Effects of ebselen on radiocontrast media-induced hepatotoxicity in rats.

Abstract:

:Oxidative stress is accepted as a potential responsible mechanism in the pathogenesis of radiocontrast media (RCM)-induced hepatotoxicity. Therefore, we aimed to investigate the protective effects of ebselen against RCM-induced hepatotoxicity by measuring tissue oxidant/antioxidant parameters and histological changes in rats. Wistar albino rats were randomly separated into four groups consisting of eight rats per group. Normal saline was given to the rats in control group (group 1). RCM was given to the rats in group 2, and both RCM and ebselen were given to the rats in group 3. Only ebselen was given to the rats in group 4. Liver sections of the killed animals were analyzed to measure the levels of malondialdehyde (MDA) and activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px), as well as histopathological changes. In RCM group, SOD and CAT levels were found increased. In RCM-ebselen group, MDA, SOD and CAT levels were found decreased. In RCM-ebselen group, however, GSH-Px activities of liver tissue increased. All these results indicated that ebselen produced a protective mechanism against RCM-induced hepatotoxicity and took part in oxidative stress.

journal_name

Toxicol Ind Health

authors

Basarslan F,Yilmaz N,Davarci I,Akin M,Ozgur M,Yilmaz C,Ulutas KT

doi

10.1177/0748233712442730

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

746-52

issue

8

eissn

0748-2337

issn

1477-0393

pii

0748233712442730

journal_volume

29

pub_type

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