Abstract:
:The purpose of this study is to follow-up the distribution, lethality percentile doses (LDs) and bioaccumulation of aluminium oxide nanoparticles (Al2O3-NPs, average diameter 9.83 ± 1.61 nm) in some tissues of male albino rats, and to evaluate its genotoxicity to the brain tissues, during acute and sublethal experiments. The LDs of Al2O3-NPs, including median lethal dose (LD50), were estimated after intraperitoneal injection. The computed LD50 at 24 and 48 h were 15.10 and 12.88 g/kg body weight (b.w.), respectively. For acute experiments, the bioaccumulation of aluminium (Al) in the brain, liver, kidneys, intestine and spleen was estimated after 48 h of injection with a single acute dose (3.9, 6.4 and 8.5 g/kg b.w.), while for sublethal experiments it was after 1, 3, 7, 14 and 28 days of injection with 1.3 g/kg b.w. once in 2 days. Multi-way analysis of variance affirmed that Al uptake, in acute experiments, was significantly affected by the injected doses, organs (brain, liver, kidneys, intestine and spleen) and their interactions, while for sublethal experiments an altogether effect based on time (1, 3, 7, 14, 28 days), doses (0 and 1.3 g), organs and their interactions was reported. In addition, Al accumulated in the brain, liver, kidney, intestine and spleen of rats administered with Al2O3-NPs were significantly higher than the corresponding controls, during acute and sublethal experiments. The uptake of Al by the spleen of rats injected with acute doses was greater than that accumulated by kidney>brain>intestine>liver, whereas the brain of rats injected with sublethal dose accumulated lesser amount of Al followed by the kidney journal_name journal_title authors doi subject pub_date pages issue eissn issn pii journal_volume pub_type
abstract::Many episodes of low back pain are disabling, thus making it one of the costly occupational health problem. The proper alignment and lifting operations during drilling process frequently exposed the oil-drilling workers to unusual strain on the spine and thus make them susceptible for developing low back pain. The pre...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712451771
更新日期:2014-02-01 00:00:00
abstract::The aim of this study was to evaluate the antiapoptotic and proliferative activity of curcumin (Cur) on the ovarian follicles in mice exposed to whole body ionizing radiation (Rd). The mice were exposed to 8.3 gray whole body Rd, and Cur groups were given as a daily dose of 100 mg/kg of Cur for 10 days (10 days before...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233711425080
更新日期:2012-10-01 00:00:00
abstract::In dry etching processes--one of the sources of potential exposure to toxic wastes in the semiconductor industry--complex mixtures of inorganic and organic compounds arise from reactions between feed stock gases (BCl3/Cl2), top layers (aluminium photoresist), and the carrier gas (N2). Two different fractions of the co...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379200800302
更新日期:1992-05-01 00:00:00
abstract::Pesticides are registered in Canada under the authority of the Pest Control Products Act (PCP), administered by the Department of Agriculture. The Department of Agriculture calls upon various federal departments, including Health & Welfare Canada, to provide expert advice on hazards which may be associated with the us...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823378800400305
更新日期:1988-09-01 00:00:00
abstract::Groups of five male and five female rats were fed diets containing from 0% to 2.5% di(2-ethylhexyl)terephthalate (DEHT) or 1.2% di(2-ethylhexyl)phthalate (DEHP) for 21 days. Feed consumption and body weight gains were collected and, at study termination, animals were examined for alterations in body weight, difference...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823378700300206
更新日期:1987-06-01 00:00:00
abstract:OBJECTIVES:Various authors who studied the effects of aluminium (Al) exposure on the neurocognitive system in the last 30 years have reached different and often contradictory conclusions. The aim of this study is to help clarify the effects that the metal causes on cognitive ability in a group of naval welders exposed ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712456062
更新日期:2014-05-01 00:00:00
abstract::Cisplatin (CP) is a widely used anticancer drug; however, it has several side effects such as nephrotoxicity. Ginger, the rhizome of Zingiber officinale, consumed since ancient times has numerous health benefits. The objective of this work was to evaluate the protective effect of ginger extract (GE) against CP-induced...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713483198
更新日期:2015-10-01 00:00:00
abstract::Zinc oxide nanoparticles (ZnO NPs) are produced in high tonnage each year; they are widely used in consumer and industrial products, also now finding applications in bioimaging and drug delivery. In the present study, comparison between ZnO NPs (39 nm) and its bulk/micron form (particle size = 5 µm) on liver function ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233719878970
更新日期:2019-10-01 00:00:00
abstract::In the framework of a series of experiments conducted to evaluate the carcinogenic effects of oxygenated gasoline additives, MTBE was analyzed in an oral lifetime carcinogenicity study using 8-week-old male and female Sprague-Dawley rats. These experiments were part of a large research project on gasoline carcinogenic...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379501100202
更新日期:1995-03-01 00:00:00
abstract::Glycidyl methacrylate (GMA; CAS no. 106-91-2) is a chemical monomer used in the manufacture of dental resins, can coatings and polymers. GMA has demonstrated toxicity to the ocular, digestive, respiratory and dermal systems. Human exposure occurs mainly in the workplace, but it can also happen through food. Although t...
journal_title:Toxicology and industrial health
pub_type: 信件
doi:10.1177/0748233720957816
更新日期:2020-12-01 00:00:00
abstract::The main objective of this study is to calculate the hours of diving in benzene-polluted waters acceptable for professional divers. We considered recommended absorption limit as that from pulmonary workplace absorption during an 8-h workday at recommended exposure limits set by the National Institute of Occupational S...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233708098126
更新日期:2008-09-01 00:00:00
abstract::Molecular mechanisms in the pathogenesis of silicosis are not fully understood. Exposure to crystalline silica leads to the activation of signaling pathways controlling the production and secretion of inflammatory mediators. Inflammatory cytokines are noted as important candidate genes for fibrotic lung diseases. Cyto...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712445048
更新日期:2013-10-01 00:00:00
abstract::Young adult CD-1 male mice were housed in individual cages throughout the study. Groups of 10 to 20 mice were given gradually increasing doses of delta-9-tetrahydrocannabinol (THC) at 6.25 to 25 mg/kg i.p., trifluoperazine (TFP) at 6 to 12 mg/kg p.o., phenobarbital sodium (PS) at 20 to 35 mg/kg p.o., morphine sulfate ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823378900500604
更新日期:1989-12-01 00:00:00
abstract::The aim of the present study was to determine the effects of extremely low-frequency magnetic field (ELF-MF) on accumulation of manganese (Mn) in the kidney, liver and brain of rats. A total of 40 rats were randomly divided into eight groups. Four control groups received 0, 3.75, 15 and 60 mg Mn per kg body weight ora...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713480204
更新日期:2015-06-01 00:00:00
abstract::As part of its mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) prepares toxicological profiles on hazardous chemicals found at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) National Priorities List (NPL) sites that have the greatest public health impact. These pro...
journal_title:Toxicology and industrial health
pub_type: 杂志文章,评审
doi:10.1177/0748233708090910
更新日期:2008-06-01 00:00:00
abstract::An analytical method using natural analcime zeolite modified with tppz (2,3,5,6-tetra-pyridylpyrazine) for preconcentration of cadmium, in a column system, and their sequential determination by flame atomic absorption spectrometry (FAAS), was developed. In this work, cadmium was adsorbed onto natural analcime zeolite ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233711422730
更新日期:2012-10-01 00:00:00
abstract::Elaeagnus angustifolia was analyzed for determination of metals, phytoconstituents, bactericidal, fungicidal and insecticidal effects and to explore its chemical and biological potential. The root, branches, leaves, stem bark and root bark parts of E. angustifolia were found to contain iron, lead, copper, cadmium, zin...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713498459
更新日期:2016-01-01 00:00:00
abstract::The technologically interesting properties of palladium nanoparticles (Pd-NPs) allowed their widespread industrial application, although concerns emerged on increasing general and occupational levels of exposure. In this context, to assess the toxicological behavior of Pd-NPs, and particularly their endocrine disrupti...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233719851702
更新日期:2019-06-01 00:00:00
abstract::An investigation was conducted to evaluate the ability of two chelators, deferasirox and desferrioxamine (DFO), in removing cadmium from biological system. The potential efficiency of those chelators were investigated after cadmium administration for 60 days following two dose levels of 20 and 40 mg/kg body weight dai...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233711403192
更新日期:2012-02-01 00:00:00
abstract::In this study, we investigated the protective effect of pentoxifilline (PTX) on smoking-induced damage in rat kidney tissues. Twenty-seven male Wistar rats were used in the study. Animals were divided into three equal groups as follows: Group 1: control group with only normal saline (NS; 0.9% NaCl) injection for 8 wee...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233710387006
更新日期:2011-05-01 00:00:00
abstract::Maneb is a dithiocarbamate fungicide that contains manganese. Dithiocarbamates are considered to be chemicals of low toxicity. An experimental group (n = 10) received maneb (obtained from Hoecht-Shering) at a concentration of 250 ppm in distilled water five days a week (treatment time is three weeks). It was orally ad...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233706070851
更新日期:2006-10-01 00:00:00
abstract::The developmental toxicity of 2,4-Pentanedione (2,4-PD; CAS No. 123-54-6), a widely used industrial chemical, was investigated by vapour exposure, because of its widespread use, and potential for human exposure. Timed-pregnant Fischer 344 rats were exposed on gestational days (gd) 6 to 15 inclusive to analytically mea...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379000600308
更新日期:1990-05-01 00:00:00
abstract::At the present time, the following parameters can be recommended for "early diagnosis" of phosgene overexposure: Phosgene indicator paper badges, to be worn by all persons involved in handling phosgene (these badges permit immediate estimation of the exposure dose in each individual case); Observation of the initial i...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823378500100208
更新日期:1985-10-01 00:00:00
abstract::Brominated flame retardants (BFRs) and heavy metals (HMs) are two main types of pollutants in electronic waste recycling sites, which are also ubiquitously detectable in environmental media and human tissues. However, the adverse health effects of exposure to the mixture of these types of pollutants are unknown. In th...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233718779478
更新日期:2018-09-01 00:00:00
abstract::Trivalent chromium (Cr) is an environmental contaminant, which is extensively used in tanning industries throughout the world and causes various forms of health hazards in tannery workers. Therefore, a cross-sectional study design was used to evaluate the DNA damage and oxidative stress condition in tannery workers ex...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712457447
更新日期:2014-06-01 00:00:00
abstract::This investigation gives detailed analysis of peripheral marker enzymes as well as neurobehavioral tests following chronic aluminium (Al) exposure (10 mg/kg b.w. for 12 weeks intragastrically). We observed a significant decrease in the levels of serum cholinesterase after toxicity. The enzymatic activity of cytochrome...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1191/0748233706th242oa
更新日期:2006-02-01 00:00:00
abstract::Microcystins (MCs) are the most potent toxins that can be produced by cyanobacteria in drinking water supplies. This study investigated the abundance of toxin-producing algae in 11 drinking water treatment plants (DWTPs). A total of 26 different algal taxa were identified in treated water, from which 12% were blue gre...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233715583203
更新日期:2016-10-01 00:00:00
abstract::Pyrrolizidine alkaloid isoline is isolated from the traditional Chinese medicine Ligularia duciformis. Our previous reports have already demonstrated isoline-induced liver injury in mice. The present study is designed to observe the involvement of intracellular reduced glutathione (GSH) in isoline-induced cytotoxicity...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712442707
更新日期:2013-07-01 00:00:00
abstract::The aim of this study was to analyze the biochemical alterations in the gills of Venus verrucosa under exposure for 6 days to three doses of lambda-cyhalothrin (λ-cyh) (100, 250, and 500 µg L-1). Malondialdehyde, lipid hydroperoxide, and hydrogen peroxide levels in the gills of treated groups increased. λ-Cyh exposure...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233720961219
更新日期:2020-11-01 00:00:00
abstract::The present study investigates the toxic effects of acrylamide (ACR) administered to rats at two doses on (i) oxidative stress and disruption of pro-oxidant/antioxidant balance in hepatic cells and (ii) its correlation with metallothioneins (MTs) genes expression, DNA damage and histomorphological changes. Treated rat...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233717696613
更新日期:2017-08-01 00:00:00