Abstract:
:This study focuses on investigating the possible protective effect of sodium selenite (Na2SeO3) and/or vitamin E against mercuric chloride (HgCl2)-induced hepatotoxicity in rat. Male rats were given HgCl2 (1 mg/kg body weight (bw)) and HgCl2 plus Na2SeO3 (0.25 mg/kg bw) and/or vitamin E (100 mg/kg bw) daily via gavage for 4 weeks. HgCl2-treated groups had significantly higher white blood cell and thrombocyte counts than the control group. Serum activities of alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, γ-glutamyl-transferase, and lactate dehydrogenase significantly increased and serum levels of total protein, albumin, triglyceride, total cholesterol, and low-density lipoprotein cholesterol significantly decreased in the HgCl2-treated groups compared with control group. Malondialdehyde level significantly increased and superoxide dismutase, catalase, and glutathione peroxidase activities decreased in liver tissue of HgCl2-treated rats. Also, HgCl2 exposure resulted in histopathological changes. Supplementation of Na2SeO3 and/or vitamin E provided partial protection in hematological and biochemical parameters that were altered by HgCl2 As a result, Na2SeO3 and/or vitamin E significantly reduced HgCl2-induced hepatotoxicity, but not protected completely.
journal_name
Toxicol Ind Healthjournal_title
Toxicology and industrial healthauthors
Uzunhisarcikli M,Aslanturk A,Kalender S,Apaydin FG,Bas Hdoi
10.1177/0748233715572561subject
Has Abstractpub_date
2016-09-01 00:00:00pages
1651-62issue
9eissn
0748-2337issn
1477-0393pii
0748233715572561journal_volume
32pub_type
杂志文章abstract::The aim of this study was to evaluate indoor air quality and factors affecting expired carbon monoxide (CO) levels in a coffeehouse environment. This cross-sectional study was conducted at 16 randomly selected coffeehouses in Duzce, Turkey, during November 2007 to March 2008. A total of 547 people, average age 46.72 ±...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233710383888
更新日期:2011-04-01 00:00:00
abstract::Lead exposure can damage cells directly by effecting DNA or indirectly by modifying proteins and enzymes. In Bangladesh, many working children are exposed to a very high level of lead during their early life due to their involvement with lead-oriented professions. This imposes a severe threat to the growth and develop...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233717754163
更新日期:2018-04-01 00:00:00
abstract::Malathion can be ingested, inhaled, or absorbed through the skin, but acute toxicity is maximized when administered orally. Intravenous lipid emulsion (ILE) treatment is used as a new therapeutic method in cases of systemic toxicity caused by some lipid soluble agents. This study aimed to examine the potential treatme...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233717748080
更新日期:2018-02-01 00:00:00
abstract::A more complicated pathology was observed in female pigs infected with Mycoplasma hyopneumoniae, when the same were exposed to 20 ppm dietary levels of fumonisin B1 (FB1) starting 14 days before infection for a period of 42 days as was assessed by gross pathology and pathomorphological examinations or computed tomogra...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233714543735
更新日期:2016-06-01 00:00:00
abstract::The effects of trona (Kaun), a food additive, on the redox status of the liver and kidney of male Wistar rats were investigated. A total of 60 male rats (145 ± 2.52 g) were grouped into four: A, B, C and D, where group A (the control) received 1 mL of distilled water orally while those in groups B, C and D (test group...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712469654
更新日期:2015-02-01 00:00:00
abstract::Phthalates are abundantly produced plasticizers, and dibutyl phthalate (DBP) is the most widely used derivative in various consumer products and medical devices. This study was conducted to further explore the potential testicular toxicity of DBP in adult rats and to elucidate the underlying mechanisms. Adult male alb...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233714566877
更新日期:2016-08-01 00:00:00
abstract::We report two cases of formaldehyde-containing hair straighteners causing new onset asthma. Formaldehyde has been reported to cause asthma in other settings. The purpose of this article is to examine two cases of asthma in hairdressers exposed to hair smoothing products and to review the relevant literature on formald...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233717750982
更新日期:2018-04-01 00:00:00
abstract::Sorption of three pesticides on geologic material ranging in organic carbon content from 0.33 to 6.9 g kg-1 was measured in soil columns using a miscible displacement technique. An octanol-water partitioning model was shown to be inappropriate for predicting sorption of the less hydrophobic pesticides on the low organ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823378800400306
更新日期:1988-09-01 00:00:00
abstract::In the recent years, there has been a growing interest in monitoring heavy metal contamination of spices/herbs. Spices and herbs are sources of many bioactive compounds that can improve the tastes of food as well as influence digestion and metabolism processes. In the present study, the levels of some essential and to...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713500822
更新日期:2016-02-01 00:00:00
abstract::Arsenic is an ubiquitous and well-documented carcinogenic metalloid. The most common source of arsenic is drinking water. The mechanism of arsenic toxicity in a cell has historically been centered around its inhibitory effects on cellular respiration and mitochondrial injury. Ascorbic acid, a low molecular weight, wat...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233710365694
更新日期:2010-06-01 00:00:00
abstract::The present study investigates the toxic effects of acrylamide (ACR) administered to rats at two doses on (i) oxidative stress and disruption of pro-oxidant/antioxidant balance in hepatic cells and (ii) its correlation with metallothioneins (MTs) genes expression, DNA damage and histomorphological changes. Treated rat...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233717696613
更新日期:2017-08-01 00:00:00
abstract::Atrazine is a commonly used herbicide that has previously been implicated as an endocrine-disrupting compound. Previous studies have shown that estrogenic endocrine-disrupting compounds affect the development of the heart, cartilage, and bone in zebrafish ( Danio rerio). To determine whether atrazine has effects simil...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233718760419
更新日期:2018-05-01 00:00:00
abstract::Zinc oxide nanoparticles (ZnONP) are manufactured on a large scale and can be found in a variety of consumer products, such as sunscreens, lotions, paints and food additives. Few studies have been carried out on its genotoxic potential and related mechanisms in whole organisms. In the present study, the in vivo genoto...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233715599472
更新日期:2016-12-01 00:00:00
abstract::The morphological changes of ricin-induced apoptosis in a human cervical cancer cell line were studied. To shed light on the mechanism of action of ricin toxin (RT) at the cellular level, we examined cell growth, apoptosis, changes of mitochondrial membrane potential (MMP) and cytochrome C translocation in HeLa cells ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233711414608
更新日期:2012-06-01 00:00:00
abstract::Groups of five male and five female rats were fed diets containing from 0% to 2.5% di(2-ethylhexyl)terephthalate (DEHT) or 1.2% di(2-ethylhexyl)phthalate (DEHP) for 21 days. Feed consumption and body weight gains were collected and, at study termination, animals were examined for alterations in body weight, difference...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823378700300206
更新日期:1987-06-01 00:00:00
abstract::2,4-dinitroanisole (DNAN) is a warhead explosive currently under investigation as a replacement for TNT in melt-cast insensitive munitions. In animal studies, DNAN is a mild ocular and skin irritant with a significant potential for dermal absorption. It is not a dermal sensitizer. Acute and subacute rat inhalation s...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233717719690
更新日期:2018-01-01 00:00:00
abstract::It is well-documented that lead (Pb) toxicity can affect almost all systems in living organisms. It can induce selective autophagy of mitochondria (mitophagy) by triggering reactive oxygen species production. Emerging evidence has suggested that Pb-induced autophagy can also be activated by the endoplasmic reticulum (...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233720971882
更新日期:2020-12-01 00:00:00
abstract::This study demonstrates the detection and dynamics of macrocyclic trichothecene mycotoxin (MTM) tissue loading using a commercially available assay in a goat model. The detection of MTMs has been difficult and complex due to the uncertainty of what tissues to examine and when to sample. Twelve goats (two groups of eac...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233709348275
更新日期:2009-10-01 00:00:00
abstract::Within hours after the terrorist attack on the Pentagon on September 11, 2001, an extensive sampling effort was initiated within the building to include surface wipe sampling for select coplanar polychlorinated biphenyls (PCBs), congeners of polychlorinated dibenzo(p)dioxins and dibenzofurans (dioxins/furans) and lead...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1191/0748233701th106oa
更新日期:2001-06-01 00:00:00
abstract::Silver nanoparticles (Ag NPs) are widely used in nanomedicine, pharmaceutical products, industry and other consumer products owing to their unique physiochemical properties with probable potential risk to human health and the ecosystems. The aim of this work was to investigate the in-life morphological effects, bioche...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233720937201
更新日期:2020-08-01 00:00:00
abstract::The aim of the present study was to assess the influence of curcumin on liver regeneration after partial hepatectomy (PH) in rats. A total of 24 male Sprague Dawley rats were divided into three groups: sham-operated (SH), PH, and PH + curcumin; each group contains eight animals. The rats in curcumin-treated groups wer...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712469658
更新日期:2015-02-01 00:00:00
abstract::Aluminum (Al) is commonly used in industrial processes and drugs and is thought to induce erythrocytes damage via activation of oxidative stress. Recently, bismuth (Bi)-containing drugs are used in the treatment of various diseases. However, uncertain effects of Bi in blood tissue may participate in the therapeutic ef...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233710381894
更新日期:2011-03-01 00:00:00
abstract::Acetaminophen (APAP) is widely used in the treatment of pain. Toxic doses of APAP cause acute liver failure, but therapeutic doses are believed to be safe. The purpose of this study is to investigate the effects of administration of subtoxic doses of APAP on liver and blood levels of insulin-like growth factor-1 (IGF-...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713498439
更新日期:2016-01-01 00:00:00
abstract::The objective of this study was to examine the potential of arsenate to induce cardiomyocyte cell death and to explore the cellular mechanisms of arsenate toxicity. Isolated cardiomyocytes in culture from embryonic chick hearts were treated with a pentavalent arsenic species (H3AsO4) or arsenate. Arsenate produced a s...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233709105593
更新日期:2009-04-01 00:00:00
abstract::Tris(2-chloroethyl)phosphate (TRCP), a flame-retardant plasticizer used in plastics, polymeric foams and synthetic fibers, was studied as part of the National Toxicology Program's class study of phosphate flame-retardants. TRCP was administered at 0, 22, 44, 88, 175 and 350 mg/kg to both sexes of rats and 0, 44, 88, 1...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379000600101
更新日期:1990-01-01 00:00:00
abstract::Most of the mobile phones in Turkey emit 900 MHz radiation which is mainly absorbed by the skin and, to a lesser extent, muscle. The aim of this study was to investigate the effects the 900 MHz electromagnetic irradiation emitted by these devices on the induction of histopathologic changes in skin and the effect of me...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1191/0748233704th207oa
更新日期:2004-09-01 00:00:00
abstract::Despite large-scale anti-smoking campaigns throughout the world, the number of smokers remains high and cigarette smoking continues to represent a life-threatening health risk. Until a smoke-free society is achieved, reduction of cigarette smoke toxins may reduce the health burden. Current cigarette filter techniques ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1191/0748233702th145oa
更新日期:2002-06-01 00:00:00
abstract::Carbendazim is a broad spectrum carbamate fungicide used in the control of various fungal pathogens. Licorice (Glycyrrhiza glabra) is one of the widely used medicinal plants in oriental nations. The present work studied the effect of licorice aqueous extract on carbendazim-induced testicular toxicity in albino rats. A...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712456059
更新日期:2014-04-01 00:00:00
abstract::Elaeagnus angustifolia was analyzed for determination of metals, phytoconstituents, bactericidal, fungicidal and insecticidal effects and to explore its chemical and biological potential. The root, branches, leaves, stem bark and root bark parts of E. angustifolia were found to contain iron, lead, copper, cadmium, zin...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713498459
更新日期:2016-01-01 00:00:00
abstract::Maneb is a dithiocarbamate fungicide that contains manganese. Dithiocarbamates are considered to be chemicals of low toxicity. An experimental group (n = 10) received maneb (obtained from Hoecht-Shering) at a concentration of 250 ppm in distilled water five days a week (treatment time is three weeks). It was orally ad...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233706070851
更新日期:2006-10-01 00:00:00