Molds, mycotoxins, and sick building syndrome.

Abstract:

:The following is a review of some of the work we have done since 2004 regarding the importance of molds and their mycotoxins in the phenomenon of sick building syndrome (SBS). In these studies we showed that the macrocyclic trichothecene mycotoxins (MTM) of Stachybotrys chartarum (SC) are easily dissociated from the surface of the organism as it grows and could therefore be consequently spread in buildings as the fungus experiences additional water events. We then showed that SC and Penicillium chrysogenum (PC) colonies remain viable long after a water source has been removed, and the MTM produced by SC remain toxic over extended periods of time. We next showed that PC when inhaled, can release in vivo, a protease allergen that can cause a significant allergic inflammatory reaction in the lungs of mice. We then showed, in a laboratory study, that the MTM of SC can become airborne attached to spores or SC particulates smaller than spores. Following that study, we next showed that the same phenomenon actually occurred in SC infested buildings where people were complaining of health problems potentially associated with SBS. Finally, we were able to demonstrate the presence of MTM in the sera of individuals who had been exposed to SC in indoor environments. This last study was done with enough mold exposed individuals to allow for the statistical significance of SC exposure to be evaluated.

journal_name

Toxicol Ind Health

authors

Straus DC

doi

10.1177/0748233709348287

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

617-35

issue

9-10

eissn

0748-2337

issn

1477-0393

pii

25/9-10/617

journal_volume

25

pub_type

杂志文章,评审
  • Low concentration of mercury induces autophagic cell death in rat hepatocytes.

    abstract::In the present study, we attempted to elucidate the induction of autophagy in rat hepatocytes by a low concentration of mercury. Hepatocytes treated with different doses of mercuric chloride (HgCl2; 1, 2.5, 5 and 10 µM) and at different time intervals (0 min, 30 min, 1 h, 2 h and 4 h) show autophagic cell death only a...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233712462442

    authors: Chatterjee S,Ray A,Mukherjee S,Agarwal S,Kundu R,Bhattacharya S

    更新日期:2014-08-01 00:00:00

  • An assessment of asbestos body formation in extrapulmonary sites: liver and spleen.

    abstract:STUDY OBJECTIVES:Asbestos bodies (ABs) form as asbestos fibers become coated by a cellular iron- and protein-rich matrix. ABs have been reported in lymph nodes and a few extrapulmonary sites, but no data exist as to their formation outside of the lung. It is not clear whether the AB found in these extrapulmonary areas ...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1191/0748233701th090oa

    authors: Williams MG,Dodson RF,Dickson EW,Fraire AE

    更新日期:2001-02-01 00:00:00

  • Genotoxic and oxidative stress potential of nanosized and bulk zinc oxide particles in Drosophila melanogaster.

    abstract::Zinc oxide nanoparticles (ZnONP) are manufactured on a large scale and can be found in a variety of consumer products, such as sunscreens, lotions, paints and food additives. Few studies have been carried out on its genotoxic potential and related mechanisms in whole organisms. In the present study, the in vivo genoto...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233715599472

    authors: Carmona ER,Inostroza-Blancheteau C,Rubio L,Marcos R

    更新日期:2016-12-01 00:00:00

  • High-altitude medicines: a short-term genotoxicity study.

    abstract::People live in the mountains distributed across the world and are exposed to reduced inspired oxygen and lower barometric pressure along with other factors that lead to high-altitude diseases. The present study was conducted to examine what extent of marketed medicines used in the management of high-altitude sickness ...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233710369125

    authors: Ghosh M,Biswas D,Mukherjee A

    更新日期:2010-08-01 00:00:00

  • Influence of chronic cadmium exposure on the tissue distribution of copper and zinc and oxidative stress parameters in rats.

    abstract::The aim of this study was to investigate the effect of oral cadmium (Cd) intoxication on the antioxidant response and its relationship with essential bioelements like copper (Cu) and zinc (Zn). The experimental group was chronically exposed to Cd daily for 8 weeks via consumption of water containing 15 ppm cadmium chl...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233714566875

    authors: Erdem O,Yazihan N,Kocak MK,Sayal A,Akcil E

    更新日期:2016-08-01 00:00:00

  • Beneficial influence of topical extra virgin olive oil application on an experimental model of penile fracture in rats.

    abstract::Penile fracture (PF) is known as a traumatic rupture of the tunica albuginea of corpus cavernosum. In this study, we aimed to investigate the healing influence of topical extra virgin olive oil (EVOO) on PF through evaluating levels of some oxidative stress biomarkers for the first time. Histopathological evaluation w...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233713483191

    authors: Gunes M,Ozkol H,Pirincci N,Gecit I,Bilici S,Yildirim S

    更新日期:2015-08-01 00:00:00

  • Description and evaluation of a peracetic acid air sampling and analysis method.

    abstract::Peracetic acid (PAA) is a corrosive chemical with a pungent odor, which is extensively used in occupational settings and causes various health hazards in exposed workers. Currently, there is no US government agency recommended method that could be applied universally for the sampling and analysis of PAA. Legacy method...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233717739165

    authors: Nordling J,Kinsky OR,Osorio M,Pechacek N

    更新日期:2017-12-01 00:00:00

  • The toxicological effects of bisphenol A and octylphenol on the reproductive system of prepubertal male rats.

    abstract::The aim of the present study was to assess and compare the individual adverse effects of bisphenol A (BPA) and octylphenol (OP) on the reproductive system of prepubertal male rats. Rats were exposed to BPA and OP at doses of 125 and 250 mg/kg/day, by gavage, for 90 days. At the end of the study, the testes, epididymis...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233715603847

    authors: Ahbab MA,Barlas N,Karabulut G

    更新日期:2017-02-01 00:00:00

  • Pentagon surface wipe sampling health risk assessment.

    abstract::Within hours after the terrorist attack on the Pentagon on September 11, 2001, an extensive sampling effort was initiated within the building to include surface wipe sampling for select coplanar polychlorinated biphenyls (PCBs), congeners of polychlorinated dibenzo(p)dioxins and dibenzofurans (dioxins/furans) and lead...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1191/0748233701th106oa

    authors: Gaborek BJ,Mullikin JM,Pitrat AT,Cummings L,May LM

    更新日期:2001-06-01 00:00:00

  • Method validation for aflatoxin M1 determination in yoghurt using immunoaffinity column clean-up prior to high-performance liquid chromatography.

    abstract::Yoghurt is a popular dairy product in Iran because of its beneficial influence on human health and nutritional value. Aflatoxin M1 (AFM1) is the metabolite of potential carcinogen aflatoxin B1, which can contaminate milk through the feed and is not eliminated by common processing heat treatment. An analytical method u...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233710394236

    authors: Tabari M,Karim G,Ghavami M,Chamani M

    更新日期:2011-08-01 00:00:00

  • Involvement of intracellular glutathione in regulating isoline-induced cytotoxicity in human normal liver L-02 cells.

    abstract::Pyrrolizidine alkaloid isoline is isolated from the traditional Chinese medicine Ligularia duciformis. Our previous reports have already demonstrated isoline-induced liver injury in mice. The present study is designed to observe the involvement of intracellular reduced glutathione (GSH) in isoline-induced cytotoxicity...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233712442707

    authors: Chen Y,Ji L,Xiong A,Yang L,Wang Z

    更新日期:2013-07-01 00:00:00

  • Metabolic adaptability in liver and gastrocnemius muscle of mice following subacute lead toxicity.

    abstract::Lead (Pb) is one of several environmental pollutants that adversely affect human health by producing toxicity at the tissue level. The aim of the study was to understand the effects of Pb on the metabolic profiles of liver and gastrocnemius muscle of mice in relation to carbohydrate and fat metabolisms. Swiss albino m...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233720937196

    authors: Das P,Pal S,Basu S

    更新日期:2020-07-01 00:00:00

  • A modulator against mercury chloride-induced genotoxic damage: Dermatocarpon intestiniforme (L.).

    abstract::Mercury has been used in many domains of human activities for many years, although in any form mercury is reported to be toxic. On the other hand, lichens have been used in the treatment of several diseases such as tuberculosis, hemorrhoids, ulcer, dysentery and cancer. Animal investigations on some common lichen spec...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233711404036

    authors: Turkez H,Dirican E

    更新日期:2012-02-01 00:00:00

  • Ameliorative effect of butylated hydroxyanisole against ferric nitrilotriacetate-induced hepatotoxicity and oxidative stress in rats.

    abstract::Ferric nitrilotriacetate (Fe-NTA) is a known renal carcinogen and has been shown to adversely induce oxidative stress and tissue toxicity after both acute and chronic exposure. Present studies were designed to study the hepatoprotective and antioxidant potential of butylated hydroxyanisole (BHA), a phenolic antioxidan...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233714554409

    authors: Ansar S,Iqbal M

    更新日期:2015-11-01 00:00:00

  • Short-term exposure to JP-8 jet fuel results in long-term immunotoxicity.

    abstract::Chronic exposure to jet fuel has been shown to have adverse effects on human liver function, to cause emotional dysfunction, to cause abnormal electroencephalograms, to cause shortened attention spans, and to decrease sensorimotor speed. Due to the decision by the United States Air Force to implement the widespread us...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/074823379701300501

    authors: Harris DT,Sakiestewa D,Robledo RF,Witten M

    更新日期:1997-09-01 00:00:00

  • Hazardous waste site frequency: use of the capture-recapture method.

    abstract::This investigation used a two-source capture-recapture method (CRM) for determining ascertainment and undercounts of non-national priority listed hazardous waste sites in the states of Arizona, Maine and Pennsylvania. These findings suggest that ascertainment of hazardous waste sites vary greatly, with some more accur...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1191/0748233703th179oa

    authors: Lange JH,Chang YF,LaPorte RE,Mastrangelo G

    更新日期:2003-07-01 00:00:00

  • Epidemiologic evidence of cancer risk in textile industry workers: a review and update.

    abstract::A meta-analysis of epidemiologic studies for textile industry workers was undertaken in an attempt to evaluate whether the cancer risk varies within the textile industry in relation to the job held or the textile fiber used. We combined studies published up until 1990, when an ad hoc IARC Monograph was issued, and tho...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章,meta分析

    doi:10.1191/0748233702th139rr

    authors: Mastrangelo G,Fedeli U,Fadda E,Milan G,Lange JH

    更新日期:2002-05-01 00:00:00

  • Protective effect of curcumin on acute lung injury induced by intestinal ischaemia/reperfusion.

    abstract::The aim of this study is to evaluate the role of curcumin on acute lung injury induced by intestinal ischaemia/reperfusion (I/R). A total of 30 male Wistar albino rats were divided into 3 groups: sham, I/R, and I/R + curcumin; each group contains 10 animals. Sham group animals underwent laparotomy without I/R injury. ...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233711430984

    authors: Guzel A,Kanter M,Guzel A,Yucel AF,Erboga M

    更新日期:2013-08-01 00:00:00

  • DNA damage as an early biomarker of effect in human health.

    abstract::In the last few decades the need for new approaches to assess DNA damage has been increasing due to the implications that different insults on genetic material may have on human health. In this context, the identification of how chemical agents with different mechanisms of action (i.e., antineoplastic drugs) damage DN...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章,评审

    doi:10.1191/0748233705th224oa

    authors: Mussali-Galante P,Avila-Costa MR,Piñón-Zarate G,Martínez-Levy G,Rodríguez-Lara V,Rojas-Lemus M,Avila-Casado MC,Fortoul TI

    更新日期:2005-09-01 00:00:00

  • Methyl-tertiary-butyl ether (MTBE)--a gasoline additive--causes testicular and lymphohaematopoietic cancers in rats.

    abstract::In the framework of a series of experiments conducted to evaluate the carcinogenic effects of oxygenated gasoline additives, MTBE was analyzed in an oral lifetime carcinogenicity study using 8-week-old male and female Sprague-Dawley rats. These experiments were part of a large research project on gasoline carcinogenic...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/074823379501100202

    authors: Belpoggi F,Soffritti M,Maltoni C

    更新日期:1995-03-01 00:00:00

  • Human exposure to polyhexamethylene guanidine phosphate from humidifiers in residential settings: Cause of serious lung disease.

    abstract::Exposure to the humidifier disinfectant, polyhexamethylene guanidine phosphate (PHMG), in mists generated from ultrasonic humidifiers was studied in a simulation chamber and apartment rooms. PHMG is suspected as a causative agent of lung disease in Korea residences. In the simulation-chamber study, the amount of disin...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233717724983

    authors: Lee JH,Yu IJ

    更新日期:2017-11-01 00:00:00

  • Environmental contaminants and reproductive abnormalities in wildlife: implications for public health?

    abstract::At the onset of the industrial age, environmental contaminants began to pose a major threat to the health of wildlife. That threat appears to continue today. In the last three decades, the focus of our concern on the health consequences of environmental pollution has been on lethal, carcinogenic, and/or extreme terato...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章,评审

    doi:10.1177/074823379601200325

    authors: Guillette LJ Jr,Guillette EA

    更新日期:1996-05-01 00:00:00

  • Recent progress in the eye irritation test.

    abstract::The rabbit eye irritation test based on the Draize method is required for the hazard assessment of chemicals and products that may come into contact with the eye. Due to the potential for the suffering of animals and subjectivity of the test, many modifications of the method have been made that involved a reduction in...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章,评审

    doi:10.1177/074823379300900602

    authors: Chu IH,Toft P

    更新日期:1993-11-01 00:00:00

  • Physiological and biochemical mechanisms of allelopathy mediated by the allelochemical extracts of Phytolacca latbenia (Moq.) H. Walter.

    abstract::In allelopathy, one plant suppresses the growth and development of other plant/plants by negatively affecting a variety of physiological and biochemical reactions. We checked the effects of methanolic extracts (allelochemical extracts) of Phytolacca latbenia (Moq.) H. Walter on antioxidant enzyme activities such as pe...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233713483205

    authors: Ullah N,Haq IU,Safdar N,Mirza B

    更新日期:2015-10-01 00:00:00

  • The effect of Plantago major Linnaeus on serum total sialic acid, lipid-bound sialic acid, some trace elements and minerals after administration of 7,12-dimethylbenz(a)anthracene in rats.

    abstract::The present study was designed to evaluate the effect of Plantago major Linnaeus (PM) extract on serum total sialic acid (TSA), lipid-bound sialic acid (LSA), some trace elements (copper (Cu), zinc (Zn) and iron) and mineral levels (magnesium, calcium and sodium) in Wistar albino rat administrated 7,12-dimethylbenz(a)...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233711412422

    authors: Oto G,Ekin S,Ozdemir H,Levent A,Berber I

    更新日期:2012-05-01 00:00:00

  • Psychological bases of symptom reporting: perceptual and emotional aspects of chemical sensitivity.

    abstract::The reporting of physical symptoms is influenced to a large degree by psychological processes. Individuals are more likely to notice subtle sensations in environments lacking in stimulation than those demanding external attention. The beliefs or schemas that people hold dictate where and how they attend to their bodie...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章,评审

    doi:

    authors: Pennebaker JW

    更新日期:1994-07-01 00:00:00

  • Preneoplastic and neoplastic changes in the Leydig cells population in mice exposed to low doses of cadmium.

    abstract::The morphological consequences of chronic exposition to low doses of cadmium (Cd) in the Leydig cells population were investigated in 40 sexually mature male mice at morphological and ultrastructural levels. Animals were orally exposed to cadmium (0.015 g/L of CdCl(2) in drinking water) for 3, 6, 12 and 18 months and ...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233710371111

    authors: Blanco A,Moyano R,Molina López AM,Blanco C,Flores-Acuña R,García-Flores JR,Espada M,Monterde JG

    更新日期:2010-09-01 00:00:00

  • River pollution in the Kosovo: Cyto- and genotoxic effects of water samples in the primary rat hepatocyte assay.

    abstract::The actual stage of the development of Kosovo is characterized by the concerning levels of environmental pollution and the serious health problems attributed to the emission of pollutants into air, soil and water. In this context, river pollution is one of the main threats due to the discharge of untreated urban and i...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233718773027

    authors: Alija AJ,Bresgen N,Bojaxhi E,Krenn M,Bajraktari ID,Eckl PM

    更新日期:2018-08-01 00:00:00

  • Effect of nanosilver on blood parameters in chickens having aflatoxicosis.

    abstract::This experiment is designed to investigate the positive effects of commercial nanosilver compound on blood parameters in experimental aflatoxicosis in broiler chickens. For this, 270 one-day-old broiler chickens were randomly divided into six treatment groups with three replicates. The experimental groups were group A...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233712452611

    authors: Gholami-Ahangaran M,Zia-Jahromi N

    更新日期:2014-03-01 00:00:00

  • Bioantioxidants: the systems reliability standpoint.

    abstract::The antioxidant power of the so-called antioxidants is negligible because their rate constants and concentrations are too small to compete with the specialized defense enzymes, like superoxide dismutase (SOD), for the reactive oxygen species. In this short review, we present a number of experimental data of our group,...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章,评审

    doi:10.1177/0748233709103029

    authors: Koltover VK

    更新日期:2009-05-01 00:00:00