Review of clinical experience in handling phosgene exposure cases.

Abstract:

:In summary, we have described our method of treating phosgene inhalation injury. We have presented two serious cases in detail which demonstrate that survival was associated with aggressive therapy. Several points should be mentioned. The pulmonary edema and resulting fluid and foam production can be so copious as to overwhelm efforts to place an endotracheal tube. The solution is early intubation by the nearest experienced person at the first hint of edema or pulmonary failure. Adequate support of the patient's blood volume is imperative to avert hypovolemic shock and renal failure. A balloon flotation catheter is desirable to monitor pulmonary wedge pressure and avoid overload. Follow-up pulmonary function studies and chest x-rays are recommended 2-3 months after hospital discharge. We have not yet found a reliable test to determine which cases will progress to pulmonary edema. The LDH appears to be the only consistently elevated sign in more serious cases. Finally, we would like to make a plea for the sharing of information from instances of fatal phosgene injury so that the facts can be studied and applied to future cases.

journal_name

Toxicol Ind Health

authors

Regan RA

doi

10.1177/074823378500100207

subject

Has Abstract

pub_date

1985-10-01 00:00:00

pages

69-72

issue

2

eissn

0748-2337

issn

1477-0393

journal_volume

1

pub_type

杂志文章
  • The New York Angler Cohort Study: exposure characterization and reproductive and developmental health.

    abstract::The New York State Angler Study will evaluate the association between past and current consumption of contaminated fish from Lake Ontario and both short- and long-term health effects in a population-based cohort. It will measure fish consumption and reproductive and developmental health among 10,518 male anglers and 6...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/074823379601200305

    authors: Vena JE,Buck GM,Kostyniak P,Mendola P,Fitzgerald E,Sever L,Freudenheim J,Greizerstein H,Zielezny M,McReynolds J,Olson J

    更新日期:1996-05-01 00:00:00

  • River pollution in the Kosovo: Cyto- and genotoxic effects of water samples in the primary rat hepatocyte assay.

    abstract::The actual stage of the development of Kosovo is characterized by the concerning levels of environmental pollution and the serious health problems attributed to the emission of pollutants into air, soil and water. In this context, river pollution is one of the main threats due to the discharge of untreated urban and i...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233718773027

    authors: Alija AJ,Bresgen N,Bojaxhi E,Krenn M,Bajraktari ID,Eckl PM

    更新日期:2018-08-01 00:00:00

  • Heavy metals content, phytochemical composition, antimicrobial and insecticidal evaluation of Elaeagnus angustifolia.

    abstract::Elaeagnus angustifolia was analyzed for determination of metals, phytoconstituents, bactericidal, fungicidal and insecticidal effects and to explore its chemical and biological potential. The root, branches, leaves, stem bark and root bark parts of E. angustifolia were found to contain iron, lead, copper, cadmium, zin...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233713498459

    authors: Khan SU,Khan AU,Shah AU,Shah SM,Hussain S,Ayaz M,Ayaz S

    更新日期:2016-01-01 00:00:00

  • Determining standards for professional divers diving in benzene polluted waters.

    abstract::The main objective of this study is to calculate the hours of diving in benzene-polluted waters acceptable for professional divers. We considered recommended absorption limit as that from pulmonary workplace absorption during an 8-h workday at recommended exposure limits set by the National Institute of Occupational S...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233708098126

    authors: Froom P

    更新日期:2008-09-01 00:00:00

  • Investigation of cytotoxic, genotoxic and oxidative properties of carvacrol in human blood cells.

    abstract::Carvacrol (CVC), a major constituent of genera Origanum and Thymus, is such a substance that has attracted attention because of its wide variety of beneficial biological activities such as antibacterial, antifungal, and anticancer effects. However, there are limited data on the cytogenetic and antioxidant effects of C...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233713506771

    authors: Türkez H,Aydın E

    更新日期:2016-04-01 00:00:00

  • Pycnogenol in cigarette filters scavenges free radicals and reduces mutagenicity and toxicity of tobacco smoke in vivo.

    abstract::Despite large-scale anti-smoking campaigns throughout the world, the number of smokers remains high and cigarette smoking continues to represent a life-threatening health risk. Until a smoke-free society is achieved, reduction of cigarette smoke toxins may reduce the health burden. Current cigarette filter techniques ...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1191/0748233702th145oa

    authors: Zhang D,Tao Y,Gao J,Zhang C,Wan S,Chen Y,Huang X,Sun X,Duan S,Schönlau F,Rohdewald P,Zhao B

    更新日期:2002-06-01 00:00:00

  • The toxicological effects of bisphenol A and octylphenol on the reproductive system of prepubertal male rats.

    abstract::The aim of the present study was to assess and compare the individual adverse effects of bisphenol A (BPA) and octylphenol (OP) on the reproductive system of prepubertal male rats. Rats were exposed to BPA and OP at doses of 125 and 250 mg/kg/day, by gavage, for 90 days. At the end of the study, the testes, epididymis...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233715603847

    authors: Ahbab MA,Barlas N,Karabulut G

    更新日期:2017-02-01 00:00:00

  • Inhalation toxicity study of methanol, toluene, and methanol/toluene mixtures in rats: effects of 28-day exposure.

    abstract::The inhalation toxicity of methanol and toluene was investigated in rats. Young Sprague Dawley rats of both sexes were exposed to vapors of methanol (300 ppm, 3000 ppm), toluene (30 ppm, 300 ppm) or methanol/toluene (300/30 ppm, 300/300 ppm, 3000/30 ppm, and 3000/300 ppm) six hrs per day, five days/week for four weeks...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/074823379401000310

    authors: Poon R,Chu I,Bjarnason S,Potvin M,Vincent R,Miller RB,Valli VE

    更新日期:1994-05-01 00:00:00

  • Early diagnosis of phosgene overexposure.

    abstract::At the present time, the following parameters can be recommended for "early diagnosis" of phosgene overexposure: Phosgene indicator paper badges, to be worn by all persons involved in handling phosgene (these badges permit immediate estimation of the exposure dose in each individual case); Observation of the initial i...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/074823378500100208

    authors: Diller WF

    更新日期:1985-10-01 00:00:00

  • The behavioral effects of prenatal and early postnatal lead exposure in the primate Macaca fascicularis.

    abstract::Female Macaca fascicularis monkeys were given daily oral doses of 3.0 and 4.25 mg/kg lead, as lead nitrate, prior to breeding, and exposure was maintained throughout gestation and terminated at parturition. No overt signs of lead toxicity were observed in the maternal monkeys. The offspring were tested at 6 to 18 mont...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/074823378600200101

    authors: Hopper DL,Kernan WJ,Lloyd WE

    更新日期:1986-07-01 00:00:00

  • Mercuric chloride induced hepatotoxic and hematologic changes in rats: The protective effects of sodium selenite and vitamin E.

    abstract::This study focuses on investigating the possible protective effect of sodium selenite (Na2SeO3) and/or vitamin E against mercuric chloride (HgCl2)-induced hepatotoxicity in rat. Male rats were given HgCl2 (1 mg/kg body weight (bw)) and HgCl2 plus Na2SeO3 (0.25 mg/kg bw) and/or vitamin E (100 mg/kg bw) daily via gavage...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233715572561

    authors: Uzunhisarcikli M,Aslanturk A,Kalender S,Apaydin FG,Bas H

    更新日期:2016-09-01 00:00:00

  • Genotoxicity studies of a desealant solvent mixture, SR-51.

    abstract::The Royal Australian Air Force (RAAF) has reported that personnel involved in F-111 fuel tank maintenance were concerned that exposure to a range of chemicals during the period 1977 to mid-1990s was the cause of health problems, including cancer. Particular concern was directed at SR-51, a desealant chemical mixture c...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233709103037

    authors: Oakes DJ,Ritchie HE,Woodman PD,Narup E,Moscova M,Picker K,Webster WS

    更新日期:2009-02-01 00:00:00

  • Factors affecting exhaled carbon monoxide levels in coffeehouses in the Western Black Sea region of Turkey.

    abstract::The aim of this study was to evaluate indoor air quality and factors affecting expired carbon monoxide (CO) levels in a coffeehouse environment. This cross-sectional study was conducted at 16 randomly selected coffeehouses in Duzce, Turkey, during November 2007 to March 2008. A total of 547 people, average age 46.72 ±...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233710383888

    authors: Bahcebasi T,Kandis H,Baltaci D,Kara IH

    更新日期:2011-04-01 00:00:00

  • In vitro evaluation of cobalt oxide nanoparticle-induced toxicity.

    abstract::Cobalt oxide (Co3O4) nanoparticles have applications in nanomedicine and nanotechnology; therefore, any possible adverse effects require thorough investigation. The present study investigated the effects of Co3O4 nanoparticles on four different cell lines: liver, HepG2 hepatocellular carcinoma cells; lung, A549 lung c...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233717706633

    authors: Abudayyak M,Gurkaynak TA,Özhan G

    更新日期:2017-08-01 00:00:00

  • Pesticide sorption on geologic material of varying organic carbon content.

    abstract::Sorption of three pesticides on geologic material ranging in organic carbon content from 0.33 to 6.9 g kg-1 was measured in soil columns using a miscible displacement technique. An octanol-water partitioning model was shown to be inappropriate for predicting sorption of the less hydrophobic pesticides on the low organ...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/074823378800400306

    authors: Bouchard DC,Wood AL

    更新日期:1988-09-01 00:00:00

  • Dietary exposures to persistent organic pollutants.

    abstract::As one of the main components of risk assessment, exposure assessment plays a key role in evaluating risk. Many different scenarios can be developed to estimate the risk from exposure to chemicals such as persistent organic pollutants (POPs). The US Food and Drug Administration (FDA)'s Center for Food Safety and Appli...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1191/0748233701th104oa

    authors: Jensen E,Egan S,Canady R,Bolger P

    更新日期:2001-06-01 00:00:00

  • Ultrastructural changes in skeletal muscles of rats treated neonatally with 6-mercaptopurine.

    abstract::The purpose of this study was to characterize the ultrastructural changes in the muscles of 2- and 6-month-old rats that were injected with 6-mercaptopurine monohydrate (6-MP) at 2 mg base/kg sc daily from 2 to 22 days of age. The earliest, usually subsarcolemmal alterations, were disorganization of fibrils at the Z-b...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/074823378600200205

    authors: Abraham AA,Veronesi B,Alleva FR,Balazs T

    更新日期:1986-09-01 00:00:00

  • Health assessment of hazardous air pollutants The Netherlands.

    abstract::In The Netherlands, risk assessment of air pollutants goes back to 1980. From 1985 onwards the risk assessment of chemicals has crystallized in a systematic multi-media approach taking into account air, water, soil, and food. Criteria Documents support the formulation of environmental quality standards. Until now, 23 ...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章,评审

    doi:

    authors: Vermeire T,van der Heijden K

    更新日期:1990-10-01 00:00:00

  • Biochemical modulation of cell energy by 2-deoxyglucose and malonate in 7,12-dimethylbenz(a)anthracene-induced carcinogenesis in rats.

    abstract::The goal of this study was to explore the impact of 2-deoxglucose or malonate individually or in combination on the level of cell energy (adenosine-5'-triphosphate) and oxidative stress in 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary proliferation in rats. A total of 60 adult female Sprague Dawley rats were r...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233712472525

    authors: Moselhy SS,Kumosani TA,Al-Malki AL,Naif AA

    更新日期:2015-04-01 00:00:00

  • Ameliorative effect of vitamin E to mouse dams and their pups following exposure of mothers to chlorpyrifos during gestation and lactation periods.

    abstract::Pesticides are omnipresent in environment, water, fruits, and vegetables and are considered as risk factors for human health. Consumers are mainly exposed to pesticides through diet, and the main question to be answered concerns the impact of such exposure on health. In this study, we developed a mouse model to mimic ...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233714548207

    authors: Mansour SA,Gamet-Payrastre L

    更新日期:2016-07-01 00:00:00

  • Comparative study of zinc oxide nanoparticles and its bulk form on liver function of Wistar rat.

    abstract::Zinc oxide nanoparticles (ZnO NPs) are produced in high tonnage each year; they are widely used in consumer and industrial products, also now finding applications in bioimaging and drug delivery. In the present study, comparison between ZnO NPs (39 nm) and its bulk/micron form (particle size = 5 µm) on liver function ...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233719878970

    authors: Moatamed ER,Hussein AA,El-Desoky MM,Khayat ZE

    更新日期:2019-10-01 00:00:00

  • Chronic prenatal exposure to the 900 megahertz electromagnetic field induces pyramidal cell loss in the hippocampus of newborn rats.

    abstract::Widespread use of mobile phones which are a major source of electromagnetic fields might affect living organisms. However, there has been no investigation concerning prenatal exposure to electromagnetic fields or their roles in the development of the pyramidal cells of the cornu ammonis in postnatal life. Two groups o...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233709106442

    authors: Bas O,Odaci E,Mollaoglu H,Ucok K,Kaplan S

    更新日期:2009-07-01 00:00:00

  • Cancer incidence among male military and civil pilots and flight attendants: an analysis on published data.

    abstract::Flight personnel are exposed to cosmic ionizing radiation, chemicals (fuel, jet engine exhausts, cabin air pollutants), electromagnetic fields from cockpit instruments, and disrupted sleep patterns. Only recently has cancer risk among these workers been investigated. With the aim of increasing the precision of risk es...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章,meta分析

    doi:10.1191/0748233705th238oa

    authors: Buja A,Lange JH,Perissinotto E,Rausa G,Grigoletto F,Canova C,Mastrangelo G

    更新日期:2005-11-01 00:00:00

  • Professional exposure to urban stressors and effects on urinary metanephrines.

    abstract::The aim of the study is to assess whether occupational exposure to urban stressors could cause alterations in urinary metanephrines levels in traffic policemen vs administrative staff of municipal police. A total of 258 subjects were included in the study: 129 traffic policemen exposed to urban stressors (68 males and...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233710387008

    authors: Sancini A,Tomei G,Ciarrocca M,Pimpinella B,Samperi I,Fiaschetti M,Scimitto L,Tasciotti Z,Caciari T,Tomei F

    更新日期:2011-05-01 00:00:00

  • Assessment of metal contents in spices and herbs from Saudi Arabia.

    abstract::In the recent years, there has been a growing interest in monitoring heavy metal contamination of spices/herbs. Spices and herbs are sources of many bioactive compounds that can improve the tastes of food as well as influence digestion and metabolism processes. In the present study, the levels of some essential and to...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233713500822

    authors: Seddigi ZS,Kandhro GA,Shah F,Danish E,Soylak M

    更新日期:2016-02-01 00:00:00

  • Effects of T-2 toxin on the regulation of steroidogenesis in mouse Leydig cells.

    abstract::T-2 toxin is one of the mycotoxins, a group of type A trichothecenes produced by several fungal genera including Fusarium species, which may lead to the decrease of testosterone secretion in primary Leydig cells derived from mouse testis. The previous study demonstrated T-2 toxin decrease the testosterone biosynthesis...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233715590516

    authors: Yang JY,Zhang YF,Li YX,Guan GP,Kong XF,Liang AM,Ma KW,Da Li G,Bai XF

    更新日期:2016-10-01 00:00:00

  • Evaluation of long-term dermal exposure to soil contaminated with spent engine oil in male Wistar rats: An experimental approach.

    abstract::Continuous occupational exposure to spent engine oil (SEO) poses physiological risks to humans, especially to automobile mechanics. This study investigated the physiological effects of SEO-contaminated soil in a male Wistar rat model. Animals were dermally exposed to soil contaminated with SEO for 120 consecutive days...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233720968466

    authors: Obiyo GE,Ogunsuyi OM,Akindele O A

    更新日期:2020-12-01 00:00:00

  • An assessment of asbestos body formation in extrapulmonary sites: liver and spleen.

    abstract:STUDY OBJECTIVES:Asbestos bodies (ABs) form as asbestos fibers become coated by a cellular iron- and protein-rich matrix. ABs have been reported in lymph nodes and a few extrapulmonary sites, but no data exist as to their formation outside of the lung. It is not clear whether the AB found in these extrapulmonary areas ...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1191/0748233701th090oa

    authors: Williams MG,Dodson RF,Dickson EW,Fraire AE

    更新日期:2001-02-01 00:00:00

  • Effect of sublethal dose of mercury toxicity on liver cells and tissue of yellowfin seabream.

    abstract::The aim of the present study was to provide baseline data on the prevalence of histopathological liver lesions in Acanthopagrus latus under experimental mercury exposure. Experimental study was at seawater recirculatory tanks. Mercury concentrations were determined using a standard cold vapour atomic absorption. Histo...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章,收录出版

    doi:10.1177/0748233711416951

    authors: Safahieh A,Hedayati A,Savari A,Movahedinia A

    更新日期:2012-08-01 00:00:00

  • In vivo effects of intravenous lipid emulsion on lung tissue in an experimental model of acute malathion intoxication.

    abstract::Malathion can be ingested, inhaled, or absorbed through the skin, but acute toxicity is maximized when administered orally. Intravenous lipid emulsion (ILE) treatment is used as a new therapeutic method in cases of systemic toxicity caused by some lipid soluble agents. This study aimed to examine the potential treatme...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233717748080

    authors: Uysal M,Karaman S

    更新日期:2018-02-01 00:00:00