Effect of paraoxonase 1 192 Q/R polymorphism on paraoxonase and acetylcholinesterase enzyme activities in a Turkish population exposed to organophosphate.

abstract：:A comparative potency method for cancer risk assessment has been developed based on a constant relative potency hypothesis. This method was developed and tested using data from a battery of short-term mutagenesis bioassays, animal tumorigenicity data and human lung cancer risk estimations. This data base was developed...

journal_title：Toxicology and industrial health

authors： Lewtas J

更新日期：1985-12-01 00:00:00

abstract：:Metalworking fluids (MWFs) are complex formulations designed for effective lubricating, cooling, and cleaning tools and parts during machining operations. Adverse health effects such as respiratory symptoms, dermatitis, and cancer have been reported in workers exposed to MWFs. Several constituents of MWFs have been im...

journal_title：Toxicology and industrial health

authors： Ryan KR,Cesta MF,Herbert R,Brix A,Cora M,Witt K,Kissling G,Morgan DL

更新日期：2017-05-01 00:00:00

abstract：:The Norplant* system is composed of a set of six Silastic* (silicone polydimethysiloxane) capsules measuring 34 mm by 2.4 mm, each containing 36 mg of levonorgestrel and sealed at either end with a medical grade silicone elastomer adhesive. Levonorgestrel is a synthetic progestin, widely used in combination oral contr...

journal_title：Toxicology and industrial health

authors： Campbell A,Brautbar N

更新日期：1995-01-01 00:00:00

abstract：:The goal of this study was to explore the impact of 2-deoxglucose or malonate individually or in combination on the level of cell energy (adenosine-5'-triphosphate) and oxidative stress in 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary proliferation in rats. A total of 60 adult female Sprague Dawley rats were r...

journal_title：Toxicology and industrial health

authors： Moselhy SS,Kumosani TA,Al-Malki AL,Naif AA

更新日期：2015-04-01 00:00:00

abstract：:This study demonstrates the detection and dynamics of macrocyclic trichothecene mycotoxin (MTM) tissue loading using a commercially available assay in a goat model. The detection of MTMs has been difficult and complex due to the uncertainty of what tissues to examine and when to sample. Twelve goats (two groups of eac...

journal_title：Toxicology and industrial health

authors： Layton RC,Purdy CW,Jumper CA,Straus DC

更新日期：2009-10-01 00:00:00

abstract：:In dry etching processes--one of the sources of potential exposure to toxic wastes in the semiconductor industry--complex mixtures of inorganic and organic compounds arise from reactions between feed stock gases (BCl3/Cl2), top layers (aluminium photoresist), and the carrier gas (N2). Two different fractions of the co...

journal_title：Toxicology and industrial health

authors： Bauer S,Wolff I,Werner N,Hoffmann P,Herzschuh R,Oemus K,Rath FW,Voigt R

更新日期：1992-05-01 00:00:00

abstract：:The purpose of this study was to characterize the ultrastructural changes in the muscles of 2- and 6-month-old rats that were injected with 6-mercaptopurine monohydrate (6-MP) at 2 mg base/kg sc daily from 2 to 22 days of age. The earliest, usually subsarcolemmal alterations, were disorganization of fibrils at the Z-b...

journal_title：Toxicology and industrial health

authors： Abraham AA,Veronesi B,Alleva FR,Balazs T

更新日期：1986-09-01 00:00:00

abstract：:This report reviews the literature on the impact of exposure to trichloroethylene (TCE) on human health. Special emphasis is given to the health effects reported in excess of national norms by participants in the TCE Subregistry of the Volatile Organic Compounds Registry of the National Exposure Registries--persons wi...

journal_title：Toxicology and industrial health

authors： Gist GL,Burg JR

更新日期：1995-05-01 00:00:00

abstract：:Cutting fluids can become contaminated with metals (e.g., nickel, Ni) and nitrosamines (e.g., N-nitrosodiethanolamine, NDELA) and there is concern that these classes of contaminants can modulate dermal disposition and ultimately the toxicity of cutting fluid additives, such as irritant biocides (e.g., triazine). Bioci...

journal_title：Toxicology and industrial health

authors： Baynes RE,Brooks JD,Barlow BM,Riviere JE

更新日期：2005-10-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AHR) is one of the principal xenobiotic, nuclear receptor that is responsible for the early events involved in the transcription of a complex set of genes comprising the CYP450 gene family. In the present computational study, homology modelling and molecular docking were carried out with...

journal_title：Toxicology and industrial health

authors： Panda R,Cleave AS,Suresh PK

更新日期：2014-09-01 00:00:00

abstract：:The aim of this study was to investigate the different testicular toxicity and the role of apoptosis in the possible mechanism induced by the two isomers of bromopropanes (BPs) in the same dosage. Following the 14-day treatment with a single dose of 1-BP and 2-BP (1 g/kg), male rats were killed and a series of experim...

journal_title：Toxicology and industrial health

authors： Xin QQ,Yong Huang,Jie Li,Zhang WJ,Tao Yu,Hua Wang,Cheng Zhang,Ye DQ,Fen Huang

更新日期：2010-09-01 00:00:00

abstract：:The morphological changes of ricin-induced apoptosis in a human cervical cancer cell line were studied. To shed light on the mechanism of action of ricin toxin (RT) at the cellular level, we examined cell growth, apoptosis, changes of mitochondrial membrane potential (MMP) and cytochrome C translocation in HeLa cells ...

journal_title：Toxicology and industrial health

authors： Liao P,Liu W,Li H,Gao H,Wang H,Li N,Xu N,Li J,Wan J,Liu L,Sun Y

更新日期：2012-06-01 00:00:00

abstract：:The aim of this study was to evaluate the effect of resveratrol on kidney tissue of rats exposed to cigarette smoke. Forty adult male Wistar Albino rats were divided into four groups. Animals in group 1 was the control group. For 6 weeks, group 2 was exposed to cigarette smoke; group 3 received daily intraperitoneal i...

journal_title：Toxicology and industrial health

authors： Kuruş M,Ugras M,Esrefoglu M

更新日期：2009-09-01 00:00:00

abstract：:Kinetic interactions among chemicals present in a mixture can influence the relationship between administered and delivered or effective dose; these interactions are distinct from dynamic interactions such as, for example, competition between two chemicals for receptor binding sites. The relationship between administe...

journal_title：Toxicology and industrial health

authors： O'Flaherty EJ

更新日期：1989-10-01 00:00:00

abstract：:The main objective of this study is to calculate the hours of diving in benzene-polluted waters acceptable for professional divers. We considered recommended absorption limit as that from pulmonary workplace absorption during an 8-h workday at recommended exposure limits set by the National Institute of Occupational S...

journal_title：Toxicology and industrial health

authors： Froom P

更新日期：2008-09-01 00:00:00

abstract：:The inhalation toxicity of methanol and toluene was investigated in rats. Young Sprague Dawley rats of both sexes were exposed to vapors of methanol (300 ppm, 3000 ppm), toluene (30 ppm, 300 ppm) or methanol/toluene (300/30 ppm, 300/300 ppm, 3000/30 ppm, and 3000/300 ppm) six hrs per day, five days/week for four weeks...

journal_title：Toxicology and industrial health

authors： Poon R,Chu I,Bjarnason S,Potvin M,Vincent R,Miller RB,Valli VE

更新日期：1994-05-01 00:00:00

abstract：:Peracetic acid (PAA) is a corrosive chemical with a pungent odor, which is extensively used in occupational settings and causes various health hazards in exposed workers. Currently, there is no US government agency recommended method that could be applied universally for the sampling and analysis of PAA. Legacy method...

journal_title：Toxicology and industrial health

authors： Nordling J,Kinsky OR,Osorio M,Pechacek N

更新日期：2017-12-01 00:00:00

abstract：:Continuous occupational exposure to spent engine oil (SEO) poses physiological risks to humans, especially to automobile mechanics. This study investigated the physiological effects of SEO-contaminated soil in a male Wistar rat model. Animals were dermally exposed to soil contaminated with SEO for 120 consecutive days...

journal_title：Toxicology and industrial health

authors： Obiyo GE,Ogunsuyi OM,Akindele O A

更新日期：2020-12-01 00:00:00

abstract：:Within hours after the terrorist attack on the Pentagon on September 11, 2001, an extensive sampling effort was initiated within the building to include surface wipe sampling for select coplanar polychlorinated biphenyls (PCBs), congeners of polychlorinated dibenzo(p)dioxins and dibenzofurans (dioxins/furans) and lead...

journal_title：Toxicology and industrial health

authors： Gaborek BJ,Mullikin JM,Pitrat AT,Cummings L,May LM

更新日期：2001-06-01 00:00:00

abstract：:Chronic exposure to jet fuel has been shown to have adverse effects on human liver function, to cause emotional dysfunction, to cause abnormal electroencephalograms, to cause shortened attention spans, and to decrease sensorimotor speed. Due to the decision by the United States Air Force to implement the widespread us...

journal_title：Toxicology and industrial health

authors： Harris DT,Sakiestewa D,Robledo RF,Witten M

更新日期：1997-09-01 00:00:00

abstract：:The assessment of risk due to environmental contaminants depends, in part, on scientific data. When such data are incomplete, as is usually the case, assumptions based on scientific judgments are made to analyze the consequences. Specifically, when health related data needed to assess the risk posed by environmental c...

journal_title：Toxicology and industrial health

authors： Cothern CR

更新日期：1989-05-01 00:00:00

abstract：:Pyrrolizidine alkaloid isoline is isolated from the traditional Chinese medicine Ligularia duciformis. Our previous reports have already demonstrated isoline-induced liver injury in mice. The present study is designed to observe the involvement of intracellular reduced glutathione (GSH) in isoline-induced cytotoxicity...

journal_title：Toxicology and industrial health

authors： Chen Y,Ji L,Xiong A,Yang L,Wang Z

更新日期：2013-07-01 00:00:00

abstract：:The following is a review of some of the work we have done since 2004 regarding the importance of molds and their mycotoxins in the phenomenon of sick building syndrome (SBS). In these studies we showed that the macrocyclic trichothecene mycotoxins (MTM) of Stachybotrys chartarum (SC) are easily dissociated from the s...

journal_title：Toxicology and industrial health

authors： Straus DC

更新日期：2009-10-01 00:00:00

abstract：:Wild alligators exposed to persistent organochlorine contaminants, municipal waste compounds, and contemporary-use herbicides exhibit reproductive alterations that are thought to be caused by endocrine disruption. This study tests the hypothesis that these alterations, at least in part, result from exposure of alligat...

journal_title：Toxicology and industrial health

authors： Crain DA,Spiteri ID,Guillette LJ Jr

更新日期：1999-01-01 00:00:00

abstract：STUDY OBJECTIVES:Asbestos bodies (ABs) form as asbestos fibers become coated by a cellular iron- and protein-rich matrix. ABs have been reported in lymph nodes and a few extrapulmonary sites, but no data exist as to their formation outside of the lung. It is not clear whether the AB found in these extrapulmonary areas ...

journal_title：Toxicology and industrial health

authors： Williams MG,Dodson RF,Dickson EW,Fraire AE

更新日期：2001-02-01 00:00:00

abstract：:Recently, we have detailed a DNA alkaline unwinding assay (DAUA) that can be used to rapidly measure chemically induced strand breaks in mammalian cells (Daniel et al., 1985). In this paper we present further development of this assay, including: (1) studies on the relationship between DNA adducts and DNA strand break...

journal_title：Toxicology and industrial health

authors： Daniel FB,Chang LW,Schenck KM,DeAngelo AB,Skelly MF

更新日期：1989-10-01 00:00:00

abstract：:Hepatocarcinogens are agents that increase the incidence of liver cancer in exposed animals or humans. It is now established that carcinogenic exposures have a widespread impact on the transcriptome, inducing both adaptive and adverse changes in the activities of genes and pathways. Chemical hepatocarcinogens have als...

journal_title：Toxicology and industrial health

authors： Nicolaidou V,Koufaris C

更新日期：2020-05-01 00:00:00

abstract：:Cucumbers grown in two different greenhouses were exposed to mancozeb and carbaryl at different times. The effects of 10-day preharvest period, water and detergent washing, peeling, predetermined storage period at 4°C (refrigeration), and fermentation on the reduction of residue levels in the plant tissues were invest...

journal_title：Toxicology and industrial health

authors： Saeedi Saravi SS,Shokrzadeh M

更新日期：2016-06-01 00:00:00

abstract：:1,2-Dichloropropane (1,2-DCP), a solvent, which is the main component of the cleaner used in the offset printing companies in Japan, is suspected to be the causative agent of bile duct cancer, which has been recently reported at high incidence in those offset printing workplaces. While there are some reports about the...

journal_title：Toxicology and industrial health

authors： Yanagiba Y,Suzuki T,Suda M,Hojo R,Gonzalez FJ,Nakajima T,Wang RS

更新日期：2016-09-01 00:00:00

abstract：:Young adult CD-1 male mice were housed in individual cages throughout the study. Groups of 10 to 20 mice were given gradually increasing doses of delta-9-tetrahydrocannabinol (THC) at 6.25 to 25 mg/kg i.p., trifluoperazine (TFP) at 6 to 12 mg/kg p.o., phenobarbital sodium (PS) at 20 to 35 mg/kg p.o., morphine sulfate ...

journal_title：Toxicology and industrial health

authors： Yen-Koo HC,Tocus EC,Balazs T

更新日期：1989-12-01 00:00:00