Physiologically-based pharmacokinetic modeling and bioactivation of xenobiotics.

abstract：:Young adult CD-1 male mice were housed in individual cages throughout the study. Groups of 10 to 20 mice were given gradually increasing doses of delta-9-tetrahydrocannabinol (THC) at 6.25 to 25 mg/kg i.p., trifluoperazine (TFP) at 6 to 12 mg/kg p.o., phenobarbital sodium (PS) at 20 to 35 mg/kg p.o., morphine sulfate ...

journal_title：Toxicology and industrial health

authors： Yen-Koo HC,Tocus EC,Balazs T

更新日期：1989-12-01 00:00:00

abstract：:The effects of trona (Kaun), a food additive, on the redox status of the liver and kidney of male Wistar rats were investigated. A total of 60 male rats (145 ± 2.52 g) were grouped into four: A, B, C and D, where group A (the control) received 1 mL of distilled water orally while those in groups B, C and D (test group...

journal_title：Toxicology and industrial health

authors： Ajiboye TO,Komolafe YO,Yakubu MT,Ogunbode SM

更新日期：2015-02-01 00:00:00

abstract：:Tris(2-chloroethyl)phosphate (TRCP), a flame-retardant plasticizer used in plastics, polymeric foams and synthetic fibers, was studied as part of the National Toxicology Program's class study of phosphate flame-retardants. TRCP was administered at 0, 22, 44, 88, 175 and 350 mg/kg to both sexes of rats and 0, 44, 88, 1...

journal_title：Toxicology and industrial health

authors： Matthews HB,Dixon D,Herr DW,Tilson H

更新日期：1990-01-01 00:00:00

abstract：:The assessment of risk due to environmental contaminants depends, in part, on scientific data. When such data are incomplete, as is usually the case, assumptions based on scientific judgments are made to analyze the consequences. Specifically, when health related data needed to assess the risk posed by environmental c...

journal_title：Toxicology and industrial health

authors： Cothern CR

更新日期：1989-05-01 00:00:00

abstract：:The aim of this study was to investigate the effect of oral cadmium (Cd) intoxication on the antioxidant response and its relationship with essential bioelements like copper (Cu) and zinc (Zn). The experimental group was chronically exposed to Cd daily for 8 weeks via consumption of water containing 15 ppm cadmium chl...

journal_title：Toxicology and industrial health

authors： Erdem O,Yazihan N,Kocak MK,Sayal A,Akcil E

更新日期：2016-08-01 00:00:00

abstract：:Kinetic interactions among chemicals present in a mixture can influence the relationship between administered and delivered or effective dose; these interactions are distinct from dynamic interactions such as, for example, competition between two chemicals for receptor binding sites. The relationship between administe...

journal_title：Toxicology and industrial health

authors： O'Flaherty EJ

更新日期：1989-10-01 00:00:00

abstract：:In the present study, we attempted to elucidate the induction of autophagy in rat hepatocytes by a low concentration of mercury. Hepatocytes treated with different doses of mercuric chloride (HgCl2; 1, 2.5, 5 and 10 µM) and at different time intervals (0 min, 30 min, 1 h, 2 h and 4 h) show autophagic cell death only a...

journal_title：Toxicology and industrial health

authors： Chatterjee S,Ray A,Mukherjee S,Agarwal S,Kundu R,Bhattacharya S

更新日期：2014-08-01 00:00:00

abstract：:People live in the mountains distributed across the world and are exposed to reduced inspired oxygen and lower barometric pressure along with other factors that lead to high-altitude diseases. The present study was conducted to examine what extent of marketed medicines used in the management of high-altitude sickness ...

journal_title：Toxicology and industrial health

authors： Ghosh M,Biswas D,Mukherjee A

更新日期：2010-08-01 00:00:00

abstract：:We recently determined that the metabolism of a series of tumorigenic pyrrolizidine alkaloids resulted in the formation of a set of 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)-derived DNA adducts. These DHP-derived DNA adducts have been proposed as potential biomarkers of pyrrolizidine alkaloid tumorige...

journal_title：Toxicology and industrial health

authors： Chou MW,Fu PP

更新日期：2006-09-01 00:00:00

abstract：:Polycyclic aromatic hydrocarbons have mutagenic and carcinogenic properties and some of them are classified as probable or possible human carcinogens. Aim of this study was to evaluate the genotoxic risk in workers exposed to diesel exaust. Environmental and biological monitoring exposure to polycyclic aromatic hydroc...

journal_title：Toxicology and industrial health

authors： Maina G,Manzari M,Palmas A,Passini V,Filon FL

更新日期：2007-02-01 00:00:00

abstract：:In the present study, the single and combined neurotoxic effects of benzo[a]pyrene ([BaP] 0.0, 0.5, and 5.0 mg/kg body weight; intragastric administration) and lead acetate (0.0, 5.4, and 54.0 mg/L; by drinking water) were examined on KunMing mice. In the Morris water maze, results showed that BaP and lead induced syn...

journal_title：Toxicology and industrial health

authors： Youbin Q,Chengzhi C,Yan T,Xuejun J,Chongying Q,Bin P,Baijie T

更新日期：2013-06-01 00:00:00

abstract：:Not only is skin cancer by far the most common human cancer but also the incidence of skin cancer has been increasing at an alarming rate in recent decades. Fortunately, most people now realize that sun exposure causes unattractive photoaging and skin cancer, so they do apply sunscreens conscientiously. However, until...

journal_title：Toxicology and industrial health

authors： Burke KE,Wei H

更新日期：2009-05-01 00:00:00

abstract：:Aflatoxin B1 (AFB1) is a toxic compound commonly found as a contaminant in human food. It is carcinogenic due its potential in inducing the oxidative stress and distortion of the most antioxidant enzymes. Since black tea possesses strong antioxidant activity, it protects cells and tissues against oxidative stress. Cur...

journal_title：Toxicology and industrial health

authors： Alm-Eldeen AA,Mona MH,Shati AA,El-Mekkawy HI

更新日期：2015-12-01 00:00:00

abstract：:Despite large-scale anti-smoking campaigns throughout the world, the number of smokers remains high and cigarette smoking continues to represent a life-threatening health risk. Until a smoke-free society is achieved, reduction of cigarette smoke toxins may reduce the health burden. Current cigarette filter techniques ...

journal_title：Toxicology and industrial health

authors： Zhang D,Tao Y,Gao J,Zhang C,Wan S,Chen Y,Huang X,Sun X,Duan S,Schönlau F,Rohdewald P,Zhao B

更新日期：2002-06-01 00:00:00

abstract：:The aim of the present study was to assess and compare the individual adverse effects of bisphenol A (BPA) and octylphenol (OP) on the reproductive system of prepubertal male rats. Rats were exposed to BPA and OP at doses of 125 and 250 mg/kg/day, by gavage, for 90 days. At the end of the study, the testes, epididymis...

journal_title：Toxicology and industrial health

authors： Ahbab MA,Barlas N,Karabulut G

更新日期：2017-02-01 00:00:00

abstract：:The objective is to present historical asbestos airborne concentrations associated with activities involving presumably asbestos-containing materials in steel mills. A total of 138 historical industrial hygiene air samples collected in three US steel mills from 1972 to 1982 were analyzed. The majority of samples were ...

journal_title：Toxicology and industrial health

authors： Hollins D,Burns A,Unice K,Paustenbach DJ

更新日期：2019-11-01 00:00:00

abstract：:In this study, the cytotoxic potential of fluoride and endosulfan in combination was investigated in Swiss albino mice bone marrow cells using the chromosomal aberration (CA) and micronucleus (MN) test systems. Fluoride (25.1 mg kg-1 body weight [bw] in water) and endosulfan (1.8 mg kg-1 bw by oral intubation) were ad...

journal_title：Toxicology and industrial health

authors： Sharma A,John P,Bhatnagar P

更新日期：2020-12-16 00:00:00

abstract：:This study was designed to determine if long-term exposure to high doses of methoxychlor (M) would alter pituitary or testicular endocrine functions in either an estrogenic or antiandrogenic manner. Weanling male Long-Evans hooded rats were dosed daily with M (po) at 0, 200, 300, or 400 mg kg-1 day-1 for 10 months. Me...

journal_title：Toxicology and industrial health

authors： Gray LE Jr,Ostby J,Cooper RL,Kelce WR

更新日期：1999-01-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AHR) is one of the principal xenobiotic, nuclear receptor that is responsible for the early events involved in the transcription of a complex set of genes comprising the CYP450 gene family. In the present computational study, homology modelling and molecular docking were carried out with...

journal_title：Toxicology and industrial health

authors： Panda R,Cleave AS,Suresh PK

更新日期：2014-09-01 00:00:00

abstract：:The distribution of [14C]-malathion, an organophosphorus pesticide, in rats after intravenous, oral and dermal administration was carried out using electronic autoradiography of whole body sections of treated animals. The study indicated that a major difference in the disposition of [14C]-malathion occurred following ...

journal_title：Toxicology and industrial health

authors： Saleh MA,Ahmed AE,Kamel A,Dary C

更新日期：1997-11-01 00:00:00

abstract：:The anti-genotoxic potential of hydrated sodium calcium aluminosilicate (HSCAS) was investigated using sister chromatid exchanges (SCEs) induced by aflatoxin B1 (AFB1) as genotoxic endpoint in human lymphocytes. Whole blood samples from two healthy male donors were used for this experiment and the effects of different...

journal_title：Toxicology and industrial health

authors： Türkez H,Sişman T

更新日期：2007-03-01 00:00:00

abstract：:Metalworking fluids (MWFs) are complex formulations designed for effective lubricating, cooling, and cleaning tools and parts during machining operations. Adverse health effects such as respiratory symptoms, dermatitis, and cancer have been reported in workers exposed to MWFs. Several constituents of MWFs have been im...

journal_title：Toxicology and industrial health

authors： Ryan KR,Cesta MF,Herbert R,Brix A,Cora M,Witt K,Kissling G,Morgan DL

更新日期：2017-05-01 00:00:00

abstract：:The US EPA and the California Air Resources Board studied the exposures of 51 residents of Los Angeles, CA to 25 volatile organic chemicals in air and drinking water in February and July of 1987. Participants carried a personal air monitor consisting of a Tenax cartridge and a small sampling pump for two consecutive 1...

journal_title：Toxicology and industrial health

authors： Wallace LA

更新日期：1991-09-01 00:00:00

abstract：:Forty-five deaths from mesothelioma have occurred among production workers in an asbestos-cement factory. This analysis examines the fit of the cubic residence time model to the incidence of mesothelioma using a case-control method proposed by de Klerk and colleagues. The cubic residence time model was found to provid...

journal_title：Toxicology and industrial health

authors： Finkelstein MM

更新日期：1990-12-01 00:00:00

abstract：:The goal of this study was to explore the impact of 2-deoxglucose or malonate individually or in combination on the level of cell energy (adenosine-5'-triphosphate) and oxidative stress in 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary proliferation in rats. A total of 60 adult female Sprague Dawley rats were r...

journal_title：Toxicology and industrial health

authors： Moselhy SS,Kumosani TA,Al-Malki AL,Naif AA

更新日期：2015-04-01 00:00:00

abstract：:Paraphenylene diamine (PPD) hair dye poisoning is a common health problem in the Middle East and Indian subcontinent. It is the most common cause of suicide intent especially among females. We hereby present a 27-year-old female who presented with a clinical feature of PPD poisoning due to a suicidal attempt, and she ...

journal_title：Toxicology and industrial health

authors： Abdelraheem MB,Elbushra M,Ali el-T,Ellidir RA,Bushara AI,Abdelraheem WB,Zijlstra EE

更新日期：2014-09-01 00:00:00

abstract：:Female Macaca fascicularis monkeys were given daily oral doses of 3.0 and 4.25 mg/kg lead, as lead nitrate, prior to breeding, and exposure was maintained throughout gestation and terminated at parturition. No overt signs of lead toxicity were observed in the maternal monkeys. The offspring were tested at 6 to 18 mont...

journal_title：Toxicology and industrial health

authors： Hopper DL,Kernan WJ,Lloyd WE

更新日期：1986-07-01 00:00:00

abstract：:The purpose of this study was to describe for asthmatic subjects the distribution of individual bronchial sensitivity to sulfur dioxide (SO2). Subjects were nonsmoking male asthmatics (n = 27) who were sensitive to inhaled methacholine. None of the subjects used corticosteroids or cromolyn sodium. Oral medications wer...

journal_title：Toxicology and industrial health

authors： Horstman D,Roger LJ,Kehrl H,Hazucha M

更新日期：1986-09-01 00:00:00

abstract：:Several classes of environmental contaminants have been claimed or suggested to possess endocrine-disrupting potency, which may result in reproductive problems and developmental disorders. In this paper the focus is on the multiple and interactive mechanisms of interference of persistent polyhalogenated aromatic hydro...

journal_title：Toxicology and industrial health

authors： Brouwer A,Morse DC,Lans MC,Schuur AG,Murk AJ,Klasson-Wehler E,Bergman A,Visser TJ

更新日期：1998-01-01 00:00:00

abstract：:Chronic exposure to jet fuel has been shown to have adverse effects on human liver function, to cause emotional dysfunction, to cause abnormal electroencephalograms, to cause shortened attention spans, and to decrease sensorimotor speed. Due to the decision by the United States Air Force to implement the widespread us...

journal_title：Toxicology and industrial health

authors： Harris DT,Sakiestewa D,Robledo RF,Witten M

更新日期：1997-09-01 00:00:00