Multi-route exposure assessment and biological monitoring of urban pesticide applicators during structural control treatments with chlorpyrifos.

Abstract:

:A preliminary study of dermal and respiratory exposure to chlorpyrifos (Dursban TC) during structural treatments was conducted with eight workers from a commercial pest control company. The compound was applied by sub-slab and soil injection to four houses, with each application involving two workers. Crawl space applications were included in three of the jobs. Field sampling extended over the entire workday, and included personal air samples and dermal exposure evaluation with patches and handwashes. A fluorescent tracer was added to the formulation for qualitative determination of skin deposition patterns. Pre-exposure and complete 72 hour urine samples were also collected. Total dermal exposure averaged 5.94 mg/hr. The major contributors were the upper legs (38%) and the forearms (34%). Accidents occurred during two of the four applications observed, and the two workers involved in the accidents were the most highly exposed individuals. The mean estimated absorbed daily dose was 9.5 ug/kg/day, with approximately 73% contributed by the dermal route. Thus, under these work conditions the Threshold Limit Value is not an appropriate guide for worker safety. The principal urinary metabolite of chlorpyrifos, 3,5,6-trichloro-2-pyridinol, was found in measurable quantities in all urine samples. Urinary metabolite levels collected 24-48 hr postexposure were highly correlated (R2 = 0.86) with total absorbed dose estimates. The high variability among individual excretion patterns suggests against the use of urine spot sampling, but longer collections may prove useful in the development of a Biological Exposure Index for chlorpyrifos.

journal_name

Toxicol Ind Health

authors

Fenske RA,Elkner KP

doi

10.1177/074823379000600301

subject

Has Abstract

pub_date

1990-05-01 00:00:00

pages

349-71

issue

3-4

eissn

0748-2337

issn

1477-0393

journal_volume

6

pub_type

杂志文章
  • Cases of organophosphate poisoning treated with high-dose of atropine in an intensive care unit and the novel treatment approaches.

    abstract::Organophosphate poisoning is a life-threatening condition, which is being responsible for the symptoms due to cholinergic effects. Clinical status and blood levels of cholinesterase are used its diagnosis. While atropine and pralidoxime (PAM) appear as essential medications, hemofiltration treatments and lipid solutio...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233712462478

    authors: Karakus A,Celik MM,Karcioglu M,Tuzcu K,Erden ES,Zeren C

    更新日期:2014-06-01 00:00:00

  • Short-term exposure to JP-8 jet fuel results in long-term immunotoxicity.

    abstract::Chronic exposure to jet fuel has been shown to have adverse effects on human liver function, to cause emotional dysfunction, to cause abnormal electroencephalograms, to cause shortened attention spans, and to decrease sensorimotor speed. Due to the decision by the United States Air Force to implement the widespread us...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/074823379701300501

    authors: Harris DT,Sakiestewa D,Robledo RF,Witten M

    更新日期:1997-09-01 00:00:00

  • Review of clinical experience in handling phosgene exposure cases.

    abstract::In summary, we have described our method of treating phosgene inhalation injury. We have presented two serious cases in detail which demonstrate that survival was associated with aggressive therapy. Several points should be mentioned. The pulmonary edema and resulting fluid and foam production can be so copious as to ...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/074823378500100207

    authors: Regan RA

    更新日期:1985-10-01 00:00:00

  • The neurotoxicity of nanoparticles: A bibliometric analysis.

    abstract::The aim of this study was to evaluate the global scientific output of neurotoxicity of nanoparticles (NPs) and explore their hot spots and research trends. Articles about the neurotoxicity of NPs between 2008 and 2017 were taken from the Web of Science Core Collection database. The VOSviewer was used to analyze annual...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233718804973

    authors: Su B,Guan Q,Yu S

    更新日期:2018-12-01 00:00:00

  • In vivo effects of intravenous lipid emulsion on lung tissue in an experimental model of acute malathion intoxication.

    abstract::Malathion can be ingested, inhaled, or absorbed through the skin, but acute toxicity is maximized when administered orally. Intravenous lipid emulsion (ILE) treatment is used as a new therapeutic method in cases of systemic toxicity caused by some lipid soluble agents. This study aimed to examine the potential treatme...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233717748080

    authors: Uysal M,Karaman S

    更新日期:2018-02-01 00:00:00

  • An analysis of workplace exposures to asbestos at three steel mills located in the United States (1972-1982).

    abstract::The objective is to present historical asbestos airborne concentrations associated with activities involving presumably asbestos-containing materials in steel mills. A total of 138 historical industrial hygiene air samples collected in three US steel mills from 1972 to 1982 were analyzed. The majority of samples were ...

    journal_title:Toxicology and industrial health

    pub_type: 历史文章,杂志文章

    doi:10.1177/0748233719893905

    authors: Hollins D,Burns A,Unice K,Paustenbach DJ

    更新日期:2019-11-01 00:00:00

  • Biochemical modulation of cell energy by 2-deoxyglucose and malonate in 7,12-dimethylbenz(a)anthracene-induced carcinogenesis in rats.

    abstract::The goal of this study was to explore the impact of 2-deoxglucose or malonate individually or in combination on the level of cell energy (adenosine-5'-triphosphate) and oxidative stress in 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary proliferation in rats. A total of 60 adult female Sprague Dawley rats were r...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233712472525

    authors: Moselhy SS,Kumosani TA,Al-Malki AL,Naif AA

    更新日期:2015-04-01 00:00:00

  • Health effects from hazardous waste incineration facilities: five case studies.

    abstract::Environmental pollution, primarily from industrialization, has caused significant adverse effects to humans, animals, and the ecosystem. Attempts have been made to reduce and prevent these pollutants through better waste management practices. Incineration is one such practice, which seeks to prevent adverse health imp...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章,评审

    doi:

    authors: Pleus RC,Kelly KE

    更新日期:1996-03-01 00:00:00

  • Recent progress in the eye irritation test.

    abstract::The rabbit eye irritation test based on the Draize method is required for the hazard assessment of chemicals and products that may come into contact with the eye. Due to the potential for the suffering of animals and subjectivity of the test, many modifications of the method have been made that involved a reduction in...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章,评审

    doi:10.1177/074823379300900602

    authors: Chu IH,Toft P

    更新日期:1993-11-01 00:00:00

  • DNA damage as an early biomarker of effect in human health.

    abstract::In the last few decades the need for new approaches to assess DNA damage has been increasing due to the implications that different insults on genetic material may have on human health. In this context, the identification of how chemical agents with different mechanisms of action (i.e., antineoplastic drugs) damage DN...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章,评审

    doi:10.1191/0748233705th224oa

    authors: Mussali-Galante P,Avila-Costa MR,Piñón-Zarate G,Martínez-Levy G,Rodríguez-Lara V,Rojas-Lemus M,Avila-Casado MC,Fortoul TI

    更新日期:2005-09-01 00:00:00

  • Prevention of cytotoxicity of nickel by quercetin: the role of reactive oxygen species and histone acetylation.

    abstract::Excessive exposure to nickel may cause health effects on the blood, lung, nose, kidney, reproductive system, skin and the unborn child. In the present study, we found that Ni²⁺ exposure led to a time- and dose-dependent proliferation arrest and death in human leukemia HL-60 cells. In the presence of 1 mM Ni²⁺, reactiv...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233711433940

    authors: Chen J,Han J,Wang J

    更新日期:2013-05-01 00:00:00

  • Mouse liver tumor data: assessment of carcinogenic activity.

    abstract::Significant numbers of chemicals have been shown to be carcinogenic in mouse liver although they do not exhibit carcinogenic activity in other organs or tissues of mice or rats. This review focuses on the reasons for the unique susceptibility of the mouse liver to these carcinogens and the extent to which the carcinog...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/074823378500100421

    authors: Pereira MA

    更新日期:1985-12-01 00:00:00

  • River pollution in the Kosovo: Cyto- and genotoxic effects of water samples in the primary rat hepatocyte assay.

    abstract::The actual stage of the development of Kosovo is characterized by the concerning levels of environmental pollution and the serious health problems attributed to the emission of pollutants into air, soil and water. In this context, river pollution is one of the main threats due to the discharge of untreated urban and i...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233718773027

    authors: Alija AJ,Bresgen N,Bojaxhi E,Krenn M,Bajraktari ID,Eckl PM

    更新日期:2018-08-01 00:00:00

  • Olfaction and multiple chemical sensitivity.

    abstract::In this paper, a description of olfactory anatomy is presented, followed by a brief review of modern procedures for testing olfactory function. Information from the sole study which has quantitatively examined olfactory function in patients with apparent multiple chemical sensitivity (MCS) is presented. In essence, th...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章,评审

    doi:

    authors: Doty RL

    更新日期:1994-07-01 00:00:00

  • Structure elucidation, protein profile and the antitumor effect of the biological active substance extracted from sea cucumber Holothuria polii.

    abstract::Holothuria polii (Delle Chiaje, 1823) (Holothuriidae) is a sea cucumber inhabiting Mediterranean Sea coast of Egypt. The bioactive compound of its tegument has antifungal, antibacterial and antiparasitic effects. The present study aims to elucidate the structure of the bioactive material of H. polii for pharmacologica...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233712466135

    authors: Omran NE,Khedr AM

    更新日期:2015-01-01 00:00:00

  • Low concentration of mercury induces autophagic cell death in rat hepatocytes.

    abstract::In the present study, we attempted to elucidate the induction of autophagy in rat hepatocytes by a low concentration of mercury. Hepatocytes treated with different doses of mercuric chloride (HgCl2; 1, 2.5, 5 and 10 µM) and at different time intervals (0 min, 30 min, 1 h, 2 h and 4 h) show autophagic cell death only a...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233712462442

    authors: Chatterjee S,Ray A,Mukherjee S,Agarwal S,Kundu R,Bhattacharya S

    更新日期:2014-08-01 00:00:00

  • Effects of co-exposure to lead and zinc on redox status, kidney variables, and histopathology in adult albino rats.

    abstract::Lead (Pb) is a toxic metal that induces a wide range of biochemical and physiological effects in humans. Oxidative damage has been proposed as a possible mechanism involved in Pb toxicity. The current study was carried out to evaluate the antioxidant activities of zinc (Zn) supplement against lead acetate-induced kidn...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233718770293

    authors: Soussi A,Gargouri M,El Feki A

    更新日期:2018-07-01 00:00:00

  • Comparative pulmonary toxicity of inhaled metalworking fluids in rats and mice.

    abstract::Metalworking fluids (MWFs) are complex formulations designed for effective lubricating, cooling, and cleaning tools and parts during machining operations. Adverse health effects such as respiratory symptoms, dermatitis, and cancer have been reported in workers exposed to MWFs. Several constituents of MWFs have been im...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233716653912

    authors: Ryan KR,Cesta MF,Herbert R,Brix A,Cora M,Witt K,Kissling G,Morgan DL

    更新日期:2017-05-01 00:00:00

  • Chemoprotective effect of Vernonia amygdalina Del. (Astereacea) against 2-acetylaminofluorene-induced hepatotoxicity in rats.

    abstract::Natural products possessing antioxidant properties play a very crucial role in ameliorating deleterious effects of reactive oxygen species. This study investigated the chemoprotective properties of methanolic extract of Vernonia amygdalina (MEVA) in an experimental model of hepatic oxidative damage induced by 2-acetyl...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233713498436

    authors: Adesanoye OA,Adekunle AE,Adewale OB,Mbagwu AE,Delima AA,Adefegha SA,Molehin OR,Farombi EO

    更新日期:2016-01-01 00:00:00

  • Evaluation of diazinon-induced hepatotoxicity and protective effects of crocin.

    abstract::Diazinon (DZN) is one of the most widely used insecticides in agricultural pest control. Previous studies have shown that DZN may induce hepatotoxicity. Reactive oxygen species and apoptosis pathways are involved in the toxicity of DZN. Crocin, a constituent of saffron, has hepatoprotective effects due to its antioxid...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233713475519

    authors: Lari P,Abnous K,Imenshahidi M,Rashedinia M,Razavi M,Hosseinzadeh H

    更新日期:2015-04-01 00:00:00

  • Food contaminant acrylamide increases expression of Cox-2 and nitric oxide synthase in breast epithelial cells.

    abstract::Acrylamide has been discovered in foods cooked at high temperature. A potentially harmful effect of this dietary component has been suggested by data indicating its association with increased breast cancer. This study investigated the potential effects of acrylamide in nontumorigenic breast cells by assessing expressi...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233710380217

    authors: Lyn-Cook LE Jr,Tareke E,Word B,Starlard-Davenport A,Lyn-Cook BD,Hammons GJ

    更新日期:2011-02-01 00:00:00

  • Modulating effects of selenium in adrenal medulla of rats exposed to 7,12-dimethylbenz[a]anthracene.

    abstract:OBJECTIVE:The aim of this study was to evaluate the chemopreventive potential of organoselenium compounds (Se I and Se II) in the well-established rat model treated with 7,12-dimethylbenz[a]anthracene (DMBA), by monitoring the extent of tyrosine hydroxylase (TH) activity, adrenomedullin (ADM) level and total RNA level ...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233711432575

    authors: Talas ZS,Ozdemir I,Ates B,Gok Y,Yilmaz I

    更新日期:2013-04-01 00:00:00

  • Bioantioxidants: the systems reliability standpoint.

    abstract::The antioxidant power of the so-called antioxidants is negligible because their rate constants and concentrations are too small to compete with the specialized defense enzymes, like superoxide dismutase (SOD), for the reactive oxygen species. In this short review, we present a number of experimental data of our group,...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章,评审

    doi:10.1177/0748233709103029

    authors: Koltover VK

    更新日期:2009-05-01 00:00:00

  • Removal of cadmium by combining deferasirox and desferrioxamine chelators in rats.

    abstract::An investigation was conducted to evaluate the ability of two chelators, deferasirox and desferrioxamine (DFO), in removing cadmium from biological system. The potential efficiency of those chelators were investigated after cadmium administration for 60 days following two dose levels of 20 and 40 mg/kg body weight dai...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233711403192

    authors: Fatemi SJ,Saljooghi AS,Balooch FD,Iranmanesh M,Golbafan MR

    更新日期:2012-02-01 00:00:00

  • Airway sensitivity of asthmatics to sulfur dioxide.

    abstract::The purpose of this study was to describe for asthmatic subjects the distribution of individual bronchial sensitivity to sulfur dioxide (SO2). Subjects were nonsmoking male asthmatics (n = 27) who were sensitive to inhaled methacholine. None of the subjects used corticosteroids or cromolyn sodium. Oral medications wer...

    journal_title:Toxicology and industrial health

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1177/074823378600200307

    authors: Horstman D,Roger LJ,Kehrl H,Hazucha M

    更新日期:1986-09-01 00:00:00

  • Genotoxic risk in health-care professionals occupationally exposed to low doses of ionizing radiation.

    abstract::The purpose of this study was to evaluate the potential influence of occupational ionizing radiation (IR) exposure on health professionals, assessing DNA damage using the comet and micronucleus (MN) assays and analyzing relative risks, correlations, and associated factors between outcomes and socioeconomic and lifesty...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233720932081

    authors: Silva-Júnior FMRD,Tavella RA,Fernandes CLF,Mortola AS,Peraza GG,Garcia EM

    更新日期:2020-05-01 00:00:00

  • The effect of Plantago major Linnaeus on serum total sialic acid, lipid-bound sialic acid, some trace elements and minerals after administration of 7,12-dimethylbenz(a)anthracene in rats.

    abstract::The present study was designed to evaluate the effect of Plantago major Linnaeus (PM) extract on serum total sialic acid (TSA), lipid-bound sialic acid (LSA), some trace elements (copper (Cu), zinc (Zn) and iron) and mineral levels (magnesium, calcium and sodium) in Wistar albino rat administrated 7,12-dimethylbenz(a)...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233711412422

    authors: Oto G,Ekin S,Ozdemir H,Levent A,Berber I

    更新日期:2012-05-01 00:00:00

  • Association between genotoxic properties of inhalation anesthetics and oxidative stress biomarkers.

    abstract::Exposure to inhalation anesthetics (IAs) has been associated with DNA damage as reflected in the increased frequency of micronuclei (MN) and chromosomal aberrations (CAs). The present study was undertaken to ascertain whether there was any correlation between increased MN and CA and the extent of oxidative stress as w...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233720935696

    authors: Neghab M,Kargar-Shouroki F,Mozdarani H,Yousefinejad S,Alipour H,Fardid R

    更新日期:2020-06-01 00:00:00

  • Inhalation toxicity study of methanol, toluene, and methanol/toluene mixtures in rats: effects of 28-day exposure.

    abstract::The inhalation toxicity of methanol and toluene was investigated in rats. Young Sprague Dawley rats of both sexes were exposed to vapors of methanol (300 ppm, 3000 ppm), toluene (30 ppm, 300 ppm) or methanol/toluene (300/30 ppm, 300/300 ppm, 3000/30 ppm, and 3000/300 ppm) six hrs per day, five days/week for four weeks...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/074823379401000310

    authors: Poon R,Chu I,Bjarnason S,Potvin M,Vincent R,Miller RB,Valli VE

    更新日期:1994-05-01 00:00:00

  • Antiapoptotic and proliferative activity of curcumin on ovarian follicles in mice exposed to whole body ionizing radiation.

    abstract::The aim of this study was to evaluate the antiapoptotic and proliferative activity of curcumin (Cur) on the ovarian follicles in mice exposed to whole body ionizing radiation (Rd). The mice were exposed to 8.3 gray whole body Rd, and Cur groups were given as a daily dose of 100 mg/kg of Cur for 10 days (10 days before...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233711425080

    authors: Aktas C,Kanter M,Kocak Z

    更新日期:2012-10-01 00:00:00