Abstract:
:Phthalates are abundantly produced plasticizers, and dibutyl phthalate (DBP) is the most widely used derivative in various consumer products and medical devices. This study was conducted to further explore the potential testicular toxicity of DBP in adult rats and to elucidate the underlying mechanisms. Adult male albino rats were treated orally with DBP at doses of 0, 200, 400, or 600 mg/kg/day for 15 consecutive days. Testicular weight, sperm count, and motility were significantly decreased. Treatment with DBP decreased serum follicle-stimulating hormone and testosterone levels and testicular lactate dehydrogenase activity. DBP treatment also decreased serum total antioxidant capacity and the activities of the testicular antioxidant enzymes, such as superoxide dismutase, catalase, and glutathione reductase. Further, DBP treatment provoked degeneration with absence of spermatogenesis and sperms and necrosis in some of seminiferous tubules. These results indicated that oxidative stress and subsequent decrease in testosterone secretion were the potential underlying mechanism of DBP-induced testicular toxicity.
journal_name
Toxicol Ind Healthjournal_title
Toxicology and industrial healthauthors
Aly HA,Hassan MH,El-Beshbishy HA,Alahdal AM,Osman AMdoi
10.1177/0748233714566877subject
Has Abstractpub_date
2016-08-01 00:00:00pages
1467-1477issue
8eissn
0748-2337issn
1477-0393pii
0748233714566877journal_volume
32pub_type
杂志文章abstract::Not only is skin cancer by far the most common human cancer but also the incidence of skin cancer has been increasing at an alarming rate in recent decades. Fortunately, most people now realize that sun exposure causes unattractive photoaging and skin cancer, so they do apply sunscreens conscientiously. However, until...
journal_title:Toxicology and industrial health
pub_type: 杂志文章,评审
doi:10.1177/0748233709106067
更新日期:2009-05-01 00:00:00
abstract::Some studies have shown that exposure to electromagnetic field (EMF) may result in structural damage to neurons. In this study, we have elucidated the alteration in the hippocampal function of offspring Wistar rats (n = 8 rats in each group) that were chronically exposed to mobile phones during their gestational perio...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233714525497
更新日期:2016-06-01 00:00:00
abstract::Cobalt oxide (Co3O4) nanoparticles have applications in nanomedicine and nanotechnology; therefore, any possible adverse effects require thorough investigation. The present study investigated the effects of Co3O4 nanoparticles on four different cell lines: liver, HepG2 hepatocellular carcinoma cells; lung, A549 lung c...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233717706633
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVES:In this study, biological exposure indicators were used to assess the exposure of workers to cadmium (Cd), lead (Pb), manganese (Mn), and nickel (Ni) in nonferrous metal smelters. METHODS:A total of 273 male participants (178 exposed and 95 nonexposed control group), working in nonferrous metal foundries lo...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233715589262
更新日期:2016-10-01 00:00:00
abstract::An analytical method using natural analcime zeolite modified with tppz (2,3,5,6-tetra-pyridylpyrazine) for preconcentration of cadmium, in a column system, and their sequential determination by flame atomic absorption spectrometry (FAAS), was developed. In this work, cadmium was adsorbed onto natural analcime zeolite ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233711422730
更新日期:2012-10-01 00:00:00
abstract::Silver nanoparticles (Ag NPs) are widely used in nanomedicine, pharmaceutical products, industry and other consumer products owing to their unique physiochemical properties with probable potential risk to human health and the ecosystems. The aim of this work was to investigate the in-life morphological effects, bioche...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233720937201
更新日期:2020-08-01 00:00:00
abstract::Nanomaterials are widely used nowadays in a range of technological and biomedical fields. Graphene as a nanomaterial used in the health-care sector and in workplaces has raised some concerns about its toxicity. This study aimed to evaluate the cytotoxicity of graphene nanoparticles (GNPs) on the A549 epithelial cells ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233718817180
更新日期:2019-01-01 00:00:00
abstract::Pyrrolizidine alkaloid isoline is isolated from the traditional Chinese medicine Ligularia duciformis. Our previous reports have already demonstrated isoline-induced liver injury in mice. The present study is designed to observe the involvement of intracellular reduced glutathione (GSH) in isoline-induced cytotoxicity...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712442707
更新日期:2013-07-01 00:00:00
abstract::The concentrations of heavy metals (cadmium (Cd), copper (Cu), nickel (Ni), lead (Pb) and zinc (Zn)) were measured in hepatopancreas and muscle of a commercial shrimp (Metapenaeus affinis), in the muscle, liver and gills of two fish species (Thryssa vitrirostris and Johnius belangerii) and in the sediment samples take...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713475498
更新日期:2015-06-01 00:00:00
abstract::We report two cases of formaldehyde-containing hair straighteners causing new onset asthma. Formaldehyde has been reported to cause asthma in other settings. The purpose of this article is to examine two cases of asthma in hairdressers exposed to hair smoothing products and to review the relevant literature on formald...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233717750982
更新日期:2018-04-01 00:00:00
abstract::The aim of this study is to evaluate the role of curcumin on acute lung injury induced by intestinal ischaemia/reperfusion (I/R). A total of 30 male Wistar albino rats were divided into 3 groups: sham, I/R, and I/R + curcumin; each group contains 10 animals. Sham group animals underwent laparotomy without I/R injury. ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233711430984
更新日期:2013-08-01 00:00:00
abstract::Zinc oxide nanoparticles (ZnO NPs) are produced in high tonnage each year; they are widely used in consumer and industrial products, also now finding applications in bioimaging and drug delivery. In the present study, comparison between ZnO NPs (39 nm) and its bulk/micron form (particle size = 5 µm) on liver function ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233719878970
更新日期:2019-10-01 00:00:00
abstract::The actual stage of the development of Kosovo is characterized by the concerning levels of environmental pollution and the serious health problems attributed to the emission of pollutants into air, soil and water. In this context, river pollution is one of the main threats due to the discharge of untreated urban and i...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233718773027
更新日期:2018-08-01 00:00:00
abstract::The aim of this study was to investigate the different testicular toxicity and the role of apoptosis in the possible mechanism induced by the two isomers of bromopropanes (BPs) in the same dosage. Following the 14-day treatment with a single dose of 1-BP and 2-BP (1 g/kg), male rats were killed and a series of experim...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233710373083
更新日期:2010-09-01 00:00:00
abstract:INTRODUCTION:Semiconductor quantum dots (QDs), especially those containing cadmium, have undergone marked improvements and are now widely used nanomaterials in applicable biological fields. However, great concerns exist regarding their toxicity in biomedical applications. Because of the lack of sufficient data regardin...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233718763517
更新日期:2018-05-01 00:00:00
abstract::The assessment of risk due to environmental contaminants depends, in part, on scientific data. When such data are incomplete, as is usually the case, assumptions based on scientific judgments are made to analyze the consequences. Specifically, when health related data needed to assess the risk posed by environmental c...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823378900500308
更新日期:1989-05-01 00:00:00
abstract::The morphological changes of ricin-induced apoptosis in a human cervical cancer cell line were studied. To shed light on the mechanism of action of ricin toxin (RT) at the cellular level, we examined cell growth, apoptosis, changes of mitochondrial membrane potential (MMP) and cytochrome C translocation in HeLa cells ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233711414608
更新日期:2012-06-01 00:00:00
abstract::The inhalation toxicity of methanol and toluene was investigated in rats. Young Sprague Dawley rats of both sexes were exposed to vapors of methanol (300 ppm, 3000 ppm), toluene (30 ppm, 300 ppm) or methanol/toluene (300/30 ppm, 300/300 ppm, 3000/30 ppm, and 3000/300 ppm) six hrs per day, five days/week for four weeks...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379401000310
更新日期:1994-05-01 00:00:00
abstract::The aim of this study was to evaluate the effect of resveratrol on kidney tissue of rats exposed to cigarette smoke. Forty adult male Wistar Albino rats were divided into four groups. Animals in group 1 was the control group. For 6 weeks, group 2 was exposed to cigarette smoke; group 3 received daily intraperitoneal i...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233709346755
更新日期:2009-09-01 00:00:00
abstract::Endocrine disrupting chemicals (EDCs) are defined as exogenous substances that can alter the development and functioning of the endocrine system. The Wnt signaling pathway is an evolutionarily conserved pathway consisting of proteins that transmit cell-to-cell receptors through cell surface receptors, regulating impor...
journal_title:Toxicology and industrial health
pub_type: 杂志文章,评审
doi:10.1177/0748233719898989
更新日期:2020-01-01 00:00:00
abstract::In this paper, a description of olfactory anatomy is presented, followed by a brief review of modern procedures for testing olfactory function. Information from the sole study which has quantitatively examined olfactory function in patients with apparent multiple chemical sensitivity (MCS) is presented. In essence, th...
journal_title:Toxicology and industrial health
pub_type: 杂志文章,评审
doi:
更新日期:1994-07-01 00:00:00
abstract::In summary, we have described our method of treating phosgene inhalation injury. We have presented two serious cases in detail which demonstrate that survival was associated with aggressive therapy. Several points should be mentioned. The pulmonary edema and resulting fluid and foam production can be so copious as to ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823378500100207
更新日期:1985-10-01 00:00:00
abstract::In this study, the cytotoxic potential of fluoride and endosulfan in combination was investigated in Swiss albino mice bone marrow cells using the chromosomal aberration (CA) and micronucleus (MN) test systems. Fluoride (25.1 mg kg-1 body weight [bw] in water) and endosulfan (1.8 mg kg-1 bw by oral intubation) were ad...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233720979423
更新日期:2020-12-16 00:00:00
abstract::Several classes of environmental contaminants have been claimed or suggested to possess endocrine-disrupting potency, which may result in reproductive problems and developmental disorders. In this paper the focus is on the multiple and interactive mechanisms of interference of persistent polyhalogenated aromatic hydro...
journal_title:Toxicology and industrial health
pub_type: 杂志文章,评审
doi:10.1177/074823379801400107
更新日期:1998-01-01 00:00:00
abstract::Environmental Impact Assessment is essentially a process comprising four elements: identification, prediction, evaluation, and monitoring. Properly conducted EIA studies can identify linkages between injurious events and/or activities and their damaging consequences. This aids in making the risk management decision. T...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379100700541
更新日期:1991-09-01 00:00:00
abstract::In allelopathy, one plant suppresses the growth and development of other plant/plants by negatively affecting a variety of physiological and biochemical reactions. We checked the effects of methanolic extracts (allelochemical extracts) of Phytolacca latbenia (Moq.) H. Walter on antioxidant enzyme activities such as pe...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713483205
更新日期:2015-10-01 00:00:00
abstract::The US Air Force has implemented the widespread use of JP-8 jet fuel in its operations, although a thorough understanding of its potential effects upon exposed personnel is unclear. Previous work has reported that JP-8 exposure is immunosuppressive. In the present study, the effects of in-utero JP-8 jet fuel exposure ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233708089045
更新日期:2007-10-01 00:00:00
abstract::The US Air Force has implemented the widespread use of JP-8 jet fuel in its operations, although a thorough understanding of its potential effects upon exposed personnel is unclear. Previous work has reported that JP-8 exposure is immunosuppressive. Exposure of mice to JP-8 for 1 h/day resulted in immediate secretion ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233708090908
更新日期:2007-11-01 00:00:00
abstract::Maneb is a dithiocarbamate fungicide that contains manganese. Dithiocarbamates are considered to be chemicals of low toxicity. An experimental group (n = 10) received maneb (obtained from Hoecht-Shering) at a concentration of 250 ppm in distilled water five days a week (treatment time is three weeks). It was orally ad...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233706070851
更新日期:2006-10-01 00:00:00
abstract::Orange B, a pyrazolone dye used to color frankfurter and sausage casings, was given in distilled drinking water to pregnant Osborne-Mendel rats throughout gestation. Assessed on the basis of fluid consumption, the dose levels of 0, 0.05, 0.1, 0.2, and 0.4% corresponded to daily Orange B consumption of 0, 67.5, 129.6, ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379501100402
更新日期:1995-07-01 00:00:00