Abstract：
:Female Macaca fascicularis monkeys were given daily oral doses of 3.0 and 4.25 mg/kg lead, as lead nitrate, prior to breeding, and exposure was maintained throughout gestation and terminated at parturition. No overt signs of lead toxicity were observed in the maternal monkeys. The offspring were tested at 6 to 18 months of age on a three-choice non-spatial form discrimination paradigm, and at 19 to 26 months of age on a response inhibition task. When compared to controls, the lead-exposed infants showed a deficit in form discrimination performance which continued during the entire period of testing. A deficit in response inhibition performance was also observed in exposed infants when compared to controls. However, the deficit was temporary, as the performance of all groups was similar at the termination of testing. The observation of a persistent deficit in form discrimination up to 18 months following the termination of exposure suggests that lead-induced behavioral changes may be permanent. These findings are cause for concern since behavioral deficits in the offspring were observed at maternal gestational whole blood lead levels within a concentration range (30 to 70 micrograms/dl) associated with occupational exposure.
journal_name
Toxicol Ind Healthjournal_title
Toxicology and industrial healthauthors
Hopper DL,Kernan WJ,Lloyd WEdoi
10.1177/074823378600200101subject
Has Abstractpub_date
1986-07-01 00:00:00pages
1-16issue
1eissn
0748-2337issn
1477-0393journal_volume
2pub_type
杂志文章abstract：:Penile fracture (PF) is known as a traumatic rupture of the tunica albuginea of corpus cavernosum. In this study, we aimed to investigate the healing influence of topical extra virgin olive oil (EVOO) on PF through evaluating levels of some oxidative stress biomarkers for the first time. Histopathological evaluation w...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233713483191
更新日期：2015-08-01 00:00:00
abstract：:This study on the effect of genetically modified (GM) and non-GM canola on soybean was carried out for physiological and biochemical biosafety assessment of GM canola. Methanolic extracts of GM and non-GM canola were assessed on seed germination and growth of soybean (Glycine max L.) under sterilized conditions. The e...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233713501366
更新日期：2016-03-01 00:00:00
abstract：:This report reviews the literature on the impact of exposure to trichloroethylene (TCE) on human health. Special emphasis is given to the health effects reported in excess of national norms by participants in the TCE Subregistry of the Volatile Organic Compounds Registry of the National Exposure Registries--persons wi...
journal_title：Toxicology and industrial health
pub_type： 杂志文章,评审
doi：10.1177/074823379501100301
更新日期：1995-05-01 00:00:00
abstract：:Some studies have shown that exposure to electromagnetic field (EMF) may result in structural damage to neurons. In this study, we have elucidated the alteration in the hippocampal function of offspring Wistar rats (n = 8 rats in each group) that were chronically exposed to mobile phones during their gestational perio...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233714525497
更新日期：2016-06-01 00:00:00
abstract：:The aim of the present study was to determine the effects of extremely low-frequency magnetic field (ELF-MF) on accumulation of manganese (Mn) in the kidney, liver and brain of rats. A total of 40 rats were randomly divided into eight groups. Four control groups received 0, 3.75, 15 and 60 mg Mn per kg body weight ora...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233713480204
更新日期：2015-06-01 00:00:00
abstract：:Phthalates are abundantly produced plasticizers, and dibutyl phthalate (DBP) is the most widely used derivative in various consumer products and medical devices. This study was conducted to further explore the potential testicular toxicity of DBP in adult rats and to elucidate the underlying mechanisms. Adult male alb...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233714566877
更新日期：2016-08-01 00:00:00
abstract：:Holothuria polii (Delle Chiaje, 1823) (Holothuriidae) is a sea cucumber inhabiting Mediterranean Sea coast of Egypt. The bioactive compound of its tegument has antifungal, antibacterial and antiparasitic effects. The present study aims to elucidate the structure of the bioactive material of H. polii for pharmacologica...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233712466135
更新日期：2015-01-01 00:00:00
abstract：STUDY OBJECTIVES:Asbestos bodies (ABs) form as asbestos fibers become coated by a cellular iron- and protein-rich matrix. ABs have been reported in lymph nodes and a few extrapulmonary sites, but no data exist as to their formation outside of the lung. It is not clear whether the AB found in these extrapulmonary areas ...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1191/0748233701th090oa
更新日期：2001-02-01 00:00:00
abstract：:In this study, we investigated the protective effect of pentoxifilline (PTX) on smoking-induced damage in rat kidney tissues. Twenty-seven male Wistar rats were used in the study. Animals were divided into three equal groups as follows: Group 1: control group with only normal saline (NS; 0.9% NaCl) injection for 8 wee...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233710387006
更新日期：2011-05-01 00:00:00
abstract：:Nanomaterials are widely used nowadays in a range of technological and biomedical fields. Graphene as a nanomaterial used in the health-care sector and in workplaces has raised some concerns about its toxicity. This study aimed to evaluate the cytotoxicity of graphene nanoparticles (GNPs) on the A549 epithelial cells ...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233718817180
更新日期：2019-01-01 00:00:00
abstract：:Pesticides are registered in Canada under the authority of the Pest Control Products Act (PCP), administered by the Department of Agriculture. The Department of Agriculture calls upon various federal departments, including Health & Welfare Canada, to provide expert advice on hazards which may be associated with the us...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/074823378800400305
更新日期：1988-09-01 00:00:00
abstract：:The antioxidant power of the so-called antioxidants is negligible because their rate constants and concentrations are too small to compete with the specialized defense enzymes, like superoxide dismutase (SOD), for the reactive oxygen species. In this short review, we present a number of experimental data of our group,...
journal_title：Toxicology and industrial health
pub_type： 杂志文章,评审
doi：10.1177/0748233709103029
更新日期：2009-05-01 00:00:00
abstract：:Carvacrol (CVC), a major constituent of genera Origanum and Thymus, is such a substance that has attracted attention because of its wide variety of beneficial biological activities such as antibacterial, antifungal, and anticancer effects. However, there are limited data on the cytogenetic and antioxidant effects of C...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233713506771
更新日期：2016-04-01 00:00:00
abstract：:2,4-dinitroanisole (DNAN) is a warhead explosive currently under investigation as a replacement for TNT in melt-cast insensitive munitions. In animal studies, DNAN is a mild ocular and skin irritant with a significant potential for dermal absorption. It is not a dermal sensitizer. Acute and subacute rat inhalation s...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233717719690
更新日期：2018-01-01 00:00:00
abstract：:The aim of this study was to investigate the different testicular toxicity and the role of apoptosis in the possible mechanism induced by the two isomers of bromopropanes (BPs) in the same dosage. Following the 14-day treatment with a single dose of 1-BP and 2-BP (1 g/kg), male rats were killed and a series of experim...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233710373083
更新日期：2010-09-01 00:00:00
abstract：:The aim of this study is to evaluate the role of curcumin on acute lung injury induced by intestinal ischaemia/reperfusion (I/R). A total of 30 male Wistar albino rats were divided into 3 groups: sham, I/R, and I/R + curcumin; each group contains 10 animals. Sham group animals underwent laparotomy without I/R injury. ...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233711430984
更新日期：2013-08-01 00:00:00
abstract：:Aflatoxin B1 (AFB1) is a toxic compound commonly found as a contaminant in human food. It is carcinogenic due its potential in inducing the oxidative stress and distortion of the most antioxidant enzymes. Since black tea possesses strong antioxidant activity, it protects cells and tissues against oxidative stress. Cur...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233713491807
更新日期：2015-12-01 00:00:00
abstract：:This paper describes the development and implementation of physiologically-based pharmacokinetic (PB-Pk) models to examine the disposition of xenobiotics and their bioactivation. In a PB-Pk model, the structure of the model is based, to as great extent as practicable, on the actual physiological and biochemical struct...
journal_title：Toxicology and industrial health
pub_type： 杂志文章,评审
doi：10.1177/074823379401000101
更新日期：1994-01-01 00:00:00
abstract：:Metalworking fluids (MWFs) are complex formulations designed for effective lubricating, cooling, and cleaning tools and parts during machining operations. Adverse health effects such as respiratory symptoms, dermatitis, and cancer have been reported in workers exposed to MWFs. Several constituents of MWFs have been im...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233716653912
更新日期：2017-05-01 00:00:00
abstract：:Yoghurt is a popular dairy product in Iran because of its beneficial influence on human health and nutritional value. Aflatoxin M1 (AFM1) is the metabolite of potential carcinogen aflatoxin B1, which can contaminate milk through the feed and is not eliminated by common processing heat treatment. An analytical method u...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233710394236
更新日期：2011-08-01 00:00:00
abstract：:Atrazine is a commonly used herbicide that has previously been implicated as an endocrine-disrupting compound. Previous studies have shown that estrogenic endocrine-disrupting compounds affect the development of the heart, cartilage, and bone in zebrafish ( Danio rerio). To determine whether atrazine has effects simil...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233718760419
更新日期：2018-05-01 00:00:00
abstract：OBJECTIVE:Polycyclic aromatic hydrocarbons (PAHs) are potent environmental pollutants. Benzo[α]pyrene (B[α]P) is the major compound of PAHs that acts by activating aryl hydrocarbon receptor (AhR) in cells. B[α]P is a known carcinogen and an immunotoxicant; however, its role with regard to nuclear factor of activated T ...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233714555153
更新日期：2016-07-01 00:00:00
abstract：:Adult female Swiss Webster and B6C3F1 mice received distilled water only or water containing 0.1, 1.0, 10, 100 or 1000 ppb of aldicarb daily for 34 days. The target concentration of aldicarb present in the 10 ppb dosing solution was analytically verified on a daily basis as was its stability over a 48-hr period. To de...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/074823378800400310
更新日期：1988-09-01 00:00:00
abstract：:Paraquat has been shown to be a highly toxic compound for humans and animals, and many cases of acute poisoning and death have been reported over the past few decades. The present study was undertaken to evaluate comprehensively herbicides (Paraquat) and some plant extracts to biochemical aspects of Lymnaea natalensis...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233713498457
更新日期：2016-01-01 00:00:00
abstract：:Chloroethane (CE) gas carcinogenicity is analyzed and determined from a National Toxicology Program (NTP) bioassay where an inhalation concentration of 15,000 ppm CE gas in air produced the highest incidence of an uncommon-to-rare tumor ever observed by the NTP. Persistently inhaled CE produces endometrial cancers in ...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233708100371
更新日期：2008-11-01 00:00:00
abstract：:The rabbit eye irritation test based on the Draize method is required for the hazard assessment of chemicals and products that may come into contact with the eye. Due to the potential for the suffering of animals and subjectivity of the test, many modifications of the method have been made that involved a reduction in...
journal_title：Toxicology and industrial health
pub_type： 杂志文章,评审
doi：10.1177/074823379300900602
更新日期：1993-11-01 00:00:00
abstract：:The effect of copper in form of copper sulphate (CuSO4 x 5 H2O) was studied in the bone marrow cells of rats of Wistar strain in an in vitro culture. Evident differences between tissue cultures of the bone marrow cells were observed between the control and experimental groups. In the experimental group, the CFU-F colo...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/074823378900500617
更新日期：1989-12-01 00:00:00
abstract：:The US Air Force has implemented the widespread use of JP-8 jet fuel in its operations, although a thorough understanding of its potential effects upon exposed personnel is unclear. Previous work has reported that JP-8 exposure is immunosuppressive. Exposure of mice to JP-8 for 1 h/day resulted in immediate secretion ...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233708090908
更新日期：2007-11-01 00:00:00
abstract：OBJECTIVES:In this study, biological exposure indicators were used to assess the exposure of workers to cadmium (Cd), lead (Pb), manganese (Mn), and nickel (Ni) in nonferrous metal smelters. METHODS:A total of 273 male participants (178 exposed and 95 nonexposed control group), working in nonferrous metal foundries lo...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233715589262
更新日期：2016-10-01 00:00:00
abstract：:The anti-genotoxic potential of hydrated sodium calcium aluminosilicate (HSCAS) was investigated using sister chromatid exchanges (SCEs) induced by aflatoxin B1 (AFB1) as genotoxic endpoint in human lymphocytes. Whole blood samples from two healthy male donors were used for this experiment and the effects of different...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233707076738
更新日期：2007-03-01 00:00:00
