Abstract:
:Acrylamide has been discovered in foods cooked at high temperature. A potentially harmful effect of this dietary component has been suggested by data indicating its association with increased breast cancer. This study investigated the potential effects of acrylamide in nontumorigenic breast cells by assessing expression levels of inducible nitric oxide synthase (iNOS) and cycloogenase-2 (Cox-2) and NOS activity, which are known to be early molecular changes in disease formation. Treatment of cells with acrylamide increased levels of iNOS (both expression and activity) and Cox-2. Its potent metabolite, glycidamide, also induced both iNOS and Cox-2, with induction of iNOS occurring at a lower concentration. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), another food-borne carcinogen, was found to induce Cox-2 expression. Combining acrylamide with PhIP did not result in a further increase. These studies suggest that further research is needed to determine the role of carcinogens formed from cooking foods in inducing early molecular changes associated with breast cancer.
journal_name
Toxicol Ind Healthjournal_title
Toxicology and industrial healthauthors
Lyn-Cook LE Jr,Tareke E,Word B,Starlard-Davenport A,Lyn-Cook BD,Hammons GJdoi
10.1177/0748233710380217subject
Has Abstractpub_date
2011-02-01 00:00:00pages
11-8issue
1eissn
0748-2337issn
1477-0393pii
0748233710380217journal_volume
27pub_type
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