Abstract:
:Endothelial adhesion plays an important role in the process of atherosclerosis, which is regulated by endothelial adhesion molecules and chemoattractant molecules. In some areas of China, citreoviridin (CIT) is considered a risk factor for the development of atherosclerosis. Here, we investigated the role of CIT in adhesion of human umbilical vein endothelial cells (HUVECs) together with the stimulation of tumor necrosis factor-α (TNF-α). Adhesion of HUVECs to monocytes was analyzed by coculture experiments using U937 cells labeled with 2,7-bis(2-carboxyethyl)-5(6)-carboxyfluorescein acetoxymethylester. The expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin was determined by Western blot and enzyme-linked immunosorbent assay (ELISA). The expression of monocyte chemoattractant protein-1 (MCP-1) was measured by reverse transcription polymerase chain reaction and ELISA. The activation of nuclear factor-κB (NF-κB) was assessed by Western blot and immunofluorescence staining. CIT markedly increased TNF-α-induced HUVECs adhesion to monocytes and the expression levels of ICAM-1, VCAM-1, E-selectin, and MCP-1. TNF-α-induced nuclear translocation of NF-κB in HUVECs was significantly elevated by CIT. Our study demonstrates that CIT upregulates TNF-α-induced endothelial adhesion via increasing activation of NF-κB, which results in the expression of ICAM-1, VCAM-1, E-selectin, and MCP-1. CIT plays a pivotal role in the process of endothelial cell adhesion and may thereby play an important role in the improvement of atherosclerosis in areas of China that have a high prevalence of CIT contamination and atherosclerosis.
journal_name
Toxicol Ind Healthjournal_title
Toxicology and industrial healthauthors
Hou H,Zhou R,Jia Q,Li Q,Kang L,Jiao P,Li D,Jiang Bdoi
10.1177/0748233713483194subject
Has Abstractpub_date
2015-03-01 00:00:00pages
193-201issue
3eissn
0748-2337issn
1477-0393pii
0748233713483194journal_volume
31pub_type
杂志文章abstract::This investigation used a two-source capture-recapture method (CRM) for determining ascertainment and undercounts of non-national priority listed hazardous waste sites in the states of Arizona, Maine and Pennsylvania. These findings suggest that ascertainment of hazardous waste sites vary greatly, with some more accur...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1191/0748233703th179oa
更新日期:2003-07-01 00:00:00
abstract::Microcystins (MCs) are the most potent toxins that can be produced by cyanobacteria in drinking water supplies. This study investigated the abundance of toxin-producing algae in 11 drinking water treatment plants (DWTPs). A total of 26 different algal taxa were identified in treated water, from which 12% were blue gre...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233715583203
更新日期:2016-10-01 00:00:00
abstract::The goal of this study was to explore the impact of 2-deoxglucose or malonate individually or in combination on the level of cell energy (adenosine-5'-triphosphate) and oxidative stress in 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary proliferation in rats. A total of 60 adult female Sprague Dawley rats were r...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712472525
更新日期:2015-04-01 00:00:00
abstract::The antioxidant power of the so-called antioxidants is negligible because their rate constants and concentrations are too small to compete with the specialized defense enzymes, like superoxide dismutase (SOD), for the reactive oxygen species. In this short review, we present a number of experimental data of our group,...
journal_title:Toxicology and industrial health
pub_type: 杂志文章,评审
doi:10.1177/0748233709103029
更新日期:2009-05-01 00:00:00
abstract::Octamethylcyclotetrasiloxane (D4; CAS No. 556-67-2) is used as a monomer in the manufacture of polymeric materials, which are widely used in various industrial and/or medical applications, such as breast implants. D4 has a relatively low order of toxicity following acute administration via the oral, dermal, and inhala...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233716670061
更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION:Semiconductor quantum dots (QDs), especially those containing cadmium, have undergone marked improvements and are now widely used nanomaterials in applicable biological fields. However, great concerns exist regarding their toxicity in biomedical applications. Because of the lack of sufficient data regardin...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233718763517
更新日期:2018-05-01 00:00:00
abstract::Insulin resistance (IR) is recognized as a contributory factor for a variety of liver diseases. The present study investigates the susceptibility of liver to the toxic actions of carbon tetrachloride (CCl(4)) in a rat model of IR, induced by feeding a high-fructose diet (60 g/100 g) for 30 days. A sub-lethal dose of C...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233709359273
更新日期:2010-03-01 00:00:00
abstract::The effects of trona (Kaun), a food additive, on the redox status of the liver and kidney of male Wistar rats were investigated. A total of 60 male rats (145 ± 2.52 g) were grouped into four: A, B, C and D, where group A (the control) received 1 mL of distilled water orally while those in groups B, C and D (test group...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712469654
更新日期:2015-02-01 00:00:00
abstract::Sorption of three pesticides on geologic material ranging in organic carbon content from 0.33 to 6.9 g kg-1 was measured in soil columns using a miscible displacement technique. An octanol-water partitioning model was shown to be inappropriate for predicting sorption of the less hydrophobic pesticides on the low organ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823378800400306
更新日期:1988-09-01 00:00:00
abstract::Penile fracture (PF) is known as a traumatic rupture of the tunica albuginea of corpus cavernosum. In this study, we aimed to investigate the healing influence of topical extra virgin olive oil (EVOO) on PF through evaluating levels of some oxidative stress biomarkers for the first time. Histopathological evaluation w...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713483191
更新日期:2015-08-01 00:00:00
abstract::Some studies have shown increased DNA damage among car painters, but other professionals working in auto body and paint shops have not been extensively assessed. The aim of this study was to assess DNA damage in different types of auto body shop workers by measuring micronucleus (MN) levels in exfoliated buccal cells....
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233710375948
更新日期:2010-10-01 00:00:00
abstract::Female Macaca fascicularis monkeys were given daily oral doses of 3.0 and 4.25 mg/kg lead, as lead nitrate, prior to breeding, and exposure was maintained throughout gestation and terminated at parturition. No overt signs of lead toxicity were observed in the maternal monkeys. The offspring were tested at 6 to 18 mont...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823378600200101
更新日期:1986-07-01 00:00:00
abstract::Aluminum (Al) is commonly used in industrial processes and drugs and is thought to induce erythrocytes damage via activation of oxidative stress. Recently, bismuth (Bi)-containing drugs are used in the treatment of various diseases. However, uncertain effects of Bi in blood tissue may participate in the therapeutic ef...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233710381894
更新日期:2011-03-01 00:00:00
abstract::2,4-dinitroanisole (DNAN) is a warhead explosive currently under investigation as a replacement for TNT in melt-cast insensitive munitions. In animal studies, DNAN is a mild ocular and skin irritant with a significant potential for dermal absorption. It is not a dermal sensitizer. Acute and subacute rat inhalation s...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233717719690
更新日期:2018-01-01 00:00:00
abstract::Cisplatin (CP) is a widely used anticancer drug; however, it has several side effects such as nephrotoxicity. Ginger, the rhizome of Zingiber officinale, consumed since ancient times has numerous health benefits. The objective of this work was to evaluate the protective effect of ginger extract (GE) against CP-induced...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713483198
更新日期:2015-10-01 00:00:00
abstract::T-2 toxin is one of the mycotoxins, a group of type A trichothecenes produced by several fungal genera including Fusarium species, which may lead to the decrease of testosterone secretion in primary Leydig cells derived from mouse testis. The previous study demonstrated T-2 toxin decrease the testosterone biosynthesis...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233715590516
更新日期:2016-10-01 00:00:00
abstract::Despite large-scale anti-smoking campaigns throughout the world, the number of smokers remains high and cigarette smoking continues to represent a life-threatening health risk. Until a smoke-free society is achieved, reduction of cigarette smoke toxins may reduce the health burden. Current cigarette filter techniques ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1191/0748233702th145oa
更新日期:2002-06-01 00:00:00
abstract::Maneb is a dithiocarbamate fungicide that contains manganese. Dithiocarbamates are considered to be chemicals of low toxicity. An experimental group (n = 10) received maneb (obtained from Hoecht-Shering) at a concentration of 250 ppm in distilled water five days a week (treatment time is three weeks). It was orally ad...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233706070851
更新日期:2006-10-01 00:00:00
abstract:STUDY OBJECTIVES:Asbestos bodies (ABs) form as asbestos fibers become coated by a cellular iron- and protein-rich matrix. ABs have been reported in lymph nodes and a few extrapulmonary sites, but no data exist as to their formation outside of the lung. It is not clear whether the AB found in these extrapulmonary areas ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1191/0748233701th090oa
更新日期:2001-02-01 00:00:00
abstract::Polycyclic aromatic hydrocarbons have mutagenic and carcinogenic properties and some of them are classified as probable or possible human carcinogens. Aim of this study was to evaluate the genotoxic risk in workers exposed to diesel exaust. Environmental and biological monitoring exposure to polycyclic aromatic hydroc...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233707077436
更新日期:2007-02-01 00:00:00
abstract::In allelopathy, one plant suppresses the growth and development of other plant/plants by negatively affecting a variety of physiological and biochemical reactions. We checked the effects of methanolic extracts (allelochemical extracts) of Phytolacca latbenia (Moq.) H. Walter on antioxidant enzyme activities such as pe...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713483205
更新日期:2015-10-01 00:00:00
abstract::Hepatocarcinogens are agents that increase the incidence of liver cancer in exposed animals or humans. It is now established that carcinogenic exposures have a widespread impact on the transcriptome, inducing both adaptive and adverse changes in the activities of genes and pathways. Chemical hepatocarcinogens have als...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233720922710
更新日期:2020-05-01 00:00:00
abstract::Using the Environmental Exposure and Sensitivity Inventory (EESI), a standardized instrument for measuring chemical sensitivity, we obtained and compared ratings of symptoms, chemical (inhalant) intolerances, other intolerances (e.g., drugs, caffeine, alcohol, skin contactants), lifeimpact, and masking (ongoing exposu...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379901500312
更新日期:1999-04-01 00:00:00
abstract::The purpose of this study is to follow-up the distribution, lethality percentile doses (LDs) and bioaccumulation of aluminium oxide nanoparticles (Al2O3-NPs, average diameter 9.83 ± 1.61 nm) in some tissues of male albino rats, and to evaluate its genotoxicity to the brain tissues, during acute and sublethal experimen...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713498449
更新日期:2016-02-01 00:00:00
abstract::At the present time, the following parameters can be recommended for "early diagnosis" of phosgene overexposure: Phosgene indicator paper badges, to be worn by all persons involved in handling phosgene (these badges permit immediate estimation of the exposure dose in each individual case); Observation of the initial i...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823378500100208
更新日期:1985-10-01 00:00:00
abstract::Chloropentafluorobenzene (CPFB) has been identified as a candidate simulant for nonpersistent chemical warfare agents. Acute toxicity studies have shown that CPFB has limited adverse effects on laboratory animals. A 21-day inhalation study of rats and mice to 2.5, 0.8, and 0.25 mg CPFB/liter resulted in reduced weight...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379100700406
更新日期:1991-07-01 00:00:00
abstract::We recently determined that the metabolism of a series of tumorigenic pyrrolizidine alkaloids resulted in the formation of a set of 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)-derived DNA adducts. These DHP-derived DNA adducts have been proposed as potential biomarkers of pyrrolizidine alkaloid tumorige...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233706071765
更新日期:2006-09-01 00:00:00
abstract::The present study was designed to evaluate the effect of Plantago major Linnaeus (PM) extract on serum total sialic acid (TSA), lipid-bound sialic acid (LSA), some trace elements (copper (Cu), zinc (Zn) and iron) and mineral levels (magnesium, calcium and sodium) in Wistar albino rat administrated 7,12-dimethylbenz(a)...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233711412422
更新日期:2012-05-01 00:00:00
abstract::The Royal Australian Air Force (RAAF) has reported that personnel involved in F-111 fuel tank maintenance were concerned that exposure to a range of chemicals during the period 1977 to mid-1990s was the cause of health problems, including cancer. Particular concern was directed at SR-51, a desealant chemical mixture c...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233709103037
更新日期:2009-02-01 00:00:00
abstract::Aflatoxin B1 (AFB1) is a toxic compound commonly found as a contaminant in human food. It is carcinogenic due its potential in inducing the oxidative stress and distortion of the most antioxidant enzymes. Since black tea possesses strong antioxidant activity, it protects cells and tissues against oxidative stress. Cur...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713491807
更新日期:2015-12-01 00:00:00