Abstract:
:Zinc oxide nanoparticles (ZnONP) are manufactured on a large scale and can be found in a variety of consumer products, such as sunscreens, lotions, paints and food additives. Few studies have been carried out on its genotoxic potential and related mechanisms in whole organisms. In the present study, the in vivo genotoxic activity of ZnONP and its bulk form was assayed using the wing-spot test and comet assay in Drosophila melanogaster Additionally, a lipid peroxidation analysis using the thiobarbituric acid assay was also performed. Results obtained with the wing-spot test showed a lack of genotoxic activity of both ZnO forms. However, when both particle sizes were tested in the comet assay using larvae haemocytes, a significant increase in DNA damage was observed for ZnONP treatments but only at the higher dose applied. In addition, the lipid peroxidation assay showed significant malondialdehyde (MDA) induction for both ZnO forms, but the induction of MDA for ZnONP was higher for the ZnO bulk, suggesting that the observed DNA strand breaks could be induced by mediated oxidative stress. The overall data suggest that the potential genotoxicity of ZnONP in Drosophila can be considered weak according to the lack of mutagenic and recombinogenic effects and the induction of primary DNA damage only at high toxic doses of ZnONP. This study is the first assessing the genotoxic and oxidative stress potential of nano and bulk ZnO particles in Drosophila.
journal_name
Toxicol Ind Healthjournal_title
Toxicology and industrial healthauthors
Carmona ER,Inostroza-Blancheteau C,Rubio L,Marcos Rdoi
10.1177/0748233715599472subject
Has Abstractpub_date
2016-12-01 00:00:00pages
1987-2001issue
12eissn
0748-2337issn
1477-0393pii
0748233715599472journal_volume
32pub_type
杂志文章abstract::Environmental pollution, primarily from industrialization, has caused significant adverse effects to humans, animals, and the ecosystem. Attempts have been made to reduce and prevent these pollutants through better waste management practices. Incineration is one such practice, which seeks to prevent adverse health imp...
journal_title:Toxicology and industrial health
pub_type: 杂志文章,评审
doi:
更新日期:1996-03-01 00:00:00
abstract::Glycidyl methacrylate (GMA; CAS no. 106-91-2) is a chemical monomer used in the manufacture of dental resins, can coatings and polymers. GMA has demonstrated toxicity to the ocular, digestive, respiratory and dermal systems. Human exposure occurs mainly in the workplace, but it can also happen through food. Although t...
journal_title:Toxicology and industrial health
pub_type: 信件
doi:10.1177/0748233720957816
更新日期:2020-12-01 00:00:00
abstract::Zinc oxide nanoparticles (ZnO NPs) are produced in high tonnage each year; they are widely used in consumer and industrial products, also now finding applications in bioimaging and drug delivery. In the present study, comparison between ZnO NPs (39 nm) and its bulk/micron form (particle size = 5 µm) on liver function ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233719878970
更新日期:2019-10-01 00:00:00
abstract::Cobalt oxide (Co3O4) nanoparticles have applications in nanomedicine and nanotechnology; therefore, any possible adverse effects require thorough investigation. The present study investigated the effects of Co3O4 nanoparticles on four different cell lines: liver, HepG2 hepatocellular carcinoma cells; lung, A549 lung c...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233717706633
更新日期:2017-08-01 00:00:00
abstract:INTRODUCTION:Spirometry is the main pulmonary function test routinely employed in the occupational medicine practice. Its interpretation depends on the choice of the theoretical reference values. Therefore, our objective was to retrospectively evaluate the differences in the spirometric interpretation according to the ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233720912059
更新日期:2020-02-01 00:00:00
abstract::The US EPA and the California Air Resources Board studied the exposures of 51 residents of Los Angeles, CA to 25 volatile organic chemicals in air and drinking water in February and July of 1987. Participants carried a personal air monitor consisting of a Tenax cartridge and a small sampling pump for two consecutive 1...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379100700523
更新日期:1991-09-01 00:00:00
abstract::Maneb is a dithiocarbamate fungicide that contains manganese. Dithiocarbamates are considered to be chemicals of low toxicity. An experimental group (n = 10) received maneb (obtained from Hoecht-Shering) at a concentration of 250 ppm in distilled water five days a week (treatment time is three weeks). It was orally ad...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233706070851
更新日期:2006-10-01 00:00:00
abstract::The aim of the present study was to assess and compare the individual adverse effects of bisphenol A (BPA) and octylphenol (OP) on the reproductive system of prepubertal male rats. Rats were exposed to BPA and OP at doses of 125 and 250 mg/kg/day, by gavage, for 90 days. At the end of the study, the testes, epididymis...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233715603847
更新日期:2017-02-01 00:00:00
abstract::A meta-analysis of epidemiologic studies for textile industry workers was undertaken in an attempt to evaluate whether the cancer risk varies within the textile industry in relation to the job held or the textile fiber used. We combined studies published up until 1990, when an ad hoc IARC Monograph was issued, and tho...
journal_title:Toxicology and industrial health
pub_type: 杂志文章,meta分析
doi:10.1191/0748233702th139rr
更新日期:2002-05-01 00:00:00
abstract::The goal of this study was to explore the impact of 2-deoxglucose or malonate individually or in combination on the level of cell energy (adenosine-5'-triphosphate) and oxidative stress in 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary proliferation in rats. A total of 60 adult female Sprague Dawley rats were r...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712472525
更新日期:2015-04-01 00:00:00
abstract::Environmental Impact Assessment is essentially a process comprising four elements: identification, prediction, evaluation, and monitoring. Properly conducted EIA studies can identify linkages between injurious events and/or activities and their damaging consequences. This aids in making the risk management decision. T...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379100700541
更新日期:1991-09-01 00:00:00
abstract::Enzymes with hydroxylating activity on alkanes have potential application as biotransformation catalysts in chemical and pharmaceutical industry. Genome of Alcanivorax borkumensis, a marine bacterium with hydrocarbon dissimilation activity, contains at least two P450 monooxygenases and two nonheme monooxygenases, AlkB...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233711416953
更新日期:2012-07-01 00:00:00
abstract::Endothelial adhesion plays an important role in the process of atherosclerosis, which is regulated by endothelial adhesion molecules and chemoattractant molecules. In some areas of China, citreoviridin (CIT) is considered a risk factor for the development of atherosclerosis. Here, we investigated the role of CIT in ad...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713483194
更新日期:2015-03-01 00:00:00
abstract::This study reports on airborne exposure levels and soil concentrations of lead in regard to abatement of a steel structure (water tank). The tank was de-leaded by abrasive sand blasting. The ball of the tank had a lead surface level that exceeded the Environmental Protection Agency (EPA) definition of lead-based paint...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1191/0748233702th127oa
更新日期:2002-02-01 00:00:00
abstract::The present paper summarizes the proposed time-dependent sensitization (TDS) and partial limbic kindling model for illness from low-level chemicals; reviews and critiques prior studies on CNS aspects of multiple chemical sensitivity (MCS); and outlines possible experimental approaches to future studies. TDS is the pro...
journal_title:Toxicology and industrial health
pub_type: 杂志文章,评审
doi:
更新日期:1994-07-01 00:00:00
abstract::Nanomaterials are widely used nowadays in a range of technological and biomedical fields. Graphene as a nanomaterial used in the health-care sector and in workplaces has raised some concerns about its toxicity. This study aimed to evaluate the cytotoxicity of graphene nanoparticles (GNPs) on the A549 epithelial cells ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233718817180
更新日期:2019-01-01 00:00:00
abstract::Hepatocytes that were isolated from 48 hr starved rats and incubated in Krebs-Henseleit bicarbonate buffer containing 10 microM A23187, 10mM l-lactate, 1mM pyruvate and 2mM l-lysine were found to contain 0.064 mumol of inorganic pyrophosphate/g wet wgt cells. Addition of either 20mM acetate or butyrate, which caused t...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823378600200308
更新日期:1986-09-01 00:00:00
abstract::This study was designed to determine if long-term exposure to high doses of methoxychlor (M) would alter pituitary or testicular endocrine functions in either an estrogenic or antiandrogenic manner. Weanling male Long-Evans hooded rats were dosed daily with M (po) at 0, 200, 300, or 400 mg kg-1 day-1 for 10 months. Me...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379901500105
更新日期:1999-01-01 00:00:00
abstract::This experiment is designed to investigate the positive effects of commercial nanosilver compound on blood parameters in experimental aflatoxicosis in broiler chickens. For this, 270 one-day-old broiler chickens were randomly divided into six treatment groups with three replicates. The experimental groups were group A...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712452611
更新日期:2014-03-01 00:00:00
abstract::The technologically interesting properties of palladium nanoparticles (Pd-NPs) allowed their widespread industrial application, although concerns emerged on increasing general and occupational levels of exposure. In this context, to assess the toxicological behavior of Pd-NPs, and particularly their endocrine disrupti...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233719851702
更新日期:2019-06-01 00:00:00
abstract::Despite large-scale anti-smoking campaigns throughout the world, the number of smokers remains high and cigarette smoking continues to represent a life-threatening health risk. Until a smoke-free society is achieved, reduction of cigarette smoke toxins may reduce the health burden. Current cigarette filter techniques ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1191/0748233702th145oa
更新日期:2002-06-01 00:00:00
abstract::The aim of the present study was to provide baseline data on the prevalence of histopathological liver lesions in Acanthopagrus latus under experimental mercury exposure. Experimental study was at seawater recirculatory tanks. Mercury concentrations were determined using a standard cold vapour atomic absorption. Histo...
journal_title:Toxicology and industrial health
pub_type: 杂志文章,收录出版
doi:10.1177/0748233711416951
更新日期:2012-08-01 00:00:00
abstract:STUDY OBJECTIVES:Asbestos bodies (ABs) form as asbestos fibers become coated by a cellular iron- and protein-rich matrix. ABs have been reported in lymph nodes and a few extrapulmonary sites, but no data exist as to their formation outside of the lung. It is not clear whether the AB found in these extrapulmonary areas ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1191/0748233701th090oa
更新日期:2001-02-01 00:00:00
abstract::This study aimed to evaluate the extrapulmonary effects of exposure to cigarette smoke (CS) through the analysis of blood components and histopathological examinations of the trachea and diaphragm muscle (DM) in C57BL/6 mice. Thirty-six animals were exposed to six cigarettes per day for 5 days. The mice were divided i...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233717715187
更新日期:2017-09-01 00:00:00
abstract::Phthalates are abundantly produced plasticizers, and dibutyl phthalate (DBP) is the most widely used derivative in various consumer products and medical devices. This study was conducted to further explore the potential testicular toxicity of DBP in adult rats and to elucidate the underlying mechanisms. Adult male alb...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233714566877
更新日期:2016-08-01 00:00:00
abstract::People live in the mountains distributed across the world and are exposed to reduced inspired oxygen and lower barometric pressure along with other factors that lead to high-altitude diseases. The present study was conducted to examine what extent of marketed medicines used in the management of high-altitude sickness ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233710369125
更新日期:2010-08-01 00:00:00
abstract::Molecular mechanisms in the pathogenesis of silicosis are not fully understood. Exposure to crystalline silica leads to the activation of signaling pathways controlling the production and secretion of inflammatory mediators. Inflammatory cytokines are noted as important candidate genes for fibrotic lung diseases. Cyto...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712445048
更新日期:2013-10-01 00:00:00
abstract::Silver nanoparticles (Ag NPs) are widely used in nanomedicine, pharmaceutical products, industry and other consumer products owing to their unique physiochemical properties with probable potential risk to human health and the ecosystems. The aim of this work was to investigate the in-life morphological effects, bioche...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233720937201
更新日期:2020-08-01 00:00:00
abstract::Most of the mobile phones in Turkey emit 900 MHz radiation which is mainly absorbed by the skin and, to a lesser extent, muscle. The aim of this study was to investigate the effects the 900 MHz electromagnetic irradiation emitted by these devices on the induction of histopathologic changes in skin and the effect of me...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1191/0748233704th207oa
更新日期:2004-09-01 00:00:00
abstract:OBJECTIVES:In this study, biological exposure indicators were used to assess the exposure of workers to cadmium (Cd), lead (Pb), manganese (Mn), and nickel (Ni) in nonferrous metal smelters. METHODS:A total of 273 male participants (178 exposed and 95 nonexposed control group), working in nonferrous metal foundries lo...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233715589262
更新日期:2016-10-01 00:00:00