Fatty acid profile and antioxidant status in Venus verrucosa gills as λ-cyhalothrin toxic effects.

Abstract:

:The aim of this study was to analyze the biochemical alterations in the gills of Venus verrucosa under exposure for 6 days to three doses of lambda-cyhalothrin (λ-cyh) (100, 250, and 500 µg L-1). Malondialdehyde, lipid hydroperoxide, and hydrogen peroxide levels in the gills of treated groups increased. λ-Cyh exposure significantly increased the protein carbonyl and reduced glutathione levels in the gills of all treated groups. Moreover, the activities of superoxide dismutase and glutathione peroxidase were increased. In our study, the polyunsaturated fatty acid (FA), omega-6, eicosapentaenoic acid (C20:5n-3), and docosahexaenoic acid (C22:6n-3) were increased in the treated groups. A significant decrease in the saturated FAs, omega-3, and arachidonic acid (C20:4n-6) levels was observed. The content of monounsaturated FA was changed in the groups treated with 100 and 250 µg L-1 of λ-cyh. As a corollary, desaturase and elongase activities were significantly increased. Our study provides evidence of the underlying toxic mechanism of λ-cyh and its capacity to create oxidative stress and revealed that FA profiling is a new approach for elucidating the λ-cyh toxicity.

journal_name

Toxicol Ind Health

authors

Fouzai C,Trabelsi W,Rabeh I,Bejaoui S,Telahigue K,El Cafsi M,Soudani N

doi

10.1177/0748233720961219

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

898-907

issue

11

eissn

0748-2337

issn

1477-0393

journal_volume

36

pub_type

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