Abstract：
:The morphological consequences of chronic exposition to low doses of cadmium (Cd) in the Leydig cells population were investigated in 40 sexually mature male mice at morphological and ultrastructural levels. Animals were orally exposed to cadmium (0.015 g/L of CdCl(2) in drinking water) for 3, 6, 12 and 18 months and then sacrificed, samples were collected for toxicological, light and electron microscope studies. Vascular lesions were evident from 6 months of Cd exposure, the severity of the morphological changes observed in the testicular vases were highly and clearly correlated to the time of exposure to Cd. The severity of the Leydig cells morphological changes were increasing along the time of exposure. Presence of cytoplasm vacuolization and degenerative images of the cells were frequent after 12 months of Cd exposure. Also two Leydig cells tumours after 12 and 18 months Cd exposure were presented. These results indicate that prolonged exposures to low doses of Cd are able to induce morphological damage on the Leydig cells.
journal_name
Toxicol Ind Healthjournal_title
Toxicology and industrial healthauthors
Blanco A,Moyano R,Molina López AM,Blanco C,Flores-Acuña R,García-Flores JR,Espada M,Monterde JGdoi
10.1177/0748233710371111subject
Has Abstractpub_date
2010-09-01 00:00:00pages
451-7issue
8eissn
0748-2337issn
1477-0393pii
0748233710371111journal_volume
26pub_type
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