Abstract：
:Orange B, a pyrazolone dye used to color frankfurter and sausage casings, was given in distilled drinking water to pregnant Osborne-Mendel rats throughout gestation. Assessed on the basis of fluid consumption, the dose levels of 0, 0.05, 0.1, 0.2, and 0.4% corresponded to daily Orange B consumption of 0, 67.5, 129.6, 266.6, and 532.3 mg/kg body weight, respectively. On gestation day 20, the females were euthanized and cesarean sections were performed. Throughout gestation, the treated animals consumed less fluid than did the controls, but the decreases were not dose-related. Feed consumption and maternal weight gain were not affected. No dose-related changes were seen in maternal clinical findings, implantations, fetal viability, or fetal size (weight and length). No compound-related effects were seen in sternebral development. Ossification of the interparietal bones was reduced at some dose levels, but the decreases were considered random because of absence of dose response. No dose-related effect was seen in the incidence of skeletal variations in fetuses or in the number of litters containing fetuses with skeletal variations. Skeletal development, as measured by the average number of ossified vertebrae, was similar in all groups. Soft-tissue development was not affected by dose levels of 0.05 to 0.2%. In animals treated with 0.4% Orange B, significant increases were seen in the incidence of hydroureters (severe and moderate), in the average numbers of fetuses with at least one and at least two soft-tissue variations per litter, and in the percentage of litters containing fetuses with at least two soft-tissue variations.
journal_name
Toxicol Ind Healthjournal_title
Toxicology and industrial healthauthors
Collins TF,Black TN,Ruggles DIdoi
10.1177/074823379501100402subject
Has Abstractpub_date
1995-07-01 00:00:00pages
387-97issue
4eissn
0748-2337issn
1477-0393journal_volume
11pub_type
杂志文章abstract：:Cytochrome P450 2E1 (CYP2E1) can be induced by diabetes mellitus, nonalcoholic liver disease, and obesity. This study assessed the protective effects of three sulfur compounds, namely phenethyl isothiocyanate (PEITC), dimethyl trisulfide (DMTS), and sodium thiosulfate (STS), on acrylonitrile (ACN)-induced acute toxici...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233719839847
更新日期：2019-05-01 00:00:00
abstract：:The aim of the study is to assess whether occupational exposure to urban stressors could cause alterations in urinary metanephrines levels in traffic policemen vs administrative staff of municipal police. A total of 258 subjects were included in the study: 129 traffic policemen exposed to urban stressors (68 males and...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233710387008
更新日期：2011-05-01 00:00:00
abstract：:Microbiological studies were carried out on microbial contamination and antimicrobial activity of sea cucumber Holothuria polii collected from Mediterranean Sea at Abu-kir shore of Alexandria, Egypt. The obtained results revealed the presence of isolates of five human Gram-negative pathogenic bacteria, representing fi...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233712448116
更新日期：2013-11-01 00:00:00
abstract：:Some studies have shown that exposure to electromagnetic field (EMF) may result in structural damage to neurons. In this study, we have elucidated the alteration in the hippocampal function of offspring Wistar rats (n = 8 rats in each group) that were chronically exposed to mobile phones during their gestational perio...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233714525497
更新日期：2016-06-01 00:00:00
abstract：:Despite large-scale anti-smoking campaigns throughout the world, the number of smokers remains high and cigarette smoking continues to represent a life-threatening health risk. Until a smoke-free society is achieved, reduction of cigarette smoke toxins may reduce the health burden. Current cigarette filter techniques ...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1191/0748233702th145oa
更新日期：2002-06-01 00:00:00
abstract：:The US Air Force has implemented the widespread use of JP-8 jet fuel in its operations, although a thorough understanding of its potential effects upon exposed personnel is unclear. Previous work has reported that JP-8 exposure is immunosuppressive. In the present study, the effects of in-utero JP-8 jet fuel exposure ...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233708089045
更新日期：2007-10-01 00:00:00
abstract：:The objective is to present historical asbestos airborne concentrations associated with activities involving presumably asbestos-containing materials in steel mills. A total of 138 historical industrial hygiene air samples collected in three US steel mills from 1972 to 1982 were analyzed. The majority of samples were ...
journal_title：Toxicology and industrial health
pub_type： 历史文章,杂志文章
doi：10.1177/0748233719893905
更新日期：2019-11-01 00:00:00
abstract：:1,2-Dichloropropane (1,2-DCP), a solvent, which is the main component of the cleaner used in the offset printing companies in Japan, is suspected to be the causative agent of bile duct cancer, which has been recently reported at high incidence in those offset printing workplaces. While there are some reports about the...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233714568801
更新日期：2016-09-01 00:00:00
abstract：:Octamethylcyclotetrasiloxane (D4; CAS No. 556-67-2) is used as a monomer in the manufacture of polymeric materials, which are widely used in various industrial and/or medical applications, such as breast implants. D4 has a relatively low order of toxicity following acute administration via the oral, dermal, and inhala...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233716670061
更新日期：2017-01-01 00:00:00
abstract：:Organophosphate (OP) compounds are the most commonly used pesticide groups and they are commercially used in the market for local and industrial purposes. Paraoxonase 1 (PON1) enzyme plays an important role in biotransformation of OP compounds, which shows toxic effects via inhibiting the acetylcholinesterase (AChE). ...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233713487246
更新日期：2015-12-01 00:00:00
abstract：:The Norplant* system is composed of a set of six Silastic* (silicone polydimethysiloxane) capsules measuring 34 mm by 2.4 mm, each containing 36 mg of levonorgestrel and sealed at either end with a medical grade silicone elastomer adhesive. Levonorgestrel is a synthetic progestin, widely used in combination oral contr...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/074823379501100104
更新日期：1995-01-01 00:00:00
abstract：OBJECTIVE:Printing workers experience a high rate of musculoskeletal disorders (MSDs). This study aims to determine the prevalence of MSDs, estimate serum biomarkers denoting musculoskeletal tissue changes, and determine some individual risk factors for MSDs among Egyptian printing workers. METHODS:Eighty-five male pr...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233720977399
更新日期：2021-01-01 00:00:00
abstract：:Zinc oxide nanoparticles (ZnO NPs) are produced in high tonnage each year; they are widely used in consumer and industrial products, also now finding applications in bioimaging and drug delivery. In the present study, comparison between ZnO NPs (39 nm) and its bulk/micron form (particle size = 5 µm) on liver function ...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233719878970
更新日期：2019-10-01 00:00:00
abstract：:The following is a review of some of the work we have done since 2004 regarding the importance of molds and their mycotoxins in the phenomenon of sick building syndrome (SBS). In these studies we showed that the macrocyclic trichothecene mycotoxins (MTM) of Stachybotrys chartarum (SC) are easily dissociated from the s...
journal_title：Toxicology and industrial health
pub_type： 杂志文章,评审
doi：10.1177/0748233709348287
更新日期：2009-10-01 00:00:00
abstract：:The antioxidant power of the so-called antioxidants is negligible because their rate constants and concentrations are too small to compete with the specialized defense enzymes, like superoxide dismutase (SOD), for the reactive oxygen species. In this short review, we present a number of experimental data of our group,...
journal_title：Toxicology and industrial health
pub_type： 杂志文章,评审
doi：10.1177/0748233709103029
更新日期：2009-05-01 00:00:00
abstract：:The rabbit eye irritation test based on the Draize method is required for the hazard assessment of chemicals and products that may come into contact with the eye. Due to the potential for the suffering of animals and subjectivity of the test, many modifications of the method have been made that involved a reduction in...
journal_title：Toxicology and industrial health
pub_type： 杂志文章,评审
doi：10.1177/074823379300900602
更新日期：1993-11-01 00:00:00
abstract：:Glycidyl methacrylate (GMA; CAS no. 106-91-2) is a chemical monomer used in the manufacture of dental resins, can coatings and polymers. GMA has demonstrated toxicity to the ocular, digestive, respiratory and dermal systems. Human exposure occurs mainly in the workplace, but it can also happen through food. Although t...
journal_title：Toxicology and industrial health
pub_type： 信件
doi：10.1177/0748233720957816
更新日期：2020-12-01 00:00:00
abstract：:In allelopathy, one plant suppresses the growth and development of other plant/plants by negatively affecting a variety of physiological and biochemical reactions. We checked the effects of methanolic extracts (allelochemical extracts) of Phytolacca latbenia (Moq.) H. Walter on antioxidant enzyme activities such as pe...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233713483205
更新日期：2015-10-01 00:00:00
abstract：:The effect of copper in form of copper sulphate (CuSO4 x 5 H2O) was studied in the bone marrow cells of rats of Wistar strain in an in vitro culture. Evident differences between tissue cultures of the bone marrow cells were observed between the control and experimental groups. In the experimental group, the CFU-F colo...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/074823378900500617
更新日期：1989-12-01 00:00:00
abstract：:Most of the mobile phones in Turkey emit 900 MHz radiation which is mainly absorbed by the skin and, to a lesser extent, muscle. The aim of this study was to investigate the effects the 900 MHz electromagnetic irradiation emitted by these devices on the induction of histopathologic changes in skin and the effect of me...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1191/0748233704th207oa
更新日期：2004-09-01 00:00:00
abstract：:Elaeagnus angustifolia was analyzed for determination of metals, phytoconstituents, bactericidal, fungicidal and insecticidal effects and to explore its chemical and biological potential. The root, branches, leaves, stem bark and root bark parts of E. angustifolia were found to contain iron, lead, copper, cadmium, zin...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233713498459
更新日期：2016-01-01 00:00:00
abstract：INTRODUCTION:Spirometry is the main pulmonary function test routinely employed in the occupational medicine practice. Its interpretation depends on the choice of the theoretical reference values. Therefore, our objective was to retrospectively evaluate the differences in the spirometric interpretation according to the ...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233720912059
更新日期：2020-02-01 00:00:00
abstract：:Hepatocytes that were isolated from 48 hr starved rats and incubated in Krebs-Henseleit bicarbonate buffer containing 10 microM A23187, 10mM l-lactate, 1mM pyruvate and 2mM l-lysine were found to contain 0.064 mumol of inorganic pyrophosphate/g wet wgt cells. Addition of either 20mM acetate or butyrate, which caused t...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/074823378600200308
更新日期：1986-09-01 00:00:00
abstract：:T-2 toxin is one of the mycotoxins, a group of type A trichothecenes produced by several fungal genera including Fusarium species, which may lead to the decrease of testosterone secretion in primary Leydig cells derived from mouse testis. The previous study demonstrated T-2 toxin decrease the testosterone biosynthesis...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233715590516
更新日期：2016-10-01 00:00:00
abstract：:This study reports on airborne exposure levels and soil concentrations of lead in regard to abatement of a steel structure (water tank). The tank was de-leaded by abrasive sand blasting. The ball of the tank had a lead surface level that exceeded the Environmental Protection Agency (EPA) definition of lead-based paint...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1191/0748233702th127oa
更新日期：2002-02-01 00:00:00
abstract：INTRODUCTION:Semiconductor quantum dots (QDs), especially those containing cadmium, have undergone marked improvements and are now widely used nanomaterials in applicable biological fields. However, great concerns exist regarding their toxicity in biomedical applications. Because of the lack of sufficient data regardin...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233718763517
更新日期：2018-05-01 00:00:00
abstract：:This study focuses on investigating the possible protective effect of sodium selenite (Na2SeO3) and/or vitamin E against mercuric chloride (HgCl2)-induced hepatotoxicity in rat. Male rats were given HgCl2 (1 mg/kg body weight (bw)) and HgCl2 plus Na2SeO3 (0.25 mg/kg bw) and/or vitamin E (100 mg/kg bw) daily via gavage...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233715572561
更新日期：2016-09-01 00:00:00
abstract：:The assessment of risk due to environmental contaminants depends, in part, on scientific data. When such data are incomplete, as is usually the case, assumptions based on scientific judgments are made to analyze the consequences. Specifically, when health related data needed to assess the risk posed by environmental c...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/074823378900500308
更新日期：1989-05-01 00:00:00
abstract：:The aim of this study was to analyze the biochemical alterations in the gills of Venus verrucosa under exposure for 6 days to three doses of lambda-cyhalothrin (λ-cyh) (100, 250, and 500 µg L-1). Malondialdehyde, lipid hydroperoxide, and hydrogen peroxide levels in the gills of treated groups increased. λ-Cyh exposure...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233720961219
更新日期：2020-11-01 00:00:00
abstract：:The risk assessment process must encompass all available toxicological data and scientific evidence on the plausible toxicities of a chemical or chemical mixture. As an extension to the approaches used to conduct risk assessments on chemical mixtures, a preliminary scheme, analogous to the IARC classification of carci...
journal_title：Toxicology and industrial health
pub_type： 杂志文章,评审
doi：
更新日期：1992-11-01 00:00:00
