Beneficial influence of topical extra virgin olive oil application on an experimental model of penile fracture in rats.

Abstract:

:Penile fracture (PF) is known as a traumatic rupture of the tunica albuginea of corpus cavernosum. In this study, we aimed to investigate the healing influence of topical extra virgin olive oil (EVOO) on PF through evaluating levels of some oxidative stress biomarkers for the first time. Histopathological evaluation was also realized. A total of 18 male Sprague-Dawley albino rats were divided into three groups of six rats each as control group, in PF (alone) group, and PF + EVOO group. Experimental PF was formed via incising from the proximal dorsal side of the penis in the rats of all groups except control. While in PF (alone) group, fracture was formed and the incision was primarily closed, in PF + EVOO group in addition to foregoing processes, EVOO was also administrated topically twice a day for 3 weeks. At the end of the experiment, all rats were killed and penectomy was carried out. While malondialdehyde, myeloperoxidase, lipid hyroperoxide, and total oxidant status significantly (p < 0.05) increased, reduced glutathione and total free sulfhydryl groups markedly (p < 0.05) decreased in PF (alone) group when compared with PF + EVOO group. Levels of these parameters were reversed to nearly normal values by topical EVOO application. Protection by EVOO is further substantiated via the improved histological findings in PF + EVOO group as against degenerative changes in the rats of PF (alone) group. Our data revealed that EVOO has protective effect in penile cavernosal tissue through probably its antioxidant, free radical defusing, anti-inflammatory, and antimicrobial effects.

journal_name

Toxicol Ind Health

authors

Gunes M,Ozkol H,Pirincci N,Gecit I,Bilici S,Yildirim S

doi

10.1177/0748233713483191

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

704-11

issue

8

eissn

0748-2337

issn

1477-0393

pii

0748233713483191

journal_volume

31

pub_type

杂志文章
  • Fluoride and endosulfan together potentiate cytogenetic effects in Swiss albino mice bone marrow cells.

    abstract::In this study, the cytotoxic potential of fluoride and endosulfan in combination was investigated in Swiss albino mice bone marrow cells using the chromosomal aberration (CA) and micronucleus (MN) test systems. Fluoride (25.1 mg kg-1 body weight [bw] in water) and endosulfan (1.8 mg kg-1 bw by oral intubation) were ad...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233720979423

    authors: Sharma A,John P,Bhatnagar P

    更新日期:2020-12-16 00:00:00

  • Spirometric reference values in the occupational medicine practice.

    abstract:INTRODUCTION:Spirometry is the main pulmonary function test routinely employed in the occupational medicine practice. Its interpretation depends on the choice of the theoretical reference values. Therefore, our objective was to retrospectively evaluate the differences in the spirometric interpretation according to the ...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233720912059

    authors: Cioffi DL,Leso V,Carbone U,Iavicoli I

    更新日期:2020-02-01 00:00:00

  • Metal mixture inhalation (Cd-Pb) and its effects on the bronchiolar epithelium. An ultrastructural approach.

    abstract::The current study explores the effects of the inhalation of lead (Pb), Cd and its mixture (Pb-Cd) in a mice model, analysing metal concentrations in the lung, and the morphological modifications in the bronchiolar epithelium identified by scanning electron microscopy after eight weeks of inhalation. Our results indica...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1191/0748233704th196oa

    authors: Fortoul TI,Avila-Costa MR,Espejel-Maya G,Mussali-Galante P,Avila-Casado Mdel C,Hernández-Serrato MI,Saldivar-Osorio L

    更新日期:2004-06-01 00:00:00

  • In vitro effect of copper on the stromal cells of bone marrow in rats.

    abstract::The effect of copper in form of copper sulphate (CuSO4 x 5 H2O) was studied in the bone marrow cells of rats of Wistar strain in an in vitro culture. Evident differences between tissue cultures of the bone marrow cells were observed between the control and experimental groups. In the experimental group, the CFU-F colo...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/074823378900500617

    authors: Miszta H

    更新日期:1989-12-01 00:00:00

  • The synergistic effect of benzo[a]pyrene and lead on learning and memory of mice.

    abstract::In the present study, the single and combined neurotoxic effects of benzo[a]pyrene ([BaP] 0.0, 0.5, and 5.0 mg/kg body weight; intragastric administration) and lead acetate (0.0, 5.4, and 54.0 mg/L; by drinking water) were examined on KunMing mice. In the Morris water maze, results showed that BaP and lead induced syn...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233711433932

    authors: Youbin Q,Chengzhi C,Yan T,Xuejun J,Chongying Q,Bin P,Baijie T

    更新日期:2013-06-01 00:00:00

  • Morphological changes of ricin toxin-induced apoptosis in human cervical cancer cells.

    abstract::The morphological changes of ricin-induced apoptosis in a human cervical cancer cell line were studied. To shed light on the mechanism of action of ricin toxin (RT) at the cellular level, we examined cell growth, apoptosis, changes of mitochondrial membrane potential (MMP) and cytochrome C translocation in HeLa cells ...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233711414608

    authors: Liao P,Liu W,Li H,Gao H,Wang H,Li N,Xu N,Li J,Wan J,Liu L,Sun Y

    更新日期:2012-06-01 00:00:00

  • Epidemiologic evidence of cancer risk in textile industry workers: a review and update.

    abstract::A meta-analysis of epidemiologic studies for textile industry workers was undertaken in an attempt to evaluate whether the cancer risk varies within the textile industry in relation to the job held or the textile fiber used. We combined studies published up until 1990, when an ad hoc IARC Monograph was issued, and tho...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章,meta分析

    doi:10.1191/0748233702th139rr

    authors: Mastrangelo G,Fedeli U,Fadda E,Milan G,Lange JH

    更新日期:2002-05-01 00:00:00

  • Mercuric chloride induced hepatotoxic and hematologic changes in rats: The protective effects of sodium selenite and vitamin E.

    abstract::This study focuses on investigating the possible protective effect of sodium selenite (Na2SeO3) and/or vitamin E against mercuric chloride (HgCl2)-induced hepatotoxicity in rat. Male rats were given HgCl2 (1 mg/kg body weight (bw)) and HgCl2 plus Na2SeO3 (0.25 mg/kg bw) and/or vitamin E (100 mg/kg bw) daily via gavage...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233715572561

    authors: Uzunhisarcikli M,Aslanturk A,Kalender S,Apaydin FG,Bas H

    更新日期:2016-09-01 00:00:00

  • Protective effect of curcumin on acute lung injury induced by intestinal ischaemia/reperfusion.

    abstract::The aim of this study is to evaluate the role of curcumin on acute lung injury induced by intestinal ischaemia/reperfusion (I/R). A total of 30 male Wistar albino rats were divided into 3 groups: sham, I/R, and I/R + curcumin; each group contains 10 animals. Sham group animals underwent laparotomy without I/R injury. ...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233711430984

    authors: Guzel A,Kanter M,Guzel A,Yucel AF,Erboga M

    更新日期:2013-08-01 00:00:00

  • An epidemiological study of low back pain among oil drilling workers in India.

    abstract::Many episodes of low back pain are disabling, thus making it one of the costly occupational health problem. The proper alignment and lifting operations during drilling process frequently exposed the oil-drilling workers to unusual strain on the spine and thus make them susceptible for developing low back pain. The pre...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233712451771

    authors: Tiwari RR,Saha A

    更新日期:2014-02-01 00:00:00

  • 1-Bromopropane-induced apoptosis in OVCAR-3 cells via oxidative stress and inactivation of Nrf2.

    abstract::The bromoalkane, 1-bromopropane (1-BP), may damage the reproductive system though oxidative stress, while the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) plays an important role in regulating intracellular antioxidant levels against oxidative stress. This study explored the role of oxidativ...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233720979427

    authors: Yang G,Xiang Y,Zhou W,Zhong X,Zhang Y,Lin D,Huang X

    更新日期:2020-12-11 00:00:00

  • The New York Angler Cohort Study: exposure characterization and reproductive and developmental health.

    abstract::The New York State Angler Study will evaluate the association between past and current consumption of contaminated fish from Lake Ontario and both short- and long-term health effects in a population-based cohort. It will measure fish consumption and reproductive and developmental health among 10,518 male anglers and 6...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/074823379601200305

    authors: Vena JE,Buck GM,Kostyniak P,Mendola P,Fitzgerald E,Sever L,Freudenheim J,Greizerstein H,Zielezny M,McReynolds J,Olson J

    更新日期:1996-05-01 00:00:00

  • Telomere length, telomerase expression, and oxidative stress in lead smelters.

    abstract::The negative health effects caused by lead (Pb) exposure are widely recognized; however, the molecular mechanisms remain unknown. The aim of this study was to assess the effect of occupational Pb exposure on telomere length and to investigate the potential mechanisms leading to telomere shortening. A cohort of 334 mal...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233715601758

    authors: Pawlas N,Płachetka A,Kozłowska A,Mikołajczyk A,Kasperczyk A,Dobrakowski M,Kasperczyk S

    更新日期:2016-12-01 00:00:00

  • Thrombocytosis induced in mice after subacute and subchronic V2O5 inhalation.

    abstract::Reports about vanadium (V) inhalation toxicity on the hematopoietic system, specifically about coagulation are limited. Therefore, we decided to evaluate the effects of V with a complete blood count and morphologic analysis of platelets on blood smears. CD-1 male mice inhaled V2O5 0.02 M 1 h twice weekly over 12 weeks...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1191/0748233706th250oa

    authors: González-Villalva A,Fortoul TI,Avila-Costa MR,Piñón-Zarate G,Rodriguez-Laraa V,Martínez-Levy G,Rojas-Lemus M,Bizarro-Nevarez P,Díaz-Bech P,Mussali-Galante P,Colin-Barenque L

    更新日期:2006-04-01 00:00:00

  • Health effects from hazardous waste incineration facilities: five case studies.

    abstract::Environmental pollution, primarily from industrialization, has caused significant adverse effects to humans, animals, and the ecosystem. Attempts have been made to reduce and prevent these pollutants through better waste management practices. Incineration is one such practice, which seeks to prevent adverse health imp...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章,评审

    doi:

    authors: Pleus RC,Kelly KE

    更新日期:1996-03-01 00:00:00

  • Multi-route exposure assessment and biological monitoring of urban pesticide applicators during structural control treatments with chlorpyrifos.

    abstract::A preliminary study of dermal and respiratory exposure to chlorpyrifos (Dursban TC) during structural treatments was conducted with eight workers from a commercial pest control company. The compound was applied by sub-slab and soil injection to four houses, with each application involving two workers. Crawl space appl...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/074823379000600301

    authors: Fenske RA,Elkner KP

    更新日期:1990-05-01 00:00:00

  • Blood chromium levels of children working in gem-polishing industries in India.

    abstract::The gem-polishing industry in Jaipur, India employs a substantial proportion of children. The process of polishing may result in exposure to chromium in working children. Thus, this study aims to find out the levels of chromium in these working children and the associated factors. Blood samples were analysed for chrom...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233711409483

    authors: Tiwari RR,Saha A,Sathwara NG,Parikh JR

    更新日期:2012-03-01 00:00:00

  • Sub-chronic palladium nanoparticle effects on the endocrine reproductive system of female Wistar rats: Preliminary data.

    abstract::The technologically interesting properties of palladium nanoparticles (Pd-NPs) allowed their widespread industrial application, although concerns emerged on increasing general and occupational levels of exposure. In this context, to assess the toxicological behavior of Pd-NPs, and particularly their endocrine disrupti...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233719851702

    authors: Leso V,Fontana L,Marinaccio A,Leopold K,Fanali C,Lucchetti D,Sgambato A,Iavicoli I

    更新日期:2019-06-01 00:00:00

  • Environmental Impact Assessment as a tool for risk management.

    abstract::Environmental Impact Assessment is essentially a process comprising four elements: identification, prediction, evaluation, and monitoring. Properly conducted EIA studies can identify linkages between injurious events and/or activities and their damaging consequences. This aids in making the risk management decision. T...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/074823379100700541

    authors: Ratanachai C

    更新日期:1991-09-01 00:00:00

  • In vivo effects of intravenous lipid emulsion on lung tissue in an experimental model of acute malathion intoxication.

    abstract::Malathion can be ingested, inhaled, or absorbed through the skin, but acute toxicity is maximized when administered orally. Intravenous lipid emulsion (ILE) treatment is used as a new therapeutic method in cases of systemic toxicity caused by some lipid soluble agents. This study aimed to examine the potential treatme...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233717748080

    authors: Uysal M,Karaman S

    更新日期:2018-02-01 00:00:00

  • Cancer incidence among male military and civil pilots and flight attendants: an analysis on published data.

    abstract::Flight personnel are exposed to cosmic ionizing radiation, chemicals (fuel, jet engine exhausts, cabin air pollutants), electromagnetic fields from cockpit instruments, and disrupted sleep patterns. Only recently has cancer risk among these workers been investigated. With the aim of increasing the precision of risk es...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章,meta分析

    doi:10.1191/0748233705th238oa

    authors: Buja A,Lange JH,Perissinotto E,Rausa G,Grigoletto F,Canova C,Mastrangelo G

    更新日期:2005-11-01 00:00:00

  • Citreoviridin enhances tumor necrosis factor-α-induced adhesion of human umbilical vein endothelial cells.

    abstract::Endothelial adhesion plays an important role in the process of atherosclerosis, which is regulated by endothelial adhesion molecules and chemoattractant molecules. In some areas of China, citreoviridin (CIT) is considered a risk factor for the development of atherosclerosis. Here, we investigated the role of CIT in ad...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233713483194

    authors: Hou H,Zhou R,Jia Q,Li Q,Kang L,Jiao P,Li D,Jiang B

    更新日期:2015-03-01 00:00:00

  • Effects of administration of subtoxic doses of acetaminophen on liver and blood levels of insulin-like growth factor-1 in rats.

    abstract::Acetaminophen (APAP) is widely used in the treatment of pain. Toxic doses of APAP cause acute liver failure, but therapeutic doses are believed to be safe. The purpose of this study is to investigate the effects of administration of subtoxic doses of APAP on liver and blood levels of insulin-like growth factor-1 (IGF-...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233713498439

    authors: Ozdemir D,Aksu I,Baykara B,Ates M,Sisman AR,Kiray M,Buyuk A,Uysal N

    更新日期:2016-01-01 00:00:00

  • Protective effects of vitamin E on aluminium sulphate-induced testicular damage.

    abstract::Male infertility can be caused by environmental factors, genetic defects, physiological and endocrine deficiencies and testicular pathologies. Aluminium (Al) can cause male infertility through a number of mechanisms. The aim of our study was thus to determine whether vitamin E (VitE) has protective effects on Al-induc...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233720919663

    authors: Ulfanov O,Cil N,Adiguzel E

    更新日期:2020-04-01 00:00:00

  • Ascorbic acid improves mitochondrial function in liver of arsenic-treated rat.

    abstract::Arsenic is an ubiquitous and well-documented carcinogenic metalloid. The most common source of arsenic is drinking water. The mechanism of arsenic toxicity in a cell has historically been centered around its inhibitory effects on cellular respiration and mitochondrial injury. Ascorbic acid, a low molecular weight, wat...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233710365694

    authors: Singh S,Rana SV

    更新日期:2010-06-01 00:00:00

  • Food contaminant acrylamide increases expression of Cox-2 and nitric oxide synthase in breast epithelial cells.

    abstract::Acrylamide has been discovered in foods cooked at high temperature. A potentially harmful effect of this dietary component has been suggested by data indicating its association with increased breast cancer. This study investigated the potential effects of acrylamide in nontumorigenic breast cells by assessing expressi...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233710380217

    authors: Lyn-Cook LE Jr,Tareke E,Word B,Starlard-Davenport A,Lyn-Cook BD,Hammons GJ

    更新日期:2011-02-01 00:00:00

  • Studies on fate and toxicity of nanoalumina in male albino rats: Lethality, bioaccumulation and genotoxicity.

    abstract::The purpose of this study is to follow-up the distribution, lethality percentile doses (LDs) and bioaccumulation of aluminium oxide nanoparticles (Al2O3-NPs, average diameter 9.83 ± 1.61 nm) in some tissues of male albino rats, and to evaluate its genotoxicity to the brain tissues, during acute and sublethal experimen...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233713498449

    authors: Morsy GM,El-Ala KS,Ali AA

    更新日期:2016-02-01 00:00:00

  • Chemical-specific health consultation for chromated copper arsenate chemical mixture: port of Djibouti.

    abstract::The Agency for Toxic Substances and Disease Registry (ATSDR) prepared this health consultation to provide support for assessing the public health implications of hazardous chemical exposure, primarily through drinking water, related to releases of chromated copper arsenate (CCA) in the port of Djibouti. CCA from a shi...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233707076810

    authors: Chou S,Colman J,Tylenda C,De Rosa C

    更新日期:2007-05-01 00:00:00

  • Asthma from hair straightening treatment containing formaldehyde: Two cases and a review of the literature.

    abstract::We report two cases of formaldehyde-containing hair straighteners causing new onset asthma. Formaldehyde has been reported to cause asthma in other settings. The purpose of this article is to examine two cases of asthma in hairdressers exposed to hair smoothing products and to review the relevant literature on formald...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233717750982

    authors: Dahlgren JG,Talbott PJ

    更新日期:2018-04-01 00:00:00

  • Comparative toxicity of Paraquat herbicide and some plant extracts in Lymnaea natalensis snails.

    abstract::Paraquat has been shown to be a highly toxic compound for humans and animals, and many cases of acute poisoning and death have been reported over the past few decades. The present study was undertaken to evaluate comprehensively herbicides (Paraquat) and some plant extracts to biochemical aspects of Lymnaea natalensis...

    journal_title:Toxicology and industrial health

    pub_type: 杂志文章

    doi:10.1177/0748233713498457

    authors: Bakry FA,Eleiwa ME,Taha SA,Ismil SM

    更新日期:2016-01-01 00:00:00