Dibutyl phthalate induces oxidative stress and impairs spermatogenesis in adult rats.

Abstract:

:Phthalates are abundantly produced plasticizers, and dibutyl phthalate (DBP) is the most widely used derivative in various consumer products and medical devices. This study was conducted to further explore the potential testicular toxicity of DBP in adult rats and to elucidate the underlying mechanisms. Adult male albino rats were treated orally with DBP at doses of 0, 200, 400, or 600 mg/kg/day for 15 consecutive days. Testicular weight, sperm count, and motility were significantly decreased. Treatment with DBP decreased serum follicle-stimulating hormone and testosterone levels and testicular lactate dehydrogenase activity. DBP treatment also decreased serum total antioxidant capacity and the activities of the testicular antioxidant enzymes, such as superoxide dismutase, catalase, and glutathione reductase. Further, DBP treatment provoked degeneration with absence of spermatogenesis and sperms and necrosis in some of seminiferous tubules. These results indicated that oxidative stress and subsequent decrease in testosterone secretion were the potential underlying mechanism of DBP-induced testicular toxicity.

journal_name

Toxicol Ind Health

authors

Aly HA,Hassan MH,El-Beshbishy HA,Alahdal AM,Osman AM

doi

10.1177/0748233714566877

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

1467-1477

issue

8

eissn

0748-2337

issn

1477-0393

pii

0748233714566877

journal_volume

32

pub_type

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