Abstract:
:The technologically interesting properties of palladium nanoparticles (Pd-NPs) allowed their widespread industrial application, although concerns emerged on increasing general and occupational levels of exposure. In this context, to assess the toxicological behavior of Pd-NPs, and particularly their endocrine disruptive potential, has become a public health priority. Therefore, we evaluated Pd-NP impact on the female endocrine reproductive system of Wistar rats sub-chronically treated for 90 days with increasing doses of this xenobiotic (0.12, 1.2, and 12 µg/kg, administered at days 1, 30, and 60 for cumulative doses of 0.36, 3.6, and 36 µg/kg) via the intravenous route. In this regard, we investigated potential alterations in different sex hormone, for example, estradiol, follicle-stimulating hormone (FSH), luteinizing hormone, progesterone, and testosterone, serum concentrations. All treated groups showed significantly greater levels of FSH compared to controls, suggesting a possible impact of Pd-NPs on the regulatory system that controls the normal physiology of female reproductive function. Although relevant, since obtained under sub-chronic, low-dose conditions of exposure resembling those encountered in real-world scenarios, the present results are preliminary and require confirmation as well as identification of the possible underlining molecular mechanisms. From a public and occupational health perspective, implications for the reproductive health of exposed subjects and the next generations of women exposed during their childbearing age or pregnancy should be elucidated. This information is essential to elaborate adequate preventive strategies for assessing and controlling possible Pd-NPs adverse effects on the endocrine system.
journal_name
Toxicol Ind Healthjournal_title
Toxicology and industrial healthauthors
Leso V,Fontana L,Marinaccio A,Leopold K,Fanali C,Lucchetti D,Sgambato A,Iavicoli Idoi
10.1177/0748233719851702subject
Has Abstractpub_date
2019-06-01 00:00:00pages
403-409issue
6eissn
0748-2337issn
1477-0393journal_volume
35pub_type
杂志文章abstract::Yoghurt is a popular dairy product in Iran because of its beneficial influence on human health and nutritional value. Aflatoxin M1 (AFM1) is the metabolite of potential carcinogen aflatoxin B1, which can contaminate milk through the feed and is not eliminated by common processing heat treatment. An analytical method u...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233710394236
更新日期:2011-08-01 00:00:00
abstract::The effects of different methylmercury (MeHg) forms on the immune system and the hypothalamic pituitary adrenal (HPA) axis were assessed. The lymphocyte response to Concanavalin A (Con A) stimulation, blood levels of interleukin-6 (IL-6), adrenocorticotrophin hormone (ACTH), and corticosterone in the presence of diffe...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379701300105
更新日期:1997-01-01 00:00:00
abstract::Octamethylcyclotetrasiloxane (D4; CAS No. 556-67-2) is used as a monomer in the manufacture of polymeric materials, which are widely used in various industrial and/or medical applications, such as breast implants. D4 has a relatively low order of toxicity following acute administration via the oral, dermal, and inhala...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233716670061
更新日期:2017-01-01 00:00:00
abstract::This paper describes the development and implementation of physiologically-based pharmacokinetic (PB-Pk) models to examine the disposition of xenobiotics and their bioactivation. In a PB-Pk model, the structure of the model is based, to as great extent as practicable, on the actual physiological and biochemical struct...
journal_title:Toxicology and industrial health
pub_type: 杂志文章,评审
doi:10.1177/074823379401000101
更新日期:1994-01-01 00:00:00
abstract::Oxidative stress is accepted as a potential responsible mechanism in the pathogenesis of radiocontrast media (RCM)-induced hepatotoxicity. Therefore, we aimed to investigate the protective effects of ebselen against RCM-induced hepatotoxicity by measuring tissue oxidant/antioxidant parameters and histological changes ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712442730
更新日期:2013-09-01 00:00:00
abstract:INTRODUCTION:Spirometry is the main pulmonary function test routinely employed in the occupational medicine practice. Its interpretation depends on the choice of the theoretical reference values. Therefore, our objective was to retrospectively evaluate the differences in the spirometric interpretation according to the ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233720912059
更新日期:2020-02-01 00:00:00
abstract::Exposure to inhalation anesthetics (IAs) has been associated with DNA damage as reflected in the increased frequency of micronuclei (MN) and chromosomal aberrations (CAs). The present study was undertaken to ascertain whether there was any correlation between increased MN and CA and the extent of oxidative stress as w...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233720935696
更新日期:2020-06-01 00:00:00
abstract::This study was designed to determine if long-term exposure to high doses of methoxychlor (M) would alter pituitary or testicular endocrine functions in either an estrogenic or antiandrogenic manner. Weanling male Long-Evans hooded rats were dosed daily with M (po) at 0, 200, 300, or 400 mg kg-1 day-1 for 10 months. Me...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379901500105
更新日期:1999-01-01 00:00:00
abstract::Reports about vanadium (V) inhalation toxicity on the hematopoietic system, specifically about coagulation are limited. Therefore, we decided to evaluate the effects of V with a complete blood count and morphologic analysis of platelets on blood smears. CD-1 male mice inhaled V2O5 0.02 M 1 h twice weekly over 12 weeks...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1191/0748233706th250oa
更新日期:2006-04-01 00:00:00
abstract::Most of the mobile phones in Turkey emit 900 MHz radiation which is mainly absorbed by the skin and, to a lesser extent, muscle. The aim of this study was to investigate the effects the 900 MHz electromagnetic irradiation emitted by these devices on the induction of histopathologic changes in skin and the effect of me...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1191/0748233704th207oa
更新日期:2004-09-01 00:00:00
abstract::A more complicated pathology was observed in female pigs infected with Mycoplasma hyopneumoniae, when the same were exposed to 20 ppm dietary levels of fumonisin B1 (FB1) starting 14 days before infection for a period of 42 days as was assessed by gross pathology and pathomorphological examinations or computed tomogra...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233714543735
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVES:Various authors who studied the effects of aluminium (Al) exposure on the neurocognitive system in the last 30 years have reached different and often contradictory conclusions. The aim of this study is to help clarify the effects that the metal causes on cognitive ability in a group of naval welders exposed ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712456062
更新日期:2014-05-01 00:00:00
abstract::Brominated flame retardants (BFRs) and heavy metals (HMs) are two main types of pollutants in electronic waste recycling sites, which are also ubiquitously detectable in environmental media and human tissues. However, the adverse health effects of exposure to the mixture of these types of pollutants are unknown. In th...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233718779478
更新日期:2018-09-01 00:00:00
abstract::Zinc oxide nanoparticles (ZnO NPs) are produced in high tonnage each year; they are widely used in consumer and industrial products, also now finding applications in bioimaging and drug delivery. In the present study, comparison between ZnO NPs (39 nm) and its bulk/micron form (particle size = 5 µm) on liver function ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233719878970
更新日期:2019-10-01 00:00:00
abstract::Chloropentafluorobenzene (CPFB) has been identified as a candidate simulant for nonpersistent chemical warfare agents. Acute toxicity studies have shown that CPFB has limited adverse effects on laboratory animals. A 21-day inhalation study of rats and mice to 2.5, 0.8, and 0.25 mg CPFB/liter resulted in reduced weight...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379100700406
更新日期:1991-07-01 00:00:00
abstract::Trans-1,1,1,4,4,4-hexafluoro-2-butene (HFO-133mzz-E) is an odorless gas that finds uses as a foam transfer agent, heat transfer fluid, and specialty gas. The acute 4-h LC50 (in rats) for HFO-133mzz-E is > 17,000 ppm; it was not an eye or dermal irritant in 3- and 13-week repeated-dose inhalation studies in rats at con...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233719825529
更新日期:2019-03-01 00:00:00
abstract::The risk assessment process must encompass all available toxicological data and scientific evidence on the plausible toxicities of a chemical or chemical mixture. As an extension to the approaches used to conduct risk assessments on chemical mixtures, a preliminary scheme, analogous to the IARC classification of carci...
journal_title:Toxicology and industrial health
pub_type: 杂志文章,评审
doi:
更新日期:1992-11-01 00:00:00
abstract::Paraphenylene diamine (PPD) hair dye poisoning is a common health problem in the Middle East and Indian subcontinent. It is the most common cause of suicide intent especially among females. We hereby present a 27-year-old female who presented with a clinical feature of PPD poisoning due to a suicidal attempt, and she ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712448118
更新日期:2014-09-01 00:00:00
abstract::A meta-analysis of epidemiologic studies for textile industry workers was undertaken in an attempt to evaluate whether the cancer risk varies within the textile industry in relation to the job held or the textile fiber used. We combined studies published up until 1990, when an ad hoc IARC Monograph was issued, and tho...
journal_title:Toxicology and industrial health
pub_type: 杂志文章,meta分析
doi:10.1191/0748233702th139rr
更新日期:2002-05-01 00:00:00
abstract::The effects of trona (Kaun), a food additive, on the redox status of the liver and kidney of male Wistar rats were investigated. A total of 60 male rats (145 ± 2.52 g) were grouped into four: A, B, C and D, where group A (the control) received 1 mL of distilled water orally while those in groups B, C and D (test group...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712469654
更新日期:2015-02-01 00:00:00
abstract::Pyrrolizidine alkaloid isoline is isolated from the traditional Chinese medicine Ligularia duciformis. Our previous reports have already demonstrated isoline-induced liver injury in mice. The present study is designed to observe the involvement of intracellular reduced glutathione (GSH) in isoline-induced cytotoxicity...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712442707
更新日期:2013-07-01 00:00:00
abstract::The effect of copper in form of copper sulphate (CuSO4 x 5 H2O) was studied in the bone marrow cells of rats of Wistar strain in an in vitro culture. Evident differences between tissue cultures of the bone marrow cells were observed between the control and experimental groups. In the experimental group, the CFU-F colo...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823378900500617
更新日期:1989-12-01 00:00:00
abstract::The rabbit eye irritation test based on the Draize method is required for the hazard assessment of chemicals and products that may come into contact with the eye. Due to the potential for the suffering of animals and subjectivity of the test, many modifications of the method have been made that involved a reduction in...
journal_title:Toxicology and industrial health
pub_type: 杂志文章,评审
doi:10.1177/074823379300900602
更新日期:1993-11-01 00:00:00
abstract::As one of the main components of risk assessment, exposure assessment plays a key role in evaluating risk. Many different scenarios can be developed to estimate the risk from exposure to chemicals such as persistent organic pollutants (POPs). The US Food and Drug Administration (FDA)'s Center for Food Safety and Appli...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1191/0748233701th104oa
更新日期:2001-06-01 00:00:00
abstract::The aim of the present study was to assess the influence of curcumin on liver regeneration after partial hepatectomy (PH) in rats. A total of 24 male Sprague Dawley rats were divided into three groups: sham-operated (SH), PH, and PH + curcumin; each group contains eight animals. The rats in curcumin-treated groups wer...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712469658
更新日期:2015-02-01 00:00:00
abstract::The Norplant* system is composed of a set of six Silastic* (silicone polydimethysiloxane) capsules measuring 34 mm by 2.4 mm, each containing 36 mg of levonorgestrel and sealed at either end with a medical grade silicone elastomer adhesive. Levonorgestrel is a synthetic progestin, widely used in combination oral contr...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379501100104
更新日期:1995-01-01 00:00:00
abstract::In response to reported increased cancer risks among farmers, the Agricultural Health Study (AHS) was designed to examine health outcomes and environmental exposures among farm families in the United States. In the pilot phase of the AHS, food, beverage, air, dermal, dust, surface wipe, and biological specimens (blood...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379801400117
更新日期:1998-01-01 00:00:00
abstract::Cobalt oxide (Co3O4) nanoparticles have applications in nanomedicine and nanotechnology; therefore, any possible adverse effects require thorough investigation. The present study investigated the effects of Co3O4 nanoparticles on four different cell lines: liver, HepG2 hepatocellular carcinoma cells; lung, A549 lung c...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233717706633
更新日期:2017-08-01 00:00:00
abstract::Cucumbers grown in two different greenhouses were exposed to mancozeb and carbaryl at different times. The effects of 10-day preharvest period, water and detergent washing, peeling, predetermined storage period at 4°C (refrigeration), and fermentation on the reduction of residue levels in the plant tissues were invest...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233714552295
更新日期:2016-06-01 00:00:00
abstract::Lead exposure can damage cells directly by effecting DNA or indirectly by modifying proteins and enzymes. In Bangladesh, many working children are exposed to a very high level of lead during their early life due to their involvement with lead-oriented professions. This imposes a severe threat to the growth and develop...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233717754163
更新日期:2018-04-01 00:00:00