Abstract:
:Polycyclic aromatic hydrocarbons have mutagenic and carcinogenic properties and some of them are classified as probable or possible human carcinogens. Aim of this study was to evaluate the genotoxic risk in workers exposed to diesel exaust. Environmental and biological monitoring exposure to polycyclic aromatic hydrocarbons was carried out on fifty-two workers exposed to diesel exhaust. Urinary 1-hydroxypyrene was employed as a biomarker of internal dose. Significant urinary 1-hydroxypyrene differences between smokers and non-smokers were found. Twenty per cent of urinary 1-hydroxypyrene values exceeded benchmark level for genotoxic effect, while the results of environmental monitoring excluded the existence of exposure to polycyclic aromatic hydrocarbons. In the absence of greater knowledge about the relationship between urinary 1-hydroxypyrene and genotoxic effects under the conditions of very low exposure, extreme caution is recommended when this biomarker of internal dose is employed as an indicator of genotoxic risk.
journal_name
Toxicol Ind Healthjournal_title
Toxicology and industrial healthauthors
Maina G,Manzari M,Palmas A,Passini V,Filon FLdoi
10.1177/0748233707077436subject
Has Abstractpub_date
2007-02-01 00:00:00pages
55-9issue
1eissn
0748-2337issn
1477-0393journal_volume
23pub_type
杂志文章abstract::Cytochrome P450 2E1 (CYP2E1) can be induced by diabetes mellitus, nonalcoholic liver disease, and obesity. This study assessed the protective effects of three sulfur compounds, namely phenethyl isothiocyanate (PEITC), dimethyl trisulfide (DMTS), and sodium thiosulfate (STS), on acrylonitrile (ACN)-induced acute toxici...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233719839847
更新日期:2019-05-01 00:00:00
abstract::Molecular mechanisms in the pathogenesis of silicosis are not fully understood. Exposure to crystalline silica leads to the activation of signaling pathways controlling the production and secretion of inflammatory mediators. Inflammatory cytokines are noted as important candidate genes for fibrotic lung diseases. Cyto...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712445048
更新日期:2013-10-01 00:00:00
abstract::This study was designed to determine if long-term exposure to high doses of methoxychlor (M) would alter pituitary or testicular endocrine functions in either an estrogenic or antiandrogenic manner. Weanling male Long-Evans hooded rats were dosed daily with M (po) at 0, 200, 300, or 400 mg kg-1 day-1 for 10 months. Me...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379901500105
更新日期:1999-01-01 00:00:00
abstract::Two prospective, longitudinal studies-one in North Carolina and one in Michigan-have examined effects of prenatal polychlorinated biphenyl (PCB) exposure on behavioral and cognitive development in infants and children. The Michigan cohort was selected to overrepresent the offspring of women who had eaten relatively la...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379601200315
更新日期:1996-05-01 00:00:00
abstract::Arsenic poisoning is well-known for its innumerable toxic and carcinogenic effects. In vivo data on reproductive toxicity are also known but in vitro data are scant. Presently, we evaluated the in vitro toxic effects of sodium arsenite (NaAsO2) on adult mice testes and epididymal tissues using organ cultures. Testicul...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233719885574
更新日期:2019-10-01 00:00:00
abstract::Enzymes with hydroxylating activity on alkanes have potential application as biotransformation catalysts in chemical and pharmaceutical industry. Genome of Alcanivorax borkumensis, a marine bacterium with hydrocarbon dissimilation activity, contains at least two P450 monooxygenases and two nonheme monooxygenases, AlkB...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233711416953
更新日期:2012-07-01 00:00:00
abstract::Orange B, a pyrazolone dye used to color frankfurter and sausage casings, was given in distilled drinking water to pregnant Osborne-Mendel rats throughout gestation. Assessed on the basis of fluid consumption, the dose levels of 0, 0.05, 0.1, 0.2, and 0.4% corresponded to daily Orange B consumption of 0, 67.5, 129.6, ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379501100402
更新日期:1995-07-01 00:00:00
abstract::In summary, we have described our method of treating phosgene inhalation injury. We have presented two serious cases in detail which demonstrate that survival was associated with aggressive therapy. Several points should be mentioned. The pulmonary edema and resulting fluid and foam production can be so copious as to ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823378500100207
更新日期:1985-10-01 00:00:00
abstract::The Royal Australian Air Force (RAAF) has reported that personnel involved in F-111 fuel tank maintenance were concerned that exposure to a range of chemicals during the period 1977 to mid-1990s was the cause of health problems, including cancer. Particular concern was directed at SR-51, a desealant chemical mixture c...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233709103037
更新日期:2009-02-01 00:00:00
abstract::Hepato-toxicity of cadmium in alloxan induced diabetic rats has been studied by estimating a few enzymes viz serum glutamic oxalacetic transaminase, glutamic pyruvic transaminase, alkaline phosphatase and gamma-glutamyltranspeptidase. Present results suggest that cadmium manifests different effects in normal and diabe...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379801400306
更新日期:1998-05-01 00:00:00
abstract::The Norplant* system is composed of a set of six Silastic* (silicone polydimethysiloxane) capsules measuring 34 mm by 2.4 mm, each containing 36 mg of levonorgestrel and sealed at either end with a medical grade silicone elastomer adhesive. Levonorgestrel is a synthetic progestin, widely used in combination oral contr...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379501100104
更新日期:1995-01-01 00:00:00
abstract::The aim of this study was to evaluate indoor air quality and factors affecting expired carbon monoxide (CO) levels in a coffeehouse environment. This cross-sectional study was conducted at 16 randomly selected coffeehouses in Duzce, Turkey, during November 2007 to March 2008. A total of 547 people, average age 46.72 ±...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233710383888
更新日期:2011-04-01 00:00:00
abstract::In this study, the cytotoxic potential of fluoride and endosulfan in combination was investigated in Swiss albino mice bone marrow cells using the chromosomal aberration (CA) and micronucleus (MN) test systems. Fluoride (25.1 mg kg-1 body weight [bw] in water) and endosulfan (1.8 mg kg-1 bw by oral intubation) were ad...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233720979423
更新日期:2020-12-16 00:00:00
abstract::Reports about vanadium (V) inhalation toxicity on the hematopoietic system, specifically about coagulation are limited. Therefore, we decided to evaluate the effects of V with a complete blood count and morphologic analysis of platelets on blood smears. CD-1 male mice inhaled V2O5 0.02 M 1 h twice weekly over 12 weeks...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1191/0748233706th250oa
更新日期:2006-04-01 00:00:00
abstract::Young adult CD-1 male mice were housed in individual cages throughout the study. Groups of 10 to 20 mice were given gradually increasing doses of delta-9-tetrahydrocannabinol (THC) at 6.25 to 25 mg/kg i.p., trifluoperazine (TFP) at 6 to 12 mg/kg p.o., phenobarbital sodium (PS) at 20 to 35 mg/kg p.o., morphine sulfate ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823378900500604
更新日期:1989-12-01 00:00:00
abstract::A meta-analysis of epidemiologic studies for textile industry workers was undertaken in an attempt to evaluate whether the cancer risk varies within the textile industry in relation to the job held or the textile fiber used. We combined studies published up until 1990, when an ad hoc IARC Monograph was issued, and tho...
journal_title:Toxicology and industrial health
pub_type: 杂志文章,meta分析
doi:10.1191/0748233702th139rr
更新日期:2002-05-01 00:00:00
abstract::Organophosphate (OP) compounds are the most commonly used pesticide groups and they are commercially used in the market for local and industrial purposes. Paraoxonase 1 (PON1) enzyme plays an important role in biotransformation of OP compounds, which shows toxic effects via inhibiting the acetylcholinesterase (AChE). ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713487246
更新日期:2015-12-01 00:00:00
abstract::Maneb is a dithiocarbamate fungicide that contains manganese. Dithiocarbamates are considered to be chemicals of low toxicity. An experimental group (n = 10) received maneb (obtained from Hoecht-Shering) at a concentration of 250 ppm in distilled water five days a week (treatment time is three weeks). It was orally ad...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233706070851
更新日期:2006-10-01 00:00:00
abstract::The objective is to present historical asbestos airborne concentrations associated with activities involving presumably asbestos-containing materials in steel mills. A total of 138 historical industrial hygiene air samples collected in three US steel mills from 1972 to 1982 were analyzed. The majority of samples were ...
journal_title:Toxicology and industrial health
pub_type: 历史文章,杂志文章
doi:10.1177/0748233719893905
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVE:Polycyclic aromatic hydrocarbons (PAHs) are potent environmental pollutants. Benzo[α]pyrene (B[α]P) is the major compound of PAHs that acts by activating aryl hydrocarbon receptor (AhR) in cells. B[α]P is a known carcinogen and an immunotoxicant; however, its role with regard to nuclear factor of activated T ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233714555153
更新日期:2016-07-01 00:00:00
abstract::In response to reported increased cancer risks among farmers, the Agricultural Health Study (AHS) was designed to examine health outcomes and environmental exposures among farm families in the United States. In the pilot phase of the AHS, food, beverage, air, dermal, dust, surface wipe, and biological specimens (blood...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379801400117
更新日期:1998-01-01 00:00:00
abstract::The purpose of this study was to evaluate the potential influence of occupational ionizing radiation (IR) exposure on health professionals, assessing DNA damage using the comet and micronucleus (MN) assays and analyzing relative risks, correlations, and associated factors between outcomes and socioeconomic and lifesty...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233720932081
更新日期:2020-05-01 00:00:00
abstract::The aim of this study was to investigate the effect of oral cadmium (Cd) intoxication on the antioxidant response and its relationship with essential bioelements like copper (Cu) and zinc (Zn). The experimental group was chronically exposed to Cd daily for 8 weeks via consumption of water containing 15 ppm cadmium chl...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233714566875
更新日期:2016-08-01 00:00:00
abstract::Many episodes of low back pain are disabling, thus making it one of the costly occupational health problem. The proper alignment and lifting operations during drilling process frequently exposed the oil-drilling workers to unusual strain on the spine and thus make them susceptible for developing low back pain. The pre...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712451771
更新日期:2014-02-01 00:00:00
abstract::The aim of this study was to analyze the biochemical alterations in the gills of Venus verrucosa under exposure for 6 days to three doses of lambda-cyhalothrin (λ-cyh) (100, 250, and 500 µg L-1). Malondialdehyde, lipid hydroperoxide, and hydrogen peroxide levels in the gills of treated groups increased. λ-Cyh exposure...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233720961219
更新日期:2020-11-01 00:00:00
abstract::The inhalation toxicity of methanol and toluene was investigated in rats. Young Sprague Dawley rats of both sexes were exposed to vapors of methanol (300 ppm, 3000 ppm), toluene (30 ppm, 300 ppm) or methanol/toluene (300/30 ppm, 300/300 ppm, 3000/30 ppm, and 3000/300 ppm) six hrs per day, five days/week for four weeks...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379401000310
更新日期:1994-05-01 00:00:00
abstract::The effects of different methylmercury (MeHg) forms on the immune system and the hypothalamic pituitary adrenal (HPA) axis were assessed. The lymphocyte response to Concanavalin A (Con A) stimulation, blood levels of interleukin-6 (IL-6), adrenocorticotrophin hormone (ACTH), and corticosterone in the presence of diffe...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379701300105
更新日期:1997-01-01 00:00:00
abstract::Environmental Impact Assessment is essentially a process comprising four elements: identification, prediction, evaluation, and monitoring. Properly conducted EIA studies can identify linkages between injurious events and/or activities and their damaging consequences. This aids in making the risk management decision. T...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379100700541
更新日期:1991-09-01 00:00:00
abstract::Diazinon (DZN) is one of the most widely used insecticides in agricultural pest control. Previous studies have shown that DZN may induce hepatotoxicity. Reactive oxygen species and apoptosis pathways are involved in the toxicity of DZN. Crocin, a constituent of saffron, has hepatoprotective effects due to its antioxid...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713475519
更新日期:2015-04-01 00:00:00
abstract::Pyrrolizidine alkaloid isoline is isolated from the traditional Chinese medicine Ligularia duciformis. Our previous reports have already demonstrated isoline-induced liver injury in mice. The present study is designed to observe the involvement of intracellular reduced glutathione (GSH) in isoline-induced cytotoxicity...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712442707
更新日期:2013-07-01 00:00:00