Abstract:
:We recently determined that the metabolism of a series of tumorigenic pyrrolizidine alkaloids resulted in the formation of a set of 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)-derived DNA adducts. These DHP-derived DNA adducts have been proposed as potential biomarkers of pyrrolizidine alkaloid tumorigenicity, as well as pyrrolizidine alkaloid exposure. In this paper, we report that DHP-derived DNA adducts are formed in the liver of female F344 rats, gavaged with three dietary supplements (comfrey root extract, comfrey compound oil, and coltsfoot root extract), or an extract of a Chinese herbal plant, flos farfara (Kuan Tong Hua).
journal_name
Toxicol Ind Healthjournal_title
Toxicology and industrial healthauthors
Chou MW,Fu PPdoi
10.1177/0748233706071765subject
Has Abstractpub_date
2006-09-01 00:00:00pages
321-7issue
8eissn
0748-2337issn
1477-0393journal_volume
22pub_type
杂志文章abstract::Female Macaca fascicularis monkeys were given daily oral doses of 3.0 and 4.25 mg/kg lead, as lead nitrate, prior to breeding, and exposure was maintained throughout gestation and terminated at parturition. No overt signs of lead toxicity were observed in the maternal monkeys. The offspring were tested at 6 to 18 mont...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823378600200101
更新日期:1986-07-01 00:00:00
abstract::The technologically interesting properties of palladium nanoparticles (Pd-NPs) allowed their widespread industrial application, although concerns emerged on increasing general and occupational levels of exposure. In this context, to assess the toxicological behavior of Pd-NPs, and particularly their endocrine disrupti...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233719851702
更新日期:2019-06-01 00:00:00
abstract::It is well-documented that lead (Pb) toxicity can affect almost all systems in living organisms. It can induce selective autophagy of mitochondria (mitophagy) by triggering reactive oxygen species production. Emerging evidence has suggested that Pb-induced autophagy can also be activated by the endoplasmic reticulum (...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233720971882
更新日期:2020-12-01 00:00:00
abstract::An analytical method using natural analcime zeolite modified with tppz (2,3,5,6-tetra-pyridylpyrazine) for preconcentration of cadmium, in a column system, and their sequential determination by flame atomic absorption spectrometry (FAAS), was developed. In this work, cadmium was adsorbed onto natural analcime zeolite ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233711422730
更新日期:2012-10-01 00:00:00
abstract::In the present study, we attempted to elucidate the induction of autophagy in rat hepatocytes by a low concentration of mercury. Hepatocytes treated with different doses of mercuric chloride (HgCl2; 1, 2.5, 5 and 10 µM) and at different time intervals (0 min, 30 min, 1 h, 2 h and 4 h) show autophagic cell death only a...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712462442
更新日期:2014-08-01 00:00:00
abstract::Penile fracture (PF) is known as a traumatic rupture of the tunica albuginea of corpus cavernosum. In this study, we aimed to investigate the healing influence of topical extra virgin olive oil (EVOO) on PF through evaluating levels of some oxidative stress biomarkers for the first time. Histopathological evaluation w...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713483191
更新日期:2015-08-01 00:00:00
abstract::This study on the effect of genetically modified (GM) and non-GM canola on soybean was carried out for physiological and biochemical biosafety assessment of GM canola. Methanolic extracts of GM and non-GM canola were assessed on seed germination and growth of soybean (Glycine max L.) under sterilized conditions. The e...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713501366
更新日期:2016-03-01 00:00:00
abstract::In this study, we investigated the protective effect of pentoxifilline (PTX) on smoking-induced damage in rat kidney tissues. Twenty-seven male Wistar rats were used in the study. Animals were divided into three equal groups as follows: Group 1: control group with only normal saline (NS; 0.9% NaCl) injection for 8 wee...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233710387006
更新日期:2011-05-01 00:00:00
abstract::The Norplant* system is composed of a set of six Silastic* (silicone polydimethysiloxane) capsules measuring 34 mm by 2.4 mm, each containing 36 mg of levonorgestrel and sealed at either end with a medical grade silicone elastomer adhesive. Levonorgestrel is a synthetic progestin, widely used in combination oral contr...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379501100104
更新日期:1995-01-01 00:00:00
abstract::Hepatocytes that were isolated from 48 hr starved rats and incubated in Krebs-Henseleit bicarbonate buffer containing 10 microM A23187, 10mM l-lactate, 1mM pyruvate and 2mM l-lysine were found to contain 0.064 mumol of inorganic pyrophosphate/g wet wgt cells. Addition of either 20mM acetate or butyrate, which caused t...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823378600200308
更新日期:1986-09-01 00:00:00
abstract:OBJECTIVES:In this study, biological exposure indicators were used to assess the exposure of workers to cadmium (Cd), lead (Pb), manganese (Mn), and nickel (Ni) in nonferrous metal smelters. METHODS:A total of 273 male participants (178 exposed and 95 nonexposed control group), working in nonferrous metal foundries lo...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233715589262
更新日期:2016-10-01 00:00:00
abstract::The hypolipidemic effect of 10% fruit fibers in rats fed with high-fat diet (HFD) was evaluated. This study was conducted on a total of 50 male Albino rats divided into 10 equal groups fed with different types of dietary fruits. The feeding period lasted for 24 weeks. Fasting blood samples were collected and sera sepa...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712472526
更新日期:2015-03-01 00:00:00
abstract::The developmental toxicity of 2,4-Pentanedione (2,4-PD; CAS No. 123-54-6), a widely used industrial chemical, was investigated by vapour exposure, because of its widespread use, and potential for human exposure. Timed-pregnant Fischer 344 rats were exposed on gestational days (gd) 6 to 15 inclusive to analytically mea...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379000600308
更新日期:1990-05-01 00:00:00
abstract::A comparative potency method for cancer risk assessment has been developed based on a constant relative potency hypothesis. This method was developed and tested using data from a battery of short-term mutagenesis bioassays, animal tumorigenicity data and human lung cancer risk estimations. This data base was developed...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823378500100412
更新日期:1985-12-01 00:00:00
abstract::The effects of trona (Kaun), a food additive, on the redox status of the liver and kidney of male Wistar rats were investigated. A total of 60 male rats (145 ± 2.52 g) were grouped into four: A, B, C and D, where group A (the control) received 1 mL of distilled water orally while those in groups B, C and D (test group...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712469654
更新日期:2015-02-01 00:00:00
abstract::Octamethylcyclotetrasiloxane (D4; CAS No. 556-67-2) is used as a monomer in the manufacture of polymeric materials, which are widely used in various industrial and/or medical applications, such as breast implants. D4 has a relatively low order of toxicity following acute administration via the oral, dermal, and inhala...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233716670061
更新日期:2017-01-01 00:00:00
abstract::Metalworking fluids (MWFs) are complex formulations designed for effective lubricating, cooling, and cleaning tools and parts during machining operations. Adverse health effects such as respiratory symptoms, dermatitis, and cancer have been reported in workers exposed to MWFs. Several constituents of MWFs have been im...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233716653912
更新日期:2017-05-01 00:00:00
abstract::The aim of this study was to investigate the different testicular toxicity and the role of apoptosis in the possible mechanism induced by the two isomers of bromopropanes (BPs) in the same dosage. Following the 14-day treatment with a single dose of 1-BP and 2-BP (1 g/kg), male rats were killed and a series of experim...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233710373083
更新日期:2010-09-01 00:00:00
abstract::Elaeagnus angustifolia was analyzed for determination of metals, phytoconstituents, bactericidal, fungicidal and insecticidal effects and to explore its chemical and biological potential. The root, branches, leaves, stem bark and root bark parts of E. angustifolia were found to contain iron, lead, copper, cadmium, zin...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713498459
更新日期:2016-01-01 00:00:00
abstract::Aflatoxin B1 (AFB1) is a toxic compound commonly found as a contaminant in human food. It is carcinogenic due its potential in inducing the oxidative stress and distortion of the most antioxidant enzymes. Since black tea possesses strong antioxidant activity, it protects cells and tissues against oxidative stress. Cur...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713491807
更新日期:2015-12-01 00:00:00
abstract::A preliminary study of dermal and respiratory exposure to chlorpyrifos (Dursban TC) during structural treatments was conducted with eight workers from a commercial pest control company. The compound was applied by sub-slab and soil injection to four houses, with each application involving two workers. Crawl space appl...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379000600301
更新日期:1990-05-01 00:00:00
abstract::Molecular mechanisms in the pathogenesis of silicosis are not fully understood. Exposure to crystalline silica leads to the activation of signaling pathways controlling the production and secretion of inflammatory mediators. Inflammatory cytokines are noted as important candidate genes for fibrotic lung diseases. Cyto...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712445048
更新日期:2013-10-01 00:00:00
abstract::The assessment of risk due to environmental contaminants depends, in part, on scientific data. When such data are incomplete, as is usually the case, assumptions based on scientific judgments are made to analyze the consequences. Specifically, when health related data needed to assess the risk posed by environmental c...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823378900500308
更新日期:1989-05-01 00:00:00
abstract::The US EPA and the California Air Resources Board studied the exposures of 51 residents of Los Angeles, CA to 25 volatile organic chemicals in air and drinking water in February and July of 1987. Participants carried a personal air monitor consisting of a Tenax cartridge and a small sampling pump for two consecutive 1...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379100700523
更新日期:1991-09-01 00:00:00
abstract::'Toxicant-induced loss of tolerance' (or TILT) describes a two-step disease process in which (1) certain chemical exposures, e.g., indoor air contaminants, chemical spills, or pesticide applications, cause certain susceptible persons to lose their prior natural tolerance for common chemicals, foods, and drugs (initiat...
journal_title:Toxicology and industrial health
pub_type: 杂志文章,评审
doi:10.1177/074823379901500302
更新日期:1999-04-01 00:00:00
abstract::Wild alligators exposed to persistent organochlorine contaminants, municipal waste compounds, and contemporary-use herbicides exhibit reproductive alterations that are thought to be caused by endocrine disruption. This study tests the hypothesis that these alterations, at least in part, result from exposure of alligat...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1191/074823399678846565
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:Printing workers experience a high rate of musculoskeletal disorders (MSDs). This study aims to determine the prevalence of MSDs, estimate serum biomarkers denoting musculoskeletal tissue changes, and determine some individual risk factors for MSDs among Egyptian printing workers. METHODS:Eighty-five male pr...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233720977399
更新日期:2021-01-01 00:00:00
abstract::Endothelial adhesion plays an important role in the process of atherosclerosis, which is regulated by endothelial adhesion molecules and chemoattractant molecules. In some areas of China, citreoviridin (CIT) is considered a risk factor for the development of atherosclerosis. Here, we investigated the role of CIT in ad...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713483194
更新日期:2015-03-01 00:00:00
abstract::Insulin resistance (IR) is recognized as a contributory factor for a variety of liver diseases. The present study investigates the susceptibility of liver to the toxic actions of carbon tetrachloride (CCl(4)) in a rat model of IR, induced by feeding a high-fructose diet (60 g/100 g) for 30 days. A sub-lethal dose of C...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233709359273
更新日期:2010-03-01 00:00:00
abstract::Cytochrome P450 2E1 (CYP2E1) can be induced by diabetes mellitus, nonalcoholic liver disease, and obesity. This study assessed the protective effects of three sulfur compounds, namely phenethyl isothiocyanate (PEITC), dimethyl trisulfide (DMTS), and sodium thiosulfate (STS), on acrylonitrile (ACN)-induced acute toxici...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233719839847
更新日期:2019-05-01 00:00:00