Abstract:
:An investigation was conducted to evaluate the ability of two chelators, deferasirox and desferrioxamine (DFO), in removing cadmium from biological system. The potential efficiency of those chelators were investigated after cadmium administration for 60 days following two dose levels of 20 and 40 mg/kg body weight daily to male rats. However, abnormalities were observed in clinical signs after cadmium administration, such as yellowish discoloration of hair, flaccid and hypotonic muscles, irritability, weakness and loss of weight. The hypothesis that the two chelators might be more efficient as combined therapy than single therapy in removing metal ions from the body was considered. In this way, two known chelators, deferasirox and DFO were chosen and tested in the acute rat model. The chelation therapy results show that deferasirox and DFO are able (?)to remove cadmium ions from the body, while iron concentration returned to the normal level and symptoms are decreased.
journal_name
Toxicol Ind Healthjournal_title
Toxicology and industrial healthauthors
Fatemi SJ,Saljooghi AS,Balooch FD,Iranmanesh M,Golbafan MRdoi
10.1177/0748233711403192subject
Has Abstractpub_date
2012-02-01 00:00:00pages
35-41issue
1eissn
0748-2337issn
1477-0393pii
0748233711403192journal_volume
28pub_type
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