcitrate (at dose 5 microg/mL) compared with controls. However, lichen extracts had no genotoxic effect. The order of antigenotoxicity efficacy against colloidal bismuth subcitrate was Pseudevernia furfuracea, Dermotocarpon intestiniforme, Ramalina capitata, Parmelia pulla, respectively. However, Rhizoplaca melanophthalma did not show any effect against colloidal bismuth subcitrate genotoxicity. Present findings showed that the protective roles of lichens studied were dose related. In conclusion, this is the first study report describing the therapeutic potential of lichens against drug genotoxicity in human blood.

journal_name

Toxicol Ind Health

authors

Geyikoglu F,Turkez H,Aslan A

doi

10.1177/0748233708089044

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

487-92

issue

8

eissn

0748-2337

issn

1477-0393

journal_volume

23

pub_type

杂志文章
  • Metabolic adaptability in liver and gastrocnemius muscle of mice following subacute lead toxicity.

    abstract::Lead (Pb) is one of several environmental pollutants that adversely affect human health by producing toxicity at the tissue level. The aim of the study was to understand the effects of Pb on the metabolic profiles of liver and gastrocnemius muscle of mice in relation to carbohydrate and fat metabolisms. Swiss albino m...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233720937196

    authors: Das P,Pal S,Basu S

    更新日期:2020-07-01 00:00:00

  • Influence of chronic cadmium exposure on the tissue distribution of copper and zinc and oxidative stress parameters in rats.

    abstract::The aim of this study was to investigate the effect of oral cadmium (Cd) intoxication on the antioxidant response and its relationship with essential bioelements like copper (Cu) and zinc (Zn). The experimental group was chronically exposed to Cd daily for 8 weeks via consumption of water containing 15 ppm cadmium chl...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233714566875

    authors: Erdem O,Yazihan N,Kocak MK,Sayal A,Akcil E

    更新日期:2016-08-01 00:00:00

  • Effects of administration of subtoxic doses of acetaminophen on liver and blood levels of insulin-like growth factor-1 in rats.

    abstract::Acetaminophen (APAP) is widely used in the treatment of pain. Toxic doses of APAP cause acute liver failure, but therapeutic doses are believed to be safe. The purpose of this study is to investigate the effects of administration of subtoxic doses of APAP on liver and blood levels of insulin-like growth factor-1 (IGF-...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233713498439

    authors: Ozdemir D,Aksu I,Baykara B,Ates M,Sisman AR,Kiray M,Buyuk A,Uysal N

    更新日期:2016-01-01 00:00:00

  • Screening of microbial contamination and antimicrobial activity of sea cucumber Holothuria polii.

    abstract::Microbiological studies were carried out on microbial contamination and antimicrobial activity of sea cucumber Holothuria polii collected from Mediterranean Sea at Abu-kir shore of Alexandria, Egypt. The obtained results revealed the presence of isolates of five human Gram-negative pathogenic bacteria, representing fi...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233712448116

    authors: Omran NE,Allam NG

    更新日期:2013-11-01 00:00:00

  • Effects of washing, peeling, storage, and fermentation on residue contents of carbaryl and mancozeb in cucumbers grown in greenhouses.

    abstract::Cucumbers grown in two different greenhouses were exposed to mancozeb and carbaryl at different times. The effects of 10-day preharvest period, water and detergent washing, peeling, predetermined storage period at 4°C (refrigeration), and fermentation on the reduction of residue levels in the plant tissues were invest...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233714552295

    authors: Saeedi Saravi SS,Shokrzadeh M

    更新日期:2016-06-01 00:00:00

  • Respiratory symptoms and ventilatory function among health-care workers exposed to cleaning and disinfectant chemicals, a 2-year follow-up study.

    abstract::Previous cross-sectional studies have shown that exposure to cleaning chemicals among health-care workers (HCWs) is associated with respiratory disorders and ventilatory function changes. This study aimed to further explore this association using a longitudinal approach. A prospective 2-year follow-up study was carrie...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233715610043

    authors: El-Helaly M,Balkhy HH,Waseem K,Khawaja S

    更新日期:2016-12-01 00:00:00

  • Effect of resveratrol on tubular damage and interstitial fibrosis in kidneys of rats exposed to cigarette smoke.

    abstract::The aim of this study was to evaluate the effect of resveratrol on kidney tissue of rats exposed to cigarette smoke. Forty adult male Wistar Albino rats were divided into four groups. Animals in group 1 was the control group. For 6 weeks, group 2 was exposed to cigarette smoke; group 3 received daily intraperitoneal i...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233709346755

    authors: Kuruş M,Ugras M,Esrefoglu M

    更新日期:2009-09-01 00:00:00

  • Dose-response in perinatal exposure to polychlorinated biphenyls (PCBs): the Michigan and North Carolina cohort studies.

    abstract::Two prospective, longitudinal studies-one in North Carolina and one in Michigan-have examined effects of prenatal polychlorinated biphenyl (PCB) exposure on behavioral and cognitive development in infants and children. The Michigan cohort was selected to overrepresent the offspring of women who had eaten relatively la...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/074823379601200315

    authors: Jacobson JL,Jacobson SW

    更新日期:1996-05-01 00:00:00

  • The effect of Plantago major Linnaeus on serum total sialic acid, lipid-bound sialic acid, some trace elements and minerals after administration of 7,12-dimethylbenz(a)anthracene in rats.

    abstract::The present study was designed to evaluate the effect of Plantago major Linnaeus (PM) extract on serum total sialic acid (TSA), lipid-bound sialic acid (LSA), some trace elements (copper (Cu), zinc (Zn) and iron) and mineral levels (magnesium, calcium and sodium) in Wistar albino rat administrated 7,12-dimethylbenz(a)...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233711412422

    authors: Oto G,Ekin S,Ozdemir H,Levent A,Berber I

    更新日期:2012-05-01 00:00:00

  • The toxicological effects of bisphenol A and octylphenol on the reproductive system of prepubertal male rats.

    abstract::The aim of the present study was to assess and compare the individual adverse effects of bisphenol A (BPA) and octylphenol (OP) on the reproductive system of prepubertal male rats. Rats were exposed to BPA and OP at doses of 125 and 250 mg/kg/day, by gavage, for 90 days. At the end of the study, the testes, epididymis...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233715603847

    authors: Ahbab MA,Barlas N,Karabulut G

    更新日期:2017-02-01 00:00:00

  • The efficiacy of bismuth subnitrate against genotoxicity and oxidative stress induced by aluminum sulphate.

    abstract::Aluminum (Al) is commonly used in industrial processes and drugs and is thought to induce erythrocytes damage via activation of oxidative stress. Recently, bismuth (Bi)-containing drugs are used in the treatment of various diseases. However, uncertain effects of Bi in blood tissue may participate in the therapeutic ef...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233710381894

    authors: Turkez H,Geyikoglu F

    更新日期:2011-03-01 00:00:00

  • Asthma from hair straightening treatment containing formaldehyde: Two cases and a review of the literature.

    abstract::We report two cases of formaldehyde-containing hair straighteners causing new onset asthma. Formaldehyde has been reported to cause asthma in other settings. The purpose of this article is to examine two cases of asthma in hairdressers exposed to hair smoothing products and to review the relevant literature on formald...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233717750982

    authors: Dahlgren JG,Talbott PJ

    更新日期:2018-04-01 00:00:00

  • DNA damage as an early biomarker of effect in human health.

    abstract::In the last few decades the need for new approaches to assess DNA damage has been increasing due to the implications that different insults on genetic material may have on human health. In this context, the identification of how chemical agents with different mechanisms of action (i.e., antineoplastic drugs) damage DN...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章,评审

    doi:10.1191/0748233705th224oa

    authors: Mussali-Galante P,Avila-Costa MR,Piñón-Zarate G,Martínez-Levy G,Rodríguez-Lara V,Rojas-Lemus M,Avila-Casado MC,Fortoul TI

    更新日期:2005-09-01 00:00:00

  • Prevention of cytotoxicity of nickel by quercetin: the role of reactive oxygen species and histone acetylation.

    abstract::Excessive exposure to nickel may cause health effects on the blood, lung, nose, kidney, reproductive system, skin and the unborn child. In the present study, we found that Ni²⁺ exposure led to a time- and dose-dependent proliferation arrest and death in human leukemia HL-60 cells. In the presence of 1 mM Ni²⁺, reactiv...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233711433940

    authors: Chen J,Han J,Wang J

    更新日期:2013-05-01 00:00:00

  • Description and evaluation of a peracetic acid air sampling and analysis method.

    abstract::Peracetic acid (PAA) is a corrosive chemical with a pungent odor, which is extensively used in occupational settings and causes various health hazards in exposed workers. Currently, there is no US government agency recommended method that could be applied universally for the sampling and analysis of PAA. Legacy method...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233717739165

    authors: Nordling J,Kinsky OR,Osorio M,Pechacek N

    更新日期:2017-12-01 00:00:00

  • Genotoxicity studies of a desealant solvent mixture, SR-51.

    abstract::The Royal Australian Air Force (RAAF) has reported that personnel involved in F-111 fuel tank maintenance were concerned that exposure to a range of chemicals during the period 1977 to mid-1990s was the cause of health problems, including cancer. Particular concern was directed at SR-51, a desealant chemical mixture c...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233709103037

    authors: Oakes DJ,Ritchie HE,Woodman PD,Narup E,Moscova M,Picker K,Webster WS

    更新日期:2009-02-01 00:00:00

  • Enhanced steroidogenic and altered antioxidant response by ZnO nanoparticles in mouse testis Leydig cells.

    abstract::Zinc oxide nanoparticles (ZnO NPs) are important nanomaterials with myriad applications and in widespread use. The main aim of this study was to evaluate the direct effect of ZnO NPs on steroidogenesis by considering mouse testicular Leydig cells (TM3) as an in vitro model system. The uptake, intracellular behaviour, ...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233718774220

    authors: Bara N,Kaul G

    更新日期:2018-08-01 00:00:00

  • Chemoprotective effect of Vernonia amygdalina Del. (Astereacea) against 2-acetylaminofluorene-induced hepatotoxicity in rats.

    abstract::Natural products possessing antioxidant properties play a very crucial role in ameliorating deleterious effects of reactive oxygen species. This study investigated the chemoprotective properties of methanolic extract of Vernonia amygdalina (MEVA) in an experimental model of hepatic oxidative damage induced by 2-acetyl...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233713498436

    authors: Adesanoye OA,Adekunle AE,Adewale OB,Mbagwu AE,Delima AA,Adefegha SA,Molehin OR,Farombi EO

    更新日期:2016-01-01 00:00:00

  • Trans-1,1,1,4,4,4-hexafluoro-2-butene (HFO-1336mzz-E) (2018).

    abstract::Trans-1,1,1,4,4,4-hexafluoro-2-butene (HFO-133mzz-E) is an odorless gas that finds uses as a foam transfer agent, heat transfer fluid, and specialty gas. The acute 4-h LC50 (in rats) for HFO-133mzz-E is > 17,000 ppm; it was not an eye or dermal irritant in 3- and 13-week repeated-dose inhalation studies in rats at con...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233719825529

    authors:

    更新日期:2019-03-01 00:00:00

  • Effects of in utero JP-8 jet fuel exposure on the immune systems of pregnant and newborn mice.

    abstract::The US Air Force has implemented the widespread use of JP-8 jet fuel in its operations, although a thorough understanding of its potential effects upon exposed personnel is unclear. Previous work has reported that JP-8 exposure is immunosuppressive. In the present study, the effects of in-utero JP-8 jet fuel exposure ...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233708089045

    authors: Harris DT,Sakiestewa D,He X,Titone D,Witten M

    更新日期:2007-10-01 00:00:00

  • Human exposure assessment. I: Understanding the uncertainties.

    abstract::Exposure estimates produced using predictive exposure assessment methods are associated with a number of uncertainties that relate to the inherent variability of the values for a given input parameter (e.g., body weight, ingestion rate, inhalation rate) and to unknowns concerning the representativeness of the assumpti...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:

    authors: Whitmyre GK,Driver JH,Ginevan ME,Tardiff RG,Baker SR

    更新日期:1992-09-01 00:00:00

  • The exposure-response relationship for mesothelioma among asbestos-cement factory workers.

    abstract::Forty-five deaths from mesothelioma have occurred among production workers in an asbestos-cement factory. This analysis examines the fit of the cubic residence time model to the incidence of mesothelioma using a case-control method proposed by de Klerk and colleagues. The cubic residence time model was found to provid...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:

    authors: Finkelstein MM

    更新日期:1990-12-01 00:00:00

  • The behavioral effects of prenatal and early postnatal lead exposure in the primate Macaca fascicularis.

    abstract::Female Macaca fascicularis monkeys were given daily oral doses of 3.0 and 4.25 mg/kg lead, as lead nitrate, prior to breeding, and exposure was maintained throughout gestation and terminated at parturition. No overt signs of lead toxicity were observed in the maternal monkeys. The offspring were tested at 6 to 18 mont...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/074823378600200101

    authors: Hopper DL,Kernan WJ,Lloyd WE

    更新日期:1986-07-01 00:00:00

  • ATSDR evaluation of health effects of benzene and relevance to public health.

    abstract::As part of its mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) prepares toxicological profiles on hazardous chemicals found at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) National Priorities List (NPL) sites that have the greatest public health impact. These pro...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章,评审

    doi:10.1177/0748233708090910

    authors: Wilbur S,Wohlers D,Paikoff S,Keith LS,Faroon O

    更新日期:2008-06-01 00:00:00

  • River pollution in the Kosovo: Cyto- and genotoxic effects of water samples in the primary rat hepatocyte assay.

    abstract::The actual stage of the development of Kosovo is characterized by the concerning levels of environmental pollution and the serious health problems attributed to the emission of pollutants into air, soil and water. In this context, river pollution is one of the main threats due to the discharge of untreated urban and i...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233718773027

    authors: Alija AJ,Bresgen N,Bojaxhi E,Krenn M,Bajraktari ID,Eckl PM

    更新日期:2018-08-01 00:00:00

  • Protective effect of curcumin on acute lung injury induced by intestinal ischaemia/reperfusion.

    abstract::The aim of this study is to evaluate the role of curcumin on acute lung injury induced by intestinal ischaemia/reperfusion (I/R). A total of 30 male Wistar albino rats were divided into 3 groups: sham, I/R, and I/R + curcumin; each group contains 10 animals. Sham group animals underwent laparotomy without I/R injury. ...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233711430984

    authors: Guzel A,Kanter M,Guzel A,Yucel AF,Erboga M

    更新日期:2013-08-01 00:00:00

  • Possible peripheral markers for chronic aluminium toxicity in Wistar rats.

    abstract::This investigation gives detailed analysis of peripheral marker enzymes as well as neurobehavioral tests following chronic aluminium (Al) exposure (10 mg/kg b.w. for 12 weeks intragastrically). We observed a significant decrease in the levels of serum cholinesterase after toxicity. The enzymatic activity of cytochrome...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1191/0748233706th242oa

    authors: Kaur A,Gill KD

    更新日期:2006-02-01 00:00:00

  • Involvement of intracellular glutathione in regulating isoline-induced cytotoxicity in human normal liver L-02 cells.

    abstract::Pyrrolizidine alkaloid isoline is isolated from the traditional Chinese medicine Ligularia duciformis. Our previous reports have already demonstrated isoline-induced liver injury in mice. The present study is designed to observe the involvement of intracellular reduced glutathione (GSH) in isoline-induced cytotoxicity...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233712442707

    authors: Chen Y,Ji L,Xiong A,Yang L,Wang Z

    更新日期:2013-07-01 00:00:00

  • In vivo study of silver nanomaterials' toxicity with respect to size.

    abstract::Silver nanoparticles (Ag NPs) are widely used in nanomedicine, pharmaceutical products, industry and other consumer products owing to their unique physiochemical properties with probable potential risk to human health and the ecosystems. The aim of this work was to investigate the in-life morphological effects, bioche...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233720937201

    authors: Al-Doaiss AA,Jarrar Q,Alshehri M,Jarrar B

    更新日期:2020-08-01 00:00:00

  • Genotoxic risk in health-care professionals occupationally exposed to low doses of ionizing radiation.

    abstract::The purpose of this study was to evaluate the potential influence of occupational ionizing radiation (IR) exposure on health professionals, assessing DNA damage using the comet and micronucleus (MN) assays and analyzing relative risks, correlations, and associated factors between outcomes and socioeconomic and lifesty...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233720932081

    authors: Silva-Júnior FMRD,Tavella RA,Fernandes CLF,Mortola AS,Peraza GG,Garcia EM

    更新日期:2020-05-01 00:00:00